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1. 发明申请

US20070077662A1 APPARATUS AND METHOD FOR MEASURING 8-OHdG 审中-公开
标题翻译：用于测量8-OHdG的装置和方法
公开(公告)号：US20070077662A1
公开(公告)日：2007-04-05
申请号：US11470955
申请日：2006-09-07
申请人： Yohei Inaba , Kenji Yokoyama , Isao Karube , Narushi Ito
发明人： Yohei Inaba , Kenji Yokoyama , Isao Karube , Narushi Ito
IPC分类号： G01N1/18
CPC分类号： G01N30/88 , G01N2030/8813 , Y10T436/255
摘要： To provide a method for effectively and simply separating and condensing 8-OHdG which is present by a trace amount in body fluid, particularly in urine, and is frequently mingled with foreign substances with their peaks appearing around the peak thereof, a simple measurement method of 8-OHdG, and an apparatus for the measurement. [Solution]The present invention provides a method for effectively and simply separating and condensing 8-OHdG by an optimum combination of chromatographies. Specifically, the present invention comprises a method for separating and condensing 8-hydroxy-2′-deoxyguanosine (8-OHdG) from a body fluid, wherein a urine sample is contacted with a hydrophobic adsorbent which has, as the functional group, a straight chain hydrocarbon group having a carbon number of 6-30 and has a C % of 18% or less to capture the 8-OHdG. The method for measuring 8-OHdG and the apparatus for the measurement method according to the present invention use electrochemical reaction to measure the amount of 8-OHdG in the sample.
摘要翻译： <待解决的问题>提供一种有效且简单地分离和冷凝8-OHdG的方法，其通过微量的体液，特别是尿中存在，并且经常与外来物质混合，其峰出现在其峰顶周围，8-OHdG的简单测量方法和用于测量的装置。 [解决方案]本发明提供了通过色谱的最佳组合有效且简单地分离和冷凝8-OHdG的方法。具体地说，本发明包括从体液中分离和浓缩8-羟基-2'-脱氧鸟苷（8-OHdG）的方法，其中使尿样与疏水性吸附剂接触，所述疏水性吸附剂具有作为官能团的直链碳原子数为6〜30的碳原子数为8〜8的C-C的烃基，捕捉8-OHdG。根据本发明的用于测量8-OHdG的方法和测量方法的装置使用电化学反应来测量样品中8-OHdG的量。

2. 发明申请

US20090209753A1 COLUMN PACKING MATERIAL, COLUMN USING THE SAME, AND METHOD OF SEPARATION USING THE SAME 有权
标题翻译：柱包装材料，使用其的柱和使用其的分离方法
公开(公告)号：US20090209753A1
公开(公告)日：2009-08-20
申请号：US12388047
申请日：2009-02-18
申请人： Narushi Ito , Jun Kimura , Masayuki Mizushina , Yohei Inaba , Kenji Yokoyama
发明人： Narushi Ito , Jun Kimura , Masayuki Mizushina , Yohei Inaba , Kenji Yokoyama
IPC分类号： C07H1/06 , B01J20/22 , B01D15/26 , B01J8/02
CPC分类号： B01J20/287 , B01D15/325 , B01D15/362 , B01J20/28004
摘要： Aimed at readily and exactly separate 8-hydroxy-2′-deoxyguanosine (8-OHdG) contained in a sample, a column packing material used for separating 8-OHdG, which contains a packing material composed of a material having a straight-chain hydrocarbon group having 6 or more and 30 or less carbon atoms as a functional group, and having a carbon content over the surface of carrier of 18% or less by element ratio, wherein the packing material contains 1 cumulative percent or more and 20 cumulative percent or less, on the particle-count basis, of particles having a circle-equivalent diameter, measured using a flow-type particle image analyzer, of 0.5 μm or larger and 10 μm or smaller, is used.
摘要翻译：针对样品中所含的8-羟基-2'-脱氧鸟苷（8-OHdG）容易且精确地分离，用于分离8-OHdG的柱填充材料，其包含由具有直链烃的材料组成的包装材料具有6个或更多和30个或更少碳原子的官能团，并且在载体表面上的碳含量超过18％或更少的元素比，其中包装材料包含1个累积百分比或更多和20个累积百分比，或使用0.5μm以上且10μm以下的使用流动型粒子图像分析仪测定的具有圆当量直径的粒子，以粒子计数为基准。

3. 发明授权

US08968567B2 Column packing material, column using the same, and method of separation using the same 有权
标题翻译：柱包装材料，使用相同的柱和使用其的分离方法
公开(公告)号：US08968567B2
公开(公告)日：2015-03-03
申请号：US12388047
申请日：2009-02-18
申请人： Narushi Ito , Jun Kimura , Masayuki Mizushina , Yohei Inaba , Kenji Yokoyama
发明人： Narushi Ito , Jun Kimura , Masayuki Mizushina , Yohei Inaba , Kenji Yokoyama
IPC分类号： B01D15/32 , B01J20/28 , B01J20/287 , B01D15/36
CPC分类号： B01J20/287 , B01D15/325 , B01D15/362 , B01J20/28004
摘要： Aimed at readily and exactly separate 8-hydroxy-2′-deoxyguanosine (8-OHdG) contained in a sample, a column packing material used for separating 8-OHdG, which contains a packing material composed of a material having a straight-chain hydrocarbon group having 6 or more and 30 or less carbon atoms as a functional group, and having a carbon content over the surface of carrier of 18% or less by element ratio, wherein the packing material contains 1 cumulative percent or more and 20 cumulative percent or less, on the particle-count basis, of particles having a circle-equivalent diameter, measured using a flow-type particle image analyzer, of 0.5 μm or larger and 10 μm or smaller, is used.
摘要翻译：针对样品中所含的8-羟基-2'-脱氧鸟苷（8-OHdG）容易且精确地分离，用于分离8-OHdG的柱填充材料，其包含由具有直链烃的材料组成的包装材料具有6个或更多和30个或更少碳原子的官能团，并且在载体表面上的碳含量超过18％或更少的元素比，其中包装材料包含1个累积百分比或更多和20个累积百分比，或使用0.5μm以上且10μm以下的使用流动型粒子图像分析仪测定的具有圆当量直径的粒子，以粒子计数为基准。

4. 发明申请

US20060094124A1 Urine sugar meter 审中-公开
标题翻译：尿糖仪
公开(公告)号：US20060094124A1
公开(公告)日：2006-05-04
申请号：US11254735
申请日：2005-10-21
申请人： Narushi Ito , Akio Ohashi
发明人： Narushi Ito , Akio Ohashi
IPC分类号： G01N31/22 , G01N27/02
CPC分类号： G01N33/493 , Y10T436/143333
摘要： A urine sugar meter measures an immediately-before-meal urine sugar value by immediately-before-meal urine sugar measuring means, notifies a subject that an after-meal urine sugar value should be measured after passage of a predetermined time from this measurement by after-meal urine sugar time signal means, measures an after-meal urine sugar value after this notification by after-meal urine sugar measuring means, computes a urine sugar change value X1 which represents the difference between the after-meal urine sugar value and the immediately-before-meal urine sugar value by urine sugar change value computing means, determines acceptability of a change in the amount of sugar in a body based on this computed urine sugar change value by sugar amount change acceptability determining means, and outputs the urine sugar change value and an indicator about the acceptability of the change in the amount of sugar in the body by urine sugar change data output means.
摘要翻译：尿糖仪通过即食之前的尿糖测量装置测量即食之前的尿糖值，通知受试者在经过预定时间后测量餐后尿糖值，之后经过该测量之后食用尿糖时间信号表示在餐后尿糖测定手段通知后测定餐后尿糖值，计算尿糖变化值X 1，表示餐后尿糖值与基于尿糖变化可接受性确定装置的该计算的尿糖变化值，确定尿糖变化值计算装置之前的即食之前的尿糖值，确定通过糖量变化可接受性确定装置基于该计算的尿糖变化值改变身体中的糖的可接受性，并输出尿糖变化值和关于通过尿糖变化数据输出装置对体内糖含量变化的可接受性的指标。

5. 发明授权

US07229409B2 Method of providing a home health care service and system for providing a home health care service 失效
标题翻译：提供家庭保健服务和提供家庭保健服务的系统的方法
公开(公告)号：US07229409B2
公开(公告)日：2007-06-12
申请号：US10328222
申请日：2002-12-23
申请人： Narushi Ito , Akio Ohashi
发明人： Narushi Ito , Akio Ohashi
IPC分类号： A61B5/05
CPC分类号： A61B5/201 , A61B5/0002 , A61B5/14507 , A61B5/20 , A61B10/007 , G06F19/00 , Y10S128/92
摘要： A system for providing a home health care service includes a health care center, a service recipient device, and the Internet that connects these components. The health care center: is constructed on the Internet; includes a database for registering personal data that are necessary for the health care of registered at-home patients as basic health care data and storing measurement data that are provided from at-home patients over the course of time; and has the functions of inferring the health conditions of at-home patients based on the measurement data and the basic health care data, and offering appropriate services necessary for inferred health conditions. The service recipient device includes a biosensor and a signal processor. The biosensor detects chemical components contained in a substance that is discharged from the human body and converts detected values to electrical signals at the point of discharge.
摘要翻译：用于提供家庭保健服务的系统包括保健中心，服务接收设备和连接这些组件的因特网。保健中心：在互联网上建成; 包括用于登记登记的在家患者的医疗保健所需的个人数据的数据库作为基本卫生保健数据，并存储在家庭病人随时间提供的测量数据; 并具有根据测量数据和基本卫生保健数据推断家庭病人健康状况的功能，并提供推测健康状况所需的适当服务。服务接收装置包括生物传感器和信号处理器。生物传感器检测从人体排出的物质中含有的化学成分，并将检测值转换为放电点的电信号。

6. 发明授权

US5795774A Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US5795774A
公开(公告)日：1998-08-18
申请号：US891197
申请日：1997-07-10
申请人： Toru Matsumoto , Masako Furusawa , Narushi Ito , Shinya Nakamoto
发明人： Toru Matsumoto , Masako Furusawa , Narushi Ito , Shinya Nakamoto
IPC分类号： G01N27/327 , C12Q1/00 , C12M3/00 , G01N27/36
CPC分类号： C12Q1/002
摘要： A drop in measurement accuracy of biosensors, due to interferents in a measurement sample is avoided by an arrangement wherein: a hydrogen peroxide electrode 2 is formed on an insulated base 1, and then a .gamma.-aminopropyltriethoxysilane film 3, an acetylcellulose film 4, a perfluorocarbonsulfonic acid resin film 5, an organic macromolecular film 6 incorporating an immobilized enzyme with catalytic properties, and a polyalkylsiloxane film 7, are sequentially formed on the electrode 2.
摘要翻译：通过以下结构避免了生物传感器的测量精度的下降，其中：在绝缘基体1上形成过氧化氢电极2，然后将γ-氨基丙基三乙氧基硅烷膜3，乙酰纤维素膜4，全氟碳磺酸树脂膜5，具有催化性能的固定化酶的有机高分子膜6和聚烷基硅氧烷膜7依次形成在电极2上。

7. 发明授权

US06350273B1 Corneum puncture needle 有权
标题翻译：角膜穿刺针
公开(公告)号：US06350273B1
公开(公告)日：2002-02-26
申请号：US09265834
申请日：1999-03-10
申请人： Hirotaka Minagawa , Hiroki Tsuruta , Yasuyoshi Matsumoto , Narushi Ito
发明人： Hirotaka Minagawa , Hiroki Tsuruta , Yasuyoshi Matsumoto , Narushi Ito
IPC分类号： A61B1734
CPC分类号： A61B10/0045 , A61B17/205 , A61B2010/008
摘要： A corneum puncture needle for extracting tissue fluid from under the skin corneum includes a needle body and a stylus extending from the needle body to be inserted into a corneum of a human body. The stylus and the needle body form therebetween a stepped portion acting as a stopper when the stylus is inserted into a corneum of a human body. The needle body has a core formed in a unitary body with the stylus and a coating layer or a tube formed on the core. The stylus has a suitable length for prevention of damage of blood vessel. A plurality of puncture needles may be arranged on a holder.
摘要翻译：用于从皮肤角质层下提取组织液的角膜穿刺针包括针体和从针体延伸以插入人体角质层的触针。当将触针插入人体的角质层中时，触针和针体之间形成有作为止动件的阶梯部。针体具有与触笔一体形成的芯体和形成在芯上的涂层或管。触针具有适当的长度以防止血管损伤。多个穿刺针可以布置在保持器上。

8. 发明授权

US4909921A Electrochemical sensor facilitating repeated measurement 失效
标题翻译：电化学传感器便于重复测量
公开(公告)号：US4909921A
公开(公告)日：1990-03-20
申请号：US308597
申请日：1989-02-09
申请人： Narushi Ito
发明人： Narushi Ito
IPC分类号： C12Q1/00 , G01N27/414 , H01L29/78 , H01L29/786
CPC分类号： C12Q1/001 , G01N27/4145 , Y10S435/817
摘要： An electrochemical sensor wherein a FET for measuring chemical substances and a reference electrode are covered with a continuous hydrous polymer on an insulating substrate, and on the hydrous polymer, an enzyme-immobilized film is formed in a region positioned on a channel part of FET for measuring chemical substances.

9. 发明申请

US20070161877A1 Noninvasive measuring device for substance in blood via nail and a nail evaporation device 有权
标题翻译：通过钉子和指甲蒸发装置的血液中物质的无创测量装置
公开(公告)号：US20070161877A1
公开(公告)日：2007-07-12
申请号：US11606155
申请日：2006-11-30
申请人： Tsunenori Arai , Yuki Kawase , Yasunobu Oka , Narushi Ito
发明人： Tsunenori Arai , Yuki Kawase , Yasunobu Oka , Narushi Ito
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B18/203 , A61B2017/00765 , A61B2018/00452
摘要： A device and method for optically measuring a substance in blood using the nail as an optical window are provided. A device for optically measuring a test substance in blood by using the nail as an optical window and correcting or eliminating fluctuation of a measurement value based on optical characteristics of the nail plate, comprising irradiation means applying light within a wavelength range for measuring absorption by the test substance to the nail of a subject, detection means detecting light diffused/reflected from or transmitted through the body of the subject, and processing means processing a signal obtained by the detection means to convert the signal into a concentration of the test substance.
摘要翻译：提供了使用钉子作为光学窗口来光学测量血液中的物质的装置和方法。一种用于通过使用指甲作为光学窗口来对血液中的测试物质进行光学测量的装置，并且基于所述指甲板的光学特性来校正或消除测量值的波动，所述装置包括：在波长范围内施加用于测量吸收的光的照射装置检测物体到受试者的指甲，检测装置，其检测从被检体的身体扩散/反射或透过的物体，以及处理装置，对由检测装置获得的信号进行处理，将该信号转换成检测物质的浓度。

10. 发明授权

US4956149A Biosensor device provided with an agitator 失效
标题翻译：具有搅拌器的生物传感器装置
公开(公告)号：US4956149A
公开(公告)日：1990-09-11
申请号：US213076
申请日：1988-06-29
申请人： Yoshie Kawana , Narushi Ito
发明人： Yoshie Kawana , Narushi Ito
IPC分类号： G01N27/30 , C12Q1/00 , G01N27/28
CPC分类号： C12Q1/001
摘要： A biosensor includes an elastic substrate, a sensor tip, and a piezoelectric actuator. The sensor tip is mounted on one end of the substrate. The piezoelectric actuator is provided on the other end of the substrate.
摘要翻译：生物传感器包括弹性基底，传感器尖端和压电致动器。传感器尖端安装在基板的一端。压电致动器设置在基板的另一端。

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