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1. 发明授权

US06608061B2 Bisaryl compound and medicament for cancer treatment comprising the same 失效
标题翻译：二芳基化合物和包含其的用于癌症治疗的药物
公开(公告)号：US06608061B2
公开(公告)日：2003-08-19
申请号：US09424352
申请日：2000-02-14
申请人： Yoshiyuki Yonetani , Takeshi Takahashi , Yuko Kanda , Tamio Mizukami , Tatsuya Tamaoki , Shun-ichi Ikeda , Masanobu Takashima , Naoki Asanuma , Tadashi Inaba , Hiroshi Takeuchi , Hiroshi Kawamoto , Yoshihisa Tsukada , Masato Satomura , Hiroshi Kitaguchi
发明人： Yoshiyuki Yonetani , Takeshi Takahashi , Yuko Kanda , Tamio Mizukami , Tatsuya Tamaoki , Shun-ichi Ikeda , Masanobu Takashima , Naoki Asanuma , Tadashi Inaba , Hiroshi Takeuchi , Hiroshi Kawamoto , Yoshihisa Tsukada , Masato Satomura , Hiroshi Kitaguchi
IPC分类号： A61K3110
CPC分类号： C07D207/08 , C07C323/16 , C07C323/25 , C07C323/40 , C07D211/58 , C07D211/60 , C07D213/32 , C07D215/06 , C07D233/64 , C07D239/42 , C07D239/58 , C07D251/38 , C07D277/56 , C07D309/38 , C07D317/22 , C07D317/28 , C07D319/06 , C07H5/06 , C07H15/18
摘要： A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar1—S—R1—S—Ar2 wherein R1 represents a nonmetal bridging group; Ar1 and Ar2 independently represent a group selected from the group consisting of an aryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group and said aryl group may have one to three substituents other than hydroxyl group on its ring; and a heteroaryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group, and said heteroaryl group may have one to three substituents other than hydroxyl group on its ring.
摘要翻译：一种用于治疗癌症的药物，其包含由以下通式（I）表示的化合物或其生理学上可接受的盐：其中R1表示非金属桥连基团; Ar 1和Ar 2独立地表示选自以下的基团：在其环上具有1〜3个任选被一价基团取代的羟基的芳基，所述芳基可以在其上具有1-3个除羟基以外的取代基环; 和在其环上具有任选被一价基团取代的一至三个羟基的杂芳基，并且所述杂芳基可以在其环上具有一至三个除羟基以外的取代基。

2. 发明申请

US20120298875A1 Radiation Measurement Apparatus and Method of Measuring Radiation 审中-公开
标题翻译：辐射测量装置和辐射测量方法
公开(公告)号：US20120298875A1
公开(公告)日：2012-11-29
申请号：US13456629
申请日：2012-04-26
申请人： Katsunori UENO , Takahiro Tadokoro , Hiroshi Kitaguchi , Mizuho Tsuyuki , Nobuyuki Ota , Makoto Nagase
发明人： Katsunori UENO , Takahiro Tadokoro , Hiroshi Kitaguchi , Mizuho Tsuyuki , Nobuyuki Ota , Makoto Nagase
IPC分类号： G01T1/36
CPC分类号： G01T1/17
摘要： In a radiation measurement apparatus, an analog pulse signal output from a semiconductor radiation detector is converted to a plurality of digital signals by an analog-to-digital converter for each analog pulse signal. A threshold circuit for inputting these digital signals discriminates digital signals exceeding a threshold value. A digital signal integration circuit integrates the plurality of discriminated digital signals for each analog pulse signal and obtains an integrated value for each analog pulse signal. A spectrum generation circuit for inputting the respective integrated values generates a radiation energy spectrum using the integrated values and accurately performs the quantitative analysis and energy analysis of a radioactive nuclide using the radiation energy spectrum. A quantitative analysis and an energy analysis of a radioactive nuclide can be accurately performed while a time resolution of a radiation detector can be maintained.
摘要翻译：在辐射测量装置中，从半导体辐射检测器输出的模拟脉冲信号通过用于每个模拟脉冲信号的模拟 - 数字转换器转换成多个数字信号。用于输入这些数字信号的阈值电路鉴别超过阈值的数字信号。数字信号积分电路对每个模拟脉冲信号集成多个鉴别数字信号，并获得每个模拟脉冲信号的积分值。用于输入各个积分值的光谱产生电路使用积分值产生辐射能谱，并使用辐射能谱精确地执行放射性核素的定量分析和能量分析。可以准确地进行放射性核素的定量分析和能量分析，同时可以维持放射线检测器的时间分辨率。

3. 发明授权

US08190398B2 Environmental radioactivity measurement system of administration and an analysis method of the radioactivity 有权
标题翻译：环境放射性测量系统和放射性分析方法
公开(公告)号：US08190398B2
公开(公告)日：2012-05-29
申请号：US12193143
申请日：2008-08-18
申请人： Hiroshi Kitaguchi , Takahiro Tadokoro , Akihisa Kaihara
发明人： Hiroshi Kitaguchi , Takahiro Tadokoro , Akihisa Kaihara
IPC分类号： G06F19/00 , G06F17/00
CPC分类号： G01T7/00
摘要： At a worksite of a client, progeny nuclides of radon and thoron are collected into a filter, then making the gross measurement on α-ray amount within an hour from the collection. Next, the filter is sent to an analysis center with information added thereto, such as collection-condition information, gross-measurement information, and sampling-worksite information. At the analysis center, the gross measurement on the filter sent thereto is made again. Also, the radioactive-nuclide analysis is made to perform evaluation of the radioactivity intensity. Moreover, radon amount and thoron amount at the measurement-specimen sampling points-in-time at the worksite are calculated, then reporting the analysis result of the radon and thoron amounts to the client.
摘要翻译：在客户的现场，将氡气和钍气的后代核素收集到过滤器中，然后在收集后一小时内对α射线量进行总体测量。接下来，将过滤器发送到具有添加信息的分析中心，例如收集条件信息，总测量信息和采样站点信息。在分析中心，再次进行发送到其上的滤波器的总测量。此外，进行放射性核素分析以进行放射性强度的评价。此外，计算工地现场测量样本采集点的氡量和钍气量，然后向客户报告氡气和钍气量的分析结果。

4. 发明授权

US07952076B2 Radiation imaging system and nuclear medicine diagnosis instrument therefor 有权
标题翻译：辐射成像系统及其核医学诊断仪器
公开(公告)号：US07952076B2
公开(公告)日：2011-05-31
申请号：US12424104
申请日：2009-04-15
申请人： Katsutoshi Tsuchiya , Tsuneaki Kawaguchi , Yuichi Morimoto , Masatoshi Tanaka , Hiroshi Kitaguchi , Kazuma Yokoi , Takafumi Ishitsu , Naoki Kubo , Nagara Tamaki
发明人： Katsutoshi Tsuchiya , Tsuneaki Kawaguchi , Yuichi Morimoto , Masatoshi Tanaka , Hiroshi Kitaguchi , Kazuma Yokoi , Takafumi Ishitsu , Naoki Kubo , Nagara Tamaki
IPC分类号： G01T1/161
CPC分类号： G01T1/2928
摘要： A radiation imaging system is configured by a collimator 30A including a detector 21 with a discrete detection pixel corresponding with a pixel and a plurality of radiation passages 31 and looks into a plurality of detectors 21 through one radiation passage 31 to set a step width of rotation around a rotation center axis X1 only for an angle θp made by lines provided by connecting a center detector 21 of the radiation passage 31 and the adjacent two detectors 21. In the case of generating a flat plane projection image for one direction, radio-graphing is carried out on a projection image in a plurality of predetermined angle positions (−θp, 0, +θp) in the circumferential direction of the rotation center axis X1 and thereby one plane projection image is obtained.
摘要翻译：辐射成像系统由包括具有与像素对应的离散检测像素和多个辐射通道31的检测器21的准直仪30A配置，并且通过一个辐射通道31查看多个检测器21，以设置旋转的台阶宽度围绕旋转中心轴线X1旋转，仅通过将辐射通道31的中心检测器21与相邻的两个检测器21连接而提供的角度＆amp; p所构成。在生成一个方向的平面投影图像的情况下，在旋转中心轴X1的圆周方向上的多个预定角度位置（ - ＆amp; t; p，0，+＆amp; t; p）中的投影图像上进行一次平面投影图像的拍摄。

5. 发明授权

US07615757B2 Semiconductor radiological detector and semiconductor radiological imaging apparatus 有权
标题翻译：半导体放射性检测器和半导体放射成像装置
公开(公告)号：US07615757B2
公开(公告)日：2009-11-10
申请号：US11705595
申请日：2007-02-13
申请人： Kazuma Yokoi , Hiroshi Kitaguchi , Takafumi Ishitsu , Kensuke Amemiya , Yuuichirou Ueno , Katsutoshi Tsuchiya , Norihito Yanagita , Shinichi Kojima
发明人： Kazuma Yokoi , Hiroshi Kitaguchi , Takafumi Ishitsu , Kensuke Amemiya , Yuuichirou Ueno , Katsutoshi Tsuchiya , Norihito Yanagita , Shinichi Kojima
IPC分类号： G01J1/42 , G01T1/20 , G01T1/00
CPC分类号： G01T1/2018 , G01T1/2928
摘要： The semiconductor radiological detector 1 minimizes a dead space resulting from the draw-out of a signal line from an electrode and which allows a number of semiconductor devices to be densely arranged to improve sensitivity and spatial resolution. The semiconductor radiological detector 1 comprises a semiconductor device 2, an anode 3 attached to one surface of the semiconductor device 2, and a cathode 4 attached to the other surface of the semiconductor device 2. A signal line 5 is provided on the anode 3; the signal line 5 extends straight from the anode 3 and is connected to an X axis wire 12. Another signal line 13 is provided on the cathode 4; the signal line 13 extends straight from the cathode 4 and is connected to a Y axis wire 14.
摘要翻译：半导体放射检测器1使从电极引出的信号线引起的死空间最小化，并且允许多个半导体器件被密集地布置以提高灵敏度和空间分辨率。半导体放射线检测器1包括半导体器件2，安装在半导体器件2的一个表面上的阳极3和附着到半导体器件2的另一个表面的阴极4.信号线5设置在阳极3上; 信号线5从阳极3直线延伸并连接到X轴线12.另一个信号线13设置在阴极4上; 信号线13从阴极4直线延伸并连接到Y轴线14。

6. 发明申请

US20090108208A1 RADIATION DETECTION MODULE, PRINTED CIRCUIT BOARD, AND RADIOLOGICAL IMAGING APPARATUS 有权
标题翻译：辐射检测模块，印刷电路板和放射成像装置
公开(公告)号：US20090108208A1
公开(公告)日：2009-04-30
申请号：US11517437
申请日：2006-09-08
申请人： Norihito Yanagita , Katsutoshi Tsuchiya , Hiroshi Kitaguchi , Kensuke Amemiya , Yuichiro Ueno , Kazuma Yokoi , Ryuji Jinnai
发明人： Norihito Yanagita , Katsutoshi Tsuchiya , Hiroshi Kitaguchi , Kensuke Amemiya , Yuichiro Ueno , Kazuma Yokoi , Ryuji Jinnai
IPC分类号： G01T1/24
CPC分类号： G01T1/2985 , A61B6/037
摘要： There are provided a radiation detection module, a printed circuit board, and a radiological imaging apparatus which make it possible to enhance spatial resolution without increasing channel number, and thereby to perform high-accuracy diagnosis. The radiation detection module includes a plurality of radiation detectors, and a wiring board on which the plurality of radiation detectors are mounted in a manner of being arranged in at least a radiation traveling direction. Here, on the wiring board, a pair of the radiation detectors which are adjacent to each other in the radiation traveling direction are electrically connected to each other, thereby configuring one detector structure (i.e., detection channel). Moreover, the radiation detectors are mounted onto the wiring board such that respective connection parts of electrodes, which are to be electrically connected to each other, are in a mutually-facing state.
摘要翻译：提供了一种辐射检测模块，印刷电路板和放射成像装置，其可以在不增加通道数的情况下增强空间分辨率，从而执行高精度诊断。放射线检测模块包括多个辐射检测器和布置基板，多个辐射检测器以布置在至少一个辐射传播方向上的方式安装在该布线板上。这里，在配线基板上，在辐射行进方向上彼此相邻的一对辐射检测器电连接，从而构成一个检测结构（即，检测通道）。此外，辐射检测器被安装到布线板上，使得彼此电连接的电极的相应连接部分处于相互面对的状态。

7. 发明申请

US20090070070A1 ENVIRONMENTAL RADIOACTIVITY MEASUREMENT SYSTEM OF ADMINISTRATION AND AN ANALYSIS METHOD OF THE RADIOACTIVITY 有权
标题翻译：管理的环境放射性测量系统和放射性分析方法
公开(公告)号：US20090070070A1
公开(公告)日：2009-03-12
申请号：US12193143
申请日：2008-08-18
申请人： Hiroshi Kitaguchi , Takahiro Tadokoro , Akihisa Kaihara
发明人： Hiroshi Kitaguchi , Takahiro Tadokoro , Akihisa Kaihara
IPC分类号： G06F15/00
CPC分类号： G01T7/00
摘要： At a worksite of a client, progeny nuclides of radon and thoron are collected into a filter, then making the gross measurement on α-ray amount within an hour from the collection. Next, the filter is sent to an analysis center with information added thereto, such as collection-condition information, gross-measurement information, and sampling-worksite information. At the analysis center, the gross measurement on the filter sent thereto is made again. Also, the radioactive-nuclide analysis is made to perform accurate evaluation of the radioactivity intensity. Moreover, radon amount and thoron amount at the measurement-specimen sampling points-in-time at the worksite are calculated, then reporting the analysis result of the radon and thoron amounts to the client. There are provided an environmental-radioactivity measurement/management system which allows measurement specimens for measuring the environmental radioactivity to be processed at low cost and in large amounts, and the analysis method for the radioactivity intensity.
摘要翻译：在客户的现场，将氡气和钍气的后代核素收集到过滤器中，然后在收集后一小时内对α射线量进行总体测量。接下来，将过滤器发送到具有添加信息的分析中心，例如收集条件信息，总测量信息和采样站点信息。在分析中心，再次进行发送到其上的滤波器的总测量。此外，进行放射性核素分析以对放射性强度进行精确评估。此外，计算工地现场测量样本采集点的氡量和钍气量，然后向客户报告氡气和钍气量的分析结果。提供了一种环境放射性测量/管理系统，其允许以低成本和大量的方式处理用于测量环境放射性的测量样本和放射性强度的分析方法。

8. 发明授权

US07442937B2 Radiation imaging apparatus and nuclear medicine diagnosis apparatus using the same 失效
标题翻译：放射成像装置及其使用的核医学诊断装置
公开(公告)号：US07442937B2
公开(公告)日：2008-10-28
申请号：US11822031
申请日：2007-06-29
申请人： Katsutoshi Tsuchiya , Hiroshi Kitaguchi , Yuichi Morimoto , Shinya Kominami , Kazuma Yokoi , Tsuneaki Kawaguchi , Masatoshi Tanaka , Takafumi Ishitsu
发明人： Katsutoshi Tsuchiya , Hiroshi Kitaguchi , Yuichi Morimoto , Shinya Kominami , Kazuma Yokoi , Tsuneaki Kawaguchi , Masatoshi Tanaka , Takafumi Ishitsu
IPC分类号： G21K1/02
CPC分类号： G01T1/1648 , A61B6/037
摘要： Disclosed herein is a radiation imaging apparatus and radiation-imaging-apparatus-based nuclear medicine diagnosis apparatus having a collimator in which a plurality of rectangular through-holes are arranged in a grid pattern and separated by septa is rotated through a predetermined angle as viewed from above in relation to the layout of a plurality of rectangular detectors that are arranged in a grid pattern. The predetermined angle ranges from 20 to 70 degree and more preferably from 30 deg to 60 deg. With this configuration, the influence of sensitivity variations (moire patterns) that are included in an image picked up due to interference with a collimator when pixel type detectors are used is eliminated.
摘要翻译：本发明公开了一种辐射成像装置和基于放射成像装置的核医学诊断装置，其具有准直仪，其中多个矩形通孔以网格图案排列并且由隔片隔开，从而从其观察时旋转预定角度相对于以网格图案排列的多个矩形检测器的布局。预定角度为20至70度，更优选为30度至60度。利用这种配置，消除了当使用像素型检测器时由于与准直器的干涉而拾取的图像中包括的灵敏度变化（莫尔图案）的影响。

9. 发明申请

US20080137804A1 Radiological imaging apparatus 有权
标题翻译：放射成像装置
公开(公告)号：US20080137804A1
公开(公告)日：2008-06-12
申请号：US11907115
申请日：2007-10-09
申请人： Shinichi Kojima , Takashi Okazaki , Yuuichirou Ueno , Kikuo Umegaki , Kensuke Amemiya , Kazuhiro Takeuchi , Hiroshi Kitaguchi , Kazuma Yokoi , Norihito Yanagita
发明人： Shinichi Kojima , Takashi Okazaki , Yuuichirou Ueno , Kikuo Umegaki , Kensuke Amemiya , Kazuhiro Takeuchi , Hiroshi Kitaguchi , Kazuma Yokoi , Norihito Yanagita
IPC分类号： G01N23/00
CPC分类号： G01T1/1611 , A61B6/037 , A61B6/4241 , A61B6/5235 , G01N23/046 , G01N2223/419 , G01N2223/612 , G01T1/2985 , Y10S378/901
摘要： A radiological imaging apparatus of the present invention comprises an image pickup device and a medical examinee holding device that is provided with a bed. The image pickup device includes a large number of radiation detectors and radiation detector support plates. A large number of radiation detectors are mounted around the circumference of a through-hole and arranged in the axial direction of the through-hole. The radiation detectors are arranged in three layers formed radially with respect to the center of the through-hole and mounted on the lateral surfaces of the radiation detector support plates. Since the radiation detectors are not only arranged in the axial direction and circumferential direction of the through-hole but also arrayed in the radial direction, it is possible to obtain accurate information about a γ-ray arrival position in the radial direction of the through-hole (the positional information about a radiation detector from which a γ-ray image pickup signal is output). The use of accurate information about γ-ray arrival increases the tomogram accuracy. As a result, the present invention enhances the tomogram accuracy, that is, the PET examination accuracy.
摘要翻译：本发明的放射学成像装置包括：图像拾取装置和设有床的医疗检查者保持装置。图像拾取装置包括大量的辐射检测器和辐射检测器支撑板。大量的辐射探测器安装在通孔的圆周周围并沿通孔的轴向布置。辐射检测器被布置成相对于通孔的中心径向形成的三层，并且安装在辐射检测器支撑板的侧表面上。由于辐射检测器不仅沿着通孔的轴向方向和圆周方向布置，而且沿径向排列，可以获得关于通孔的径向方向上的伽马射线到达位置的准确信息，（关于从其输出伽马射线摄像信号的放射线检测器的位置信息）。使用关于伽马射线到达的准确信息增加了断层图像的准确性。结果，本发明增强了断层图像精度，即PET检查精度。

10. 发明授权

US07372035B2 Radiological imaging apparatus 有权
标题翻译：放射成像装置
公开(公告)号：US07372035B2
公开(公告)日：2008-05-13
申请号：US11206738
申请日：2005-08-19
申请人： Kazuma Yokoi , Hiroshi Kitaguchi , Takafumi Ishitsu , Naoyuki Yamada , Kensuke Amemiya , Yuuichirou Ueno , Katsutoshi Tsuchiya , Norihito Yanagita
发明人： Kazuma Yokoi , Hiroshi Kitaguchi , Takafumi Ishitsu , Naoyuki Yamada , Kensuke Amemiya , Yuuichirou Ueno , Katsutoshi Tsuchiya , Norihito Yanagita
IPC分类号： G01T1/24
CPC分类号： G01T1/241 , G01T1/249
摘要： In a radiological imaging apparatus, a radiation detecting section includes semiconductor detectors arranged in four columns and four rows. Each of the semiconductor detectors includes a semiconductor base material, and an anode electrode film (first electrode film) and a cathode electrode film (second electrode film) lying opposite each other so as to sandwich the semiconductor base material between them. A first conductive member is installed on each first electrode film. Second electrode films of four semiconductor detectors within a row are connected together using one second conductive member. A shaping amplifier connected to the first conductive members with a wire executes a waveform shaping process using a shaping time shorter than that of a shaping amplifier connected to the second conductive member with a wire; the first conductive members are provided for the four semiconductor detectors within a column.
摘要翻译：在放射线成像装置中，放射线检测部包括以四列四列排列的半导体检测器。每个半导体检测器包括半导体基底材料，以及彼此相对放置以将半导体基底材料夹在它们之间的阳极电极膜（第一电极膜）和阴极电极膜（第二电极膜）。第一导电构件安装在每个第一电极膜上。一行中的四个半导体检测器的第二电极膜使用一个第二导电构件连接在一起。使用导线连接到第一导电部件的整形放大器使用比使用导线连接到第二导电部件的整形放大器的成形时间短的成形时间来执行波形整形处理; 为列中的四个半导体检测器提供第一导电构件。

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