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1. 发明申请

US20060024396A1 Method of treating diabetes and obesity using carbohydrate absorption inhibitors 审中-公开
标题翻译：使用碳水化合物吸收抑制剂治疗糖尿病和肥胖的方法
公开(公告)号：US20060024396A1
公开(公告)日：2006-02-02
申请号：US10803873
申请日：2004-03-19
申请人： Yotaro Konishi , Michio Aitani , Hiroshi Yamaguchi , Tsutomu Arimura , Tadashi Okada , Hiromichi Murai
发明人： Yotaro Konishi , Michio Aitani , Hiroshi Yamaguchi , Tsutomu Arimura , Tadashi Okada , Hiromichi Murai
IPC分类号： A61K36/30
CPC分类号： C07D493/06 , A61K36/185 , C07D311/62
摘要： This invention provides carbohydrate absorption inhibitor derived from evening primrose seed which is significantly effective to prevent and cure diabetes mellitus and prevent obesity, and the manufacturing method of the same. Carbohydrate absorption inhibitor in this invention is characterized that the effective component is an alcohol extract of evening primrose seed. The aforementioned evening primrose seed is preferably a defatted evening primrose seed. Extracting solvent of the aforementioned evening primrose seed is preferably ethanol, or preferably a 70 to 85% (v/v) aqueous ethanol. Also, this invention is characterized that the carbohydrate absorption inhibitor is an effective component of polyphenol derived from evening primrose seed. The polyphenol is preferably one or more substances selected from among gallic acid, ellagic acid, catechin, pentagalloylglucose, procyanidin, and proantocyanidin. The manufacturing method of the carbohydrate absorption inhibitor in this invention is characterized to be composed of the following processes A to C. Process A: evening primrose is compressed, oil is separated then the compressed cake is obtained. Process B: The aforementioned compressed cake is defatted in fat-soluble organic solvent, and defatted substance is obtained. Process C: The aforementioned defatted substance is extracted by alcohol, and then this extracted liquid is concentrated or evaporated.
摘要翻译：本发明提供了源自月见草种子的碳水化合物吸收抑制剂，其对于预防和治疗糖尿病并预防肥胖有显着的效果及其制造方法。本发明的碳水化合物吸收抑制剂的特征在于有效成分是月见草种子的醇提取物。上述的月见草种子优选是脱脂的月见草种子。上述月见草种子的提取溶剂优选为乙醇，优选70-85％（v / v）乙醇水溶液。此外，本发明的特征在于碳水化合物吸收抑制剂是源自月见草种子的多酚的有效成分。多酚优选为选自没食子酸，鞣花酸，儿茶素，五加酰基葡萄糖，原花青素和原花青素中的一种以上的物质。本发明的碳水化合物吸收抑制剂的制造方法的特征在于以下方法A〜C。方法A：将月见草被压缩，分离油分，得到压缩饼。方法B：将上述压缩饼在脂溶性有机溶剂中脱脂，得到脱脂物质。方法C：将上述脱脂物质用醇萃取，然后将该提取液浓缩或蒸发。

2. 发明授权

US06932990B2 Carbohydrate absorption inhibitor and method for manufacturing the same 失效
标题翻译：碳水化合物吸收抑制剂及其制造方法
公开(公告)号：US06932990B2
公开(公告)日：2005-08-23
申请号：US10343488
申请日：2001-07-26
申请人： Yotaro Konishi , Michio Aitani , Hiroshi Yamaguchi , Tsutomi Arimuba , Tadashi Okada , Hiromichi Murai
发明人： Yotaro Konishi , Michio Aitani , Hiroshi Yamaguchi , Tsutomi Arimuba , Tadashi Okada , Hiromichi Murai
IPC分类号： A61K36/185 , A61P3/04 , A61P3/08 , A61P3/10 , A61P43/00 , C07D311/62 , C07D493/06 , A61K35/78
CPC分类号： C07D493/06 , A61K36/185 , C07D311/62
摘要： This invention provides carbohydrate absorption inhibitor derived from evening primrose seed which is significantly effective to prevent and cure diabetes mellitus and prevent obesity, and the manufacturing method of the same.Carbohydrate absorption inhibitor in this invention is characterized that the effective component is an alcohol extract of evening primrose seed. The aforementioned evening primrose seed is preferably a defatted evening primrose seed. Extracting solvent of the aforementioned evening primrose seed is preferably ethanol, or preferably a 70 to 85% (v/v) aqueous ethanol. Also, this invention is characterized that the carbohydrate absorption inhibitor is an effective component of polyphenol derived from evening primrose seed. The polyphenol is preferably one or more substances selected from among gallic acid, ellagic acid, catechin, pentagalloylglucose, procyanidin, and proantocyanidin. The manufacturing method of the carbohydrate absorption inhibitor in this invention is characterized to be composed of the following processes A to C. Process A: evening primrose is compressed, oil is separated then the compressed cake is obtained. Process B: The aforementioned compressed cake is defatted in fat-soluble organic solvent, and defatted substance is obtained. Process C: The aforementioned defatted substance is extracted by alcohol, and then this extracted liquid is concentrated or evaporated.
摘要翻译：本发明提供了源自月见草种子的碳水化合物吸收抑制剂，其对于预防和治疗糖尿病并预防肥胖有显着的效果及其制造方法。本发明的碳水化合物吸收抑制剂的特征在于有效成分是月见草种子的醇提取物。上述的月见草种子优选是脱脂的月见草种子。上述月见草种子的提取溶剂优选为乙醇，优选70-85％（v / v）乙醇水溶液。此外，本发明的特征在于碳水化合物吸收抑制剂是源自月见草种子的多酚的有效成分。多酚优选为选自没食子酸，鞣花酸，儿茶素，五加酰基葡萄糖，原花青素和原花青素中的一种以上的物质。本发明的碳水化合物吸收抑制剂的制造方法的特征在于以下方法A〜C。方法A：将月见草被压缩，分离油分，得到压缩饼。方法B：将上述压缩饼在脂溶性有机溶剂中脱脂，得到脱脂物质。方法C：将上述脱脂物质用醇萃取，然后将该提取液浓缩或蒸发。

3. 发明授权

US08802164B2 Method for promoting carnitine palmitoyltransferase activity using green coffee bean extract 有权
标题翻译：使用绿咖啡豆提取物促进肉碱棕榈酰转移酶活性的方法
公开(公告)号：US08802164B2
公开(公告)日：2014-08-12
申请号：US13038513
申请日：2011-03-02
申请人： Hiroshi Shimoda , Michio Aitani , Tomoko Sugishita , Tadashi Okada , Hiromichi Murai , Emi Yamada
发明人： Hiroshi Shimoda , Michio Aitani , Tomoko Sugishita , Tadashi Okada , Hiromichi Murai , Emi Yamada
IPC分类号： A61K36/74
CPC分类号： A61Q19/00 , A23F5/02 , A61K8/97 , A61K36/74 , A61Q19/06
摘要： (PROBLEMS) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes. (MEANS FOR SOLVING PROBLEMS) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt/wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia. This dietetic composition is usable as a material for foods, drinks, drugs, or skin preparations for external use.
摘要翻译：（问题）提供源自绿咖啡豆的高度安全的饮食组合，通过该饮食组合可以获得优异的饮食效果，并且有助于预防和治疗诸如糖尿病的生活方式相关疾病。（解决问题的手段）一种饮食组合物，其特征在于，含有脱脂生咖啡豆的极性溶剂提取物作为活性成分。优选上述极性溶剂提取物是通过使用含水乙醇，更优选乙醇浓度为40〜90％（wt / wt）的含水乙醇得到的提取物。优选上述脱脂生咖啡豆是通过用N-己烷萃取生咖啡豆而得到的咖啡豆，从而分离出油性成分。建议将上述饮食组合物与选自沙拉提取物，月见草提取物，芝麻素和藤黄的一种或多种组合物组合。这种饮食组合物可用作食品，饮料，药物或外用皮肤制剂的材料。

4. 发明申请

US20090274777A1 Dietetic composition 审中-公开
标题翻译：饮食组成
公开(公告)号：US20090274777A1
公开(公告)日：2009-11-05
申请号：US10569970
申请日：2004-10-05
申请人： Hiroshi Shimoda , Michio Aitani , Tomoko Sugishita , Tadashi Okada , Hiromichi Murai , Emi Yamada
发明人： Hiroshi Shimoda , Michio Aitani , Tomoko Sugishita , Tadashi Okada , Hiromichi Murai , Emi Yamada
IPC分类号： A61K36/74 , A61P3/04
CPC分类号： A61Q19/00 , A23F5/02 , A61K8/97 , A61K36/74 , A61Q19/06
摘要： (Problems) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes.(Means for Solving Problems) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt/wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia. This dietetic composition is usable as a material for foods, drinks, drugs, or skin preparations for external use.
摘要翻译：（问题）提供源自绿咖啡豆的高度安全的饮食组合，通过该饮食组合可以获得优异的饮食效果，并且有助于预防和治疗诸如糖尿病的生活方式相关疾病。（解决问题的手段）一种饮食组合物，其特征在于，含有脱脂生咖啡豆的极性溶剂提取物作为活性成分。优选上述极性溶剂提取物是通过使用含水乙醇，更优选乙醇浓度为40〜90％（wt / wt）的含水乙醇得到的提取物。优选上述脱脂生咖啡豆是通过用N-己烷萃取生咖啡豆而得到的咖啡豆，从而分离出油性成分。建议将上述饮食组合物与选自沙拉提取物，月见草提取物，芝麻素和藤黄的一种或多种组合物组合。这种饮食组合物可用作食品，饮料，药物或外用皮肤制剂的材料。

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