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1. 发明申请

US20100321683A1 Surface enhanced raman scattering nano-tagging particle and method for preparing thereof 有权
标题翻译：表面增强拉曼散射纳米标记颗粒及其制备方法
公开(公告)号：US20100321683A1
公开(公告)日：2010-12-23
申请号：US12308505
申请日：2006-09-29
申请人： Yoon-Sik Lee , Dae-Hong Jeong , Jong-Ho Kim , Hee-Jeong Choi , Sang-Myung Lee
发明人： Yoon-Sik Lee , Dae-Hong Jeong , Jong-Ho Kim , Hee-Jeong Choi , Sang-Myung Lee
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B82Y15/00
摘要： There is provided a method for manufacturing a surface enhanced Raman scattering nano-tagging particle, the method including the steps of: introducing silver nanoparticles on the surface of a silica core particle; immobilizing tagging materials and silica shell precursors on the silver nanoparticles; and forming a silica shell surrounding the silica core particle to which the tagging materials and the silica shell precursor are immobilized.
摘要翻译：提供了一种制造表面增强拉曼散射纳米标记颗粒的方法，所述方法包括以下步骤：在二氧化硅核颗粒的表面上引入银纳米颗粒; 将标记材料和二氧化硅壳前体固定在银纳米颗粒上; 并且形成围绕二氧化硅核心颗粒的二氧化硅壳，所述标记材料和二氧化硅壳前体被固定在该二氧化硅芯颗粒上。

2. 发明授权

US07982870B2 Surface enhanced raman scattering nano-tagging particle and method for preparing thereof 有权
标题翻译：表面增强拉曼散射纳米标记颗粒及其制备方法
公开(公告)号：US07982870B2
公开(公告)日：2011-07-19
申请号：US12308505
申请日：2006-09-29
申请人： Yoon-Sik Lee , Dae-Hong Jeong , Jong-Ho Kim , Hee-Jeong Choi , Sang-Myung Lee
发明人： Yoon-Sik Lee , Dae-Hong Jeong , Jong-Ho Kim , Hee-Jeong Choi , Sang-Myung Lee
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658 , B82Y15/00
摘要： There is provided a method for manufacturing a surface enhanced Raman scattering nano-tagging particle, the method including the steps of: introducing silver nanoparticles on the surface of a silica core particle; immobilizing tagging materials and silica shell precursors on the silver nanoparticles; and forming a silica shell surrounding the silica core particle to which the tagging materials and the silica shell precursor are immobilized.
摘要翻译：提供了一种制造表面增强拉曼散射纳米标记颗粒的方法，所述方法包括以下步骤：在二氧化硅核颗粒的表面上引入银纳米颗粒; 将标记材料和二氧化硅壳前体固定在银纳米颗粒上; 并且形成围绕二氧化硅核心颗粒的二氧化硅壳，所述标记材料和二氧化硅壳前体被固定在该二氧化硅芯颗粒上。

3. 发明申请

US20100072067A1 Label-Free High Throughput Screening Method by Using Sers Spectroscopic Encoded Bead and Dielectrophoresis 审中-公开
标题翻译：通过使用SERS光谱编码珠和介电泳的无标记高通量筛选方法
公开(公告)号：US20100072067A1
公开(公告)日：2010-03-25
申请号：US11992017
申请日：2006-09-15
申请人： Yoon-Sik Lee , Yong-Kweon Kim , Dae-Hong Jeong , Jong-Ho Kim , Min-Soo Kim , Hee-Jeong Choi , Bong-Hyun Jun
发明人： Yoon-Sik Lee , Yong-Kweon Kim , Dae-Hong Jeong , Jong-Ho Kim , Min-Soo Kim , Hee-Jeong Choi , Bong-Hyun Jun
IPC分类号： G01N27/26
CPC分类号： G01N33/54346 , G01N33/54373
摘要： Provided is a method for screening a biological molecule rapidly and economically with high-throughput using microbeads encoded with silver nanoparticles and a chemical compound and dielectrophoresis. A biological screening method particularly utilizes microbeads encoded with silver nanoparticles and a specific chemical compound and dielectrophoresis. Since this screening method does not use a fluorescent material and a dying agent, which are typically used in the conventional screening method, it is non-toxic and economical. Also, this screening method allows simultaneous identification of many target materials. Accordingly, a leading compound can be screened within a short period of time, and thus, this screening method can be implemented as an economical and effective system for developing new pharmaceutical products.
摘要翻译：本发明提供了一种利用银纳米颗粒和化学化合物和介电电泳编织的微珠以高通量快速且经济地筛选生物分子的方法。生物筛选方法特别利用银纳米颗粒和特定化学化合物和介电电泳编码的微珠。由于该筛选方法不使用通常在常规筛选方法中使用的荧光材料和染色剂，因此是无毒和经济的。此外，该筛选方法允许同时鉴定许多目标材料。因此，可以在短时间内筛选前导化合物，因此，该筛选方法可以实现为开发新药品的经济有效的系统。

4. 发明授权

US08018582B2 Simultaneous detection apparatus of raman and light scattering 有权
标题翻译：拉曼和光散射的同时检测装置
公开(公告)号：US08018582B2
公开(公告)日：2011-09-13
申请号：US12442109
申请日：2007-08-30
申请人： Dae-Hong Jeong , Yoon-Sik Lee , Myung-Haing Cho , Yong-Kweon Kim
发明人： Dae-Hong Jeong , Yoon-Sik Lee , Myung-Haing Cho , Yong-Kweon Kim
IPC分类号： G01J3/44 , G01N21/47 , G01N21/64 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0227 , G01J3/0291 , G01J3/44 , G01N2015/0038 , G01N2015/0092 , G01N2015/1493
摘要： Provided is a detection apparatus of Raman scattering and light scattering, and more particularly, a simultaneous detection apparatus of Raman scattering and dynamic light scattering and a detection method using the same. The simultaneous detection apparatus of Raman scattering and light scattering includes: a detection unit for applying incident light to a sample, and detecting Raman scattering in 90° or 180° geometry and light scattering in 90° or 180° geometry in order to simultaneously collect Raman scattering and light scattering; and a computer connected to the detection unit to obtain at least one of the size and distribution of particles from the detected light scattering, and to obtain information of the molecular structure from the detected Raman scattering. This apparatus may simultaneously observe the size of nano-sized or larger material and molecular information thereof, and phenomena accompanying changes in molecular environment according to material variation and changes of the material in size and distribution, and thus is very useful for studying nano materials and protein antigens and antibodies.
摘要翻译：提供了拉曼散射和光散射的检测装置，更具体地，涉及拉曼散射和动态光散射的同时检测装置以及使用该检测装置的检测方法。拉曼散射和光散射的同时检测装置包括：用于将入射光施加到样品的检测单元，并且以90°或180°几何形状检测拉曼散射并以90°或180°几何形状的光散射检测拉曼散射，以便同时收集拉曼散射和光散射; 以及连接到检测单元的计算机，以从所检测到的光散射中获得粒子的大小和分布中的至少一个，并且从检测到的拉曼散射获得分子结构的信息。该装置可以根据材料的尺寸和分布的材料变化和材料的变化同时观察纳米尺寸或更大的材料的尺寸及其分子信息，以及伴随分子环境变化的现象，因此对于研究纳米材料和蛋白质抗原和抗体。

5. 发明申请

US20100020312A1 SIMULTANEOUS DETECTION APPARATUS OF RAMAN AND LIGHT SCATTERING 有权
标题翻译：拉曼和光散射同时检测装置
公开(公告)号：US20100020312A1
公开(公告)日：2010-01-28
申请号：US12442109
申请日：2007-08-30
申请人： Dae-Hong Jeong , Yoon-Sik Lee , Myung-Haing Cho , Yong-Kweon Kim
发明人： Dae-Hong Jeong , Yoon-Sik Lee , Myung-Haing Cho , Yong-Kweon Kim
IPC分类号： G01N21/65 , G01N21/47
CPC分类号： G01J3/02 , G01J3/0227 , G01J3/0291 , G01J3/44 , G01N2015/0038 , G01N2015/0092 , G01N2015/1493
摘要： Provided is a detection apparatus of Raman scattering and light scattering, and more particularly, a simultaneous detection apparatus of Raman scattering and dynamic light scattering and a detection method using the same. The simultaneous detection apparatus of Raman scattering and light scattering includes: a detection unit for applying incident light to a sample, and detecting Raman scattering in 90° or 180° geometry and light scattering in 90° or 180° geometry in order to simultaneously collect Raman scattering and light scattering; and a computer connected to the detection unit to obtain at least one of the size and distribution of particles from the detected light scattering, and to obtain information of the molecular structure from the detected Raman scattering. This apparatus may simultaneously observe the size of nano-sized or larger material and molecular information thereof, and phenomena accompanying changes in molecular environment according to material variation and changes of the material in size and distribution, and thus is very useful for studying nano materials and protein antigens and antibodies.
摘要翻译：提供了拉曼散射和光散射的检测装置，更具体地，涉及拉曼散射和动态光散射的同时检测装置以及使用该检测装置的检测方法。拉曼散射和光散射的同时检测装置包括：用于将入射光施加到样品的检测单元，并且以90°或180°几何形状检测拉曼散射并以90°或180°几何形状的光散射检测拉曼散射，以便同时收集拉曼散射和光散射; 以及连接到检测单元的计算机，以从所检测到的光散射中获得粒子的大小和分布中的至少一个，并且从检测到的拉曼散射获得分子结构的信息。该装置可以根据材料的尺寸和分布的材料变化和材料的变化同时观察纳米尺寸或更大的材料的尺寸及其分子信息，以及伴随分子环境变化的现象，因此对于研究纳米材料和蛋白质抗原和抗体。

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