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1. 发明授权

US07578990B2 Proton conductor and method for manufacturing the same, and electrochemical device 失效
标题翻译：质子导体及其制造方法及电化学装置
公开(公告)号：US07578990B2
公开(公告)日：2009-08-25
申请号：US11533674
申请日：2006-09-20
申请人： Yong Ming Li , Koichiro Hinokuma
发明人： Yong Ming Li , Koichiro Hinokuma
IPC分类号： B01J19/08 , C01B31/02
CPC分类号： H01B1/122 , B82Y30/00 , H01M6/181 , H01M8/1018 , H01M2300/0082 , Y02P70/56
摘要： A proton conductor, a method for manufacturing the same, and an electrochemical device using the proton conductor are provided. The proton conductor includes a carbon derivative which has a carbon material selected from the group consisting of a fullerene molecule, a cluster consisting essentially of carbon, a fiber-shaped carbon anPlease do not hesitate to contact us with any questions d a tube-regarding this matter shaped carbon, and mixtures thereof, and at least a proton dissociative group, the proton dissociative group being bonded to the carbon material via a cyclic structure of tricyclic or more. The method includes the steps of obtaining the carbon derivative, hydrolyzing the derivative with alkali hydroxide, subjecting the hydrolyzed product to ion exchange, and forming a group with proton-dissociating properties.
摘要翻译：提供质子导体，其制造方法和使用该质子导体的电化学装置。质子导体包括碳衍生物，其具有选自富勒烯分子，基本上由碳组成的簇的碳材料，纤维状碳。请勿随时与我们联系任何关于该事项的问题和至少一个质子解离基团，质子解离基团通过三环或更多的环状结构键合到碳材料上。该方法包括以下步骤：获得碳衍生物，用碱金属氢氧化物水解衍生物，使水解产物进行离子交换，并形成质子解离性质的基团。

2. 发明授权

US07128888B2 Proton conductor and method for manufacturing the same, and electrochemical device 有权
公开(公告)号：US07128888B2
公开(公告)日：2006-10-31
申请号：US10195235
申请日：2002-07-15
申请人： Yong Ming Li , Koichiro Hinokuma
发明人： Yong Ming Li , Koichiro Hinokuma
IPC分类号： B01J19/08 , C01B31/02
CPC分类号： H01B1/122 , B82Y30/00 , H01M6/181 , H01M8/1018 , H01M2300/0082 , Y02P70/56
摘要： A proton conductor, a method for manufacturing the same, and an electrochemical device using the proton conductor are provided. The proton conductor includes a carbon derivative which has a carbon material selected from the group consisting of a fullerene molecule, a cluster consisting essentially of carbon, a fiber-shaped carbon and a tube-shaped carbon, and mixtures thereof; and at least a proton dissociative group, the proton dissociative group being bonded to the carbon material via a cyclic structure of tricyclic or more. The method includes the steps of obtaining the carbon derivative, hydrolyzing the derivative with alkali hydroxide, subjecting the hydrolyzed product to ion exchange, and forming a group with proton-dissociating properties.

3. 发明授权

US5962245A Methods for detecting the presence of advanced glycosylation endproducts 失效
标题翻译：检测高级糖基化终产物存在的方法
公开(公告)号：US5962245A
公开(公告)日：1999-10-05
申请号：US475055
申请日：1995-06-07
申请人： Yong Ming Li , Helen Vlassara , Anthony Cerami
发明人： Yong Ming Li , Helen Vlassara , Anthony Cerami
IPC分类号： A61K8/64 , A61K38/00 , A61K38/03 , A61K38/16 , A61K38/47 , A61Q11/00 , C07K14/79 , C12N9/36 , C12Q1/00 , C12Q1/34 , G01N33/573 , G01N33/66 , G01N33/68 , G01N33/566
CPC分类号： A61Q11/00 , A61K8/64 , C07K14/79 , G01N33/573 , G01N33/66 , G01N33/68 , G01N33/6842 , A61K38/00 , G01N2333/79 , G01N2333/924 , G01N2333/936
摘要： The present invention is directed to methods for detecting the presence of advanced glycosylation endproducts using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to diagnostic methods for diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample.
摘要翻译：本发明涉及使用意想不到的发现来检测高级糖基化终产物的存在的方法，某些抗菌蛋白，特别是溶菌酶和乳铁蛋白与高亲和力的晚期糖基化终产物（AGE）结合，并且该结合活性基本上是非竞争性的具有细菌碳水化合物与抗菌蛋白质的结合。因此，本发明涉及与增加水平的AGE相关的疾病和病症的诊断方法，通过使用具有与其相关联的分子的组合物，所述组分具有亲水环结构域，该结构域与AGE结合活性相关，以及包含这种结构域的组合物。本发明还涉及用于将AGEs分离离开样品的组合物和装置。

4. 发明授权

US5891341A Compositions and devices for partitioning advanced glycosylation endproducts, and methods of their use 失效
标题翻译：用于分配高级糖基化终产物的组合物和装置及其使用方法
公开(公告)号：US5891341A
公开(公告)日：1999-04-06
申请号：US628380
申请日：1996-04-05
申请人： Yong Ming Li , Helen Vlassara , Anthony Cerami
发明人： Yong Ming Li , Helen Vlassara , Anthony Cerami
IPC分类号： G01N33/566 , A61K8/00 , A61K8/64 , A61K9/06 , A61K9/22 , A61K38/00 , A61K38/16 , A61K38/40 , A61K38/46 , A61K49/00 , A61P13/02 , A61P15/00 , A61P31/04 , A61Q11/00 , A61Q17/04 , B01D11/04 , C07K7/08 , C07K14/79 , C12N9/36 , G01N33/68 , G01N35/00 , A01N1/02
CPC分类号： A61Q11/00 , A61K8/64 , C07K14/79 , C12N9/2462 , G01N33/68 , G01N33/6842 , A61K38/00 , B01L2400/0406 , G01N2333/79 , G01N2333/924 , G01N2333/936 , G01N35/00069 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The present invention is directed to compositions and devices based upon the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions and devices having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample.
摘要翻译：本发明涉及基于意想不到的发现的某些抗菌蛋白质，特别是溶菌酶和乳铁蛋白与高亲和力的晚期糖基化终产物（AGE）结合的组合物和装置，并且该结合活性与细菌碳水化合物的结合基本上是非竞争性的对抗菌蛋白质。因此，本发明涉及通过使用与其相关联的具有亲水环结构域的分子的组合物和装置来治疗与增加的AGE水平相关的疾病和病症的方法，该结构域与AGE结合活性相关，以及包含这种域。本发明还涉及用于将AGEs分离离开样品的组合物和装置。

5. 发明授权

US5861238A Methods for partitioning advanced glycosylation endproducts 失效
标题翻译：分配高级糖基化终产物的方法
公开(公告)号：US5861238A
公开(公告)日：1999-01-19
申请号：US487058
申请日：1995-06-07
申请人： Yong Ming Li , Helen Vlassara , Anthony Cerami
发明人： Yong Ming Li , Helen Vlassara , Anthony Cerami
IPC分类号： A61K8/64 , A61K38/00 , A61K38/03 , A61K38/16 , A61K38/47 , A61Q11/00 , C07K14/79 , C12N9/36 , C12Q1/00 , C12Q1/34 , G01N33/573 , G01N33/66 , G01N33/68 , A01N1/02
CPC分类号： A61Q11/00 , A61K8/64 , C07K14/79 , G01N33/573 , G01N33/66 , G01N33/68 , G01N33/6842 , A61K38/00 , G01N2333/79 , G01N2333/924 , G01N2333/936
摘要： The present invention is directed to methods for partitioning advanced glycosylation endproducts out of a biological sample using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions and devices for partitioning AGEs away from a sample.
摘要翻译：本发明涉及使用意想不到的发现，即某些抗菌蛋白，特别是溶菌酶及其特定片段以高亲和力结合晚期糖基化终产物（AGE）而将生物样品中的高级糖基化终产物分配的方法，并且该结合活性与细菌碳水化合物与抗菌蛋白的结合基本上是非竞争性的。因此，本发明涉及用于治疗与增加水平的AGE相关的疾病和病症的治疗方法，通过使用具有与其相关联的具有亲水环结构域的分子的组合物，该结构域与AGE结合活性相关，以及包含这种结构域的组合物从生物材料中去除AGEs。本发明还涉及用于将AGEs分离离开样品的组合物和装置。

6. 发明授权

US5855882A Methods for inhibiting the cross-linking of advanced glycosylation endproducts 失效
标题翻译：抑制晚期糖基化终产物交联的方法
公开(公告)号：US5855882A
公开(公告)日：1999-01-05
申请号：US485948
申请日：1995-06-07
申请人： Yong Ming Li , Helen Vlassara , Anthony Cerami
发明人： Yong Ming Li , Helen Vlassara , Anthony Cerami
IPC分类号： A61K8/64 , A61K38/00 , A61K38/03 , A61K38/16 , A61K38/47 , A61Q11/00 , C07K14/79 , C12N9/36 , C12Q1/00 , C12Q1/34 , G01N33/573 , G01N33/66 , G01N33/68
CPC分类号： A61Q11/00 , A61K8/64 , C07K14/79 , G01N33/573 , G01N33/66 , G01N33/68 , G01N33/6842 , A61K38/00 , G01N2333/79 , G01N2333/924 , G01N2333/936
摘要： The present invention is directed to methods for inhibiting the cross-linking of advanced glycosylation endproducts in a subject suspected of having elevated levels of AGEs by using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions for inhibiting the cross-linking of AGEs in a subject in need of such therapy.
摘要翻译：本发明涉及通过使用意想不到的发现，某些抗菌蛋白，特别是溶菌酶及其特定片段与晚期糖基化终产物结合来抑制怀疑具有升高水平的AGE的受试者中晚期糖基化终产物的交联的方法（AGEs），并且该结合活性与细菌碳水化合物与抗菌蛋白的结合基本上是非竞争性的。因此，本发明涉及用于治疗与增加水平的AGE相关的疾病和病症的治疗方法，通过使用具有与其相关联的具有亲水环结构域的分子的组合物，该结构域与AGE结合活性相关，以及包含这种结构域的组合物从生物材料中去除AGEs。本发明还涉及用于抑制需要这种治疗的受试者中AGEs交联的组合物。

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