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1. 发明授权

US08765115B2 Method of treatment of gastrointestinal disorders with IL-10 有权
标题翻译：用IL-10治疗胃肠道疾病的方法
公开(公告)号：US08765115B2
公开(公告)日：2014-07-01
申请号：US13307782
申请日：2011-11-30
申请人： Yoshihiro Fujiwara , Kenji Sekikawa , Fumio Takaiwa , Noriko Tsuji
发明人： Yoshihiro Fujiwara , Kenji Sekikawa , Fumio Takaiwa , Noriko Tsuji
IPC分类号： A61K38/20 , C07K14/54 , C12N15/82
CPC分类号： A61K38/2066 , C07K14/5428 , C12N15/8242 , C12N15/8257
摘要： Providing a new method of treating inflammatory gastrointestinal disorders and a food product for the prevention or improvement of inflammatory gastrointestinal disorders. Prevention or treatment of inflammatory gastrointestinal disorders is possible by oral administration of recombinant IL-10 expressed in rice plant seeds.
摘要翻译：提供治疗炎症性胃肠疾病的新方法和用于预防或改善炎性胃肠道疾病的食品。通过口服施用在水稻种子中表达的重组IL-10可以预防或治疗炎性胃肠道疾病。

2. 发明申请

US20120328561A1 METHOD FOR TREATMENT OF INFLAMMATORY GASTROINTESTINAL DISORDERS 有权
标题翻译：治疗炎性胃肠疾病的方法
公开(公告)号：US20120328561A1
公开(公告)日：2012-12-27
申请号：US13307782
申请日：2011-11-30
申请人： Yoshihiro Fujiwara , Kenji Sekikawa , Fumio Takaiwa , Noriko Tsuji
发明人： Yoshihiro Fujiwara , Kenji Sekikawa , Fumio Takaiwa , Noriko Tsuji
IPC分类号： A61K38/20 , A61P1/00 , A61K36/899
CPC分类号： A61K38/2066 , C07K14/5428 , C12N15/8242 , C12N15/8257
摘要： Providing a new method of treating inflammatory gastrointestinal disorders and a food product for the prevention or improvement of inflammatory gastrointestinal disorders. Prevention or treatment of inflammatory gastrointestinal disorders is possible by oral administration of recombinant IL-10 expressed in rice plant seeds.
摘要翻译：提供治疗炎症性胃肠疾病的新方法和用于预防或改善炎性胃肠道疾病的食品。通过口服施用在水稻种子中表达的重组IL-10可以预防或治疗炎性胃肠道疾病。

3. 发明申请

US20110159552A1 LACTIC ACID BACTERIA-DERIVED DOUBLE-STRANDED RNA 有权
标题翻译： LACTIC ACID BACTERIA衍生的双链RNA
公开(公告)号：US20110159552A1
公开(公告)日：2011-06-30
申请号：US12452405
申请日：2008-07-03
申请人： Ikuko Masuda , Daisuke Kaneko , Tadaomi Kawashima , Noriko Tsuji , Akemi Kosaka
发明人： Ikuko Masuda , Daisuke Kaneko , Tadaomi Kawashima , Noriko Tsuji , Akemi Kosaka
IPC分类号： C12P19/34 , C07H21/02
CPC分类号： A61K31/713 , A61K35/744 , A61K35/747 , C12N15/117 , C12N2310/17 , C12N2330/10
摘要： It is intended to provide an immunomodulator, which has a high safety and can be effectively incorporated into cells, and a method of producing the same. A double-stranded RNA originating in a lactic acid bacterium; an immunomodulator comprising the double-stranded RNA originating in a lactic acid bacterium as the active ingredient; and a method of producing the double-stranded RNA originating in a lactic acid bacterium. Lactic acid bacterial cells belonging to the genus Tetragenococcus, Pediococcus, Lactobacillus, Streptococcus, Leuconostoc, etc. can produce a double-stranded RNA having an immunomodulation effect therein.
摘要翻译：本发明提供一种具有高安全性且能够有效并入细胞的免疫调节剂及其制造方法。源于乳酸菌的双链RNA; 包含源自乳酸菌的双链RNA作为活性成分的免疫调节剂; 以及产生来自乳酸菌的双链RNA的方法。属于四源球菌属，类球菌属，乳杆菌属，链球菌属，明串珠星菌属等的乳酸菌细胞可以产生其中具有免疫调节作用的双链RNA。

4. 发明申请

US20110256611A1 INTERFERON BETA PRODUCTION PROMOTER AND A METHOD FOR PRODUCING THEREOF 审中-公开
标题翻译：干燥生产促进剂及其生产方法
公开(公告)号：US20110256611A1
公开(公告)日：2011-10-20
申请号：US12452414
申请日：2008-07-03
申请人： Tadaomi Kawashima , Daisuke Kaneko , Ikuko Masuda , Noriko Tsuji , Akemi Kosaka
发明人： Tadaomi Kawashima , Daisuke Kaneko , Ikuko Masuda , Noriko Tsuji , Akemi Kosaka
IPC分类号： C12N1/20 , C07H21/02
CPC分类号： A61K38/21 , A23L29/065 , A23L33/10
摘要： An interferon β production promoter and a method for producing thereof are provided. The interferon β production promoter has a culture, a cell or cell components of lactic acid bacteria as an active ingredient thereof. RNA can be used for the cell component. In addition, bacteria belonging to the genus Lactobacillus, Tetragenococcus, Pediococcus or Streptococcus can be used for the lactic acid bacteria. The interferon β production promoter can be produced by culturing lactic acid bacteria and collecting a culture, a cell or cell components thereof.
摘要翻译：干扰素提供了生产促进剂及其制备方法。干扰素生产促进剂具有作为其活性成分的乳酸菌的培养物，细胞或细胞成分。 RNA可用于细胞组分。此外，属于乳杆菌属，四源球菌属，球菌属或链球菌属的细菌可用于乳酸菌。干扰素可以通过培养乳酸菌并收集培养物，细胞或细胞成分来制备生产促进剂。

5. 发明授权

US6068862A Tea-derived feed additive and animal feed containing the same 失效
标题翻译：茶源饲料添加剂和含有饲料的动物饲料
公开(公告)号：US6068862A
公开(公告)日：2000-05-30
申请号：US997798
申请日：1997-12-24
申请人： Noriyuki Ishihara , Souichi Mamiya , Shigemitsu Akachi , Noriko Tsuji , Senji Sakanaka , Izumi Ozeki , Ken Tsuda
发明人： Noriyuki Ishihara , Souichi Mamiya , Shigemitsu Akachi , Noriko Tsuji , Senji Sakanaka , Izumi Ozeki , Ken Tsuda
IPC分类号： A23K1/16 , A23K1/18 , A01K29/00
CPC分类号： A23K50/60 , A23K20/10 , A23K20/121 , A23K50/00 , A23K50/10 , A23K50/75
摘要： The present invention relates to a feed additive for animals comprising tea extract, to a feed additive for animals of which active ingredient is tea leaf fiber, and to an animal feed comprising the feed additive for animals. The tea extract in the present invention exerts great effects in preventing and treating noninfectious and infectious diarrhea in domestic animals, poultry, and pet animals, improving milk quality of fresh milk, increasing milk yield, and improving reproductive efficiency. Also, the tea leaf fiber of the present invention improves intestinal function in domestic animals, decreases the occurrence of diarrhea, increases milk yield, improves feed efficiency and removes malodor of feces and urine.
摘要翻译：本发明涉及包含茶提取物的动物饲料添加剂，活性成分为茶叶纤维的动物饲料添加剂，以及包含动物饲料添加剂的动物饲料。本发明的茶提取物在预防和治疗家畜，家禽和宠物中的非感染性和感染性腹泻方面发挥重要的作用，提高了鲜牛奶的质量，提高了产奶量，提高了生殖效率。此外，本发明的茶叶纤维改善家畜的肠功能，减少腹泻的发生，提高产奶量，提高饲料效率，消除粪便和尿液的恶臭。

6. 发明授权

US08334371B2 Lactic acid bacteria-derived double-stranded RNA 有权
标题翻译：乳酸菌衍生的双链RNA
公开(公告)号：US08334371B2
公开(公告)日：2012-12-18
申请号：US12452405
申请日：2008-07-03
申请人： Ikuko Masuda , Daisuke Kaneko , Tadaomi Kawashima , Noriko Tsuji , Akemi Kosaka
发明人： Ikuko Masuda , Daisuke Kaneko , Tadaomi Kawashima , Noriko Tsuji , Akemi Kosaka
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , C12P19/34
CPC分类号： A61K31/713 , A61K35/744 , A61K35/747 , C12N15/117 , C12N2310/17 , C12N2330/10
摘要： An immunoregulator that is safe and efficiently incorporated into cells along with a production process thereof are provided. Double-stranded RNA derived from lactic acid bacteria, an immunoregulator having for an active ingredient thereof double-stranded RNA derived from lactic acid bacteria, and a process for producing double-stranded RNA derived from lactic acid bacteria are provided. Bacteria cells of a strains of lactic acid bacteria such as genus Tetragenococcus, genus Pediococcus, genus Lactobacillus, genus Streptococcus or genus Leuconostoc are able to produce double-stranded RNA having immunoregulatory action therein.
摘要翻译：提供了一种安全有效地并入细胞中的免疫调节剂及其制备方法。提供了衍生自乳酸菌的双链RNA，其具有活性成分的免疫调节剂，其衍生自乳酸菌的双链RNA，以及由乳酸菌生产双链RNA的方法。乳酸菌菌株如四源球菌属，球菌属，乳杆菌属，链球菌属或明串珠菌属的细菌细胞能够产生其中具有免疫调节作用的双链RNA。

7. 发明申请

US20050158292A1 Lactic acid bacteria and their cellular components inducing immunoregulatory function, and method of obtaining the same 失效
标题翻译：诱导免疫调节功能的乳酸菌及其细胞成分及其获得方法
公开(公告)号：US20050158292A1
公开(公告)日：2005-07-21
申请号：US10996463
申请日：2004-11-26
申请人： Noriko Tsuji , Hiromi Kimoto
发明人： Noriko Tsuji , Hiromi Kimoto
IPC分类号： A23K1/16 , A23C9/00 , A23C19/00 , A23C19/032 , A23K1/00 , A23L1/03 , A23L1/30 , A61K35/74 , A61P1/04 , A61P37/02 , A61P37/08 , C12N1/20 , C12P21/02 , C12Q1/00 , C12Q1/02 , A61K45/00
CPC分类号： C12R1/46 , A23C19/0323 , A23K10/16 , A23K10/18 , A23L33/135 , A23Y2240/41 , A61K35/744
摘要： To provide a microorganism and an ingredient thereof that contribute to prevention and treatment of immune diseases including allergy, autoimmune diseases and inflammatory bowel diseases (e.g., large-intestinal ulcer), a method of effectively selecting the microorganism, and a method of efficiently inducing immunoregulatory cells that play an important role on maintaining immunological homeostasis using the microorganism or the ingredient thereof. The present invention provides a Lactococcus and an ingredient thereof which induce production of IL-10 from mammalian dendritic or spleen cells, a method of obtaining the microorganism or the ingredient thereof by co-culturing a microorganism such as Lactococcus strains with mammalian dendritic or spleen cells to select a microbial cell having a high IL-10 production ability, a method of selecting the microorganism or the ingredient thereof by co-culturing an intestinal epithelial cell with a microorganism such as the lactic acid bacteria and selecting the cells on the basis of a caspase-1 activity and the ability of inducing the production of IL-18, and a food product or material and an animal feeding stuff or medical and pharmaceutical products which contain the lactic acid bacteria as an effective ingredient.
摘要翻译：提供有助于预防和治疗包括过敏，自身免疫疾病和炎性肠病（例如大肠溃疡）的免疫疾病的微生物及其成分，有效选择微生物的方法和有效诱导免疫调节的方法在使用微生物或其成分维持免疫稳态方面起重要作用的细胞。本发明提供了一种从哺乳动物树突细胞或脾细胞诱导产生IL-10的乳球菌及其成分，通过与哺乳动物树突细胞或脾细胞共培养诸如乳球菌属菌株的微生物获得微生物或其成分的方法选择具有高IL-10生产能力的微生物细胞，通过与微生物如乳酸菌共培养肠上皮细胞来选择微生物或其成分的方法，并且基于半胱氨酸蛋白酶-1活性和诱导IL-18产生的能力以及含有乳酸菌作为有效成分的食品或物质以及动物饲料或医药产品。

8. 发明授权

US07642081B2 Lactic acid bacteria and their cellular components inducing immunoregulatory function, and method of obtaining the same 失效
标题翻译：诱导免疫调节功能的乳酸菌及其细胞成分及其获得方法
公开(公告)号：US07642081B2
公开(公告)日：2010-01-05
申请号：US10996463
申请日：2004-11-26
申请人： Noriko Tsuji , Hiromi Kimoto
发明人： Noriko Tsuji , Hiromi Kimoto
IPC分类号： C12N1/20
CPC分类号： C12R1/46 , A23C19/0323 , A23K10/16 , A23K10/18 , A23L33/135 , A23Y2240/41 , A61K35/744
摘要： To provide a microorganism and an ingredient thereof that contribute to prevention and treatment of immune diseases including allergy, autoimmune diseases and inflammatory bowel diseases (e.g., large-intestinal ulcer), a method of effectively selecting the microorganism, and a method of efficiently inducing immunoregulatory cells that play an important role on maintaining immunological homeostasis using the microorganism or the ingredient thereof. The present invention provides a Lactococcus and an ingredient thereof which induce production of IL-10 from mammalian dendritic or spleen cells, a method of obtaining the microorganism or the ingredient thereof by co-culturing a microorganism such as Lactococcus strains with mammalian dendritic or spleen cells to select a microbial cell having a high IL-10 production ability, a method of selecting the microorganism or the ingredient thereof by co-culturing an intestinal epithelial cell with a microorganism such as the lactic acid bacteria and selecting the cells on the basis of a caspase-1 activity and the ability of inducing the production of IL-18, and a food product or material and an animal feeding stuff or medical and pharmaceutical products which contain the lactic acid bacteria as an effective ingredient.
摘要翻译：提供有助于预防和治疗包括过敏，自身免疫疾病和炎性肠病（例如大肠溃疡）的免疫疾病的微生物及其成分，有效选择微生物的方法和有效诱导免疫调节的方法在使用微生物或其成分维持免疫稳态方面起重要作用的细胞。本发明提供了一种从哺乳动物树突细胞或脾细胞诱导产生IL-10的乳球菌及其成分，通过与哺乳动物树突细胞或脾细胞共培养诸如乳球菌属菌株的微生物获得微生物或其成分的方法选择具有高IL-10生产能力的微生物细胞，通过与微生物如乳酸菌共培养肠上皮细胞来选择微生物或其成分的方法，并且基于半胱氨酸蛋白酶-1活性和诱导IL-18产生的能力以及含有乳酸菌作为有效成分的食品或物质以及动物饲料或医药产品。

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