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1. 发明申请

US20100039094A1 PHYSICAL QUANTITY SENSOR 有权
标题翻译：物理量传感器
公开(公告)号：US20100039094A1
公开(公告)日：2010-02-18
申请号：US12442437
申请日：2007-09-21
申请人： Yoichi Nagata , Tohru Yanagisawa
发明人： Yoichi Nagata , Tohru Yanagisawa
IPC分类号： G01N27/00 , G01R27/08
CPC分类号： G01P15/097 , G01C19/56 , G01D3/021
摘要： A physical quantity sensor 1 comprises a driving circuit 4 that drives a sensor element based on a reference signal; the sensor element 3 that is driven by the driving circuit 4 to convert an externally applied physical quantity to an electrical signal; and an amplifier circuit 5 that amplifies an output signal of the sensor element 3. The driving circuit 4 controls a driving signal, which drives the sensor element, based on the reference signal so that the driving signal is at a fixed level, and the amplifier circuit 5 has a gain characteristic that amplifies the output signal in a direction reverse to a direction in which the reference signal varies or the driving signal of the driving circuit varies. This configuration allows the physical quantity sensor to reduce output level variations in the sensor output against signal level variations in the reference signal and to make the sensitivity constant.
摘要翻译：物理量传感器1包括基于参考信号驱动传感器元件的驱动电路4; 由驱动电路4驱动以将外部施加的物理量转换为电信号的传感器元件3; 以及放大电路5，其放大传感器元件3的输出信号。驱动电路4根据参考信号控制驱动传感器元件的驱动信号，使得驱动信号处于固定电平，放大器电路5具有在与参考信号变化的方向相反的方向或驱动电路的驱动信号变化的方向上放大输出信号的增益特性。该配置允许物理量传感器降低传感器输出中的输出电平变化，防止参考信号中的信号电平变化，并使灵敏度保持不变。

2. 发明授权

US08037755B2 Physical quantity sensor 有权
标题翻译：物理量传感器
公开(公告)号：US08037755B2
公开(公告)日：2011-10-18
申请号：US12442437
申请日：2007-09-21
申请人： Yoichi Nagata , Tohru Yanagisawa
发明人： Yoichi Nagata , Tohru Yanagisawa
IPC分类号： G01P9/00
CPC分类号： G01P15/097 , G01C19/56 , G01D3/021
摘要： A physical quantity sensor 1 comprises a driving circuit 4 that drives a sensor element based on a reference signal; the sensor element 3 that is driven by the driving circuit 4 to convert an externally applied physical quantity to an electrical signal; and an amplifier circuit 5 that amplifies an output signal of the sensor element 3. The driving circuit 4 controls a driving signal, which drives the sensor element, based on the reference signal so that the driving signal is at a fixed level, and the amplifier circuit 5 has a gain characteristic that amplifies the output signal in a direction reverse to a direction in which the reference signal varies or the driving signal of the driving circuit varies. This configuration allows the physical quantity sensor to reduce output level variations in the sensor output against signal level variations in the reference signal and to make the sensitivity constant.
摘要翻译：物理量传感器1包括基于参考信号驱动传感器元件的驱动电路4; 由驱动电路4驱动以将外部施加的物理量转换为电信号的传感器元件3; 以及放大电路5，其放大传感器元件3的输出信号。驱动电路4根据参考信号控制驱动传感器元件的驱动信号，使得驱动信号处于固定电平，放大器电路5具有在与参考信号变化的方向相反的方向或驱动电路的驱动信号变化的方向上放大输出信号的增益特性。该配置允许物理量传感器降低传感器输出中的输出电平变化，防止参考信号中的信号电平变化，并使灵敏度保持不变。

3. 发明授权

US07981618B2 Diagnostic and therapeutic methods and compositions involving PTEN and breast cancer 有权
标题翻译：涉及PTEN和乳腺癌的诊断和治疗方法和组合物
公开(公告)号：US07981618B2
公开(公告)日：2011-07-19
申请号：US10983011
申请日：2004-11-05
申请人： Dihua Yu , Xiaoyan Zhou , Yoichi Nagata , Francisco J. Esteva , Aysegul A. Sahin
发明人： Dihua Yu , Xiaoyan Zhou , Yoichi Nagata , Francisco J. Esteva , Aysegul A. Sahin
IPC分类号： C12Q1/00 , G01N1/00 , G01N33/48 , G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q1/42 , C12Q2600/106 , G01N33/5011 , G01N33/573 , G01N33/57415 , Y10T436/25
摘要： Patients with ErbB2-overexpressing cancers can be given an ErbB2 targeting agent as a therapeutic regimen but not all patients are responsive. The present invention concerns the diagnostic, prognostic and therapeutic methods and compositions for evaluating potential efficacy of an ErbB2 targeting agent in an ErbB2-overexpressing cancers by evaluating PTEN expression, which is predictive of responsiveness or resistance to ErbB2 targeting agents such as trastuzumab. Low PTEN expression is predictive of a patient who will respond poorly to trastuzumab.
摘要翻译：患有ErbB2过度表达癌症的患者可以给予ErbB2靶向药物作为治疗方案，但并不是所有患者都有反应。本发明涉及用于通过评估PTEN表达来评价ErbB2靶向剂在ErbB2过表达癌症中的潜在功效的诊断，预后和治疗方法和组合物，其是预测对ErbB2靶向剂（例如曲妥珠单抗）的反应性或抗性。低PTEN表达预测了对曲妥单抗敏感的患者。

4. 发明申请

US20100011856A1 PHYSICAL QUANTITY SENSOR 有权
标题翻译：物理量传感器
公开(公告)号：US20100011856A1
公开(公告)日：2010-01-21
申请号：US11916221
申请日：2006-05-31
申请人： Yoichi Nagata
发明人： Yoichi Nagata
IPC分类号： G01C19/56 , G01P9/04
CPC分类号： G01P15/097 , G01C19/56 , G01D3/02 , G01P15/08
摘要： A physical quantity sensor comprises a sensor circuit that converts an externally applied physical quantity to an electrical signal and outputs a detection signal; an adjustment circuit that adjusts the detection signal, which is received from the sensor circuit, to a predetermined signal; and an output circuit that forms an output signal from the signal of the adjustment circuit wherein the sensor circuit and the output circuit are driven by a common power supply voltage. The adjustment circuit comprises a pulse generation circuit that generates a pulse modulation signal based on the power supply voltage; and an amplifier circuit that amplifies the detection signal, which is received from the sensor circuit, with a gain made variable by the pulse modulation signal, wherein the detection sensitivity of the output signal is made variable according to the power supply voltage. This configuration enables the amplifier circuit, provided in the adjustment circuit, to output a sensor output that has high linearity characteristics and, as a result, implements a physical quantity sensor with highly accurate sensor detection sensitivity and allows the physical quantity sensor to have good detection-sensitivity ratiometrics characteristics, high linearity, and desired-characteristic detection sensitivity.
摘要翻译：物理量传感器包括将外部施加的物理量转换为电信号并输出检测信号的传感器电路; 将从传感器电路接收到的检测信号调整为预定信号的调整电路; 以及输出电路，其从调节电路的信号形成输出信号，其中传感器电路和输出电路由公共电源电压驱动。调整电路包括：脉冲发生电路，其基于电源电压产生脉冲调制信号; 以及放大器电路，其以从所述传感器电路接收到的所述检测信号以由所述脉冲调制信号变化的增益放大，其中，所述输出信号的检测灵敏度根据所述电源电压而变化。该配置使得调节电路中设置的放大器电路能够输出具有高线性特性的传感器输出，结果实现具有高精度的传感器检测灵敏度的物理量传感器，并允许物理量传感器具有良好的检测灵敏度比例特性，高线性度和期望特性检测灵敏度。

5. 发明申请

US20090288486A1 VIBRATION BODY FOR ANGULAR SPEED SENSOR 有权
标题翻译：用于角速度传感器的振动体
公开(公告)号：US20090288486A1
公开(公告)日：2009-11-26
申请号：US12096858
申请日：2007-01-11
申请人： Isao Arai , Yoichi Nagata
发明人： Isao Arai , Yoichi Nagata
IPC分类号： G01P3/44
CPC分类号： G01C19/5607
摘要： A vibration body 1 includes a vibrator 2 having vibration pieces 7 and a supporting part 5, and a mounting substrate 11 for mounting the vibrator. The mounting substrate has a seat part 13 for supporting the supporting part, and a base part 12. The seat part 13 has a level difference above the base part, the level difference being at least equal to or higher than the oscillation width of the vibration pieces, and the seat part is also provided with an edge portion 14 having a curved line shape. A normal line direction at each position on the edge portion is the same as a reference direction determined for the mounting substrate, or has at least one different angle with respect to the reference direction. When the vibrator is mounted on the seat part 13, tangential directions at the end portion of the supporting part and the edge portion of the seat part coincide with each other at a mounting position selected from the edge portion having the curved line shape of the seat part. The angle for mounting the vibrator on the mounting substrate is determined by the normal direction at the edge portion of the seat part by the position adjustment between the end portion and the edge portion. In mounting the vibrator on the angular speed sensor, oscillation of the vibrator is not impeded, and a preferable fixing of the vibrator is achieved as well as being set at any angle within a predetermined angle range.
摘要翻译：振动体1包括具有振动片7的振动器2和支撑部5，以及用于安装振动器的安装基板11。安装基板具有用于支撑支撑部的座部13和基部12.座部13在基部上方具有水平差，水平差至少等于或高于振动的振动宽度座部分还设置有具有曲线形状的边缘部分14。在边缘部分的每个位置处的法线方向与为安装基板确定的基准方向相同，或者相对于基准方向具有至少一个不同的角度。当振动器安装在座椅部分13上时，在从座椅的曲线形状的边缘部分中选择的安装位置处，支撑部分的端部处的切向方向和座椅部分的边缘部分彼此重合部分。通过端部和边缘部之间的位置调节，用于将振动器安装在安装基板上的角度由座部的边缘部分处的法线方向决定。在将振动器安装在角速度传感器上时，不会妨碍振动器的振动，并且实现振动器的优选固定以及设定在预定角度范围内的任何角度。

6. 发明授权

US06580665B1 Electronic timepiece having power generating function 有权
标题翻译：具有发电功能的电子钟表
公开(公告)号：US06580665B1
公开(公告)日：2003-06-17
申请号：US09547038
申请日：2000-04-11
申请人： Yasuo Kamiyama , Tomomi Murakami , Masao Mafune , Yoichi Nagata
发明人： Yasuo Kamiyama , Tomomi Murakami , Masao Mafune , Yoichi Nagata
IPC分类号： G04B4766
CPC分类号： G04C10/04 , G04G19/12
摘要： An electronic timepiece is formed of a power generating device for generating power, a control device for driving on receipt of a power supply from the power generating device, a display device for displaying a time by an operation of the control device, a detecting device for detecting a state of the power generating device, and a deciding device for deciding whether or not the power generating device generates power based on a detection signal sent from the detecting device. The control device controls such that a power generating state of the power generating device is displayed on the display device based on a decision of the deciding device. It is possible to reduce power consumption by stopping hands if required.
摘要翻译：电子钟表由发电装置的发电装置，从发电装置接收电力驱动的控制装置，通过控制装置的动作显示时间的显示装置，检测装置检测所述发电装置的状态，以及决定装置，其基于从所述检测装置发送的检测信号来判定所述发电装置是否发电。控制装置进行控制，使得基于判定装置的决定，在显示装置上显示发电装置的发电状态。如果需要，可以通过停止手来降低功耗。

7. 发明授权

US06232543B1 Thermoelectric system 失效
标题翻译：热电系统
公开(公告)号：US06232543B1
公开(公告)日：2001-05-15
申请号：US09343458
申请日：1999-06-30
申请人： Yoichi Nagata
发明人： Yoichi Nagata
IPC分类号： H01L3502
CPC分类号： G04C10/00 , G04G19/04
摘要： In order to optimally control supply of electric power to a load means and efficiently utilize generated energy of a thermoelectric power generator in consideration of influence of the Peltier effect against generated voltage of the thermoelectric power generator, a thermoelectric system is structured by connecting a load means (20) utilizing the generated power of the thermoelectric power generator (10), and a controller (30) for measuring the generated voltage (V1) of the thermoelectric power generator (10) and controlling power supply and suspension of the power supply to the load means (20) in accordance with the measured result to the thermoelectric power generator (10) provided with a plurality of thermocouples electrically in series, and a compensating means to perform measurement with compensating for the generated voltage when power is supplied from the thermoelectric power generator (10) to the load means (20) continuously for more than a predetermined period of time, is provided to the controller.
摘要翻译：考虑到珀尔帖效应对热电发电机的发电电压的影响，为了最佳地控制对负载装置的电力供给并有效地利用热电发电机的产生的能量，热电系统通过将负载装置（20）利用所述热电发电机（10）的发电功率;以及控制器（30），用于测量所述热电发电机（10）的发电电压（V1），并控制所述电源根据与设置有多个电串联的多个热电偶的热电发电机（10）的测量结果的负载装置（20），以及补偿装置，用于当从热电功率供电时，补偿发电电压，进行测量发电机（10）连续到负载装置（20）超过预定时间段给控制器。

8. 发明授权

US4987568A Monitor system for multiplex equipment 失效
标题翻译：多功能设备监控系统
公开(公告)号：US4987568A
公开(公告)日：1991-01-22
申请号：US179306
申请日：1988-04-08
申请人： Sigeo Shinada , Hiroyuki Fujita , Yoichi Nagata
发明人： Sigeo Shinada , Hiroyuki Fujita , Yoichi Nagata
IPC分类号： H04J3/14
CPC分类号： H04J3/14
摘要： A monitor system for a multiplex equipment is disclosed, in which a multiplexer and a demultiplexer are monitored by direct comparison of input and output signals thereof. Low-bit-rate output interfaces and high-bit-rate output interfaces include signal-loss detectors respectively. Low-bit-rates input interfaces and high-bit-rate input interfaces, on the other hand, include signal-loss detectors or frame alignment-loss detectors and selectors for loop outputs of the output interfaces of respective speeds back upon the input sides of the input interfaces of respective speeds. An economical monitor circuit for detecting a fault of a multiplex converter and accurately is thus configured without using any bipolar signal switching circuit or low- or high-bit-rate B/U converters.
摘要翻译：公开了一种用于多路复用设备的监视器系统，其中通过对其输入和输出信号进行直接比较来监视多路复用器和解复用器。低比特率输出接口和高比特率输出接口分别包括信号丢失检测器。另一方面，低比特率输入接口和高比特率输入接口包括信号丢失检测器或帧对准损耗检测器和用于各个速度的输出接口的环路输出的选择器，各个速度的输入接口。因此，在不使用任何双极性信号切换电路或低或高比特率B / U转换器的情况下，构成用于检测多路转换器的故障的经济的监视电路。

9. 发明申请

US20120039875A1 DIAGNOSTIC AND THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING PTEN AND BREAST CANCER 审中-公开
标题翻译：涉及PTEN和乳腺癌的诊断和治疗方法和组合物
公开(公告)号：US20120039875A1
公开(公告)日：2012-02-16
申请号：US13184269
申请日：2011-07-15
申请人： Dihua Yu , Xiaoyan Zhou , Yoichi Nagata , Francisco J. Esteva , Aysegul A. Sahin
发明人： Dihua Yu , Xiaoyan Zhou , Yoichi Nagata , Francisco J. Esteva , Aysegul A. Sahin
IPC分类号： A61K39/395 , A61P35/00 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/42 , C12Q2600/106 , G01N33/5011 , G01N33/573 , G01N33/57415 , Y10T436/25
摘要： Patients with ErbB2-overexpressing cancers can be given an ErbB2 targeting agent as a therapeutic regimen but not all patients are responsive. The present invention concerns the diagnostic, prognostic and therapeutic methods and compositions for evaluating potential efficacy of an ErbB2 targeting agent in an ErbB2-overexpressing cancers by evaluating PTEN expression, which is predictive of responsiveness or resistance to ErbB2 targeting agents such as trastuzumab. Low PTEN expression is predictive of a patient who will respond poorly to trastuzumab.
摘要翻译：患有ErbB2过度表达癌症的患者可以给予ErbB2靶向药物作为治疗方案，但并不是所有患者都有反应。本发明涉及用于通过评估PTEN表达来评价ErbB2靶向剂在ErbB2过表达癌症中的潜在功效的诊断，预后和治疗方法和组合物，其是预测对ErbB2靶向剂（例如曲妥珠单抗）的反应性或抗性。低PTEN表达预测了对曲妥单抗敏感的患者。

10. 发明申请

US20110150868A1 DIAGNOSTIC AND THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING PTEN AND BREAST CANCER 审中-公开
标题翻译：涉及PTEN和乳腺癌的诊断和治疗方法和组合物
公开(公告)号：US20110150868A1
公开(公告)日：2011-06-23
申请号：US12943644
申请日：2010-11-10
申请人： Dihua Yu , Xiaoyan Zhou , Yoichi Nagata , Francisco J. Esteva , Aysegul A. Sahin
发明人： Dihua Yu , Xiaoyan Zhou , Yoichi Nagata , Francisco J. Esteva , Aysegul A. Sahin
IPC分类号： A61K39/395 , A61P35/00 , C12Q1/68 , G01N33/573 , C12Q1/42
CPC分类号： C12Q1/6886 , C12Q1/42 , C12Q2600/106 , G01N33/5011 , G01N33/573 , G01N33/57415 , Y10T436/25
摘要： Patients with ErbB2-overexpressing cancers can be given an ErbB2 targeting agent as a therapeutic regimen but not all patients are responsive. The present invention concerns the diagnostic, prognostic and therapeutic methods and compositions for evaluating potential efficacy of an ErbB2 targeting agent in an ErbB2-overexpressing cancers by evaluating PTEN expression, which is predictive of responsiveness or resistance to ErbB2 targeting agents such as trastuzumab. Low PTEN expression is predictive of a patient who will respond poorly to trastuzumab.
摘要翻译：患有ErbB2过度表达癌症的患者可以给予ErbB2靶向药物作为治疗方案，但并不是所有患者都有反应。本发明涉及用于通过评估PTEN表达来评价ErbB2靶向剂在ErbB2过表达癌症中的潜在功效的诊断，预后和治疗方法和组合物，其是预测对ErbB2靶向剂（例如曲妥珠单抗）的反应性或抗性。低PTEN表达预测了对曲妥单抗敏感的患者。

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