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1. 发明授权

US5116858A 4-imidazoline derivatives 失效
标题翻译： 4-咪唑啉衍生物
公开(公告)号：US5116858A
公开(公告)日：1992-05-26
申请号：US514832
申请日：1990-04-26
申请人： Yoshio Hayashi , Yasuhiro Morinaka , Masaki Shinoda , Hiroyoshi Nishi , Kazutoshi Watanabe , Nobuko Fukushima
发明人： Yoshio Hayashi , Yasuhiro Morinaka , Masaki Shinoda , Hiroyoshi Nishi , Kazutoshi Watanabe , Nobuko Fukushima
IPC分类号： A61K31/415 , A61P25/28 , A61P43/00 , C07D233/70
CPC分类号： C07D233/70
摘要： 4-Imidazoline derivatives represented by the formula (I) and/or formula (II): ##STR1## wherein R.sup.1 represents C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 alkenyl, C.sub.3 -C.sub.8 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, or optionally substituted aralkyl; R.sup.2 and R.sup.3 independently represent hydrogen, C.sub.3 -C.sub.20 alkyl, C.sub.3 -C.sub.20 alkenyl, C.sub.3 -C.sub.20 alkynyl, C.sub.3 -C.sub.20 alkoxy, C.sub.3 -C.sub.20 alkenyloxy, C.sub.3 -C.sub.20 alkynyloxy, C.sub.3 -C.sub.8 cyloalkyl, C.sub.1 -C.sub.10 alkylthio, or optionally substituted aralkyl or aralkyloxy; R.sup.4 represents C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, or optionally substituted aralkyl; provided that R.sup.2 and R.sup.3 cannot be hydrogen at the same time, and pharmaceutically acceptable salts thereof. A pharmaceutical formulation containing the compound is also provided.

2. 发明授权

US4749701A Aminostyryl compound, leukotriene antagonistic composition containing the same as effective ingredients and method of antagonizing SRS by employing the same 失效
标题翻译：氨基苯乙烯基化合物，含有与有效成分相同的白三烯拮抗组合物和通过使用其拮抗SRS的方法
公开(公告)号：US4749701A
公开(公告)日：1988-06-07
申请号：US941807
申请日：1986-12-15
申请人： Yoshio Hayashi , Tomei Oguri , Masaki Shinoda , Kazuo Takahashi
发明人： Yoshio Hayashi , Tomei Oguri , Masaki Shinoda , Kazuo Takahashi
IPC分类号： A61K31/195 , A61K31/19 , A61K31/33 , A61K31/38 , A61K31/381 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/517 , A61P11/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C227/00 , C07C229/18 , C07C231/00 , C07C233/07 , C07C233/09 , C07C233/38 , C07D213/40 , C07D215/12 , C07D217/18 , C07D235/12 , C07D235/14 , C07D237/08 , C07D239/26 , C07D239/74 , C07D239/90 , C07D239/91 , C07D241/12 , C07D263/56 , C07D333/58 , C07D521/00 , C07D239/30 , C07D239/34
CPC分类号： C07D213/40 , C07C233/07 , C07C233/09 , C07D215/12 , C07D217/18 , C07D235/14 , C07D237/08 , C07D239/26 , C07D239/74 , C07D239/91 , C07D241/12 , C07D263/56 , C07D333/58
摘要： Disclosed are an aminostyryl compound represented by Formula I: ##STR1## wherein A represents a linking group having 3 to 4 chain members; B represents an unsubstituted or substituted 5 to 6-membered monocyclic type heterocyclic residue containing 1 to 2 hetero atoms, an unsubstituted or substituted condensed heterocyclic residue which contains 5 to 6-membered monocyclic type heterocycle containing 1 to 2 hetero atoms, a naphthyl group or an alkyl group having 5 to 7 carbon atoms,a composition having leukotriene antagonism which contains an aminostyryl compound represented by Formula I as the effective ingredient, and a method of antagonizing SRS based on leukotriene antagonistic activity by employing the same.
摘要翻译：公开了由式I表示的氨基苯乙烯基化合物：其中A表示具有3至4个链成员的连接基团; B表示含有1〜2个杂原子的未取代或取代的5〜6元单环型杂环残基，含有1〜2个杂原子的5〜6元单环型杂环的未取代或取代的稠合杂环残基，萘基或具有5至7个碳原子的烷基，具有白三烯拮抗作用的组合物，其含有由式I表示的氨基苯乙烯基化合物作为有效成分，以及通过使用该拮抗作用来拮抗基于白三烯拮抗活性的SRS的方法。

3. 发明授权

US4925861A Carboxystyrene derivatives and drugs containing them as effective ingredients 失效
标题翻译：羧甲基苯乙烯衍生物和含有它们的药物作为有效成分
公开(公告)号：US4925861A
公开(公告)日：1990-05-15
申请号：US181156
申请日：1988-04-13
申请人： Yoshio Hayashi , Oguri Tomei , Masaki Shinoda , Kazuo Takahashi , Munehiro Hashimoto
发明人： Yoshio Hayashi , Oguri Tomei , Masaki Shinoda , Kazuo Takahashi , Munehiro Hashimoto
IPC分类号： C07D233/64 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/517 , A61P9/08 , A61P9/10 , A61P11/00 , A61P29/00 , A61P43/00 , C07D215/12 , C07D215/14 , C07D223/04 , C07D223/16 , C07D233/54 , C07D235/12 , C07D235/16 , C07D239/72 , C07D239/74 , C07D239/90 , C07D241/42 , C07D277/20 , C07D277/30 , C07D277/56 , C07D277/64 , C07D417/10
CPC分类号： C07D233/64 , C07D215/12 , C07D235/16 , C07D239/74 , C07D239/90 , C07D241/42 , C07D277/30 , C07D277/56 , C07D277/64
摘要： According to the present invention, there are provided novel carboxystyrene derivatives of the general formula (I): wherein the symbols are as defined hereinabove. Also provided herein are leukotriene antagonists and phospholipase inhibitors containing the carboxystyrene derivative or pharmaceutically acceptable salt thereof as an effective ingredient.

4. 发明授权

US4699921A Pharmaceuticals containing prostaglandin I.sub.2 失效
标题翻译：含有前列腺素I2的药物
公开(公告)号：US4699921A
公开(公告)日：1987-10-13
申请号：US763618
申请日：1985-08-08
申请人： Masakatsu Shibasaki , Mikiko Sodeoka , Yuji Ogawa , Toshiaki Mase , Akira Ishibashi , Daijiro Horii , Toshiji Kanayama , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Ishiyama , Yoshio Hayashi
发明人： Masakatsu Shibasaki , Mikiko Sodeoka , Yuji Ogawa , Toshiaki Mase , Akira Ishibashi , Daijiro Horii , Toshiji Kanayama , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Ishiyama , Yoshio Hayashi
IPC分类号： C07C59/46 , A61K31/557 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/12 , C07C51/00 , C07C67/00 , C07C69/732 , C07C405/00
CPC分类号： C07C405/0083 , A61K31/557 , Y02P20/55
摘要： Disclosed is a pharmaceutical composition having circulation ameliorating effect and antiulcer effect containing a prostaglandin I.sub.2 analogue represented by the formula shown below or a non-toxic salt or a cyclodextrin inclusion compound thereof as the effective ingredient: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms or a phenyl group, A represents a pentyl group, a cyclopentyl group, a cyclohexyl group, a 1-methyl-3-hexynyl group, a 2-methyl-3-hexynyl group, a 1-methylhexyl group, a 2-phenethyl group, a 1,1-dimethylpentyl group, a 2-methylpentyl group, a 1-cyclohexylethyl group, a 2-methylhexyl group, a 1-methyl-3-pentynyl group or a 2,6-dimethyl-5-heptenyl group; the double bond between the carbon atoms at 4- and 5-positions is E or Z or a mixture thereof; the asymmetric center in the substituent represented by A is in the R-configuration or the S-configuration or a mixture thereof.Pharmaceutical compositions containing, as an active ingredient, prostaglandin I.sub.2 analogues of the present invention have potent platelet aggregation inhibiting effect, blood pressure depressing effect, vasodilative effect and antiulcer effect, and are also low in toxicity.
摘要翻译：本发明公开了一种具有循环改善作用和抗溃疡效果的药物组合物，其含有下述式表示的前列腺素I 2类似物或其无毒性盐或环糊精包合物作为有效成分：其中R 1表示氢原子，碳原子数1〜12的烷基，碳原子数4〜7的环烷基或苯基，A表示戊基，环戊基，环己基，1-甲基-3-己炔基，2 1-甲基-3-己炔基，1-甲基己基，2-苯乙基，1,1-二甲基戊基，2-甲基戊基，1-环己基乙基，2-甲基己基，1-甲基 -3-戊炔基或2,6-二甲基-5-庚烯基; 4-和5-位的碳原子之间的双键是E或Z或它们的混合物; 由A表示的取代基中的不对称中心是R构型或S-构型或其混合物。含有本发明的前列腺素I2类似物作为活性成分的药物组合物具有有效的血小板聚集抑制作用，降血压作用，血管扩张作用和抗溃疡作用，毒性也低。

5. 发明授权

US5053526A Pharmaceuticals containing prostaglandin I.sub.2 失效
标题翻译：含有前列腺素I2的药物
公开(公告)号：US5053526A
公开(公告)日：1991-10-01
申请号：US511945
申请日：1990-04-16
申请人： Masakatsu Shibasaki , Mikiko Sodeoka , Yuji Ogawa , Toshiaki Mase , Akira Ishibashi , Daijiro Horii , Toshiji Kanayama , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Ishiyama , Yoshio Hayashi
发明人： Masakatsu Shibasaki , Mikiko Sodeoka , Yuji Ogawa , Toshiaki Mase , Akira Ishibashi , Daijiro Horii , Toshiji Kanayama , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Ishiyama , Yoshio Hayashi
IPC分类号： A61K31/557 , C07C405/00
CPC分类号： C07C405/0083 , A61K31/557
摘要： Disclosed is a pharmaceutical having circulation ameliorating effect and antiulcer effect containing a prostaglandin I.sub.2 analogue represented by the formula shown below or a non-toxic salt of its salt or a cyclodextrin inclusion compound thereof as the effective ingredient: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms or a phenyl group; A represents a pentyl group, a cyclopentyl group, a cyclohexyl group, a 1-methyl-3-hexynyl group, a 2-methyl-3-hexynyl group, a 1-methylhexyl group, a 2-phenethyl group, a 1,1-dimethylpentyl group, a 2-methylpentyl group, a 1-cyclohexylethyl group, a 2-methylhexyl group, a 1-methyl-3-pentynyl group or 1 2,6-dimethyl-5-heptenyl group; the double bond between the carbon atoms at 4- and 5-positions is E or Z or a mixture thereof, the asymmetric center in the substituent represented by A is R-configuration or S-configuration or a mixture thereof.The pharmaceuticals containing, as an active ingredient, prostaglandin I.sub.2 analogues of the present invention have potent platelet aggregation inhibiting effect, blood pressure depressing effect, vasodilative effect and antiulcer effect, and are also low in toxicity.
摘要翻译：本发明公开了一种具有循环改善作用和抗溃疡效果的药物，其含有下述式表示的前列腺素I2类似物或其盐的无毒性盐或其环糊精包合物作为有效成分：其中R1表示氢原子，碳原子数1〜12的烷基，碳原子数4〜7的环烷基或苯基; A表示戊基，环戊基，环己基，1-甲基-3-己炔基，2-甲基-3-己炔基，1-甲基己基，2-苯乙基，1,1 2-甲基戊基，2-甲基戊基，1-环己基乙基，2-甲基己基，1-甲基-3-戊炔基或1,6-二甲基-5-庚烯基; 在4-和5-位碳原子之间的双键是E或Z或其混合物，由A表示的取代基中的不对称中心是R-构型或S-构型或其混合物。含有本发明的前列腺素I2类似物作为活性成分的药物具有有效的血小板聚集抑制作用，降血压作用，血管扩张作用和抗溃疡作用，毒性也低。

6. 发明授权

US4810805A (2-chloro-3-oxo-1-alkenyl)bicyclo(3.3.0)octane derivative 失效
标题翻译：（2-氯-3-氧代-1-烯基）双环（3.3.0）辛烷衍生物
公开(公告)号：US4810805A
公开(公告)日：1989-03-07
申请号：US943484
申请日：1986-12-19
申请人： Masakatsu Shibasaki , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Aoki , Yoshio Hayashi
发明人： Masakatsu Shibasaki , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Aoki , Yoshio Hayashi
IPC分类号： C07F9/38 , C07C67/343 , C07C69/738 , C07C405/00 , C07F9/40 , C07D309/12
CPC分类号： C07C405/0083
摘要： There are disclosed a (2-chloro-3-oxo-1-alkenyl)-bicyclo[3.3.0 octene derivative represented by the formula: ##STR1## wherein R.sup.1 represents --CH.sub.2 CH.sub.2 CH.sub.2 COOR.sup.5, --CH.sub.2 CH.sub.2 --O--CH.sub.2 COOR.sup.5, --CH.dbd.CHCH.sub.2 COOR.sup.5 or --CH.sub.2 CH.sub.2 C.tbd.C--COOR.sup.5 group where R.sup.5 in the groups represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R.sup.2 represents a hydrogen atom, an acyl group having 1 to 7 carbon atoms, a tri(1 to 7 carbon atoms)-hydrocarbylsilyl group or a group forming an acetal bonding with an oxygen atom of a hydroxy group; R.sup.3 represents a straight or branched alkyl group having 3 to 10 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms, which may be substituted by at least one alkyl group having 1 to 4 carbon atoms, a straight or branched alkenyl group having 3 to 12 carbom atoms, a straight or branched alkynyl group having 3 to 8 carbon atoms, a phenyl group or a phenoxy group which may have substituents, an alkoxy group having 1 to 6 carbon atoms or an alkyl group substituted by a cycloalkyl group having 5 to 8 carbon atoms, and a process for preparing the same which comprises reacting an aldehyde represented by the formula: ##STR2## wherein R.sup.1 and R.sup.2 have the same meanings as defined above, with kotophosphonate represented by the formula: ##STR3## wherein R.sup.3 has the same meaning as defined above and R.sup.4 represents an alkyl group having 1 to 10 carbon atoms, in the presence of a base.
摘要翻译：公开了由下式表示的（2-氯-3-氧代-1-烯基） - 二环[3.3.0辛烯衍生物：其中R 1表示-CH 2 CH 2 CH 2 COOR 5，-CH 2 CH 2 -O-CH 2 COOR 5，-CH = CHCH 2 COOR 5 或-CH 2 CH 2 C 3 CON COROR 5基团，其中基团中的R 5表示氢原子或具有1至6个碳原子的烷基; R2表示氢原子，碳原子数1〜7的酰基，三（1〜7个碳原子） - 烃基甲硅烷基或与羟基形成缩醛键的基团。 R3表示可以被至少一个具有1至4个碳原子的烷基取代的具有3至10个碳原子的直链或支链烷基，具有4至7个碳原子的环烷基，具有3个碳原子的直链或支链烯基至12个碳原子，具有3至8个碳原子的直链或支链炔基，可具有取代基的苯基或苯氧基，具有1至6个碳原子的烷氧基或被具有5个环烷基的环烷基取代的烷基至8个碳原子，及其制备方法，其包括使由下式表示的醛：其中R 1和R 2具有与上述相同的含义，与下式表示的焦磷酸酯反应：其中R 3具有在碱的存在下，与上述定义相同，R 4表示具有1至10个碳原子的烷基。

7. 发明授权

US5801479A Color cathode-ray tube and method of manufacturing the same 失效
标题翻译：彩色阴极射线管及其制造方法
公开(公告)号：US5801479A
公开(公告)日：1998-09-01
申请号：US681333
申请日：1996-07-23
申请人： Masaki Shinoda
发明人： Masaki Shinoda
IPC分类号： H01J29/07 , H01J29/06
CPC分类号： H01J29/07 , H01J2229/0761
摘要： A cathode-ray tube consuppress deterioration and reduce unevenness in color of a picture by preventing an electrode element thereof from being twisted. The color cathode-ray tube includes a frame and an aperture grill stretched across and fixed on the frame and having an electrode element. The aperture grill is stretched across and fixed on the frame in a state that the frame is applied with a compressive force and the aperture grill is applied with a tension. In a process of stretching and fixing the aperture grill across and on the frame, of the tension applied to the aperture grill, a maximum tension applied to the electrode element is set within the range from 30% to 85% of a tensile strength of the electrode element.
摘要翻译：阴极射线管通过防止其电极元件扭曲而抑制图像的劣化并减少图像的颜色不均匀。彩色阴极射线管包括一个框架和一个横跨并固定在框架上并具有电极元件的孔格栅。孔格栅在被施加压缩力并且孔格栅施加张力的状态下被拉伸并固定在框架上。在将孔格栅拉伸并固定在框架上并在框架上施加到孔格栅上的张力的过程中，施加到电极元件的最大张力设定在拉伸强度的30％至85％的范围内电极元件。

8. 发明授权

US5216321A Shadow-mask type color cathode-ray tube 失效
标题翻译：阴影掩模型彩色阴极射线管
公开(公告)号：US5216321A
公开(公告)日：1993-06-01
申请号：US441965
申请日：1989-11-28
申请人： Takao Kawamura , Masaharu Kumada , Hideo Tanabe , Masaki Shinoda
发明人： Takao Kawamura , Masaharu Kumada , Hideo Tanabe , Masaki Shinoda
IPC分类号： G09F9/00 , H01J29/07 , H01J29/86 , H01J29/89 , H01J31/20
CPC分类号： H01J29/073 , H01J29/861
摘要： Disclosed is a shadow-mask type color cathode-ray tube comprising a faceplate having a curved inner surface which prevents degrouping and a substantially flat outer surface. In this color cathode-ray tube, the resolution is not deteriorated in the peripheral portion and an inespensive flat material is usable as a glass plate provided with a reflection reducing coating or a touch panel attached to the outer surface of the faceplate. Since a shadow mask supported with a tension applied thereto is usable, the positional deviation of the apertures due to the expansion of the shadow mask during operation is prevented.
摘要翻译：公开了一种荫罩型彩色阴极射线管，其包括具有弯曲内表面的面板，其防止分组和基本平坦的外表面。在该彩色阴极射线管中，周边部分的分辨率不会变差，并且可以使用无阻碍的平面材料作为设置有安装在面板的外表面的反射减少涂层或触摸面板的玻璃板。由于可以使用由其施加的张力支撑的荫罩，因此防止了由于操作期间荫罩的膨胀而引起的孔的位置偏差。

9. 发明授权

US4839388A Prostacyclins and pharmaceuticals containing the same 失效
标题翻译：前列环素和含有相同的药物
公开(公告)号：US4839388A
公开(公告)日：1989-06-13
申请号：US060870
申请日：1987-05-18
申请人： Masakatsu Sibasaki , Mikiko Sodeoka , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Aoki , Yosio Hayasi , Toshiji Kanayama
发明人： Masakatsu Sibasaki , Mikiko Sodeoka , Katsuhiko Iseki , Masaki Shinoda , Chiyoko Aoki , Yosio Hayasi , Toshiji Kanayama
IPC分类号： C07C59/125 , A61K31/557 , A61K31/695 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/12 , C07C51/00 , C07C59/46 , C07C59/54 , C07C59/62 , C07C59/64 , C07C59/72 , C07C67/00 , C07C69/03 , C07C69/708 , C07C69/732 , C07C69/734 , C07C231/00 , C07C235/06 , C07C235/30 , C07C235/34 , C07C405/00 , C07D295/18 , C07F7/18
CPC分类号： C07C405/0083
摘要： This invention relates to a novel prostacyclin represented by the formula: ##STR1## [wherein R.sup.1 represents --CO.sub.2 R.sup.5 group or --CONR.sup.6 R.sup.7 group; A is(i) --CH.dbd.CH--CH.sub.2 CH.sub.2 -- or(ii) --CH.sub.2 CH.sub.2 --O--CH.sub.2 --;B represents --C.tbd.C-- group; R.sup.2 represents an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, a phenyl group or a phenoxy group;R.sup.3 represents a hydrogen atom, a methyl group or a vinyl group; R.sup.4 represents a hydrogen atom, an acyl group, a tri(1 to 7 carbon atoms)hydrocarbyl-silyl group or a group forming an acetal bond with an oxygen atom of a hydroxy group; a double bond in the substituent represented by A is E or Z, or a mixture thereof; asymmetric center in the substituent represented by R.sup.2 is an R-configuration or S-configuration, or a mixture thereof];and uses in which they are employed as circulation ameliorating pharmaceuticals for blood flow ameliorating, antithrombus and the like, or antiulcer pharmaceuticals.
摘要翻译： PCT No.PCT / JP86 / 00486 Sec。 371日期1987年5月18日 102（e）日期1987年5月18日PCT提交1986年9月18日PCT公布。公开号WO87 / 01696 日本公开号为1987年3月26日。本发明涉及由下式表示的新型前列环素：其中R1表示-CO2R5基或-CONR6R7基; A是（i）-CH = CH-CH 2 CH 2 - 或（ii）-CH 2 CH 2 -O-CH 2 - ; B表示-C3OND C-基团; R2表示烷基，环烷基，烯基，炔基，苯基或苯氧基; R3表示氢原子，甲基或乙烯基; R 4表示氢原子，酰基，三（1〜7个碳原子）烃基 - 甲硅烷基或与羟基的氧原子形成缩醛键的基团。由A表示的取代基中的双键为E或Z，或其混合物; 由R2表示的取代基中的不对称中心是R构型或S-构型，或其混合物]; 以及它们被用作改善血流改善药物的循环改善剂，抗凝血剂等或抗溃疡药物的用途。

10. 发明授权

US06809622B2 Coil Device 失效
标题翻译：线圈装置
公开(公告)号：US06809622B2
公开(公告)日：2004-10-26
申请号：US10124368
申请日：2002-04-18
申请人： Toru Hirohashi , Kiyoshi Hironaka , Yasuo Yamashita , Masaki Shinoda
发明人： Toru Hirohashi , Kiyoshi Hironaka , Yasuo Yamashita , Masaki Shinoda
IPC分类号： H01F2729
CPC分类号： H01F27/292 , H01F27/027
摘要： A coil device, which has a coil composed of a core and a winding on the core, and a terminal having a base seat for holding the coil and terminal elements. The coil device has a flange on one side of the core with no flange being provided on the other side of the core. This allows molding by using a mold and can reduce a thickness of the flange of the core and thereby realize a reduction in the thickness of the coil device.
摘要翻译：一种线圈装置，其具有由芯体和芯体上的绕组构成的线圈，以及具有用于保持线圈和端子元件的基座的端子。线圈装置在芯的一侧具有凸缘，在芯的另一侧上没有设置凸缘。这允许通过使用模具进行模制，并且可以减小芯的凸缘的厚度，从而实现线圈装置的厚度的减小。

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