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1. 发明授权

US07309718B2 Dibenzocycloheptene compound 失效
标题翻译：二苯并环庚烯化合物
公开(公告)号：US07309718B2
公开(公告)日：2007-12-18
申请号：US10481752
申请日：2002-06-27
申请人： Yoshiaki Kuroki , Hitoshi Ueno , Tetsushi Katsube , Tetsuo Kawaguchi , Eiji Okanari , Ichiro Tanaka , Masayuki Tanaka , Masahiko Hagihara
发明人： Yoshiaki Kuroki , Hitoshi Ueno , Tetsushi Katsube , Tetsuo Kawaguchi , Eiji Okanari , Ichiro Tanaka , Masayuki Tanaka , Masahiko Hagihara
IPC分类号： A61K31/19 , C07C61/00 , C07C63/00
CPC分类号： C07D215/18 , C07D215/12
摘要： The present invention discloses a dibenzocycloheptene compound represented by the formula (I): wherein R1: hydrogen atom, halogen atom, etc., R2: hydrogen atom, halogen atom, etc., A: 5-membered or 6-membered heteroaromatic ring group containing 1 to 3 hetero atom(s) selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom, and the heteroaromatic ring group, etc. may have halogen atom, nitrogen atom, etc. as substituent(s), B: formula; —CH═CH—, formula; —CH2O—, etc., Y: C1-C10 alkylene group which may have halogen atom, etc. as substituent(s), etc., Z: carboxyl group which may be protected, etc., m: an integer of 1 to 4, n: an integer of 1 to 3, represents a single bond or a double bond, or a pharmaceutically acceptable salt thereof and a medical composition containing the same as an effective ingredient which has leukotriene C4 antagonistic action and leukotriene E4 antagonistic action in addition to potent leukotriene D4 antagonistic action, and useful as antiasthmatic agent, antiallergic agent and anti-inflammatory agent.
摘要翻译：本发明公开了式（I）表示的二苯并环庚烯化合物：其中R 1：氢原子，卤素原子等，R 2：氢原子，卤素原子等，含有1〜3个选自氮原子，氧原子和硫原子的杂原子的5元或6元杂芳族环基和杂芳环基等可以具有卤素原子，氮原子等作为取代基，B：式; -CH-CH-，式 -CH 2 O - 等，Y：C 1 -C 10亚烷基，其可以具有卤素原子等作为取代基（ s）等，Z：可被保护的羧基等，m：1〜4的整数，n：1〜3的整数，表示单键或双键，或其药学上可接受的盐和含有与有效成分相同的药物组合物，除了有效的白三烯外，还具有白三烯C 4拮抗作用和白三烯E 4拮抗作用 D 4拮抗作用，可用作止喘剂，抗过敏剂和抗炎剂。

2. 发明授权

US06265418B1 N-acylamino acid amide compounds and intermediates for preparation thereof 失效
标题翻译： N-酰氨基酰胺化合物及其制备中间体
公开(公告)号：US06265418B1
公开(公告)日：2001-07-24
申请号：US09463753
申请日：2000-01-31
申请人： Yoshiaki Kuroki , Hitoshi Ueno , Masayuki Tanaka , Katsunori Takata , Takahiro Motoyama , Kousuke Baba
发明人： Yoshiaki Kuroki , Hitoshi Ueno , Masayuki Tanaka , Katsunori Takata , Takahiro Motoyama , Kousuke Baba
IPC分类号： A61K31435
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention discloses the compound represented by the formula (I): wherein A represents the following formula (a-1) or the following formula (a-2): B represents the following formula (b): (wherein the symbols are each as defined in the specification) or a pharmaceutically acceptable salts thereof, and intermediates for the preparation thereof, which have excellent platelet aggregation inhibitory activity and other properties and useful as prophylactic or therapeutic agents for diseases associated with a fibrinogen receptor, thrombosis, infarction and the like.
摘要翻译：本发明公开了由式（I）表示的化合物：其中A表示下式（a-1）或下式（a-2）：B表示下式（b）:(其中各符号分别为如本说明书中所定义）或其药学上可接受的盐及其制备的中间体，其具有优异的血小板聚集抑制活性和其它性质，并且可用作与纤维蛋白原受体，血栓形成，梗塞相关的疾病的预防或治疗剂喜欢。

3. 发明授权

US06610708B1 Cyclic amino compounds 有权
标题翻译：环状氨基化合物
公开(公告)号：US06610708B1
公开(公告)日：2003-08-26
申请号：US09622849
申请日：2000-08-24
申请人： Fumitoshi Asai , Atsuhiro Sugidachi , Toshihiko Ikeda , Haruo Iwabuchi , Yoshiaki Kuroki , Teruhiko Inoue , Ryo Iwamura , Nobuhiko Shibakawa
发明人： Fumitoshi Asai , Atsuhiro Sugidachi , Toshihiko Ikeda , Haruo Iwabuchi , Yoshiaki Kuroki , Teruhiko Inoue , Ryo Iwamura , Nobuhiko Shibakawa
IPC分类号： A61K31445
CPC分类号： C07D471/08 , C07D205/04 , C07D207/12 , C07D211/52 , C07D211/54 , C07D211/72
摘要： A cyclic amino compound represented by the following formula: or a pharmacologically acceptable salt thereof. R1 is a substitutable phenyl group. R2 is a substitutable aliphatic acyl group, a substitutable benzoyl group or an alkoxycarbonyl group. R3 is a substituted, saturated cyclic amino group which may optionally have a fused ring. These compounds and salts have excellent platelet aggregation inhibitory action. They are useful for the prevention and/or treatment of embolism, thrombosis or arteriosclerosis and other conditions resulting from platelet aggregation.
摘要翻译：由下式表示的环状氨基化合物或其药理学上可接受的盐。 R1是可取代的苯基。 R2是可取代的脂族酰基，可取代的苯甲酰基或烷氧基羰基。 R3是可以任选地具有稠合环的取代的饱和环状氨基。这些化合物和盐具有优异的血小板聚集抑制作用。它们可用于预防和/或治疗由血小板聚集引起的栓塞，血栓形成或动脉硬化以及其它病症。

4. 发明授权

US4421925A 4-Alkoxy-1,3-dioxane-5-carbonitriles and process for preparing the same 失效
标题翻译： 4-烷氧基-1,3-二恶烷-5-腈和其制备方法
公开(公告)号：US4421925A
公开(公告)日：1983-12-20
申请号：US375203
申请日：1982-05-05
申请人： Sumio Umemura , Kozo Fujii , Keigo Nishihira , Hiroyuki Sawada , Shuji Tanaka , Mamoru Nakai , Hiroshi Yoshida , Yoshiaki Kuroki
发明人： Sumio Umemura , Kozo Fujii , Keigo Nishihira , Hiroyuki Sawada , Shuji Tanaka , Mamoru Nakai , Hiroshi Yoshida , Yoshiaki Kuroki
IPC分类号： C07D319/06
CPC分类号： C07D319/06
摘要： There are disclosed a 4-alkoxy-1,3-dioxane-5-carbonitrile which is a novel compound represented by the formula ##STR1## wherein R represents a lower-alkyl group, and which is useful as an intermediate for the synthesis of Vitamin B.sub.1, and a process for preparing the novel compound by subjecting a 3-alkoxy-2-propenenitrile to reaction with a formaldehyde in the presence of an acid catalyst.
摘要翻译：公开了4-烷氧基-1,3-二恶烷-5-腈，它是由下式表示的新化合物：其中R代表低级烷基，可用作合成维生素的中间体 B1和通过在酸催化剂存在下使3-烷氧基-2-丙烯腈与甲醛反应来制备新化合物的方法。

5. 发明授权

US07887684B2 Lamination-type gas sensor element and gas sensor 有权
标题翻译：层压式气体传感器元件和气体传感器
公开(公告)号：US07887684B2
公开(公告)日：2011-02-15
申请号：US11174583
申请日：2005-07-06
申请人： Shinya Awano , Keisuke Makino , Yoshiaki Kuroki , Takao Kojima , Masashi Ando
发明人： Shinya Awano , Keisuke Makino , Yoshiaki Kuroki , Takao Kojima , Masashi Ando
IPC分类号： G01N27/407
CPC分类号： G01N27/4071
摘要： A gas sensor element having an element body, the element body including: a ceramic heater having ceramic layers and a heater element embedded in the ceramic layers; and a solid electrolyte layer including a detection section covered by a pair of electrodes, the solid electrolyte layer being laminated together with the ceramic heater. Furthermore, the element body has a width at a front portion including the detection section smaller than at a rear portion, and at least both side edge faces of the front portion of the element body are covered with a porous layer.
摘要翻译：一种具有元件体的气体传感器元件，所述元件主体包括：具有陶瓷层的陶瓷加热器和嵌入在所述陶瓷层中的加热元件; 以及包含由一对电极覆盖的检测部的固体电解质层，所述固体电解质层与所述陶瓷加热器层压在一起。此外，元件主体在包括检测部的前部具有比后部更小的宽度，并且元件主体的前部的至少两个侧边面被多孔层覆盖。

6. 发明授权

US5895591A Ceramic heater and oxygen sensor 失效
标题翻译：陶瓷加热器和氧气传感器
公开(公告)号：US5895591A
公开(公告)日：1999-04-20
申请号：US837126
申请日：1997-04-14
申请人： Takao Kojima , Yoshiaki Kuroki , Kunio Yanagi
发明人： Takao Kojima , Yoshiaki Kuroki , Kunio Yanagi
IPC分类号： G01N27/406 , G01N27/00
CPC分类号： G01N27/4067
摘要： A ceramic heater for heating a sensor such as an oxygen sensor has a ceramic substrate and a heater pattern formed on the substrate. A heater pattern 22 is tightly interposed between first and second alumina substrates 15 and 21. This heater pattern 22 has a meandering heating section 25 and a pair of leads 26 for connecting both ends of the heating section 25 to two terminals at the base side end. The heating section 25 is divided into a tip side subsection 25a located near the tip side end of the device, and a base side subsection 25b. Specifically, the wire width is made greater in the tip side subsection 25a than in the base side subsection 25b so that the resistance per unit length is lower in the tip side subsection 25a. The thus-designed heater section 25 produces a less amount of heat in the tip side subsection than in the base side subsection, and this distribution of heat generation can reduce the possibility of cracks and breakage of a wire.
摘要翻译：用于加热诸如氧传感器的传感器的陶瓷加热器具有形成在基板上的陶瓷基板和加热器图案。加热器图案22紧密地插入在第一和第二氧化铝基板15和21之间。该加热器图案22具有弯曲加热部25和用于将加热部25的两端连接到基端侧的两个端子的一对引线26 。加热部分25被分成位于装置的尖端侧端部附近的尖端侧子部25a和基部侧部分25b。具体地说，在尖端侧子部25a中比在基部侧部分25b中的线宽度更大，使得在尖端侧子部25a中单位长度的电阻较低。如此设计的加热器部分25在尖端侧子部分中产生的热量比基部侧部分小得多，并且这种发热分布可以降低线材的裂纹和断裂的可能性。

7. 发明申请

US20070007136A1 Lamination-type gas sensor element and gas sensor 有权
标题翻译：层压式气体传感器元件和气体传感器
公开(公告)号：US20070007136A1
公开(公告)日：2007-01-11
申请号：US11174583
申请日：2005-07-06
申请人： Shinya Awano , Keisuke Makino , Yoshiaki Kuroki , Takao Kojima , Masashi Ando
发明人： Shinya Awano , Keisuke Makino , Yoshiaki Kuroki , Takao Kojima , Masashi Ando
IPC分类号： G01N27/26
CPC分类号： G01N27/4071
摘要： A gas sensor element having an element body, the element body including: a ceramic heater having ceramic layers and a heater element embedded in the ceramic layers; and a solid electrolyte layer including a detection section covered by a pair of electrodes, the solid electrolyte layer being laminated together with the ceramic heater. Furthermore, the element body has a width at a front portion including the detection section smaller than at a rear portion, and at least both side edge faces of the front portion of the element body are covered with a porous layer.
摘要翻译：一种具有元件体的气体传感器元件，所述元件主体包括：具有陶瓷层的陶瓷加热器和嵌入在所述陶瓷层中的加热元件; 以及包含由一对电极覆盖的检测部的固体电解质层，所述固体电解质层与所述陶瓷加热器层压在一起。此外，元件主体在包括检测部的前部具有比后部更小的宽度，并且元件主体的前部的至少两个侧边面被多孔层覆盖。

8. 发明授权

US06746586B2 Multi-layer gas sensor element and gas sensor comprising the same 失效
标题翻译：包括其的多层气体传感器元件和气体传感器
公开(公告)号：US06746586B2
公开(公告)日：2004-06-08
申请号：US09917874
申请日：2001-07-31
申请人： Yoshiaki Kuroki , Kunio Yanagi , Tomohiro Mabuchi , Shinya Awano , Hiroyuki Hayashi
发明人： Yoshiaki Kuroki , Kunio Yanagi , Tomohiro Mabuchi , Shinya Awano , Hiroyuki Hayashi
IPC分类号： G01N27407
CPC分类号： G01N27/4071 , G01N27/419
摘要： A multi-layer gas sensor element is described which comprises a solid electrolytic member, a substrate, and a porous member, wherein each of the substrate and the porous member has a thickness larger than that of the solid electrolytic member with respect to a lamination direction; the substrate and the porous member face each other and sandwich the solid electrolytic member; a ceramic component constituting the substrate in the highest volume percent is the same as the ceramic component constituting the porous member in the highest volume percent thereof; and the volume percent (R2) of the ceramic component contained in the porous member is 80% or more the volume percent (R1) of the ceramic component contained in the substrate.
摘要翻译：描述了一种多层气体传感器元件，其包括固体电解部件，基板和多孔部件，其中，基板和多孔部件的厚度相对于层叠方向具有比固体电解部件的厚度大 ; 基板和多孔构件彼此面对并夹持固体电解构件; 构成最高体积百分比的基板的陶瓷构件与构成多孔构件的最高体积百分比的陶瓷构件相同; 并且包含在多孔构件中的陶瓷成分的体积百分比（R2）为包含在基材中的陶瓷成分的体积百分比（R1）的80％以上。

9. 发明授权

US06676817B2 Solid electrolyte containing insulating ceramic grains for gas sensor 有权
标题翻译：含固体电解质的绝缘陶瓷颗粒用于气体传感器
公开(公告)号：US06676817B2
公开(公告)日：2004-01-13
申请号：US09497645
申请日：2000-02-03
申请人： Yoshiro Noda , Ryohei Aoki , Yutaka Adachi , Yoshiaki Kuroki , Takao Kojima , Sinya Awano , Koichi Imaeda
发明人： Yoshiro Noda , Ryohei Aoki , Yutaka Adachi , Yoshiaki Kuroki , Takao Kojima , Sinya Awano , Koichi Imaeda
IPC分类号： G01N27407
CPC分类号： G01N27/4073 , Y10T29/49002
摘要： A solid electrolyte layer or body capable of being co-fired with an insulating ceramic substrate or body to be used as a gas sensor laminate. The gas sensor laminate is preferably composed of an alumina substrate (1) and an oxygen-ion conductive solid electrolyte layer (6) bonded to the alumina substrate (1) by firing. The oxygen-ion conductive solid electrolyte layer or body is formed from partially or wholly stabilized zirconia, which layer contains alumina in an amount of 10% to 80% by weight, particularly 30% to 75% by weight. In this manner, another ceramic layer; particularly, a ceramic layer (7) of alumina can further be bonded to the oxygen-ion conductive solid electrolyte layer. The relative density of the ceramic layer can be 60% to 99.5%, preferably 80% to 99.5%.
摘要翻译：能够与用作气体传感器层叠体的绝缘陶瓷基板或主体共烧的固体电解质层或主体。气体传感器层叠体优选由氧化铝基板（1）和通过烧结而结合到氧化铝基板（1）的氧离子导电性固体电解质层（6）构成。氧离子导电固体电解质层或主体由部分或全部稳定的氧化锆形成，该氧化锆层含有10重量％至80重量％，特别是30重量％至75重量％的氧化铝。以这种方式，另一陶瓷层; 特别地，氧化铝的陶瓷层（7）可以进一步与氧离子传导性固体电解质层结合。陶瓷层的相对密度可以为60％至99.5％，优选为80％至99.5％。

10. 发明授权

US4929618A Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same 失效
标题翻译：哌啶和哌嗪衍生物，以及含有它们的抗组胺药物组合物
公开(公告)号：US4929618A
公开(公告)日：1990-05-29
申请号：US325306
申请日：1989-03-16
申请人： Akihide Koda , Jun'ichiro Kita , Yoshiaki Kuroki , Hiroshi Fujiwara , Shinji Takamura , Kayoko Yamano
发明人： Akihide Koda , Jun'ichiro Kita , Yoshiaki Kuroki , Hiroshi Fujiwara , Shinji Takamura , Kayoko Yamano
IPC分类号： C07D211/46 , C07D235/28 , C07D277/74 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14
CPC分类号： C07D401/12 , C07D211/46 , C07D235/28 , C07D277/74 , C07D413/12 , C07D413/14 , C07D417/14
摘要： Disclosed is a compound represented by Formula (I): ##STR1## wherein Ar.sup.1, Ar.sup.2, n, A, B and Z are as defined in claims. Disclosed are also a process for preparing the compound and pharmaceutical compositions containing the compound.The compound has an antihistamic and antiallergic effect.

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