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1. 发明申请

US20120114577A1 Peptide Having Activity of Transforming Growth Factor and Production Method Therefor 有权
标题翻译：具有转化生长因子活性的肽及其生产方法
公开(公告)号：US20120114577A1
公开(公告)日：2012-05-10
申请号：US13264290
申请日：2009-04-14
申请人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Jeong Jin Choi , Jun Young Choi
发明人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Jeong Jin Choi , Jun Young Choi
IPC分类号： A61K8/64 , C07K7/08 , A61K38/08 , A61Q19/02 , A61P19/08 , A61P29/00 , A61P27/02 , A61P35/00 , C07K7/06 , A61P9/10
CPC分类号： A61K8/64 , A61K38/00 , A61Q19/02 , A61Q19/08 , C07K14/495
摘要： The present invention relates to a transforming growth factor-beta (TGF-β)-mimicking peptide containing a particular amino acid sequence and a composition for preventing or treating TGF-β-effective disorders or conditions using the same. The peptide of the present invention may be much higher stability than natural-occurring TGF-β and improve drawbacks caused by high molecular weight of natural-occurring TGF-β. The peptide of this invention can be advantageously applied to treatment or improvement of TGF-β-effective disorders or conditions and have excellent efficacies on skin whitening and wrinkle improvement.
摘要翻译：本发明涉及含有特定氨基酸序列的转化生长因子-β（TGF-β）模拟肽和用于预防或治疗TGF-β1有效性障碍或使用其的病症的组合物。本发明的肽可能比天然存在的TGF- 并改善由高分子量天然存在的TGF-β受体引起的缺陷。本发明的肽可有利地应用于治疗或改善TGF-βB活性障碍或病症，并且具有优异的皮肤美白和皱纹改善的功效。

2. 发明授权

US08691195B2 Peptide having activity of transforming growth factor and production method therefor 有权
标题翻译：具有转化生长因子活性的肽及其制备方法
公开(公告)号：US08691195B2
公开(公告)日：2014-04-08
申请号：US13264290
申请日：2009-04-14
申请人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Jeong Jin Choi , Jun Young Choi
发明人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Jeong Jin Choi , Jun Young Choi
IPC分类号： A61K8/64 , C07K7/08
CPC分类号： A61K8/64 , A61K38/00 , A61Q19/02 , A61Q19/08 , C07K14/495
摘要： The present invention relates to a transforming growth factor-beta (TGF-β)-mimicking peptide containing a particular amino acid sequence and a composition for preventing or treating TGF-β-effective disorders or conditions using the same. The peptide of the present invention may be much higher stability than natural-occurring TGF-β and improve drawbacks caused by high molecular weight of natural-occurring TGF-β. The peptide of this invention can be advantageously applied to treatment or improvement of TGF-β-effective disorders or conditions and have excellent efficacies on skin whitening and wrinkle improvement.
摘要翻译：本发明涉及含有特定氨基酸序列的转化生长因子-β（TGF-β）模拟肽和用于预防或治疗TGF-β1有效性障碍或使用其的病症的组合物。本发明的肽可能比天然存在的TGF- 并改善由高分子量天然存在的TGF-β受体引起的缺陷。本发明的肽可有利地应用于治疗或改善TGF-βB活性障碍或病症，并且具有优异的皮肤美白和皱纹改善的功效。

3. 发明授权

US08729028B2 Noggin-derived peptide and use thereof 有权
标题翻译：来源于肽的肽及其用途
公开(公告)号：US08729028B2
公开(公告)日：2014-05-20
申请号：US13145390
申请日：2009-11-24
申请人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Sang Su Song , Il Hong , Kyoung Mi Cho , Su Mi Kim , Sang Min Han
发明人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Sang Su Song , Il Hong , Kyoung Mi Cho , Su Mi Kim , Sang Min Han
IPC分类号： A61K38/03 , C07K4/00
CPC分类号： C07K14/475 , A61K38/00 , C07K5/1019 , C07K2319/00
摘要： Disclosed are a noggin-derived peptide and a composition containing the same for promoting hair growth, improving skin conditions, providing anti-inflammatory function, or preventing or treating bone diseases. The disclosed noggin-derived peptide performs a function identical or similar to that of natural human noggin and is superior in stability and skin permeability as compared thereto. The composition containing the peptide of the present disclosure as an active ingredient exhibits remarkably superior effects in treating, preventing or improving growth factor-related symptoms, e.g. hair loss, skin conditions or cut, or treating, preventing or improving growth factor overexpression-related symptoms. Therefore, the superior activity and stability of the peptide of the present disclosure are greatly advantageous in application to medicine, quasi-drugs and cosmetics.
摘要翻译：公开了一种头蛋白衍生肽和含有其的组合物，其用于促进毛发生长，改善皮肤状况，提供抗炎功能，或预防或治疗骨骼疾病。所公开的头蛋白衍生肽具有与天然人头蛋白相同或相似的功能，并且与其相比具有优异的稳定性和皮肤渗透性。含有本公开的肽作为活性成分的组合物在治疗，预防或改善生长因子相关症状方面表现出显着的优异效果，例如，脱发，皮肤状况或切割，或治疗，预防或改善生长因子过表达相关症状。因此，本公开的肽的优异的活性和稳定性在应用于医药，准药物和化妆品方面是非常有利的。

4. 发明申请

US20110312884A1 Noggin-Derived Peptide and Use Thereof 有权
标题翻译： Noggin衍生肽及其用途
公开(公告)号：US20110312884A1
公开(公告)日：2011-12-22
申请号：US13145390
申请日：2009-11-24
申请人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Sang Su Song , Il Hong , Kyoung Mi Cho , Su Mi Kim , Sang Min Han
发明人： Young Ji Chung , Young Deug Kim , Eun Mi Kim , Sang Su Song , Il Hong , Kyoung Mi Cho , Su Mi Kim , Sang Min Han
IPC分类号： A61K38/10 , C07K7/08 , A61K38/08 , A61P29/00 , A61K8/64 , A61P19/08 , A61Q19/00 , A61Q19/08 , A61Q7/00 , C07K7/06 , A61P17/00
CPC分类号： C07K14/475 , A61K38/00 , C07K5/1019 , C07K2319/00
摘要： Disclosed are a noggin-derived peptide and a composition containing the same for promoting hair growth, improving skin conditions, providing anti-inflammatory function, or preventing or treating bone diseases. The disclosed noggin-derived peptide performs a function identical or similar to that of natural human noggin and is superior in stability and skin permeability as compared thereto. The composition containing the peptide of the present disclosure as an active ingredient exhibits remarkably superior effects in treating, preventing or improving growth factor-related symptoms, e.g. hair loss, skin conditions or cut, or treating, preventing or improving growth factor overexpression-related symptoms. Therefore, the superior activity and stability of the peptide of the present disclosure are greatly advantageous in application to medicine, quasi-drugs and cosmetics.
摘要翻译：公开了一种头蛋白衍生肽和含有其的组合物，其用于促进毛发生长，改善皮肤状况，提供抗炎功能，或预防或治疗骨骼疾病。所公开的头蛋白衍生肽具有与天然人头蛋白相同或相似的功能，并且与其相比具有优异的稳定性和皮肤渗透性。含有本公开的肽作为活性成分的组合物在治疗，预防或改善生长因子相关症状方面表现出显着的优异效果，例如，脱发，皮肤状况或切割，或治疗，预防或改善生长因子过表达相关症状。因此，本公开的肽的优异的活性和稳定性在应用于医药，准药物和化妆品方面是非常有利的。

5. 发明授权

US08501689B2 Growth factor-mimicking peptides and uses thereof 有权
标题翻译：生长因子模拟肽及其用途
公开(公告)号：US08501689B2
公开(公告)日：2013-08-06
申请号：US12936962
申请日：2009-03-06
申请人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi
发明人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi
IPC分类号： A61K38/18 , A61P17/02 , A61K38/00 , A61K38/08
CPC分类号： C07K14/475 , A61K8/64 , A61K38/00 , A61Q7/02 , A61Q19/00 , A61Q19/02 , A61Q19/06 , C07K14/50
摘要： The present invention relates to a growth factor-mimicking peptide having an activity of the growth factor, and a composition and a method for improving skin conditions or for treating a wound using the same. The growth factor-mimicking peptides of this invention have identical functions or actions to natural-occurring human growth factor, and much better stability and skin penetration potency than natural-occurring growth factor. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding growth factor activities. In addition, excellent activity and stability of the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有生长因子活性的生长因子模拟肽，以及改善皮肤状况的组合物和方法，或使用该方法治疗伤口。本发明的生长因子模拟肽对天然存在的人生长因子具有相同的功能或作用，并且比天然存在的生长因子具有更好的稳定性和皮肤穿透效力。在这些连接中，包含本发明的肽的组合物可以在治疗，预防和改善需要生长因子活性的疾病或病症方面表现出优异的功效。此外，本发明的肽的优异的活性和稳定性可以有利地应用于药物组合物，准药物和化妆品。

6. 发明申请

US20110160131A1 Growth Factor-Mimicking Peptides and Uses Thereof 有权
标题翻译：生长因子模拟肽及其用途
公开(公告)号：US20110160131A1
公开(公告)日：2011-06-30
申请号：US12936962
申请日：2009-03-06
申请人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi
发明人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi
IPC分类号： A61K38/18 , A61K8/64 , A61P17/02 , A61P17/10 , A61Q19/08 , A61P17/14 , A61Q7/00 , A61Q19/00
CPC分类号： C07K14/475 , A61K8/64 , A61K38/00 , A61Q7/02 , A61Q19/00 , A61Q19/02 , A61Q19/06 , C07K14/50
摘要： The present invention relates to a growth factor-mimicking peptide having an activity of the growth factor, and a composition and a method for improving skin conditions or for treating a wound using the same. The growth factor-mimicking peptides of this invention have identical functions or actions to natural-occurring human growth factor, and much better stability and skin penetration potency than natural-occurring growth factor. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding growth factor activities. In addition, excellent activity and stability of the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有生长因子活性的生长因子模拟肽，以及改善皮肤状况或使用其的伤口治疗的组合物和方法。本发明的生长因子模拟肽对天然存在的人生长因子具有相同的功能或作用，并且比天然存在的生长因子具有更好的稳定性和皮肤穿透效力。在这些连接中，包含本发明的肽的组合物可以在治疗，预防和改善需要生长因子活性的疾病或病症方面表现出优异的功效。此外，本发明的肽的优异的活性和稳定性可以有利地应用于药物组合物，准药物和化妆品。

7. 发明授权

US08188049B2 Peptides having activities of epidermal growth factor and its uses 有权
标题翻译：具有表皮生长因子活性的肽及其用途
公开(公告)号：US08188049B2
公开(公告)日：2012-05-29
申请号：US12444874
申请日：2007-10-08
申请人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Sang Su Song
发明人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Sang Su Song
IPC分类号： A61K38/00 , A61K38/04 , A61P17/00 , A61P17/14 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/485 , A61K8/64 , A61K38/00 , A61Q7/00 , A61Q19/00 , A61Q19/08 , Y02P20/55
摘要： The present invention relates to peptides comprising the amino acid sequence represented by the following formula 1 and having the activities of epidermal growth factor and their uses: Cys-Met-Tyr-Ile-Glu-Linker-Arg-Gly-Asp (1) The EGF-mimicking peptides of the present invention possess identical functions or activities to natural-occurring human EGF and are able to promote the generation of autocrine EGF in cells. In addition the peptides of the present invention are much higher stability and skin penetration potency than natural-occurring EGF. Therefore, the composition containing the peptide exhibits excellent treatment and prevention efficacies on diseases or conditions demanding EGF activities, and can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.
摘要翻译：本发明涉及包含由下式1表示的氨基酸序列并具有表皮生长因子活性及其用途的肽：Cys-Met-Tyr-Ile-Glu-Linker-Arg-Gly-Asp（1）本发明的EGF模拟肽对天然存在的人类EGF具有相同的功能或活性，并且能促进细胞中自分泌EGF的产生。此外，本发明的肽比天然存在的EGF具有高得多的稳定性和皮肤穿透效力。因此，含有肽的组合物对于要求EGF活性的疾病或病症表现出优异的治疗和预防功效，并且可以有利地应用于药物组合物，准药物和化妆品。

8. 发明申请

US20100160238A1 TGFP-CAP Peptide and its Uses 有权
标题翻译： TGFP-CAP肽及其用途
公开(公告)号：US20100160238A1
公开(公告)日：2010-06-24
申请号：US12596479
申请日：2007-09-12
申请人： Yong Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Jin Seuk Kim , Sang Su Song , Kyoung Mi Cho
发明人： Yong Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Jin Seuk Kim , Sang Su Song , Kyoung Mi Cho
IPC分类号： C07K14/495 , C07K7/06 , C07K7/08 , A61K38/08 , A61K38/10 , A61K38/16 , A61P37/06 , A61P35/00 , A61P27/06 , A61P19/02 , A61P29/00 , A61P25/28 , A61P17/02 , A61P17/06 , A61P9/10 , A61P1/00
CPC分类号： C07K14/495 , A61K8/64 , A61K38/00 , A61K38/1841 , A61Q19/02 , C07K7/08
摘要： The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-β1 (transforming growth factor-β1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF-β1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF-β1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有衍生自TGF-β1（转化生长因子-β1）的氨基酸序列的GFP-CAP肽和细胞粘附序列，其中衍生自TGF-β1的氨基酸序列由的SEQ ID NO：1的氨基酸序列和TGFP-CAP肽由下式I表示：Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-细胞粘附序列（I）。本发明的TGFP-CAP肽表现出优异的抗血管生成活性。此外，本发明的TGFP-CAP肽有效地防止皮肤中的黑色素产生，从而具有皮肤美白效果。本发明的肽比天然存在的TGF-β1显示出更高的对皮肤的稳定性和渗透性。本发明肽的这种合理的活性和安全性有利地适用于药物，准药物和化妆品。

9. 发明授权

US08969296B2 TGFP-CAP peptide and its uses 有权
标题翻译： TGFP-CAP肽及其用途
公开(公告)号：US08969296B2
公开(公告)日：2015-03-03
申请号：US12596479
申请日：2007-09-12
申请人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Jin Seuk Kim , Sang Su Song , Kyoung Mi Cho
发明人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Jin Seuk Kim , Sang Su Song , Kyoung Mi Cho
IPC分类号： A61K8/64 , C07K7/08 , A61K38/00 , C07K14/495 , A61K38/18 , A61Q19/02
CPC分类号： C07K14/495 , A61K8/64 , A61K38/00 , A61K38/1841 , A61Q19/02 , C07K7/08
摘要： The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-β1 (transforming growth factor-β1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF-β1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF-β1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有衍生自TGF-β1（转化生长因子-β1）的氨基酸序列的GFP-CAP肽和细胞粘附序列，其中衍生自TGF-β1的氨基酸序列由的SEQ ID NO：1的氨基酸序列和TGFP-CAP肽由下式I表示：Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-细胞粘附序列（I）。本发明的TGFP-CAP肽表现出优异的抗血管生成活性。此外，本发明的TGFP-CAP肽有效地防止皮肤中的黑色素产生，从而具有皮肤美白效果。本发明的肽比天然存在的TGF-β1显示出更高的对皮肤的稳定性和渗透性。本发明肽的这种合理的活性和安全性有利地适用于药物，准药物和化妆品。

10. 发明申请

US20100120696A1 Peptides Having Activities of Epidermal Growth Factor and Its Uses 有权
标题翻译：具有表皮生长因子活性的肽及其用途
公开(公告)号：US20100120696A1
公开(公告)日：2010-05-13
申请号：US12444874
申请日：2007-10-08
申请人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Sang Su Song
发明人： Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Sang Su Song
IPC分类号： A61K38/03 , C07K7/00 , A61K8/64 , A61P25/00 , A61P17/02 , A61P7/00 , A61P17/00 , A61Q19/00
CPC分类号： C07K14/485 , A61K8/64 , A61K38/00 , A61Q7/00 , A61Q19/00 , A61Q19/08 , Y02P20/55
摘要： The present invention relates to peptides comprising the amino acid sequence represented by the following formula 1 and having the activities of epidermal growth factor and their uses: Cys-Met-Tyr-Ile-Glu-Linker-Arg-Gly-Asp (1) The EGF-mimicking peptides of the present invention possess identical functions or activities to natural-occurring human EGF and are able to promote the generation of autocrine EGF in cells. In addition the peptides of the present invention are much higher stability and skin penetration potency than natural-occurring EGF. Therefore, the composition containing the peptide exhibits excellent treatment and prevention efficacies on diseases or conditions demanding EGF activities, and can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.
摘要翻译：本发明涉及包含由下式1表示的氨基酸序列并具有表皮生长因子活性及其用途的肽：Cys-Met-Tyr-Ile-Glu-Linker-Arg-Gly-Asp（1）本发明的EGF模拟肽对天然存在的人类EGF具有相同的功能或活性，并且能促进细胞中自分泌EGF的产生。此外，本发明的肽比天然存在的EGF具有高得多的稳定性和皮肤穿透效力。因此，含有肽的组合物对于要求EGF活性的疾病或病症表现出优异的治疗和预防功效，并且可以有利地应用于药物组合物，准药物和化妆品。

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