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1. 发明申请

US20120214729A1 COMPOSITION FOR PREVENTING OR TREATING INFLAMMATION 有权
标题翻译：用于预防或治疗炎症的组合物
公开(公告)号：US20120214729A1
公开(公告)日：2012-08-23
申请号：US13390888
申请日：2010-08-17
申请人： Young Sook Son , Hyung Sook Hong , Do Yeon Kim , Eun Kyung Lee
发明人： Young Sook Son , Hyung Sook Hong , Do Yeon Kim , Eun Kyung Lee
IPC分类号： A61K38/08 , A61P11/06 , A61P19/02 , A61P11/00 , A61P31/14 , A61P1/04 , A61P1/00 , A61P17/02 , A61P25/00 , A61P25/28 , A61P27/02 , A61P17/00 , A61P9/00 , A61P37/00 , A61P37/06 , A61P3/10 , A61P17/14 , A61P17/06 , A61P7/06 , A61P1/16 , A61P13/12 , A61P29/00
CPC分类号： A61K38/08
摘要： The present invention relates to a composition containing Substance P for preventing or treating an inflammation. The composition containing Substance P according to the present invention exhibits the effect of decreasing leukocytes, neutrophils and hematopoietic stem cells in a blood, which are associated with the inflammation, and of increasing anti-inflammatory cytokines, regulatory T-lymphocytes, anti-inflammatory macrophages and the like, thereby terminating inflammatory response at an early stage, and is thus highly effective in preventing and treating the inflammation caused by a non-traumatic, traumatic, infectious or ischemic retinal injury.
摘要翻译：本发明涉及含有用于预防或治疗炎症的物质P的组合物。含有根据本发明的物质P的组合物具有降低血液中与炎症相关的白细胞，嗜中性粒细胞和造血干细胞以及增加抗炎细胞因子，调节性T淋巴细胞，抗炎巨噬细胞的作用从而在早期终止炎症反应，因此在预防和治疗由非创伤性，创伤性，感染性或缺血性视网膜损伤引起的炎症方面非常有效。

2. 发明授权

US08575089B2 Composition for preventing or treating inflammation 有权
标题翻译：用于预防或治疗炎症的组合物
公开(公告)号：US08575089B2
公开(公告)日：2013-11-05
申请号：US13390888
申请日：2010-08-17
申请人： Young Sook Son , Hyun Sook Hong , Do Yeon Kim , Eun Kyung Lee
发明人： Young Sook Son , Hyun Sook Hong , Do Yeon Kim , Eun Kyung Lee
IPC分类号： A61K38/00 , A61P5/00
CPC分类号： A61K38/08
摘要： The present invention relates to a composition containing Substance P for preventing or treating an inflammation. The composition containing Substance P according to the present invention exhibits the effect of decreasing leukocytes, neutrophils and hematopoietic stem cells in a blood, which are associated with the inflammation, and of increasing anti-inflammatory cytokines, regulatory T-lymphocytes, anti-inflammatory macrophages and the like, thereby terminating inflammatory response at an early stage, and is thus highly effective in preventing and treating the inflammation caused by a non-traumatic, traumatic, infectious or ischemic retinal injury.
摘要翻译：本发明涉及含有用于预防或治疗炎症的物质P的组合物。含有根据本发明的物质P的组合物具有降低血液中与炎症相关的白细胞，嗜中性粒细胞和造血干细胞以及增加抗炎细胞因子，调节性T淋巴细胞，抗炎巨噬细胞的作用从而在早期终止炎症反应，因此在预防和治疗由非创伤性，创伤性，感染性或缺血性视网膜损伤引起的炎症方面非常有效。

3. 发明授权

US07846901B2 Method for inhibiting or treating intestinal damage caused by radiotherapy or chemotherapy comprising administering substance-P 有权
标题翻译：用于抑制或治疗由放射治疗或化学疗法引起的肠损伤的方法，包括施用物质-P
公开(公告)号：US07846901B2
公开(公告)日：2010-12-07
申请号：US12245969
申请日：2008-10-06
申请人： Young Sook Son , Do Yeon Kim , Hyun Sook Hong
发明人： Young Sook Son , Do Yeon Kim , Hyun Sook Hong
IPC分类号： A61K38/00 , A61K38/03 , A61K38/08
CPC分类号： A61K38/046
摘要： Disclosed herein are a composition for prevention or treatment of gastrointestinal damage comprising Substance-P as an active ingredient, a use of Substance-P for the preparation of a medicament for prevention or treatment of gastrointestinal damage, and a method for prevention or treatment of gastrointestinal damage comprising administering a therapeutically effective amount of Substance-P to a mammal.
摘要翻译：本文公开了一种用于预防或治疗消化道损伤的组合物，其包含物质-P作为活性成分，使用物质-P用于制备用于预防或治疗胃肠道损伤的药物，以及预防或治疗胃肠道损伤的方法损伤包括向哺乳动物施用治疗有效量的物质-P。

4. 发明授权

US09694034B2 Artificial cartilage containing chondrocytes obtained from costal cartilage and preparation process thereof 有权
公开(公告)号：US09694034B2
公开(公告)日：2017-07-04
申请号：US12159204
申请日：2006-10-31
申请人： Young Sook Son , Jung Sun Lee , Eun Kyung Lee , Jin Yeon Lee
发明人： Young Sook Son , Jung Sun Lee , Eun Kyung Lee , Jin Yeon Lee
IPC分类号： C12N15/86 , A61K35/28 , A61K35/32 , C12N5/077 , C12N5/0775 , A61L27/20 , A61L27/38 , A61K35/12
CPC分类号： A61K35/28 , A61K35/12 , A61K35/32 , A61L27/20 , A61L27/3804 , A61L27/3852 , A61L2430/06 , C12N5/0655 , C12N5/0668 , C12N2501/115 , C08L5/08
摘要： The present invention relates to an artificial cartilage containing mesenchymal stem cell (MSC)-like dedifferentiated cells obtained by passage culturing costal chondrocytes, and a preparation process thereof.

5. 发明申请

US20090228105A1 ARTIFICIAL CARTILAGE CONTAINING CHONDROCYTES OBTAINED FROM COSTAL CARTILAGE AND PREPARATION PROCESS THEREOF 有权
标题翻译：含有从成本中获得的人造丝的人造AGE AGE AGE OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF
公开(公告)号：US20090228105A1
公开(公告)日：2009-09-10
申请号：US12159204
申请日：2006-10-31
申请人： Young Sook Son , Jung Sun Lee , Eun Kyung Lee , Jin Yeon Lee
发明人： Young Sook Son , Jung Sun Lee , Eun Kyung Lee , Jin Yeon Lee
IPC分类号： A61F2/08
CPC分类号： A61K35/28 , A61K35/12 , A61K35/32 , A61L27/20 , A61L27/3804 , A61L27/3852 , A61L2430/06 , C12N5/0655 , C12N5/0668 , C12N2501/115 , C08L5/08
摘要： The present invention relates to an artificial cartilage containing mesenchymal stem cell (MSC)-like dedifferentiated cells obtained by passage culturing costal chondrocytes, and a preparation process thereof.
摘要翻译：本发明涉及通过培养肋软骨细胞获得的含有间充质干细胞（MSC）的去分化细胞的人造软骨及其制备方法。

6. 发明授权

US09078851B2 Composition for preventing or treating a spinal cord injury 有权
标题翻译：用于预防或治疗脊髓损伤的组合物
公开(公告)号：US09078851B2
公开(公告)日：2015-07-14
申请号：US13390892
申请日：2010-08-17
申请人： Young Sook Son , Mei Hua Jiang
发明人： Young Sook Son , Mei Hua Jiang
IPC分类号： A01N37/18 , A61K38/00 , A61K38/10
CPC分类号： A61K38/10
摘要： The present invention relates to a novel use of substance P. The substance P of the present invention exhibits effects of decreasing microglia activity, decreasing proinflammatory cytokines, inhibiting apoptosis, etc. The substance P of the present invention effectively treats degenerative central nervous system diseases or disorders such as a spinal cord injury caused by a traumatic injury (flexion injury, vertical compression injury, hyperextension injury, flexion-rotation injury) and by a non-traumatic injury (vascular dysfunction, arthritis, or degenerative arthritis), Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, depressive disorder, epilepsy, etc.
摘要翻译：本发明涉及物质P的新用途。本发明的物质P具有降低小胶质细胞活性，降低促炎细胞因子，抑制凋亡等作用。本发明的物质P有效治疗退行性中枢神经系统疾病或由创伤性损伤（屈曲损伤，垂直压迫性损伤，过度伸张损伤，屈曲旋转损伤）和非创伤性损伤（血管功能障碍，关节炎或退行性关节炎）引起的脊髓损伤，帕金森氏病，阿尔茨海默病疾病，肌萎缩性侧索硬化，亨廷顿病，抑郁障碍，癫痫等。

7. 发明申请

US20120225821A1 COMPOSITION FOR PREVENTING OR TREATING A SPINAL CORD INJURY 有权
标题翻译：用于预防或治疗脊髓损伤的组合物
公开(公告)号：US20120225821A1
公开(公告)日：2012-09-06
申请号：US13390892
申请日：2010-08-17
申请人： Young Sook Son , Mei Hua Jiang
发明人： Young Sook Son , Mei Hua Jiang
IPC分类号： A61K38/08 , A61P25/28 , C07K7/06 , A61P25/14 , A61P25/24 , A61P25/08 , A61P25/16 , A61P25/00
CPC分类号： A61K38/10
摘要： The present invention relates to a novel use of substance P. The substance P of the present invention exhibits effects of decreasing microglia activity, decreasing proinflammatory cytokines, inhibiting apoptosis, etc. The substance P of the present invention effectively treats degenerative central nervous system diseases or disorders such as a spinal cord injury caused by a traumatic injury (flexion injury, vertical compression injury, hyperextension injury, flexion-rotation injury) and by a non-traumatic injury (vascular dysfunction, arthritis, or degenerative arthritis), Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, depressive disorder, epilepsy, etc.
摘要翻译：本发明涉及物质P的新用途。本发明的物质P具有降低小胶质细胞活性，降低促炎细胞因子，抑制凋亡等作用。本发明的物质P有效治疗退行性中枢神经系统疾病或由创伤性损伤（屈曲损伤，垂直压迫性损伤，过度伸张损伤，屈曲旋转损伤）和非创伤性损伤（血管功能障碍，关节炎或退行性关节炎）引起的脊髓损伤，帕金森氏病，阿尔茨海默病疾病，肌萎缩性侧索硬化，亨廷顿病，抑郁障碍，癫痫等。

8. 发明申请

US20120252040A1 KIT FOR DIAGNOSING PROSTATE CANCER AND DIAGNOSIS METHOD 审中-公开
标题翻译：用于诊断前列腺癌和诊断方法的工具箱
公开(公告)号：US20120252040A1
公开(公告)日：2012-10-04
申请号：US13516460
申请日：2010-11-29
申请人： Kang Jun Yoon , Young Sook Son , Hyun Sook Hong , Hyeongwon Choi
发明人： Kang Jun Yoon , Young Sook Son , Hyun Sook Hong , Hyeongwon Choi
IPC分类号： G01N33/574 , C07K16/40
CPC分类号： G01N33/57434
摘要： The present invention relates to a kit and method for diagnosing prostate cancer, which use an antibody to prostate-specific antigen (PSA) to detect PSA in human urine. More specifically, the invention relates to a kit for diagnosing prostate cancer, which comprises an antibody to PSA and uses human urine as a sample, and to a method for diagnosing prostate cancer, which comprises brining a human urine sample into contact with an antibody to PSA in order to detect PSA in the sample.
摘要翻译：本发明涉及一种用于诊断前列腺癌的试剂盒和方法，其使用前列腺特异性抗原（PSA）的抗体来检测人尿中的PSA。更具体地，本发明涉及用于诊断前列腺癌的试剂盒，其包含PSA的抗体并使用人尿作为样品，以及用于诊断前列腺癌的方法，其包括使人尿样品与抗体接触 PSA以检测样品中的PSA。

9. 发明申请

US20130089529A1 AGENT FOR OSTEOGENESIS USING SUBSTANCE-P AND PREPARATION PROCESS THEREOF 审中-公开
标题翻译：使用物质P及其制备方法进行骨质疏松症的药剂
公开(公告)号：US20130089529A1
公开(公告)日：2013-04-11
申请号：US13703299
申请日：2010-06-11
申请人： Young Sook Son , Eun Ah Lee , Hyun Sook Hong
发明人： Young Sook Son , Eun Ah Lee , Hyun Sook Hong
IPC分类号： A61K35/28
CPC分类号： A61K35/28
摘要： The present invention relates to an agent for osteogenesis containing as an active ingredient mesenchymal stem cells (MSCs) that have been mobilized from bone marrow into blood by administration of Substance-P; and a process of preparing the agent.
摘要翻译：本发明涉及含有作为活性成分的间质干细胞（MSC）的成骨剂，其通过给予物质-P从骨髓移入血液; 以及制备该试剂的方法。

10. 发明申请

US20130078291A1 BIO-ADHESIVE AGENT COMPRISING SURFACE-MODIFIED HYDROXYAPATITE AND USE THEREOF 有权
标题翻译：包含表面改性羟基脂肪酸的生物胶粘剂及其用途
公开(公告)号：US20130078291A1
公开(公告)日：2013-03-28
申请号：US13702852
申请日：2011-11-10
申请人： Young Sook Son , Eun Ah Lee , Seung Woo Nam
发明人： Young Sook Son , Eun Ah Lee , Seung Woo Nam
IPC分类号： A61L24/00
CPC分类号： A61L24/00 , A61L24/02 , A61L27/32 , A61L2400/18
摘要： The present invention relates to a bio-adhesive agent comprising a surface-modified hydroxyapatite and its use. More specifically, the present invention relates to a bio-adhesive agent for the adhesion between bone and bone, bone and tissue, bone and cartilage, or bone and tendon, or for the adhesion of a shield between bones or of an artificial joint, which comprises a surface-modified hydroxyapatite as an active ingredient, wherein the surface-modified hydroxyapatite is characterized in that a certain linker compound is covalently bonded to the surface of the hydroxyapatite; a method for coating the surface of a metal prosthesis using the surface-modified hydroxyapatite; and a metal prosthesis coated with the surface-modified hydroxyapatite obtained by said method.
摘要翻译：本发明涉及包含表面改性羟基磷灰石的生物粘合剂及其用途。更具体地，本发明涉及用于骨与骨，骨和组织，骨和软骨或骨和腱之间的粘附的生物粘合剂，或用于在骨骼或人造关节之间粘合屏蔽物包括表面改性的羟基磷灰石作为活性成分，其中表面改性的羟基磷灰石的特征在于某些连接体化合物与羟基磷灰石的表面共价键合; 使用表面改性羟基磷灰石涂覆金属假体的表面的方法; 以及通过所述方法获得的涂覆有表面改性羟基磷灰石的金属假体。

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