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1. 发明授权

US08389684B2 Tumor biomarker 有权
标题翻译：肿瘤生物标志物
公开(公告)号：US08389684B2
公开(公告)日：2013-03-05
申请号：US12880265
申请日：2010-09-13
申请人： Yongzhang Luo , Xiaomin Song , Xiaofeng Wang , Wei Zhuo , Guodong Chang , Yan Fu
发明人： Yongzhang Luo , Xiaomin Song , Xiaofeng Wang , Wei Zhuo , Guodong Chang , Yan Fu
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , G01N33/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K14/4702 , C07K16/18 , C07K2317/14 , C07K2317/24 , C07K2317/73 , G01N33/57415 , G01N33/57438 , G01N33/6893 , G01N2440/14 , Y10T436/25
摘要： The present invention relates to the diagnosis and treatment of cancer, and specifically to a method of diagnosing the presence or metastasis of cancer by detecting plasma Hsp90α having the amino acid sequence of SEQ ID No. 1 as a tumor marker. In addition, the present invention also relates to a method for the treatment of cancer and metastasis.
摘要翻译：本发明涉及癌症的诊断和治疗，具体涉及通过检测具有SEQ ID No.1的氨基酸序列的血浆Hsp90α作为肿瘤标记物来诊断癌症存在或转移的方法。此外，本发明还涉及治疗癌症和转移的方法。

2. 发明申请

US20130023479A1 USE OF NUCLEOLIN AS A BIOMARKER FOR LYMPHANGIOGENESIS IN CANCER PROGNOSIS AND THERAPY 审中-公开
标题翻译：作为生物标记物的核蛋白用于癌症预防和治疗中的淋巴细胞生成
公开(公告)号：US20130023479A1
公开(公告)日：2013-01-24
申请号：US13554913
申请日：2012-07-20
申请人： Yongzhang Luo , Wei Zhuo , Yan Fu , Guodong Chang
发明人： Yongzhang Luo , Wei Zhuo , Yan Fu , Guodong Chang
IPC分类号： G01N33/574 , A61K38/17 , A61P35/04 , C40B30/04
CPC分类号： G01N33/574 , A61K38/39 , C07K16/28 , C07K2317/76 , G01N2333/515 , G01N2800/52 , G01N2800/56 , G01N2800/7014
摘要： The present invention relates to a method of identifying cancer subjects, in particular human patients, who are suitable for anti-lymphangiogenesis therapy to prevent tumor growth and tumor metastasis. The present invention also relates to a new approach, which uses nucleolin as a bait to search and screen for lymphangiogenesis inhibitors or cancer suppressors, which function in a manner that is analogous to endostatin. The invention is based upon the discovery that nucleolin is specifically expressed on lymphangiogenic vessels and functions as a specific receptor for endostatin, and thus is involved in the signal transduction pathway of endostatin as an anti-lymphangiogenesis inhibitor. The present invention also discloses that cell surface nucleolin on lymphatic endothelial cells is a biomarker for lymphangiogenic vessels, which could be used for the prediction of tumor metastasis.
摘要翻译：本发明涉及鉴定适合于抗淋巴管生成治疗以预防肿瘤生长和肿瘤转移的癌症受试者，特别是人类患者的方法。本发明还涉及使用核仁林作为诱饵来搜索和筛选淋巴管生成抑制剂或癌抑制因子的新方法，其以类似于内皮抑素的方式起作用。本发明基于以下发现：核仁林在淋巴管生成血管上特异性表达，并且作为内皮抑制素的特异性受体起作用，因此参与作为抗淋巴管生成抑制剂的内皮抑素的信号转导途径。本发明还公开了淋巴管内皮细胞上的细胞表面核仁素是淋巴管生成血管生物标志物，可用于预测肿瘤转移。

3. 发明授权

US07826816B2 Systems, methods, and apparatus for frequency conversion 有权
标题翻译：用于频率转换的系统，方法和装置
公开(公告)号：US07826816B2
公开(公告)日：2010-11-02
申请号：US11531314
申请日：2006-09-13
申请人： Wei Zhuo , Aristotele Hadjichristos , Gurkanwal S. Sahota , Solti Peng
发明人： Wei Zhuo , Aristotele Hadjichristos , Gurkanwal S. Sahota , Solti Peng
IPC分类号： H04B1/26
CPC分类号： H03D7/166 , H03H19/008 , H03H2007/0192
摘要： A method according to one embodiment includes using a quadrature set of local oscillator signals having duty cycles of substantially less than fifty percent to perform a mixing operation on a radio-frequency current signal. Other embodiments include using a quadrature set of local oscillator signals having duty cycles of less than twenty-five percent.
摘要翻译：根据一个实施例的方法包括使用具有基本上小于百分之五十的占空比的本地振荡器信号的正交组来对射频电流信号执行混频操作。其他实施例包括使用占空比小于百分之二十五的本地振荡器信号的正交集合。

4. 发明授权

US07769361B2 Systems, methods, and apparatus for frequency conversion 有权
标题翻译：用于频率转换的系统，方法和装置
公开(公告)号：US07769361B2
公开(公告)日：2010-08-03
申请号：US11531755
申请日：2006-09-14
申请人： Wei Zhuo , Solti Peng
发明人： Wei Zhuo , Solti Peng
IPC分类号： H04B1/28
CPC分类号： H03D7/1441 , H03D7/1433 , H03D7/1458 , H03D7/1466 , H03D7/165 , H03D2200/0043 , H03D2200/0047
摘要： A frequency converter according to one embodiment includes a quadrature pair of passive mixers whose input terminals are coupled to a differential radio-frequency input via the channel regions of transistors that are arranged to operate in the saturation region.
摘要翻译：根据一个实施例的变频器包括正交一对无源混频器，其输入端经由布置成在饱和区域中工作的晶体管的沟道区域耦合到差分射频输入端。

5. 发明申请

US20090075622A1 OFFSET CORRECTION FOR PASSIVE MIXERS 有权
标题翻译：被动混合器的偏差校正
公开(公告)号：US20090075622A1
公开(公告)日：2009-03-19
申请号：US11864310
申请日：2007-09-28
申请人： Wei Zhuo , Roger Brockenbrough , Solti Peng
发明人： Wei Zhuo , Roger Brockenbrough , Solti Peng
IPC分类号： H04B1/28
CPC分类号： H03D7/1441 , H03D7/1458 , H03D7/1466 , H03D2200/0043 , H03D2200/0047
摘要： A downconversion mixer includes a configurable gate or bulk bias voltage to allow calibration and correction of device offsets. Calibration may be performed on the configurable bias voltages to minimize IM2 distortion in the mixer. The techniques have minimal impact on voltage headroom, impose no requirement for a signal path to be phase-matched with a calibration path, and are particularly well-suited for passive mixers.
摘要翻译：下变频混频器包括可配置的栅极或体偏置电压，以允许校准和校正器件偏移。可以对可配置的偏置电压进行校准，以最小化混频器中的IM2失真。这些技术对电压净空的影响最小，不要求将信号路径与校准路径进行相位匹配，特别适用于被动混频器。

6. 发明授权

US08472890B2 Adjustable local oscillator path in a communication device with a transmitter 有权
标题翻译：具有发射机的通信设备中的可调本地振荡器路径
公开(公告)号：US08472890B2
公开(公告)日：2013-06-25
申请号：US11947597
申请日：2007-11-29
申请人： Wei Zhuo , Aristotele Hadjichristos , Tzu-wang Pan
发明人： Wei Zhuo , Aristotele Hadjichristos , Tzu-wang Pan
IPC分类号： H04B1/40
CPC分类号： H04B1/109 , H04B1/525
摘要： A communication device includes a transmitter and a receiver. The receiver mixes a local oscillator (LO) signal with the received signal to downconvert the received signal to an intermediate frequency (IF). The LO path that feeds the LO signal to the downconverting mixer is controlled based on the transmit power of the transmitter. For high transmit power, the drive of the LO path is increased, thereby increasing the signal-to-noise ratio of the LO signal input into the mixer. For low transmit power levels, the drive to the LO path is decreased, reducing power consumption in the communication device. In this way, receiver path noise due to mixing of the LO phase noise with the self-generated transmitter signal is selectively controlled while incurring lower power consumption penalty. The communication device may be an access terminal configured for communication with a cellular radio network.
摘要翻译：通信设备包括发射机和接收机。接收器将本地振荡器（LO）信号与接收到的信号混合，以将接收到的信号下变频到中频（IF）。基于发射机的发射功率来控制将LO信号馈送到下变频混频器的LO路径。对于高发射功率，LO路径的驱动增加，从而增加输入混频器的LO信号的信噪比。对于低发射功率电平，降低LO路径的驱动，从而降低通信设备的功耗。以这种方式，由于LO相位噪声与自发送发射机信号的混合引起的接收机路径噪声被选择性地控制，同时产生较低的功耗损失。通信设备可以是被配置为与蜂窝无线电网络进行通信的接入终端。

7. 发明授权

US08045944B2 Offset correction for passive mixers 有权
标题翻译：无源混频器的偏移校正
公开(公告)号：US08045944B2
公开(公告)日：2011-10-25
申请号：US11864310
申请日：2007-09-28
申请人： Wei Zhuo , Roger Brockenbrough , Solti Peng
发明人： Wei Zhuo , Roger Brockenbrough , Solti Peng
IPC分类号： H04B1/10 , G05F1/10
CPC分类号： H03D7/1441 , H03D7/1458 , H03D7/1466 , H03D2200/0043 , H03D2200/0047
摘要： A downconversion mixer includes a configurable gate or bulk bias voltage to allow calibration and correction of device offsets. Calibration may be performed on the configurable bias voltages to minimize IM2 distortion in the mixer. The techniques have minimal impact on voltage headroom, impose no requirement for a signal path to be phase-matched with a calibration path, and are particularly well-suited for passive mixers.
摘要翻译：下变频混频器包括可配置的栅极或体偏置电压，以允许校准和校正器件偏移。可以对可配置的偏置电压进行校准，以最小化混频器中的IM2失真。这些技术对电压净空的影响最小，不要求将信号路径与校准路径进行相位匹配，特别适用于被动混频器。

8. 发明申请

US20090130994A1 ADJUSTABLE LOCAL OSCILLATOR PATH IN A COMMUNICATION DEVICE WITH A TRANSMITTER 有权
标题翻译：在具有发射机的通信设备中可调谐的本地振荡器路径
公开(公告)号：US20090130994A1
公开(公告)日：2009-05-21
申请号：US11947597
申请日：2007-11-29
申请人： Wei Zhuo , Aristotele Hadjichristos , Tzu-wang Pan
发明人： Wei Zhuo , Aristotele Hadjichristos , Tzu-wang Pan
IPC分类号： H04B1/40 , H04B1/04
CPC分类号： H04B1/109 , H04B1/525
摘要： A communication device includes a transmitter and a receiver. The receiver mixes a local oscillator (LO) signal with the received signal to downconvert the received signal to an intermediate frequency (IF). The LO path that feeds the LO signal to the downconverting mixer is controlled based on the transmit power of the transmitter. For high transmit power, the drive of the LO path is increased, thereby increasing the signal-to-noise ratio of the LO signal input into the mixer. For low transmit power levels, the drive to the LO path is decreased, reducing power consumption in the communication device. In this way, receiver path noise due to mixing of the LO phase noise with the self-generated transmitter signal is selectively controlled while incurring lower power consumption penalty. The communication device may be an access terminal configured for communication with a cellular radio network.
摘要翻译：通信设备包括发射机和接收机。接收器将本地振荡器（LO）信号与接收到的信号混合，以将接收到的信号下变频到中频（IF）。基于发射机的发射功率来控制将LO信号馈送到下变频混频器的LO路径。对于高发射功率，LO路径的驱动增加，从而增加输入混频器的LO信号的信噪比。对于低发射功率电平，降低LO路径的驱动，从而降低通信设备的功耗。以这种方式，由于LO相位噪声与自发送发射机信号的混合引起的接收机路径噪声被选择性地控制，同时产生较低的功耗损失。通信设备可以是被配置为与蜂窝无线电网络进行通信的接入终端。

9. 发明申请

US20080020728A1 SYSTEMS, METHODS, AND APPARATUS FOR FREQUENCY CONVERSION 有权
标题翻译：用于频率转换的系统，方法和装置
公开(公告)号：US20080020728A1
公开(公告)日：2008-01-24
申请号：US11531755
申请日：2006-09-14
申请人： Wei Zhuo , Solti Peng
发明人： Wei Zhuo , Solti Peng
IPC分类号： H04B15/00
CPC分类号： H03D7/1441 , H03D7/1433 , H03D7/1458 , H03D7/1466 , H03D7/165 , H03D2200/0043 , H03D2200/0047
摘要： A frequency converter according to one embodiment includes a quadrature pair of passive mixers whose input terminals are coupled to a differential radio-frequency input via the channel regions of transistors that are arranged to operate in the saturation region.
摘要翻译：根据一个实施例的变频器包括正交一对无源混频器，其输入端经由布置成在饱和区域中工作的晶体管的沟道区域耦合到差分射频输入端。

10. 发明申请

US20080014896A1 SYSTEMS, METHODS, AND APPARATUS FOR FREQUENCY CONVERSION 有权
标题翻译：用于频率转换的系统，方法和装置
公开(公告)号：US20080014896A1
公开(公告)日：2008-01-17
申请号：US11531314
申请日：2006-09-13
申请人： Wei Zhuo , Aristotele Hadjichristos , Gurkanwal S. Sahota , Solti Peng
发明人： Wei Zhuo , Aristotele Hadjichristos , Gurkanwal S. Sahota , Solti Peng
IPC分类号： H04B1/26
CPC分类号： H03D7/166 , H03H19/008 , H03H2007/0192
摘要： A method according to one embodiment includes using a quadrature set of local oscillator signals having duty cycles of substantially less than fifty percent to perform a mixing operation on a radio-frequency current signal. Other embodiments include using a quadrature set of local oscillator signals having duty cycles of less than twenty-five percent.
摘要翻译：根据一个实施例的方法包括使用具有基本上小于百分之五十的占空比的本地振荡器信号的正交组来对射频电流信号执行混频操作。其他实施例包括使用占空比小于百分之二十五的本地振荡器信号的正交集合。

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