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1. 发明授权

US08802705B2 Pharmaceutical containing PPAR delta agonist 有权
标题翻译：含有PPARδ激动剂的药物
公开(公告)号：US08802705B2
公开(公告)日：2014-08-12
申请号：US12451564
申请日：2008-05-20
申请人： Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue
发明人： Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue
IPC分类号： A61K31/422 , A61K31/427
CPC分类号： A61K31/427 , A61K31/421 , A61K31/426 , C07D263/32 , C07D277/24 , C07D417/06
摘要： Provision of an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, and a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.A preparation containing [3-[2-[4-isopropyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazol-6-yl]oxyacetic acid, [4-[3-[2-(4-trifluoromethyl)phenyl-4-isopropyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid or [4-[3-[2-(2-hydroxy-4-chlorophenyl)-5-isopropyl-4-oxazolyl]propionyl]-2-methylphenoxy]acetic acid, or a pharmacologically acceptable salt thereof as an active ingredient is used as an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, as well as a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.
摘要翻译：提供用于促进睑板腺上皮细胞或角膜上皮细胞增殖的药剂，以及眼部疾病如睑板腺功能障碍，干眼症等的治疗剂。含有[3- [2- [4-异丙基-2-（4-三氟甲基）苯基-5-噻唑基]乙基] -5-甲基-1,2-苯并异恶唑-6-基]氧基乙酸[4- [3- [2-（4-三氟甲基）苯基-4-异丙基-5-噻唑基]丙酰] -2-甲基苯氧基]乙酸或[4- [3- [2-（2-羟基-4-氯苯基） 5-异丙基-4-恶唑基]丙酰基] -2-甲基苯氧基]乙酸或其药理学上可接受的盐作为活性成分用作促进睑板腺上皮细胞或角膜上皮细胞增殖的试剂，以及诸如睑板腺功能障碍，干眼症等眼部疾病的治疗剂。

2. 发明授权

US09096538B2 Pharmaceutical comprising PPAR agonist 有权
标题翻译：包含PPAR激动剂的药物
公开(公告)号：US09096538B2
公开(公告)日：2015-08-04
申请号：US13406990
申请日：2012-02-28
申请人： Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue
发明人： Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue
IPC分类号： A61K31/216 , A61K31/192 , C07D239/47 , A61K31/426 , A61K31/505 , C07D277/26
CPC分类号： C07D239/47 , A61K31/216 , A61K31/426 , A61K31/505 , C07D277/26
摘要： An object of the present invention is to provide an agent for promoting proliferation of a meibomian gland epithelial cell and a corneal epithelial cell, as well as provide an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye.There are provided an agent for promoting proliferation of a meibomian gland epithelial cell or a corneal epithelial cell, containing a PPARα or δ agonist as an active ingredient, as well as an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye, containing a PPARα or δ agonist as an active ingredient.
摘要翻译：本发明的目的是提供一种用于促进睑板腺上皮细胞和角膜上皮细胞增殖的药剂，以及提供用于治疗诸如睑板腺功能障碍或蒸发干眼症的眼部疾病的药剂。提供了用于促进睑板腺上皮细胞或角膜上皮细胞的增殖的试剂，其含有PPARα或δ激动剂作为活性成分，以及用于治疗眼部疾病如睑板腺功能障碍或蒸发性干眼症的药剂，含有PPARα或δ激动剂作为活性成分。

3. 发明授权

US08148389B2 Pharmaceutical comprising PPAR agonist 有权
标题翻译：包含PPAR激动剂的药物
公开(公告)号：US08148389B2
公开(公告)日：2012-04-03
申请号：US12085548
申请日：2006-11-27
申请人： Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue
发明人： Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue
IPC分类号： A01N43/54 , A01N43/78 , A01N37/10
CPC分类号： C07D239/47 , A61K31/216 , A61K31/426 , A61K31/505 , C07D277/26
摘要： An object of the present invention is to provide an agent for promoting proliferation of a meibomian gland epithelial cell and a corneal epithelial cell, as well as provide an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye.There are provided an agent for promoting proliferation of a meibomian gland epithelial cell or a corneal epithelial cell, containing a PPARα or δ agonist as an active ingredient, as well as an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye, containing a PPARα or δ agonist as an active ingredient.
摘要翻译：本发明的目的是提供一种用于促进睑板腺上皮细胞和角膜上皮细胞增殖的药剂，以及提供用于治疗诸如睑板腺功能障碍或蒸发干眼症的眼部疾病的药剂。提供了用于促进睑板腺上皮细胞或角膜上皮细胞的增殖的试剂，其含有PPARα或δ激动剂作为活性成分，以及用于治疗眼部疾病如睑板腺功能障碍或蒸发性干眼症的药剂，含有PPARα或δ激动剂作为活性成分。

4. 发明申请

US20100190833A1 PHARMACEUTICAL CONTAINING PPARA AGONIST 有权
标题翻译：含有PPARA AGONIST的药物
公开(公告)号：US20100190833A1
公开(公告)日：2010-07-29
申请号：US12451564
申请日：2008-05-20
申请人： Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue
发明人： Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue
IPC分类号： A61K31/427 , A61K31/422 , A61P27/04
CPC分类号： A61K31/427 , A61K31/421 , A61K31/426 , C07D263/32 , C07D277/24 , C07D417/06
摘要： Provision of an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, and a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.A preparation containing [3-[2-[4-isopropyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazol-6-yl]oxyacetic acid, [4-[3-[2-(4-trifluoromethyl)phenyl-4-isopropyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid or [4-[3-[2-(2-hydroxy-4-chlorophenyl)-5-isopropyl-4-oxazolyl]propionyl]-2-methylphenoxy]acetic acid, or a pharmacologically acceptable salt thereof as an active ingredient is used as an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, as well as a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.
摘要翻译：提供用于促进睑板腺上皮细胞或角膜上皮细胞增殖的药剂，以及眼部疾病如睑板腺功能障碍，干眼症等的治疗剂。含有[3- [2- [4-异丙基-2-（4-三氟甲基）苯基-5-噻唑基]乙基] -5-甲基-1,2-苯并异恶唑-6-基]氧基乙酸[4- [3- [2-（4-三氟甲基）苯基-4-异丙基-5-噻唑基]丙酰] -2-甲基苯氧基]乙酸或[4- [3- [2-（2-羟基-4-氯苯基） 5-异丙基-4-恶唑基]丙酰基] -2-甲基苯氧基]乙酸或其药理学上可接受的盐作为活性成分用作促进睑板腺上皮细胞或角膜上皮细胞增殖的试剂，以及诸如睑板腺功能障碍，干眼症等眼部疾病的治疗剂。

5. 发明申请

US20090306111A1 Pharmaceutical Comprising PPAR Agonist 有权
标题翻译：药物包括PPAR激动剂
公开(公告)号：US20090306111A1
公开(公告)日：2009-12-10
申请号：US12085548
申请日：2006-11-27
申请人： Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue
发明人： Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue
IPC分类号： A61K31/505 , A61K31/215 , A61K31/192 , A61K31/426 , A61P27/02
CPC分类号： C07D239/47 , A61K31/216 , A61K31/426 , A61K31/505 , C07D277/26
摘要： An object of the present invention is to provide an agent for promoting proliferation of a meibomian gland epithelial cell and a corneal epithelial cell, as well as provide an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye.There are provided an agent for promoting proliferation of a meibomian gland epithelial cell or a corneal epithelial cell, containing a PPARα or δ agonist as an active ingredient, as well as an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye, containing a PPARα or δ agonist as an active ingredient.
摘要翻译：本发明的目的是提供一种用于促进睑板腺上皮细胞和角膜上皮细胞增殖的药剂，以及提供用于治疗诸如睑板腺功能障碍或蒸发干眼症的眼部疾病的药剂。提供了用于促进睑板腺上皮细胞或角膜上皮细胞的增殖的试剂，其含有PPARα或δ激动剂作为活性成分，以及用于治疗眼部疾病如睑板腺功能障碍或蒸发性干眼症的药剂，含有PPARα或δ激动剂作为活性成分。

6. 发明申请

US20060252765A1 Corneal perception recovery drug containing amide compound 有权
公开(公告)号：US20060252765A1
公开(公告)日：2006-11-09
申请号：US10557415
申请日：2005-06-03
申请人： Yoshiko Takayama , Yoshikuni Nakamura , Jun Inoue , Mitsuyoshi Azuma
发明人： Yoshiko Takayama , Yoshikuni Nakamura , Jun Inoue , Mitsuyoshi Azuma
IPC分类号： A61K31/501 , A61K31/4745 , A61K31/445 , A61K31/165
CPC分类号： C07D471/04 , A61K31/165 , A61K31/437 , A61K31/445 , A61K31/4745 , A61K31/501
摘要： The amide compound of the formula (I) [each symbol is as defined in the description] has a promoting action on neuritogenesis of trigeminal nerve cells, and the compound is useful as a corneal neuritogenesis promoter, an agent for recovering corneal sensitivity by promotion of corneal neuritogenesis, and an agent for treating dry eye.

7. 发明申请

US20090118322A1 Agent for repairing corneal sensitivity containing amide compound 有权
标题翻译：修复含有酰胺化合物的角膜敏感性试剂
公开(公告)号：US20090118322A1
公开(公告)日：2009-05-07
申请号：US12289748
申请日：2008-11-03
申请人： Yoshiko Takayama , Yoshikuni Nakamura , Jun Inoue , Mitsuyoshi Azuma
发明人： Yoshiko Takayama , Yoshikuni Nakamura , Jun Inoue , Mitsuyoshi Azuma
IPC分类号： A61K31/437 , A61P25/00
CPC分类号： C07D471/04 , A61K31/165 , A61K31/437 , A61K31/445 , A61K31/4745 , A61K31/501
摘要： The amide compound of the formula (I) [each symbol is as defined in the description] has a promoting action on neuritogenesis of trigeminal nerve cells, and the compound is useful as a corneal neuritogenesis promoter, an agent for recovering corneal sensitivity by promotion of corneal neuritogenesis, and an agent for treating dry eye.
摘要翻译：式（I）的酰胺化合物[各符号如说明书中所定义]对三叉神经细胞的神经发生具有促进作用，并且该化合物可用作角膜神经发生促进剂，通过促进角膜神经发生促进剂来恢复角膜敏感性角膜神经发生，以及用于治疗干眼症的药剂。

8. 发明申请

US20060234922A1 Remedy for corneal failure 审中-公开
标题翻译：角膜失败的补救措施
公开(公告)号：US20060234922A1
公开(公告)日：2006-10-19
申请号：US10533115
申请日：2003-10-22
申请人： Yoshiko Takayama , Yoshikuni Nakamura , Jun Inoue , Mitsuyoshi Azuma
发明人： Yoshiko Takayama , Yoshikuni Nakamura , Jun Inoue , Mitsuyoshi Azuma
IPC分类号： A61K31/4545 , A61K31/454 , A61K38/12 , A61K38/10
CPC分类号： A61K38/31 , A61K31/00
摘要： The present invention provides a new type of pharmaceutical agent that recovers corneal sensitivity after corneal surgery or improves the condition of dry eye. Application of a somatostatin receptor agonist is expected to provide an improvement effect on decreased corneal sensitivity after cataract surgery or LASIK surgery, decreased corneal sensitivity and dry eye associated with corneal neurodegeneration such as neuroparalytic keratopathy, corneal ulcer, diabetic keratopathy and the like.
摘要翻译：本发明提供了在角膜手术后恢复角膜敏感性或改善干眼症状的新型药剂。预期生长抑素受体激动剂的应用对于白内障手术或LASIK手术后的角膜敏感性降低，与角膜神经变性如神经麻痹性角膜病，角膜溃疡，糖尿病性角膜病等相关的角膜敏感性和干眼症的降低有改善作用。

9. 发明授权

US07956072B2 Agent for repairing corneal sensitivity containing amide compound 有权
标题翻译：修复含有酰胺化合物的角膜敏感性试剂
公开(公告)号：US07956072B2
公开(公告)日：2011-06-07
申请号：US12289748
申请日：2008-11-03
申请人： Yoshiko Takayama , Yoshikuni Nakamura , Jun Inoue , Mitsuyoshi Azuma
发明人： Yoshiko Takayama , Yoshikuni Nakamura , Jun Inoue , Mitsuyoshi Azuma
IPC分类号： A61K31/445 , A61K31/44
CPC分类号： C07D471/04 , A61K31/165 , A61K31/437 , A61K31/445 , A61K31/4745 , A61K31/501
摘要： The amide compound of the formula (I) [each symbol is as defined in the description] has a promoting action on neuritogenesis of trigeminal nerve cells, and the compound is useful as a corneal neuritogenesis promoter, an agent for recovering corneal sensitivity by promotion of corneal neuritogenesis, and an agent for treating dry eye.
摘要翻译：式（I）的酰胺化合物[各符号如说明书中所定义]对三叉神经细胞的神经发生具有促进作用，并且该化合物可用作角膜神经发生促进剂，通过促进角膜神经发生促进剂来恢复角膜敏感性角膜神经发生，以及用于治疗干眼症的药剂。

10. 发明授权

US07485654B2 Corneal perception recovery drug containing amide compound 有权
标题翻译：角膜感知恢复药物含有酰胺化合物
公开(公告)号：US07485654B2
公开(公告)日：2009-02-03
申请号：US10557415
申请日：2005-06-03
申请人： Yoshiko Takayama , Yoshikuni Nakamura , Jun Inoue , Mitsuyoshi Azuma
发明人： Yoshiko Takayama , Yoshikuni Nakamura , Jun Inoue , Mitsuyoshi Azuma
IPC分类号： A61K31/445 , A61K31/44
CPC分类号： C07D471/04 , A61K31/165 , A61K31/437 , A61K31/445 , A61K31/4745 , A61K31/501
摘要： The amide compound of the formula (I) [each symbol is as defined in the description] has a promoting action on neuritogenesis of trigeminal nerve cells, and the compound is useful as a corneal neuritogenesis promoter, an agent for recovering corneal sensitivity by promotion of corneal neuritogenesis, and an agent for treating dry eye.
摘要翻译：式（I）的酰胺化合物[各符号如说明书中所定义]对三叉神经细胞的神经发生具有促进作用，并且该化合物可用作角膜神经发生促进剂，通过促进角膜神经发生促进剂来恢复角膜敏感性角膜神经发生，以及用于治疗干眼症的药剂。

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