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    • 1. 发明授权
    • Method for microencapsulating of a solid substance
    • 固体物质的微囊化方法
    • US6156245A
    • 2000-12-05
    • US257951
    • 1999-02-26
    • Yoshihiro TakebayashiNobuhito UedaShugo Nishi
    • Yoshihiro TakebayashiNobuhito UedaShugo Nishi
    • B01J13/06B01J13/18B01J13/02
    • B01J13/06B01J13/18Y10T428/2985
    • The present invention provides a microencapsulation method of a solid substance and the microencapsulated composition obtained from said method of: (i) preparing a dispersion phase comprising (a) a solution containing a substance which forms a middle layer and (b) a solid substance that is insoluble or difficult to dissolve in said solution, (ii) obtaining a solid substance which has a layer made of the substance which forms the middle layer by phase-separating the substance which forms the middle layer from the solution and (iii) reacting a monomer that is polymelizable by condensation in the presence of the solid substance that has a layer made of the substance which forms the middle layer.The above method can efficiently microencapsulate pharmaceutical active ingredients, pesticidal ingredients, aroma active ingredient and so on that are solid substances and affords an efficacious microencapsulated composition of solid substances.
    • 本发明提供了一种固体物质的微囊化方法和由以下方法获得的微胶囊化组合物:(i)制备分散相,其包含(a)含有形成中间层的物质的溶液和(b)固体物质, 在所述溶液中不溶或不易溶解,(ii)通过将形成中间层的物质与溶液相分离,得到具有由形成中间层的物质形成的层的固体物质,和(iii)使 在具有由形成中间层的物质制成的层的固体物质存在下,通过缩合可聚合的单体。 上述方法可以有效地将作为固体物质的药物活性成分,杀虫成分,芳香活性成分等微囊化,并提供有效的微胶囊化固体物质组合物。