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1. 发明授权

US5901777A Twin-roll continuous casting method 失效
标题翻译：双辊连铸法
公开(公告)号：US5901777A
公开(公告)日：1999-05-11
申请号：US553707
申请日：1996-01-16
申请人： Yoshikazu Matsumura , Yoshio Morimoto , Kiyomi Shio , Yoshiyuki Ueshima , Toshiaki Mizoguchi , Satoshi Akamatsu , Shigeru Ogawa , Kazuo Koyama
发明人： Yoshikazu Matsumura , Yoshio Morimoto , Kiyomi Shio , Yoshiyuki Ueshima , Toshiaki Mizoguchi , Satoshi Akamatsu , Shigeru Ogawa , Kazuo Koyama
IPC分类号： B21B1/46 , B21B41/08 , B21B45/00 , B21B45/02 , B22D11/06 , B22D11/12
CPC分类号： B21B1/463 , B22D11/0622 , B22D11/1206 , B21B2045/006 , B21B41/08 , B21B45/0218
摘要： A casting C obtained by solidification of molten metal by using a pair of water cooled casting rolls 2a, 2b is subjected to temperature adjustment in a temperature zone so that an austenite structure exists in its matrix. Thereafter, the casting is rolled by an in-line rolling mill 5 at a temperature ranging from 850.degree. C. to less than 1,350.degree. C. and at a reduction of 5 to 50%. In this way, overall variance of elongation of the steel material is kept within 5% in terms of the standard deviation.
摘要翻译： PCT No.PCT / JP95 / 00643 Sec。 371日期1996年1月16日 102（e）日期1996年1月16日PCT提交1995年4月3日PCT公布。公开号WO95 / 26840 日期1995年10月12日通过使用一对水冷铸辊2a，2b使熔融金属凝固而获得的铸件C在温度区域进行温度调节，使得其基体中存在奥氏体组织。然后，通过在线轧机5在850℃〜小于1350℃的温度和5〜50％的压下率下轧制。以这种方式，钢材的总伸长率变化在标准偏差方面保持在5％以内。

2. 发明授权

US08766715B2 Amplifier circuit 有权
标题翻译：放大器电路
公开(公告)号：US08766715B2
公开(公告)日：2014-07-01
申请号：US13511233
申请日：2011-08-29
申请人： Kazuo Koyama
发明人： Kazuo Koyama
IPC分类号： H03F3/45
CPC分类号： H03F3/45475 , H03F3/3022 , H03F3/45183 , H03F3/45928 , H03F2203/45082 , H03F2203/45528
摘要： An amplifier circuit capable of reducing load of a circuit at the previous stage by providing increased input impedance producing less noises. The amplifier circuit includes a fully-differential operational amplifier composed of an inverting input terminal, a non-inverting input terminal receiving a signal different from a signal to be input to the inverting input terminal, an inverting output terminal with the same polarity of the inverting input terminal, and a non-inverting output terminal with reverse polarity; an input impedance element with one end connected to the inverting input terminal; an input impedance element with one end connected to the non-inverting input terminal; and positive feedback impedance elements, with one end of connected to the other end of the input impedance element and the other end connected to the inverting output terminal or to the non-inverting output terminal.
摘要翻译：一种放大器电路，其能够通过提供增加的输入阻抗产生较少的噪声来减小前一电路的负载。放大器电路包括由反相输入端子，非反相输入端子接收与要输入到反相输入端子的信号不同的信号的全差分运算放大器，反相输出端子具有与反相输入端子相同极性的反相输出端子输入端子和反相输出端子; 输入阻抗元件，其一端连接到反相输入端子; 输入阻抗元件，其一端连接到非反相输入端子; 和正反馈阻抗元件，其一端连接到输入阻抗元件的另一端，另一端连接到反相输出端或非反相输出端。

3. 发明申请

US20090286809A1 Preventives or remedies for alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound 审中-公开
公开(公告)号：US20090286809A1
公开(公告)日：2009-11-19
申请号：US12458891
申请日：2009-07-27
申请人： Masaki Meguro , Tomiichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
发明人： Masaki Meguro , Tomiichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
IPC分类号： A61K31/4965 , A61K31/505 , C07D239/02 , C07D237/02 , C07D241/02 , A61K31/50 , A61P25/28
CPC分类号： C07D239/48 , A61K31/50 , A61K31/505 , A61K31/53 , C07D237/20 , C07D237/22 , C07D239/50 , C07D241/20 , C07D251/18 , C07D251/48 , C07D251/52 , C07D251/70
摘要： The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).

4. 发明授权

US07589105B2 Preventives or remedies for alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound 失效
标题翻译：阿尔茨海默病或淀粉样蛋白原纤维形成抑制剂的预防或补救措施，其包括含氮杂芳基化合物
公开(公告)号：US07589105B2
公开(公告)日：2009-09-15
申请号：US10497183
申请日：2002-11-25
申请人： Masaki Meguro , Tomiichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
发明人： Masaki Meguro , Tomiichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
IPC分类号： A01N43/60 , A01N43/42
CPC分类号： C07D239/48 , A61K31/50 , A61K31/505 , A61K31/53 , C07D237/20 , C07D237/22 , C07D239/50 , C07D241/20 , C07D251/18 , C07D251/48 , C07D251/52 , C07D251/70
摘要： Pharmaceutical compositions and methods of treatment are provided for treating amyloidosis, containing, as an active ingredient, at least one nitrogen-containing heteroaryl compound represented by the following general formula or a pharmacologically permitted salt thereof; together with nitrogen-containing heteroaryl derivatives, and pharmacologically permitted salts thereof: where, R1, R2, Z1-Z5, and A are as defined herein.
摘要翻译：提供药物组合物和治疗方法用于治疗淀粉样变性，其含有至少一种由以下通式表示的含氮杂芳基化合物或其药理学允许的盐作为活性成分; 连同含氮杂芳基衍生物及其药理学允许的盐：其中，R1，R2，Z1-Z5和A如本文所定义。

5. 发明授权

US07514475B2 Benzylamine analogues 失效
标题翻译：苄胺类似物
公开(公告)号：US07514475B2
公开(公告)日：2009-04-07
申请号：US11583499
申请日：2006-10-19
申请人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
发明人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
IPC分类号： A61K31/137 , C07C205/04
CPC分类号： C07C219/30 , C07C271/44 , C07C323/20 , C07C323/25 , C07C333/04 , C07D213/64 , C07D213/68 , C07D215/20 , C07D317/58 , C07D333/38
摘要： A compound of the formula (I): wherein R1 is a C1-C6 alkyl, an amino, a (C1-C6 alkyl)amino, a di(C1-C6 alkyl)amino or a nitrogen-containing saturated heterocyclic; R2 and R3 are the same or different and are a hydrogen or a C1-C6 alkyl; Arom is an unsubstituted or substituted aryl or an unsubstituted or substituted heteroaryl; wherein the substituted aryl is substituted at 1 to 5 positions and the substituted heteroaryl is substituted at 1 to 3 positions; wherein the heteroaryl is furyl, thiolyl, pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3 oxadiazolyl, pyranyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or quinolyl; and wherein the substituents of the substituted aryl and of the substituted heteroaryl are independently halogen, C1-C6 alkyl, halogeno C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C3 alkylenedioxy, C1-C7 alkanoyl, C2-C7 alkyloxycarbonyl, amino, C1-C7 alkanoylamino, hydroxyl, mercapto, cyano, nitro or carboxyl; A is an ethylene or propylene; Ra is a hydrogen, a C1-C6 alkyl or a C2-C6 alkenyl; E is a single bond, an oxygen, a sulfur or —NR4—, wherein R4 is a hydrogen or a C1-C7 alkanoyl; X1 and X2 are the same or different and are an oxygen or a sulfur, or a pharmacologically acceptable salt or ester thereof.
摘要翻译：式（I）的化合物：其中R1是C1-C6烷基，氨基，（C1-C6烷基）氨基，二（C1-C6烷基）氨基或含氮饱和杂环; R2和R3相同或不同，为氢或C1-C6烷基; Arom是未取代或取代的芳基或未取代或取代的杂芳基; 其中取代的芳基在1至5个位置被取代，并且取代的杂芳基在1至3个位置被取代; 吡唑基，咪唑基，恶唑基，异恶唑基，噻唑基，异噻唑基，1,2,3-恶二唑基，吡喃基，吡啶基，哒嗪基，嘧啶基，吡嗪基或喹啉基;其中杂芳基为呋喃基，噻吩基，吡咯基，并且其中取代的芳基和取代的杂芳基的取代基独立地为卤素，C 1 -C 6烷基，卤代C 1 -C 6烷基，C 1 -C 6烷氧基，C 1 -C 6烷硫基，C 1 -C 3亚烷基二氧基，C 1 -C 7烷酰基， C7烷氧基羰基，氨基，C1-C7烷酰基氨基，羟基，巯基，氰基，硝基或羧基; A是乙烯或丙烯; R a是氢，C 1 -C 6烷基或C 2 -C 6烯基; E是单键，氧，硫或-NR4-，其中R4是氢或C1-C7烷酰基; X1和X2相同或不同，为氧或硫，或其药理学上可接受的盐或酯。

6. 发明申请

US20080255095A1 Benzylamine analogues 审中-公开
标题翻译：苄胺类似物
公开(公告)号：US20080255095A1
公开(公告)日：2008-10-16
申请号：US11820218
申请日：2007-06-18
申请人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
发明人： Kazuo Koyama , Shinji Marumoto , Narihiro Toda , Hiroshi Kogen , Keiko Suzuki
IPC分类号： A61K31/55 , C07D333/22 , C07D215/38 , C07D263/34 , A61K31/50 , A61P25/28 , A61K31/4965 , C07D261/02 , C07D277/00 , C07D275/02
CPC分类号： C07C219/30 , C07C271/44 , C07C323/20 , C07C323/25 , C07C333/04 , C07D213/64 , C07D213/68 , C07D215/20 , C07D317/58 , C07D333/38
摘要： A compound of the formula (I): wherein R1 is C1-C6 alkyl, amino, (C1-C6 alkyl)amino, di(C1-C6 alkyl)amino or a nitrogen-containing saturated heterocyclic; R2 and R3 are hydrogen or C1-C6 alkyl; Arom is phenyl, idenyl, napthyl, phenanthrenyl, furyl, thiolyl, pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3 oxadiazolyl, pyranyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or quinolyl; A is C1-C6 alkylene; Ra is hydrogen, C1-C6 alkyl or C2-C6 alkenyl; E is a single bond, oxygen, sulfur or —NR4—, wherein R4 is hydrogen or C1-C7 alkanoyl; X1 and X2 are oxygen or sulfur; or a pharmacologically acceptable salt or ester thereof.
摘要翻译：式（I）的化合物：其中R 1是C 1 -C 6烷基，氨基，（C 1）（C 1 -C 6烷基）氨基或含氮饱和杂环基;（C 1 -C 6烷基）氨基， R 2和R 3是氢或C 1 -C 6烷基; 芳基是苯基，烯基，萘基，菲基，呋喃基，噻吩基，吡咯基，氮杂基，吡唑基，咪唑基，恶唑基，异恶唑基，噻唑基，异噻唑基，1,2,3-恶二唑基，吡喃基，吡啶基，哒嗪基，嘧啶基，吡嗪基或喹啉基。 A是C 1 -C 6亚烷基; R a是氢，C 1 -C 6烷基或C 2 -C 6烷基或C 2 -C 6 - 链烯基; E是单键，氧，硫或-NR 4 - ，其中R 4是氢或C 1 -C 7 烷酰基; X 1和X 2是氧或硫; 或其药理学上可接受的盐或酯。

7. 发明申请

US20080182846A1 Preventives or remedies for Alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound 失效
标题翻译：包括含氮杂芳基化合物的阿尔茨海默病或淀粉样蛋白原纤维形成抑制剂的预防或治疗
公开(公告)号：US20080182846A1
公开(公告)日：2008-07-31
申请号：US12068407
申请日：2008-02-06
申请人： Masaki Meguro , Tomichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
发明人： Masaki Meguro , Tomichiro Oda , Yasuhiro Nakagami , Shinji Marumoto , Kazuo Koyama , Isao Kaneko
IPC分类号： A61K31/53 , C07D251/18 , A61P25/28
CPC分类号： C07D239/48 , A61K31/50 , A61K31/505 , A61K31/53 , C07D237/20 , C07D237/22 , C07D239/50 , C07D241/20 , C07D251/18 , C07D251/48 , C07D251/52 , C07D251/70
摘要： The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
摘要翻译：本发明涉及阿尔茨海默病的预防药物或补救剂，或淀粉样蛋白原纤维形成抑制剂，其包括作为活性成分的下列通式（I）的化合物或其药理学允许的盐; 以及具有特定取代基的含氮杂芳基衍生物或其药理学上允许的盐，其作为阿尔茨海默氏病的预防剂或治疗剂是有价值的，或作为淀粉样蛋白原纤维形成抑制剂：（其中R 1，和R 2是H或烷基; Z 1和Z 2是H，烷基，烷氧基，卤代烷基或卤代; Z 3 烷氧基，SH，烷硫基，NH 2，单或二烷基氨基，OH或卤素; Z 4和Z 5 >为H或卤素; A为4,6-嘧啶-1,3-二基，1,3,5-三嗪-2,6-二基等）。

8. 发明授权

US5965591A Isoxazole derivatives 失效
标题翻译：异恶唑衍生物
公开(公告)号：US5965591A
公开(公告)日：1999-10-12
申请号：US806854
申请日：1997-02-26
申请人： Koichi Kojima , Junichi Sakai , Yuichi Aizawa , Naozumi Samata , Masao Kozuka , Kenji Yoshimi , Isao Kaneko , Kazuo Koyama
发明人： Koichi Kojima , Junichi Sakai , Yuichi Aizawa , Naozumi Samata , Masao Kozuka , Kenji Yoshimi , Isao Kaneko , Kazuo Koyama
IPC分类号： A61K31/42 , A61K31/423 , A61K31/424 , A61K31/44 , A61P25/16 , A61P25/24 , A61P25/28 , C07D261/20 , C07D498/02 , C07D498/04
CPC分类号： C07D261/20
摘要： An isoxazole compound having the following formula: wherein R.sup.1 represents hydrogen, halogen, alkyl, alkoxy, hydroxyl, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)thiocarbonyl, carbamoyl, nitro or cyano; R.sup.2 represents an amino; m is 1; n is 1 to 6; ring A represents a phenyl ring or a naphthyl ring; and X represents oxygen or sulfur. The isoxazole compound has an excellent monoamine oxidase inhibitory activity, and is useful for treating Parkinson's disease, depression and Alzheimer's disease.
摘要翻译：具有下式的异恶唑化合物：其中R 1表示氢，卤素，烷基，烷氧基，羟基，烷硫基，氨基，烷酰基，烷酰基氨基，烷酰氧基，烷氧基羰基，羧基，（烷硫基）硫代羰基，氨基甲酰基，硝基或氰基; R2代表氨基; m为1; n为1至6; 环A表示苯环或萘环; X表示氧或硫。异恶唑化合物具有优异的单胺氧化酶抑制活性，可用于治疗帕金森病，抑郁症和阿尔茨海默氏病。

9. 发明授权

US5855106A Film supplying apparatus and lift mechanism for a packaging machine 失效
标题翻译：包装机的薄膜供应装置和升降机构
公开(公告)号：US5855106A
公开(公告)日：1999-01-05
申请号：US669029
申请日：1996-06-17
申请人： Kazuo Koyama , Minoru Ooshita , Toshiyuki Sakata
发明人： Kazuo Koyama , Minoru Ooshita , Toshiyuki Sakata
IPC分类号： B65B41/00 , B65B11/54 , B65B41/12 , B65B57/00 , B65B57/02 , B65H20/06 , B65B53/00 , B65B11/06
CPC分类号： B65H20/06 , B65B11/54 , B65B41/12 , B65B57/02 , B65H2511/12
摘要： A packaging machine has belts for clamping both side edges of a film pulled out selectably from either of two film rolls and transporting it accordingly in either direction to a packaging station. Its film supplying apparatus includes a plurality of sensors capable of detecting both presence and absence of a film. They are disposed at both ends of the belts and each sensor is adapted to output a warning signal when either the presence or absence of a film is detected thereby, depending whether it is at the downstream or upstream end of the belt with respect to the direction of film being transported thereby. A lift mechanism for such a packaging machine for lifting loaded trays of different sizes against a stretched film includes a frame, a mechanism for moving the frame selectably upward or downward, a plurality of posts standing on the frame for supporting trays thereon, some of the posts being fixed posts, which are affixed to the frame, and the others being mobile posts, which can move horizontally in a specified direction within a specified range each towards or away from an associated one of the fixed posts, a slidable member extending perpendicularly to the specified direction and capable of sliding in this direction beyond the specified range, and a controller for stopping the slidable member at a plurality of stop positions within the specified range and wait positions outside the specified range. The controller also causes the slidable member and the mobile posts to move towards or away from each other at any of the stop positions.
摘要翻译：包装机具有用于夹紧从两个薄膜辊中的任一个选择地拉出的膜的两个侧边缘的带，并将其相应地沿任一方向传送到包装站。其膜供给装置包括能够检测膜的存在和不存在的多个传感器。它们被布置在带的两端，并且每个传感器适于在检测到有无胶卷的情况下输出警告信号，这取决于它是否位于相对于方向的带的下游或上游端的电影。用于这种用于提升不同尺寸的托盘的拉伸膜的提升机构包括框架，用于将框架可选择地向上或向下移动的机构，多个柱站在框架上用于在其上支撑托盘，其中一些柱是固定的柱，其固定在框架上，其他的是可移动的柱，其可以在指定的方向上在指定的方向上水平移动，每个朝向或远离相关联的一个固定柱，垂直于指定方向并且能够在该方向上滑动超过规定范围;以及控制器，用于使滑动构件在指定范围内的多个停止位置停止，并且在指定范围之外的等待位置。控制器还使得可滑动构件和移动柱在任何停止位置上彼此移动或远离彼此。

10. 发明授权

US5457816A Scanning receiver with stored frequencies 失效
标题翻译：具有存储频率的扫描接收机
公开(公告)号：US5457816A
公开(公告)日：1995-10-10
申请号：US86135
申请日：1993-07-01
申请人： Kazuo Koyama
发明人： Kazuo Koyama
IPC分类号： H03J1/00 , H03J7/18 , H04B1/16
CPC分类号： H03J7/18 , H03J1/0091 , H04H20/22 , H04H20/26 , H04H2201/13
摘要： Receivable frequencies based on a predetermined instruction signal are scanned in a first direction and across a frequency range extending from a first start frequency to a first end frequency. The tuning is retraced to the first start frequency, and scanning is resumed in the opposite direction across a second frequency range extending from the first start frequency to a second end frequency. Next, tuning is retraced to the second start frequency and scanning is resumed in the first direction across a third frequency range extending from the first end frequency to a third end frequency. The scan operation is repeated until predetermined upper and lower frequency limits are reached. When one of the frequency limits are reached, scanning is performed for one or more frequency ranges in the opposite direction without retrace until the second frequency limit is reached.
摘要翻译：基于预定指令信号的接收频率在第一方向和从第一起始频率延伸到第一结束频率的频率范围内被扫描。调谐回溯到第一起始频率，并且在从第一起始频率延伸到第二终止频率的第二频率范围上沿相反方向重新开始扫描。接下来，将调谐回溯到第二起始频率，并且在从第一端频率延伸到第三端频率的第三频率范围上沿第一方向重新开始扫描。重复扫描操作，直到达到预定的上限和下限频率。当达到频率限制之一时，对于一个或多个相反方向的频率范围进行扫描，而不进行回扫，直到达到第二个频率限制。

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