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1. 发明授权

US09040502B2 Anti-XDR-TB drug, anti-MDR-TB drug, and combination anti-tuberculosis drug 有权
标题翻译：抗XDR-TB药物，抗MDR-TB药物和抗结核药物组合
公开(公告)号：US09040502B2
公开(公告)日：2015-05-26
申请号：US13075356
申请日：2011-03-30
申请人： Yoshiaki Takahashi , Masayuki Igarashi , Masaji Okada
发明人： Yoshiaki Takahashi , Masayuki Igarashi , Masaji Okada
IPC分类号： C07H19/067 , A61K31/4409 , A61K31/496 , A61K31/7072
CPC分类号： C07H19/067 , A61K31/4409 , A61K31/496 , A61K31/7072 , A61K2300/00
摘要： A method for treating an individual infected with XDR-TB, the method including administering to the individual an anti-XDR-TB drug which comprises a compound having a structure expressed by Structural Formula (1) below:
摘要翻译：一种用于治疗感染XDR-TB的个体的方法，所述方法包括向个体施用包含具有由以下结构式（1）表示的结构的化合物的抗XDR-TB药物：

2. 发明申请

US20110237530A1 ANTI-XDR-TB DRUG, ANTI-MDR-TB DRUG, AND COMBINATION ANTI-TUBERCULOSIS DRUG 有权
标题翻译：抗耐药结核病药物，抗耐药结核病药物和组合抗结核药物
公开(公告)号：US20110237530A1
公开(公告)日：2011-09-29
申请号：US13075356
申请日：2011-03-30
申请人： YOSHIAKI TAKAHASHI , Masayuki Igarashi , Masaji Okada
发明人： YOSHIAKI TAKAHASHI , Masayuki Igarashi , Masaji Okada
IPC分类号： A61K31/7072 , A61P31/04 , A61P31/06
CPC分类号： C07H19/067 , A61K31/4409 , A61K31/496 , A61K31/7072 , A61K2300/00
摘要： A method for treating an individual infected with XDR-TB, the method including administering to the individual an anti-XDR-TB drug which comprises a compound having a structure expressed by Structural Formula (1) below:
摘要翻译：一种用于治疗感染XDR-TB的个体的方法，所述方法包括向个体施用包含具有由以下结构式（1）表示的结构的化合物的抗XDR-TB药物：

3. 发明申请

US20090209744A1 Antibacterial agent and therapeutic agent for Johne's disease containing the same 有权
标题翻译：抗菌剂和治疗剂含有相同的约翰氏病
公开(公告)号：US20090209744A1
公开(公告)日：2009-08-20
申请号：US12378172
申请日：2009-02-11
申请人： Yoshiaki Takahashi , Masayuki Igarashi
发明人： Yoshiaki Takahashi , Masayuki Igarashi
IPC分类号： C07H19/06
CPC分类号： A61K31/7072 , A01N43/62
摘要： An antibacterial agent having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is provided. Specifically, the antibacterial agent of the present invention having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is a caprazamycin derivative represented, for example, by the following general formula (II): wherein Me is a methyl group; and R1 is a straight or substantially straight chain alkyl group having 5 to 21 carbon atoms, a straight or substantially straight chain alkenyl group having 5 to 21 carbon atoms, a cycloalkyl group having 5 to 12 carbon atoms, or a phenyl group substituted at the para-position with a straight chain alkyl group having 1 to 14 carbon atoms, a straight chain alkoxy group having 1 to 9 carbon atoms or a cycloalkyl group having 5 to 12 carbon atoms.
摘要翻译：对鸟分枝杆菌亚种具有高抗菌活性的抗菌剂提供副结核病。具体地说，本发明的抗菌剂对鸟分枝杆菌属副结核病是例如由以下通式（II）表示的卡拉霉素衍生物：其中Me是甲基; R1为碳原子数5〜21的直链或直链状的直链状烷基，碳原子数5〜21的直链或直链状的链烯基，碳原子数5〜12的环烷基，具有1至14个碳原子的直链烷基的对位位置，具有1至9个碳原子的直链烷氧基或具有5至12个碳原子的环烷基。

4. 发明授权

US08058247B2 Antibacterial agent and therapeutic agent for johne's disease containing the same 有权
标题翻译：抗菌剂和治疗剂含有相同的约翰氏病
公开(公告)号：US08058247B2
公开(公告)日：2011-11-15
申请号：US12378172
申请日：2009-02-11
申请人： Yoshiaki Takahashi , Masayuki Igarashi
发明人： Yoshiaki Takahashi , Masayuki Igarashi
IPC分类号： A61K31/7016 , A61K31/7052 , C07G11/00 , C07H15/26
CPC分类号： A61K31/7072 , A01N43/62
摘要： An antibacterial agent having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is provided. Specifically, the antibacterial agent of the present invention having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is a caprazamycin derivative represented, for example, by the following general formula (II): wherein Me is a methyl group; and R1 is a straight or substantially straight chain alkyl group having 5 to 21 carbon atoms, a straight or substantially straight chain alkenyl group having 5 to 21 carbon atoms, a cycloalkyl group having 5 to 12 carbon atoms, or a phenyl group substituted at the para-position with a straight chain alkyl group having 1 to 14 carbon atoms, a straight chain alkoxy group having 1 to 9 carbon atoms or a cycloalkyl group having 5 to 12 carbon atoms.
摘要翻译：对鸟分枝杆菌亚种具有高抗菌活性的抗菌剂提供副结核病。具体地说，本发明的抗菌剂对鸟分枝杆菌属副结核病是由例如由以下通式（II）表示的卡拉霉素衍生物：其中Me是甲基; R1为碳原子数5〜21的直链或直链状的直链状的碳原子数为5〜21的直链或直链的烯基，碳原子数为5〜12的环烷基，具有1至14个碳原子的直链烷基的对位位置，具有1至9个碳原子的直链烷氧基或具有5至12个碳原子的环烷基。

5. 发明授权

US07482439B2 Caprazene as novel compound and derivatives thereof, and caprazol as novel compound and derivatives thereof 有权
标题翻译：作为新化合物及其衍生物，并且作为新化合物及其衍生物的螯合物，
公开(公告)号：US07482439B2
公开(公告)日：2009-01-27
申请号：US10543887
申请日：2004-01-30
申请人： Toshiaki Miyake , Masayuki Igarashi , Tetsuo Shitara , Yoshiaki Takahashi , Masa Hamada
发明人： Toshiaki Miyake , Masayuki Igarashi , Tetsuo Shitara , Yoshiaki Takahashi , Masa Hamada
IPC分类号： A61K31/7008 , A61K31/7016 , A61K31/551 , A61K31/51 , C07H17/02 , C07D243/08
CPC分类号： C07H19/067 , A61K31/7072 , C07D403/08 , C07D403/14 , C07D405/14 , C07H15/26 , C07H19/06 , Y02P20/55
摘要： Caprazene and caprazol could be synthesized by hydrolysis of a caprazamycin. There could be synthesized a caprazene-1′″-amide derivative of the formula (II) and a caprazene-1′″-ester derivative of the formula (III) from caprazene. Further, there could be synthesized a caprazol-1′″-amide derivative of the formula (V) and a caprazol-1′″-amide-3′″-ester derivative and a caprazol-3′″-ester derivative, etc. from caprazol. Furthermore, an imidazolidinone derivative could be synthesized from the ring-opened product of the 1,4-diazepinone ring of caprazol. The novel caprazene derivative, novel caprazol derivative and novel imidazolidinone derivative now synthesized exhibit excellent antibacterial activities against a variety of bacteria, including acid-fast bacteria.
摘要翻译： Caprazene和caprazol可以通过caprazamycin的水解合成。可以从癸腈合成式（II）的癸酰肼衍生物和式（III）的癸酰基-1“ - 酯衍生物。此外，可以合成式（V）的十六唑-1“ - 酰胺衍生物和十六唑-1” - 酰胺-3“ - 酯衍生物和癸酰唑-3' - 酯衍生物衍生物等。此外，咪唑啉酮衍生物可以由四唑的1,4-二氮杂环酮环的开环产物合成。现在合成的新型caprazene衍生物，新型吡唑衍生物和新型咪唑啉酮衍生物对各种细菌，包括耐酸细菌表现出优异的抗菌活性。

6. 发明授权

US08710198B2 Caprazene as a novel compound and derivatives thereof, and caprazol as a novel compound and derivatives thereof 有权
标题翻译： Caprazene作为新化合物及其衍生物，以及作为新化合物及其衍生物的螯合物
公开(公告)号：US08710198B2
公开(公告)日：2014-04-29
申请号：US12345190
申请日：2008-12-29
申请人： Toshiaki Miyake , Masayuki Igarashi , Tetsuo Shitara , Yoshiaki Takahashi , Masa Hamada
发明人： Toshiaki Miyake , Masayuki Igarashi , Tetsuo Shitara , Yoshiaki Takahashi , Masa Hamada
IPC分类号： C07H19/067 , C07D403/08 , C07D403/14 , C07D243/08 , C07D405/14
CPC分类号： C07H19/067 , A61K31/7072 , C07D403/08 , C07D403/14 , C07D405/14 , C07H15/26 , C07H19/06 , Y02P20/55
摘要： Caprazene is provided which is the compound represented by the following formula (I) wherein Me stands for methyl group, and a 5″-N-alkoxycarbonyl or 5″-N-aralkyloxycarbonyl derivative thereof, and wherein said compound has the 1H-NMR and 13C-NMR data as set forth in Table 15.
摘要翻译：提供了作为Me表示甲基的下式（I）表示的化合物和5“-N-烷氧基羰基或5”-N-芳烷氧基羰基衍生物的化合物，其中所述化合物具有1H-NMR和 13C-NMR数据如表15所示。

7. 发明申请

US20060178319A1 Caprazene as novel compound and derivatives thereof, and caprazol as novel compound and derivatives thereof 有权
标题翻译：作为新化合物及其衍生物，并且作为新化合物及其衍生物的螯合物，
公开(公告)号：US20060178319A1
公开(公告)日：2006-08-10
申请号：US10543887
申请日：2004-01-30
申请人： Toshiaki Miyake , Masayuki Igarashi , Tetsuo Shitara , Yoshiaki Takahashi , Masa Hamada
发明人： Toshiaki Miyake , Masayuki Igarashi , Tetsuo Shitara , Yoshiaki Takahashi , Masa Hamada
IPC分类号： A61K31/7072 , C07H19/048
CPC分类号： C07H19/067 , A61K31/7072 , C07D403/08 , C07D403/14 , C07D405/14 , C07H15/26 , C07H19/06 , Y02P20/55
摘要： Caprazene and caprazol could be synthesized by hydrolysis of a caprazamycin. There could be synthesized a caprazene-1′″- amide derivative of the formula (II) and a caprazene-1′″-ester derivative of the formula (III) from caprazene. Further, there could be synthesized a caprazol-1′″-amide derivative of the formula (V) and a caprazol-1′″-amide-3′″-ester derivative and a caprazol-3′″-ester derivative, etc. from caprazol. Furthermore, an imidazolidinone derivative could be synthesized from the ring-opened product of the 1,4-diazepinone ring of caprazol. The novel caprazene derivative, novel caprazol derivative and novel imidazolidinone derivative now synthesized exhibit excellent antibacterial activities against a variety of bacteria, including acid-fast bacteria.
摘要翻译： Caprazene和caprazol可以通过caprazamycin的水解合成。可以从癸腈合成式（II）的癸酰肼衍生物和式（III）的癸酰基-1“ - 酯衍生物。此外，可以合成式（V）的十六唑-1“ - 酰胺衍生物和十六唑-1” - 酰胺-3“ - 酯衍生物和癸酰唑-3' - 酯衍生物衍生物等。此外，咪唑啉酮衍生物可以由四唑的1,4-二氮杂环酮环的开环产物合成。现在合成的新型caprazene衍生物，新型吡唑衍生物和新型咪唑啉酮衍生物对各种细菌，包括耐酸细菌表现出优异的抗菌活性。

8. 发明申请

US20140155586A1 Compound Amycolamicin, Method for Producing the Same, and Use of the Same 失效
标题翻译：复方青霉胺，其制备方法及其用途
公开(公告)号：US20140155586A1
公开(公告)日：2014-06-05
申请号：US13278269
申请日：2011-10-21
申请人： Masayuki Igarashi , Ryuichi Sawa , Yoshiko Homma
发明人： Masayuki Igarashi , Ryuichi Sawa , Yoshiko Homma
IPC分类号： C07H19/044 , C12P19/44
CPC分类号： C07H19/044 , C07D405/14 , C12P17/16 , C12P19/44 , C12P19/46 , C12R1/01
摘要： A compound having a structure expressed by the following Structural Formula (1), tautomers thereof, or salts of the compound or the tautomers.
摘要翻译：具有由以下结构式（1）表示的结构的化合物，其互变异构体或化合物或互变异构体的盐。

9. 发明申请

US20110144355A1 NOVEL COMPOUND SIGNAMYCIN, METHOD FOR PRODUCTION THEREOF, AND USE THEREOF 有权
标题翻译：新型化合物SIGNMYCIN，其生产方法及其用途
公开(公告)号：US20110144355A1
公开(公告)日：2011-06-16
申请号：US13033133
申请日：2011-02-23
申请人： Masayuki Igarashi , Ryutaro Utsumi
发明人： Masayuki Igarashi , Ryutaro Utsumi
IPC分类号： C07D207/44 , C12P17/10 , C12N1/20
CPC分类号： C12P17/10 , A01N43/36 , A01N63/02 , A61K31/4015 , C07D207/44 , C12R1/465
摘要： A compound having a structure expressed by the following Structural Formula (1) and a compound having a structure expressed by the following Structural Formula (2):
摘要翻译：具有由以下结构式（1）表示的结构的化合物和具有由以下结构式（2）表示的结构的化合物：

10. 发明授权

US08742135B1 Compound amycolamicin, method for producing the same, and use of the same 失效
标题翻译：复方阿米卡霉素，其制造方法及其用途
公开(公告)号：US08742135B1
公开(公告)日：2014-06-03
申请号：US13278269
申请日：2011-10-21
申请人： Masayuki Igarashi , Ryuichi Sawa , Yoshiko Homma
发明人： Masayuki Igarashi , Ryuichi Sawa , Yoshiko Homma
IPC分类号： C07D403/14
CPC分类号： C07H19/044 , C07D405/14 , C12P17/16 , C12P19/44 , C12P19/46 , C12R1/01
摘要： A compound having a structure expressed by the following Structural Formula (1), tautomers thereof, or salts of the compound or the tautomers.
摘要翻译：具有由以下结构式（1）表示的结构的化合物，其互变异构体或化合物或互变异构体的盐。

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