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    • 2. 发明授权
    • Tetrahydrobenzazepine derivatives which inhibit lipoxygenase
    • 抑制脂氧合酶的四氢苯并吖庚因衍生物
    • US5478822A
    • 1995-12-26
    • US167959
    • 1993-12-17
    • Yoko HoshinoTakafumi Ikeda
    • Yoko HoshinoTakafumi Ikeda
    • A61K31/55A61P9/00A61P29/00A61P37/08C07D223/16G09F11/15
    • C07D223/16
    • Compounds of the formula ##STR1## wherein n is 1 to 5 and R is hydrogen, C.sub.1 to C.sub.4 alkyl, arylalkyl having from one to four carbon atoms in the alkyl moiety or arylalkyl substituted with one or more substituents selected independently from the group consisting of halogen, nitro, cyano, C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, C.sub.1 to C.sub.6 halosubstituted alkyl, C.sub.1 to C.sub.6 hydroxysubstituted alkyl, C.sub.2 to C.sub.7 alkoxycarbonyl and aminocarbonyl, and the pharmaceutically acceptable salts thereof, inhibit the enzyme lipoxygenase and are useful in treating allergy and inflammatory and cardiovascular conditions for which the action of lipoxygenase has been implicated. These compounds form the active ingredient in pharmaceutical compositions for treating such conditions.
    • PCT No.PCT / US92 / 04197 Sec。 371日期:1993年12月17日 102(e)1993年12月17日PCT PCT。1992年5月27日提交PCT。其中n为1至5,R为氢,C 1至C 4烷基,具有1至4个碳原子的芳基烷基的式 被一个或多个独立地选自卤素,硝基,氰基,C 1至C 6烷基,C 1至C 6烷氧基,C 1至C 6卤代烷基,C 1至C 6羟基取代的烷基,C 2至C 7烷氧羰基和 氨基羰基及其药学上可接受的盐抑制酶脂氧合酶,并且可用于治疗已经涉及脂氧合酶作用的过敏和炎性和心血管疾病。 这些化合物在用于治疗这些病症的药物组合物中形成活性成分。