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1. 发明申请

US20130029979A1 FUSED BICYCLIC COMPOUND 有权
标题翻译：熔融双相化合物
公开(公告)号：US20130029979A1
公开(公告)日：2013-01-31
申请号：US13561662
申请日：2012-07-30
申请人： Yoichi TAKAHASHI , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iljima
发明人： Yoichi TAKAHASHI , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iljima
IPC分类号： C07D265/16 , C07D311/04 , A61K31/352 , C07D413/04 , A61P9/06 , C07D405/04 , A61K31/4433 , A61P9/12 , A61P9/04 , A61K31/536 , C07D307/94
CPC分类号： C07D265/16 , C07D311/20 , C07D311/58 , C07D311/96 , C07D405/14 , C07D413/04
摘要： Fused bicyclic compound having an affinity to mineral corticoid receptor (MR), of formula [I]: wherein ring A is benzene having a substituent R1, fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R1, R1 is alkylsulfonylamino, etc., R2 and R3 are (a) the same of different and are hydrogen, alkyl, or optionally substituted aryl, or (b) combined with each other to form an oxo group or (c) combined with each other at its terminal together with the adjacent carbon atom to form cycloalkyl, X is ═N—, ═C(R4)— or —CH(R4)—, R4 is (a) hydrogen, (b) cyano, (c) halogen, (d) alkyl, (e) alkenyl, (f) cycloalkyl, (g) alkanoyl, (h) carbamoyl, or (i) cycloalkenyl, Ar is an optionally substituted aromatic cyclic group and a dotted line means presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, useful e.g. as an antihypertensive agent.
摘要翻译：具有式[I]的矿物质类皮质激素受体（MR）的亲和性的稠合双环化合物：其中环A是具有取代基R 1的苯，与相邻的6元杂环稠合，并且进一步任选具有除 R 1，R 1是烷基磺酰基氨基等，R 2和R 3是（a）不同的并且是氢，烷基或任选取代的芳基，或（b）彼此结合形成氧代基或（c）与 X是= N - ， - C（R4） - 或-CH（R4） - ，R4是（a）氢，（b）氰基，（c）卤素，（d）烷基，（e）烯基，（f）环烷基，（g）烷酰基，（h）氨基甲酰基或（i）环烯基，Ar是任选取代的芳族环状基团，虚线表示存在或不存在双键或其药学上可接受的盐，例如，作为抗高血压药。

2. 发明授权

US08410166B2 Fused bicyclic compound 有权
标题翻译：稠合双环化合物
公开(公告)号：US08410166B2
公开(公告)日：2013-04-02
申请号：US13561662
申请日：2012-07-30
申请人： Yoichi Takahashi , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iljima
发明人： Yoichi Takahashi , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iljima
IPC分类号： C07D265/00
CPC分类号： C07D265/16 , C07D311/20 , C07D311/58 , C07D311/96 , C07D405/14 , C07D413/04
摘要： Fused bicyclic compound having an affinity to mineral corticoid receptor (MR), of formula [I]: wherein ring A is benzene having a substituent R1, fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R1, R1 is alkylsulfonylamino, etc., R2 and R3 are (a) the same of different and are hydrogen, alkyl, or optionally substituted aryl, or (b) combined with each other to form an oxo group or (c) combined with each other at its terminal together with the adjacent carbon atom to form cycloalkyl, X is ═N—, ═C(R4)— or —CH(R4)—, R4 is (a) hydrogen, (b) cyano, (c) halogen, (d) alkyl, (e) alkenyl, (f) cycloalkyl, (g) alkanoyl, (h) carbamoyl, or (i) cycloalkenyl, Ar is an optionally substituted aromatic cyclic group and a dotted line means presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, useful e.g. as an antihypertensive agent.
摘要翻译：具有式[I]的矿物质类皮质激素受体（MR）的亲和性的稠合双环化合物：其中环A是具有取代基R 1的苯，与相邻的6元杂环稠合，并且进一步任选具有除 R 1，R 1是烷基磺酰基氨基等，R 2和R 3是（a）不同的并且是氢，烷基或任选取代的芳基，或（b）彼此结合形成氧代基或（c）与 X是= N - ， - C（R4） - 或-CH（R4） - ，R4是（a）氢，（b）氰基，（c）卤素，（d）烷基，（e）烯基，（f）环烷基，（g）烷酰基，（h）氨基甲酰基或（i）环烯基，Ar是任选取代的芳族环状基团，虚线表示存在或不存在双键或其药学上可接受的盐，例如，作为抗高血压药。

3. 发明授权

US08884190B2 Vertical-position welding method 有权
标题翻译：垂直位置焊接法
公开(公告)号：US08884190B2
公开(公告)日：2014-11-11
申请号：US12006897
申请日：2008-01-07
申请人： Terumi Nakamura , Noboru Kiji , Toru Iljima
发明人： Terumi Nakamura , Noboru Kiji , Toru Iljima
IPC分类号： B23K9/12 , B65H20/00 , F16F3/00 , B23K9/133 , B23K9/02
CPC分类号： B23K9/0213 , B23K9/12 , B23K9/126 , B23K9/133
摘要： A pair of thick steel plates are set up side by side such that an I groove with a narrow gap is formed between the facing edges of the plates, and a welding wire projecting from a welding torch of an arc welding unit with a constant voltage characteristic is inserted into the I groove obliquely from above with respect to the thickness direction of the plates. The welding torch is moved vertically while the distal end of the welding wire is caused to reciprocate inside the I groove in the thickness direction. At this time, the wire feed rate Vf is varied and also the extension L of the welding wire is increased or decreased so as to keep welding current Iw at a target value. Further, the wire feed rate Vf is subjected to incremental/decremental correction according to the moving direction of the torch.
摘要翻译：一对厚钢板并排设置，使得在板的相对边缘之间形成具有窄间隙的I槽，以及从具有恒定电压特性的电弧焊接单元的焊枪突出的焊丝相对于板的厚度方向从上方倾斜地插入到I槽中。焊枪的远端在厚度方向上在I槽内往复运动，使焊炬上下移动。此时，焊丝进给速度Vf变化，并且焊丝的延长线L也增大或减小，从而将焊接电流Iw保持在目标值。此外，焊丝进给速度Vf根据焊炬的移动方向进行增量/减量校正。

4. 发明申请

US20080210677A1 Vertical-position welding method 有权
标题翻译：垂直位置焊接法
公开(公告)号：US20080210677A1
公开(公告)日：2008-09-04
申请号：US12006897
申请日：2008-01-07
申请人： Terumi Nakamura , Noboru Kiji , Toru Iljima
发明人： Terumi Nakamura , Noboru Kiji , Toru Iljima
IPC分类号： B23K9/12
CPC分类号： B23K9/0213 , B23K9/12 , B23K9/126 , B23K9/133
摘要： A pair of thick steel plates are set up side by side such that an I groove with a narrow gap is formed between the facing edges of the plates, and a welding wire projecting from a welding torch of an arc welding unit with a constant voltage characteristic is inserted into the I groove obliquely from above with respect to the thickness direction of the plates. The welding torch is moved vertically while the distal end of the welding wire is caused to reciprocate inside the I groove in the thickness direction. At this time, the wire feed rate Vf is varied and also the extension L of the welding wire is increased or decreased so as to keep welding current Iw at a target value. Further, the wire feed rate Vf is subjected to incremental/decremental correction according to the moving direction of the torch.
摘要翻译：一对厚钢板并排设置，使得在板的相对边缘之间形成具有窄间隙的I槽，以及从具有恒定电压特性的电弧焊接单元的焊枪突出的焊丝相对于板的厚度方向从上方倾斜地插入到I槽中。焊枪的远端在厚度方向上在I槽内往复运动，使焊炬上下移动。此时，焊丝进给速度Vf变化，并且焊丝的延长线L也增大或减小，从而将焊接电流Iw保持在目标值。此外，焊丝进给速度Vf根据焊炬的移动方向进行增量/减量校正。

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