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1. 发明授权

US07282179B2 Blood testing unit and blood testing method and apparatus 失效
标题翻译：血液检测单元和血液检测方法及仪器
公开(公告)号：US07282179B2
公开(公告)日：2007-10-16
申请号：US10400585
申请日：2003-03-28
申请人： Yoshihide Iwaki , Kentarou Nakamura , Hideaki Tanaka , Yoshiki Sakaino , Kaoru Terashima , Ichizou Toya
发明人： Yoshihide Iwaki , Kentarou Nakamura , Hideaki Tanaka , Yoshiki Sakaino , Kaoru Terashima , Ichizou Toya
IPC分类号： G01N33/00
CPC分类号： B01L3/50825 , B01L3/502 , B01L3/5027 , B01L3/50273 , B01L3/502753 , B01L3/5082 , B01L2200/082 , B01L2300/042 , B01L2300/044 , B01L2300/047 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , B01L2400/049 , B01L2400/0633 , G01N33/491
摘要： A blood testing unit comprises a closed vessel having a blood introducing section formed at a certain area of the closed vessel. A blood constituent separating section is located within the closed vessel to separate plasma and/or serum from the blood sample introduced through the blood introducing section into the closed vessel. A reagent layer is located within the closed vessel, such that the reagent layer can be seen from the exterior. The reagent layer comprises a region for spreading the plasma and/or the serum, which has been separated by the blood constituent separating section from the blood sample, and a reagent supporte donor in the spreading region, the reagent undergoing a reaction with the plasma and/or the serum and forming a color as a result of the reaction.
摘要翻译：血液检查单元包括形成在密闭容器的特定区域的具有血液导入部的密闭容器。血液成分分离部位于封闭容器内，将血浆和/或血清从通过血液导入部导出的血液样品分离成密闭容器。试剂层位于密闭容器内，从而可以从外部看到试剂层。试剂层包括用于使血液成分分离部分与血液样品分离的血浆和/或血清的扩散区域和扩散区域中的试剂载体供体，与血浆反应的试剂和 /或血清，并形成反应结果的颜色。

2. 发明申请

US20060211127A1 Blood testing unit and blood testing method and apparatus 审中-公开
标题翻译：血液检测单元和血液检测方法及仪器
公开(公告)号：US20060211127A1
公开(公告)日：2006-09-21
申请号：US11435933
申请日：2006-05-18
申请人： Yoshihide Iwaki , Kentarou Nakamura , Hideaki Tanaka , Yoshiki Sakaino , Kaoru Terashima , Ichizou Toya
发明人： Yoshihide Iwaki , Kentarou Nakamura , Hideaki Tanaka , Yoshiki Sakaino , Kaoru Terashima , Ichizou Toya
IPC分类号： G01N21/00
CPC分类号： B01L3/50825 , B01L3/502 , B01L3/5027 , B01L3/50273 , B01L3/502753 , B01L3/5082 , B01L2200/082 , B01L2300/042 , B01L2300/044 , B01L2300/047 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , B01L2400/049 , B01L2400/0633 , G01N33/491
摘要： A blood testing unit comprises a closed vessel having a blood introducing section formed at a certain area of the closed vessel. A blood constituent separating section is located within the closed vessel to separate plasma and/or serum from the blood sample introduced through the blood introducing section into the closed vessel. A reagent layer is located within the closed vessel, such that the reagent layer can be seen from the exterior. The reagent layer comprises a region for spreading the plasma and/or the serum, which has been separated by the blood constituent separating section from the blood sample, and a reagent supported on or in the spreading region, the reagent undergoing a reaction with the plasma and/or the serum and forming a color as a result of the reaction.
摘要翻译：血液检查单元包括形成在密闭容器的特定区域的具有血液导入部的密闭容器。血液成分分离部位于封闭容器内，将血浆和/或血清从通过血液导入部导出的血液样品分离成密闭容器。试剂层位于密闭容器内，从而可以从外部看到试剂层。试剂层包括用于将血液成分分离部分与血液样品分离的等离子体和/或血清扩散区域，以及支撑在扩散区域上或其上的试剂，与血浆反应的试剂和/或血清，并形成作为反应结果的颜色。

3. 发明授权

US07410613B2 Humoral testing apparatus 失效
标题翻译：体液检测仪
公开(公告)号：US07410613B2
公开(公告)日：2008-08-12
申请号：US10397376
申请日：2003-03-27
申请人： Yoshihide Iwaki , Kentarou Nakamura , Hideaki Tanaka , Yoshiki Sakaino , Kaoru Terashima , Hitoshi Shimizu
发明人： Yoshihide Iwaki , Kentarou Nakamura , Hideaki Tanaka , Yoshiki Sakaino , Kaoru Terashima , Hitoshi Shimizu
IPC分类号： G01N21/78
CPC分类号： G01N21/78 , G01N21/5907
摘要： A humoral testing apparatus in which a measuring light is irradiated to a reagent area forming a color as a result of a reaction and an optical density of the reagent area is detected by a detecting operation of light intensity of the reflected light. The humoral testing apparatus enables a humoral test to be performed accurately in cases where nonuniformity occurs with the reaction of a reagent with a humoral sample within the reagent area, or in cases where fine dust is present within each detecting spot in the reagent areas. The light reflected from the reagent areas is detected with a two-dimensional photodetector. The independent light intensity detecting operations are performed with respect to the subareas of the reagent area of a reagent layer. A photo detection signal S, which represents the intensity of the reflected light is statistically processed with a signal processing section 51.
摘要翻译：通过反射光的光强度的检测操作来检测其中测量光照射到由于反应而形成颜色的试剂区域和试剂区域的光密度的体液测试装置。体液检测装置能够在试剂区域内的试剂与体液样品的反应发生不均匀的情况下，或者在试剂区域的每个检测点内存在微细粉尘的情况下，能够准确地进行体液检查。用二维光电检测器检测从试剂区反射的光。针对试剂层的试剂区域的子区域进行独立的光强度检测动作。用信号处理部分51对表示反射光强度的光检测信号S进行统计处理。

4. 发明授权

US07300629B2 Humoral testing unit 失效
标题翻译：体液检测单位
公开(公告)号：US07300629B2
公开(公告)日：2007-11-27
申请号：US10400548
申请日：2003-03-28
申请人： Yoshihide Iwaki , Kentarou Nakamura , Hideaki Tanaka , Yoshiki Sakaino , Kaoru Terashima
发明人： Yoshihide Iwaki , Kentarou Nakamura , Hideaki Tanaka , Yoshiki Sakaino , Kaoru Terashima
IPC分类号： G01N30/00
CPC分类号： G01N33/491
摘要： A blood testing unit is provided with a closed vessel having an outer vessel body and an inner vessel body, and a reagent layer is accommodated in the closed vessel. Reagents which react with a blood sample are supported on the reagent layer. The closed vessel is comprised such that at least either one of the outer vessel body and the inner vessel body is provided with an aperture, through which air is capable of being introduced from the exterior to the interior of the one vessel body, and the one vessel body is provided with a sealing member for closing the aperture.
摘要翻译：血液检查单元设置有具有外容器主体和内容器主体的封闭容器，并且将试剂层容纳在密闭容器中。与血液样品反应的试剂被支撑在试剂层上。封闭容器包括使得外部容器主体和内部容器主体中的至少一个设置有孔，空气能够从外部引入到一个容器主体的内部，并且一个容器体设置有用于封闭孔的密封构件。

5. 发明授权

US07113875B2 Humoral testing unit and a humoral testing apparatus 失效
公开(公告)号：US07113875B2
公开(公告)日：2006-09-26
申请号：US10397372
申请日：2003-03-27
申请人： Kaoru Terashima , Yoshiki Sakaino , Hideaki Tanaka , Kentarou Nakamura , Yoshihide Iwaki , Hitoshi Shimizu
发明人： Kaoru Terashima , Yoshiki Sakaino , Hideaki Tanaka , Kentarou Nakamura , Yoshihide Iwaki , Hitoshi Shimizu
IPC分类号： G01N33/48
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B2560/0233
摘要： A plurality of different kinds of reagents are supported at different positions on a reagent layer. A humoral testing apparatus irradiates measuring light which has a wavelength adapted to one of the plurality of the reagent areas which forms a color, and detects the intensity of the light reflected from the reagent areas with the photodetector with respect to each of the reagents, and thus detects the optical densities of the reagent areas.

6. 发明授权

US5972635A Sulfonic acid group buffered dry analytical element for quantitative analysis of creatine kinase or its MB isozyme 有权
标题翻译：磺酸基缓冲干燥分析元素用于定量分析肌酸激酶或其MB同工酶
公开(公告)号：US5972635A
公开(公告)日：1999-10-26
申请号：US158485
申请日：1998-09-22
申请人： Hideaki Tanaka , Yoshihiko Abe , Yoshiki Sakaino , Kaoru Terashima
发明人： Hideaki Tanaka , Yoshihiko Abe , Yoshiki Sakaino , Kaoru Terashima
IPC分类号： C12Q1/32 , C12Q1/48 , C12Q1/50 , G01N33/52 , G01N33/70
CPC分类号： G01N33/70 , C12Q1/50
摘要： A dry analytical element for quantitatively analyzing creatine kinase is composed of a support and a creatine kinase-detecting agent layer. The creatine kinase-detecting agent layer contains creatine phosphate and adenosine diphosphate which react with each other to give adenosine triphosphate in the presence of creatine kinase, a buffer compound having a sulfonic acid group which keeps the layer in the range of pH 5.5 to pH 8.5 for the formation of adenosine triphosphate, and an indicator composition which reacts with the formed adenosine triphosphate to give a spectroscopically detectable compound. An analytical element for analysis of creatine kinase MB isozyme further contains in the layer an antibody which specifically inhibits activity of M sub-unit of creatine kinase.
摘要翻译：用于定量分析肌酸激酶的干燥分析元件由载体和肌酸激酶检测剂层组成。肌酸激酶检测剂层含有磷酸肌酸和二磷酸腺苷，其在肌酸激酶存在下相互反应以产生腺苷三磷酸，其是具有磺酸基的缓冲化合物，其将该层保持在pH5.5至pH8.5的范围内用于形成三磷酸腺苷，以及与形成的三磷酸腺苷反应以产生光谱可检测化合物的指示剂组合物。用于分析肌酸激酶MB同功酶的分析元素在该层中进一步含有特异性抑制肌酸激酶M亚单位活性的抗体。

7. 发明申请

US20050002038A1 Optical measuring apparatus and optical measuring method 失效
标题翻译：光学测量仪器和光学测量方法
公开(公告)号：US20050002038A1
公开(公告)日：2005-01-06
申请号：US10849777
申请日：2004-05-21
申请人： Yoshiki Sakaino , Yoshihiko Abe , Kaoru Terashima
发明人： Yoshiki Sakaino , Yoshihiko Abe , Kaoru Terashima
IPC分类号： G01N21/01 , G01N21/27 , G01N21/31 , G01N21/47 , G01N21/59 , G01N21/86
CPC分类号： G01N21/8483 , G01N21/31 , G01N21/4738
摘要： An optical measuring apparatus comprises: an illuminating section that illuminates a first object with a first light; a light changing section that changes an intensity of the first light illuminating the first object; a light receiving device that receives a second light transmitted through or reflected from the first object; and an output section that outputs a measurement result according to i) a state of the light changing section and ii) an amount of the second light received by the light receiving device. In addition, an optical measuring apparatus comprises: the illuminating section; the light receiving device; a light receiving time changing section that changes a light receiving time of the light receiving device; and an output section that outputs a measurement result according to i) the light receiving time and ii) an amount of the second light received by the light receiving device.
摘要翻译：光学测量装置包括：用第一光照亮第一物体的照明部分; 光改变部，其改变照射第一物体的第一光的强度; 光接收装置，其接收透过或者从第一物体反射的第二光; 以及输出部，其根据i）光改变部的状态输出测量结果，以及ii）由光接收装置接收的第二光的量。另外，光学测量装置包括：照明部; 光接收装置; 光接收时间改变部，其改变所述光接收装置的光接收时间; 以及输出部，其根据i）光接收时间输出测量结果，以及ii）由光接收装置接收的第二光的量。

8. 发明授权

US07369243B2 Optical measuring apparatus and optical measuring method 失效
标题翻译：光学测量仪器和光学测量方法
公开(公告)号：US07369243B2
公开(公告)日：2008-05-06
申请号：US10849777
申请日：2004-05-21
申请人： Yoshiki Sakaino , Yoshihiko Abe , Kaoru Terashima
发明人： Yoshiki Sakaino , Yoshihiko Abe , Kaoru Terashima
IPC分类号： G01N21/47
CPC分类号： G01N21/8483 , G01N21/31 , G01N21/4738
摘要： An optical measuring apparatus comprises: an illuminating section that illuminates a first object with a first light; a light changing section that changes an intensity of the first light illuminating the first object; a light receiving device that receives a second light transmitted through or reflected from the first object; and an output section that outputs a measurement result according to i) a state of the light changing section and ii) an amount of the second light received by the light receiving device. In addition, an optical measuring apparatus comprises: the illuminating section; the light receiving device; a light receiving time changing section that changes a light receiving time of the light receiving device; and an output section that outputs a measurement result according to i) the light receiving time and ii) an amount of the second light received by the light receiving device.
摘要翻译：光学测量装置包括：用第一光照亮第一物体的照明部分; 光改变部，其改变照射第一物体的第一光的强度; 光接收装置，其接收透过或者从第一物体反射的第二光; 以及输出部，其根据i）光改变部的状态输出测量结果，以及ii）由光接收装置接收的第二光的量。另外，光学测量装置包括：照明部; 光接收装置; 光接收时间改变部，其改变所述光接收装置的光接收时间; 以及输出部，其根据i）光接收时间输出测量结果，以及ii）由光接收装置接收的第二光的量。

9. 发明授权

US06852540B2 Control serum for dry analytical element 失效
标题翻译：控制干燥分析元素的血清
公开(公告)号：US06852540B2
公开(公告)日：2005-02-08
申请号：US10659928
申请日：2003-09-11
申请人： Haijime Makiuchi , Hideaki Tanaka , Kaoru Terashima
发明人： Haijime Makiuchi , Hideaki Tanaka , Kaoru Terashima
IPC分类号： G01N33/96 , G01N31/00
CPC分类号： G01N33/96 , Y10T436/10 , Y10T436/106664 , Y10T436/25
摘要： A control serum for a dry process is provided that does not show misfit in measurement values by the dry process and a wet process. The above-mentioned control serum is obtained by freezing or freeze-drying a control serum without dialysis.
摘要翻译：提供干法处理的对照血清，其通过干法和湿法不显示测量值的错配。上述对照血清是通过冷冻或冷冻干燥对照血清而不进行透析而得到的。

10. 发明授权

US05998158A Glucose free, stable dry analytical element for quantitative analysis of creatine kinase MB isozyme 失效
标题翻译：不含葡萄糖，稳定的干燥分析元素用于定量分析肌酸激酶MB同功酶
公开(公告)号：US05998158A
公开(公告)日：1999-12-07
申请号：US158484
申请日：1998-09-22
申请人： Hideaki Tanaka , Yoshihiko Abe , Kaoru Terashima
发明人： Hideaki Tanaka , Yoshihiko Abe , Kaoru Terashima
IPC分类号： C12Q1/50
CPC分类号： C12Q1/50
摘要： A dry analytical element for quantitatively analyzing creatine kinase MB isozyme is composed of a support and a creatine kinase MB isozyme-detecting agent layer. The detecting layer contains an antibody which specifically inhibits activity of M sub-unit of creatine kinase, creatine phosphate and adenosine diphosphate which react with each other to give adenosine triphosphate in the presence of creatine kinase MB isozyme, a buffer compound which keeps the layer in the range of pH 5.5 to pH 8.5 for the formation of adenosine triphosphate, and an indicator composition which reacts with the formed adenosine triphosphate to give a spectroscopically detectable compound, said indicator composition having hexokinase, nicotinamide-adenine dinucleotide or its phosphate in an oxidized form, and glucose-6-phosphate dehydrogenase but not containing glucose in such amount as to give the spectroscopically detectable compound.
摘要翻译：用于定量分析肌酸激酶MB同功酶的干燥分析元件由载体和肌酸激酶MB同工酶检测剂层组成。检测层含有特异性抑制肌酸激酶，亚磷酸肌酸和磷酸腺苷的M亚单位的活性的抗体，其在肌酸激酶MB同功酶（一种保持该层的缓冲化合物）存在下相互反应，产生三磷酸腺苷用于形成三磷酸腺苷的pH 5.5至pH 8.5的范围，以及与形成的三磷酸腺苷反应以产生光谱可检测化合物的指示剂组合物，所述指示剂组合物具有己糖激酶，烟酰胺 - 腺嘌呤二核苷酸或其氧化形式的磷酸酯和葡萄糖-6-磷酸脱氢酶，但不含葡萄糖，其量使得可得到光谱可检测的化合物。

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