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    • 1. 发明申请
    • Asymmetric Reduction Method
    • 不对称还原法
    • US20090043110A1
    • 2009-02-12
    • US12087092
    • 2006-12-26
    • Yoshinori MatsumotoYuki TakeuchiHiroyuki Yamamoto
    • Yoshinori MatsumotoYuki TakeuchiHiroyuki Yamamoto
    • C07D209/44
    • C07B53/00C07D209/44
    • The present invention is to provide a novel method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid which is useful as a therapeutic agent for diabetes. The present invention relates to a method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid, which is characterized in that 2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid is subjected to a catalytic reduction reaction in the presence of an asymmetric catalyst prepared from a pyrrolidinebisphosphine compound (I) represented by the following general formula (I): wherein, R1 represents a linear or branched alkyl group having 1-10 carbon atoms, cycloalkyl group, aralkyl group or aryl group which may respectively have a substituent; and R2 and R3 independently represent an optionally substituted aryl group. The * mark in the pyrrolidine ring shows that the carbon atom at that position has the S configuration, and a rhodium compound.
    • 本发明提供可用作糖尿病治疗剂的(2S)-2-苄基-3-(顺式 - 六氢-2-异吲哚基羰基)丙酸的新方法。 本发明涉及(2S)-2-苄基-3-(顺 - 六氢-2-异二氢吲哚基羰基)丙酸的制备方法,其特征在于2-亚苄基-3-(顺式 - 六氢-2-异吲哚基羰基) )丙酸在由以下通式(I)表示的吡咯烷二膦化合物(I)制备的不对称催化剂存在下进行催化还原反应:其中,R1表示具有1-10个碳原子的直链或支链烷基 原子,环烷基,芳烷基或可分别具有取代基的芳基; 并且R 2和R 3独立地表示任选取代的芳基。 吡咯烷环中的*标记表示该位置的碳原子具有S构型和铑化合物。
    • 2. 发明授权
    • Asymmetric reduction method
    • 不对称还原法
    • US07847107B2
    • 2010-12-07
    • US12087092
    • 2006-12-26
    • Yoshinori MatsumotoYuki TakeuchiHiroyuki Yamamoto
    • Yoshinori MatsumotoYuki TakeuchiHiroyuki Yamamoto
    • C07D209/44
    • C07B53/00C07D209/44
    • The present invention is to provide a novel method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid which is useful as a therapeutic agent for diabetes. The present invention relates to a method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid, which is characterized in that 2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid is subjected to a catalytic reduction reaction in the presence of an asymmetric catalyst prepared from a pyrrolidinebisphosphine compound (I) represented by the following general formula (I): wherein, R1 represents a linear or branched alkyl group having 1-10 carbon atoms, cycloalkyl group, aralkyl group or aryl group which may respectively have a substituent; and R2 and R3 independently represent an optionally substituted aryl group. The * mark in the pyrrolidine ring shows that the carbon atom at that position has the S configuration, and a rhodium compound.
    • 本发明提供可用作糖尿病治疗剂的(2S)-2-苄基-3-(顺式 - 六氢-2-异吲哚基羰基)丙酸的新方法。 本发明涉及(2S)-2-苄基-3-(顺 - 六氢-2-异二氢吲哚基羰基)丙酸的制备方法,其特征在于2-亚苄基-3-(顺式 - 六氢-2-异吲哚基羰基) )丙酸在由以下通式(I)表示的吡咯烷二膦化合物(I)制备的不对称催化剂存在下进行催化还原反应:其中,R1表示具有1-10个碳原子的直链或支链烷基 原子,环烷基,芳烷基或可分别具有取代基的芳基; 并且R 2和R 3独立地表示任选取代的芳基。 吡咯烷环中的*标记表示该位置的碳原子具有S构型和铑化合物。
    • 4. 发明授权
    • Wavelength dependence correction method in optical variable attenuator
    • 光学可变衰减器中的波长依赖校正方法
    • US6144793A
    • 2000-11-07
    • US43687
    • 1998-03-26
    • Yoshinori MatsumotoHiroyuki Sugimura
    • Yoshinori MatsumotoHiroyuki Sugimura
    • G01J3/02G01J1/04G01J1/22G01J1/32G02B6/26G02B6/00H04B10/00
    • G01J1/22G01J1/04G01J1/0403G01J1/0418G01J1/32G02B6/266G02F2203/48
    • The present invention provides a wavelength dependent compensation method in a variable optical attenuator which can precisely set the amount of attenuation within a wide range of wavelengths, and to provide superior operability. An optical signal 20a is emitted from a white light source 20 incident on a monochromator 21, and under control of a CPU 24, only an optical signal 20b of a specific wavelength is extracted and is made incident on a variable optical attenuator 22; in optical attenuator 22 under control of a CPU 24, optical signal 20b is attenuated; the power of attenuated optical signal 20c is measured by power measurer 23 under control of a CPU 24, producing compensating data; and using the pulse number corresponding to the rotation angle of the motor which activates the variable optical attenuator 22 according to this compensating data, the position of variable optical attenuator 22 is compensated to attain the desired amount of attenuation.
    • PCT No.PCT / JP97 / 02616 Sec。 371日期:1998年3月26日 102(e)1998年3月26日PCT PCT 1997年7月29日PCT公布。 公开号WO98 / 04896 日期1998年2月5日本发明提供了一种可变光衰减器中的波长相关补偿方法,其可以在宽范围的波长范围内精确地设置衰减量,并提供优异的可操作性。 光信号20a从入射到单色仪21的白光源20发射,在CPU24的控制下,仅提取特定波长的光信号20b并入射到可变光衰减器22上; 在CPU24的控制下的光衰减器22中,光信号20b被衰减; 衰减光信号20c的功率在CPU24的控制下由功率测量器23测量,产生补偿数据; 并且根据该补偿数据使用与激活可变光衰减器22的电动机的旋转角相对应的脉冲数,补偿可变光衰减器22的位置以获得所需的衰减量。
    • 9. 发明授权
    • Vibrationproof device
    • 防振装置
    • US09188191B2
    • 2015-11-17
    • US13377449
    • 2010-06-10
    • Yoshinori MatsumotoMotohiro YanagidaAkira UekiMasaaki OhashiYasuyuki NagashimaYutaka Higuchi
    • Yoshinori MatsumotoMotohiro YanagidaAkira UekiMasaaki OhashiYasuyuki NagashimaYutaka Higuchi
    • F16F13/10
    • F16F13/10B60K5/1208F16F13/107
    • A vibrationproof device which is a liquid sealed vibrationproof device includes a tubular first mounting member (3) that is connected to either one of a vibration generating portion and a vibration receiving portion, a second mounting member (4) that is connected to other one, an elastic body (5) that elastically connects the first mounting member (3) and the second mounting member (4), and a partition member (8) that partitions a liquid chamber (7) of the inside of the first mounting member (3) into a main liquid chamber (7A) of an upper side having the elastic body as a portion of a wall surface and an auxiliary liquid chamber (7B) of a lower side, and a restricting passage (80) which communicates with the main liquid chamber (7A) and the auxiliary liquid chamber (7B). In addition, a first liquid (L1) is contained as a main liquid and a second liquid (L2) which is insoluble in the first liquid (L1) is contained as an added liquid in the sealed liquid (L), and the vapor pressure of the second liquid (L2) is higher than the vapor pressure of a main component of the first liquid (L1) in the same temperature and a specific gravity of the second liquid (L2) is lighter than a specific gravity of the first liquid (L1).
    • 作为液体密封防振装置的防振装置包括:连接到振动产生部和振动接收部中的任一个的管状第一安装构件(3),与另一个连接的第二安装构件(4) 弹性地连接第一安装构件(3)和第二安装构件(4)的弹性体(5)和分隔构件(8),其分隔第一安装构件(3)的内部的液体室(7) )到具有作为壁面的一部分的弹性体的上侧的主液室(7A)和下侧的辅助液室(7B),以及与主液体连通的限制通道(80) (7A)和辅助液体室(7B)。 此外,作为主液体含有第一液体(L1),作为添加液体含有不溶于第一液体(L1)的第二液体(L2),密封液体(L)中的蒸气压 的第二液体(L2)的比重高于第一液体(L1)的主要成分的蒸气压,并且第二液体(L2)的比重比第一液体的比重轻( L1)。