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1. 发明申请

US20140112877A1 SKIN LIGHTENING COMPOSITIONS 有权
标题翻译：皮肤发光组合物
公开(公告)号：US20140112877A1
公开(公告)日：2014-04-24
申请号：US13656258
申请日：2012-10-19
申请人： Yoko Niki , Masaki Yoshida , Masamitsu Ichihashi , Hideya Ando , Daniel B. Yarosh , Mary S. Matsui
发明人： Yoko Niki , Masaki Yoshida , Masamitsu Ichihashi , Hideya Ando , Daniel B. Yarosh , Mary S. Matsui
IPC分类号： A61K8/49 , A61Q19/02
CPC分类号： A61K8/4946 , A61K2800/782 , A61Q19/02
摘要： Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure: or having the structure: as defined herein.
摘要翻译：提供了用于减轻和/或脱色皮肤的组合物和方法，所述组合物包含具有如下结构：或具有如本文所定义的结构的化合物。

2. 发明申请

US20140154190A1 Skin Lightening Compositions 审中-公开
公开(公告)号：US20140154190A1
公开(公告)日：2014-06-05
申请号：US14175360
申请日：2014-02-07
申请人： Yoko Niki , Masaki Yoshida , Masamitsu Ichihashi , Hideya Ando , Daniel B. Yarosh , Mary S. Matsui
发明人： Yoko Niki , Masaki Yoshida , Masamitsu Ichihashi , Hideya Ando , Daniel B. Yarosh , Mary S. Matsui
IPC分类号： A61K8/49 , A61Q17/04 , A61Q19/02
CPC分类号： A61K8/4946 , A61K8/49 , A61K2800/782 , A61Q17/04 , A61Q19/02
摘要： Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure: wherein: R1 and R2 are same or different and are each selected from the group consisting of hydrogen, alkyl, carbomethoxy, carboethoxy, alkoxy, and alkanoyl, any of which may be halogen-substituted, and halogen; R6 is selected from the group consisting of hydrogen, methyl, and ethyl; and R3, R4 and R5 are the same or different and are each selected from the group consisting of hydrogen, methyl, methoxy, ethoxy, methoxyethoxy, ethoxyethoxy, propoxy, propoxymethoxy, and the like, any of which may be halogen-substituted; or having the structure: wherein: R2 is hydrogen, lower alkyl or hydroxy lower alkyl; R3 is lower alkyl, —CH2CN, hydroxy lower alkyl, —NO, —CH2N═C or (wherein R6 and R7 are independently selected from the group consisting of hydrogen and lower alkyl) or hydrogen provided R2 is not hydrogen; R4 is Z-T-W wherein Z represents —O—, —NH— or a single bond; T represents a straight- or branched-chain lower-alkylene group; when Z is a single bond, T also represents an ethenylene or a propenylene group wherein the unsaturated carbon is at the single bond; when Z is —O—, T also represents an allylene group wherein the saturated carbon is at the oxygen; and W represents hydrogen, when T is allylene and Z is —O—, and Ar, wherein Ar is selected from thienyl, pyridinyl, furanyl, phenyl and substituted phenyl wherein there are one or more substituents on the phenyl independently selected from halogen or lower alkyl; and R5 is hydrogen, halogen or lower alkyl; or pharmaceutically-, cosmetically- and dermatologically-acceptable salts, solvates, and bioprecursors, and stereoisomers and enantiomers of these compounds, free from or mixed with other enantiomers or stereoisomers; and such compounds in compositions with a pharmaceutically-, cosmetically- or dermatologically-acceptable carrier thereof comprising a safe and effective amount of the skin lightening or depigmenting compound.

3. 发明申请

US20110171149A1 Skin Lightening Compositions 有权
标题翻译：护肤组合物
公开(公告)号：US20110171149A1
公开(公告)日：2011-07-14
申请号：US12984159
申请日：2011-01-04
申请人： Yoko Niki , Masaki Yoshida , Masamitsu Ichihashi , Hideya Ando , Daniel B. Yarosh , Mary S. Matsui
发明人： Yoko Niki , Masaki Yoshida , Masamitsu Ichihashi , Hideya Ando , Daniel B. Yarosh , Mary S. Matsui
IPC分类号： A61K8/49 , A61Q19/02 , C12Q1/02 , G01N33/53
CPC分类号： A61K8/4946 , A61K8/49 , A61K2800/782 , A61Q17/04 , A61Q19/02
摘要： Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure: or having the structure: as defined herein.
摘要翻译：提供了用于减轻和/或脱色皮肤的组合物和方法，所述组合物包含具有如下结构：或具有如本文所定义的结构的化合物。

4. 发明申请

US20140212365A9 SKIN LIGHTENING COMPOSITIONS 有权
公开(公告)号：US20140212365A9
公开(公告)日：2014-07-31
申请号：US13656258
申请日：2012-10-19
申请人： Yoko Niki , Masaki Yoshida , Masamitsu Ichihashi , Hideya Ando , Daniel B. Yarosh , Mary S. Matsui
发明人： Yoko Niki , Masaki Yoshida , Masamitsu Ichihashi , Hideya Ando , Daniel B. Yarosh , Mary S. Matsui
IPC分类号： A61K8/49 , A61Q19/02
CPC分类号： A61K8/4946 , A61K2800/782 , A61Q19/02
摘要： Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure: or having the structure: as defined herein.

5. 发明授权

US08722026B2 Skin lightening compositions 有权
标题翻译：护肤组合物
公开(公告)号：US08722026B2
公开(公告)日：2014-05-13
申请号：US12984159
申请日：2011-01-04
申请人： Yoko Niki , Masaki Yoshida , Masamitsu Ichihashi , Hideya Ando , Daniel B. Yarosh , Mary S. Matsui
发明人： Yoko Niki , Masaki Yoshida , Masamitsu Ichihashi , Hideya Ando , Daniel B. Yarosh , Mary S. Matsui
IPC分类号： A61Q19/02
CPC分类号： A61K8/4946 , A61K8/49 , A61K2800/782 , A61Q17/04 , A61Q19/02
摘要： Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure: or having the structure: as defined herein.
摘要翻译：提供了用于减轻和/或脱色皮肤的组合物和方法，所述组合物包含具有如下结构：或具有如本文所定义的结构的化合物。

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