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1. 发明授权

US3981906A Process for preparing alkyl 4,4'-(ethylenedioxy)bis-benzoates 失效
标题翻译：制备烷基4,4（40-（亚乙二氧基）双苯甲酸酯的方法
公开(公告)号：US3981906A
公开(公告)日：1976-09-21
申请号：US575229
申请日：1975-05-07
申请人： Yohei Fukuoka , Toshio Kato , Norio Imai , Joji Nishikido , Masato Hamada , Hiroshi Mikami , Hirohumi Iwasaki , Toshihisa Koike
发明人： Yohei Fukuoka , Toshio Kato , Norio Imai , Joji Nishikido , Masato Hamada , Hiroshi Mikami , Hirohumi Iwasaki , Toshihisa Koike
IPC分类号： C07C69/92 , C07C69/76
CPC分类号： C07C69/76
摘要： Alkyl 4,4'-(ethylenedioxy)bis-benzoates having improved properties such as anti-oxidation and anti-coloration are prepared in high yield and selectivity by, at the first step, reacting an excess alkyl p-hydroxybenzoate with a recycling alkyl p-(2-chloro-ethoxy)benzoate with heating in the presence of an alkali carbonate and an inert organic solvent until almost said alkyl p-(2-chloroethoxy)benzoate is consumed to produce an alkyl 4,4'-(ethylenedioxy)bis-benzoate and at the second step adding ethylene dichloride to the reaction system and continuing the heating to produce an alkyl p-(2-chloroethoxy)benzoate which is recycled, and separating the alkyl 4,4'-(ethylenedioxy)bis-benzoate produced.
摘要翻译：通过在第一步骤中，通过使过量的对羟基苯甲酸烷基酯与再循环烷基p反应，以高产率和选择性制备具有改进性能如抗氧化和抗着色的4,4' - （亚乙二氧基）双苯甲酸烷基酯 - （2-氯 - 乙氧基）苯甲酸酯，在碱金属碳酸盐和惰性有机溶剂的存在下加热直到几乎所有的对 - （2-氯乙氧基）苯甲酸烷基酯被消耗以产生4,4' - （亚乙二氧基）双 - 苯甲酸酯，并且在第二步骤中将二氯乙烯加入到反应体系中并继续加热以产生被再循环的对 - （2-氯乙氧基）苯甲酸烷基酯，并分离生成的4,4' - （亚乙二氧基）双苯甲酸烷基酯。

2. 发明授权

US4297503A Novel benzamide derivative and method of preparing metoclopramide using same 失效
标题翻译：新型苯甲酰胺衍生物和使用其制备甲氧氯普胺的方法
公开(公告)号：US4297503A
公开(公告)日：1981-10-27
申请号：US190994
申请日：1980-09-26
申请人： Joji Nishikido , Nobuhiro Tamura , Yohei Fukuoka , Hiroyuki Yamane
发明人： Joji Nishikido , Nobuhiro Tamura , Yohei Fukuoka , Hiroyuki Yamane
IPC分类号： C07C231/00 , A61K31/165 , C07C67/00 , C07C231/02 , C07C231/12 , C07C235/50 , C07C235/60 , C07C237/44 , G07C20060101 , C07C101/74
CPC分类号： C07C235/50 , C07C231/02 , C07C231/12 , C07C235/46
摘要： 2-Chloro-4-N-(.beta.-diethylaminoethyl)aminocarbonyl-5-methoxybenzamide of the formula, ##STR1## a process for their preparation and a process for preparing metoclopramide of the formula, ##STR2## using the above described 2-chloro-4-N-(.beta.-diethylaminoethyl)aminocarbonyl-5-methoxybenzamide.
摘要翻译：具有下式的2-氯-4-N-（β-二乙基氨基乙基）氨基羰基-5-甲氧基苯甲酰胺，其制备方法和制备下式的甲氧氯普胺的方法，使用上述2-氯 -4-N-（β-二乙基氨基乙基）氨基羰基-5-甲氧基苯甲酰胺。

3. 发明授权

US4279836A Hydroxamic acid derivative and method of preparing metoclopramide using same 失效
标题翻译：羟肟酸衍生物和使用其制备甲氧氯普胺的方法
公开(公告)号：US4279836A
公开(公告)日：1981-07-21
申请号：US38696
申请日：1979-05-14
申请人： Joji Nishikido , Yohei Fukuoka , Nobuhiro Tamura
发明人： Joji Nishikido , Yohei Fukuoka , Nobuhiro Tamura
IPC分类号： C07C231/00 , C07C67/00 , C07C231/02 , C07C231/12 , C07C233/12 , C07C237/44 , C07C83/02 , C07C101/02 , C07C103/26
CPC分类号： C07C233/12
摘要： 2-Chloro-4-N-(.beta.-diethylaminoethyl)aminocarbonyl-5-methoxybenzhydroxamic acid of the formula, ##STR1## or its metal salt, a process for their preparation and a process for preparing metoclopramide of the formula, ##STR2## using the above described 2-chloro-4-N-(.beta.-diethylaminoethyl)aminocarbonyl-5-methoxybenzhydroxamic acid or its metal salt.
摘要翻译：具有下式的2-氯-4-N-（β-二乙基氨基乙基）氨基羰基-5-甲氧基苯甲肟酸，或其金属盐，其制备方法和制备下式的甲氧氯普胺的方法，使用上述2-氯-4-N-（β-二乙基氨基乙基）氨基羰基-5-甲氧基苯甲肟酸或其金属盐。

4. 发明授权

US4146730A Method for obtaining glutaric acid, succinic acid, and adipic acid from an acid mixture comprising them 失效
标题翻译：从包含它们的酸混合物中获得葡萄糖酸，酸性酸和酸的方法
公开(公告)号：US4146730A
公开(公告)日：1979-03-27
申请号：US750703
申请日：1976-12-15
申请人： Joji Nishikido , Nobuhiro Tamura , Yohei Fukuoka
发明人： Joji Nishikido , Nobuhiro Tamura , Yohei Fukuoka
IPC分类号： C07C51/487 , C07C51/42
CPC分类号： C07C51/487
摘要： A method for obtaining glutaric acid, succinic acid, and adipic acid from an acid mixture obtained as a by-product in the industry and comprising glutaric acid, succinic acid and adipic acid, which comprises the steps of: (1) contacting the acid mixture with urea of 1 to 2 moles per mole of the acid mixture, in solution, to deposit a urea-glutaric acid adduct so that the weight ratio of glutaric acid remaining in the solution to succinic acid is 1.2 or less when the adipic acid content is in the range of 0% by weight to 7% by weight and 1.4 or less when the adipic acid content is larger than 7% by weight and 30% by weight or less; separating the deposited urea-glutaric acid adduct out of the solution; (2) adding further urea to the solution and/or concentrating the solution obtained in the step (1) to deposit a urea-succinic acid adduct; separating the deposited urea-succinic acid adduct out of the solution; and (3) decomposing the separated urea-dicarboxylic acid adducts each into respective dicarboxylic acids and urea. With this method, the mixture comprising glutaric acid, succinic acid and adipic acid can, for the first time, be successfully and effectively separated into the respective components.

5. 发明授权

US4329462A Process for producing carboxylic amides 失效
标题翻译：羧酸酰胺的制备方法
公开(公告)号：US4329462A
公开(公告)日：1982-05-11
申请号：US195740
申请日：1980-04-03
申请人： Nobuhiro Tamura , Yohei Fukuoka , Joji Nishikido , Setsuo Yamamatsu , Yoshio Suzuki
发明人： Nobuhiro Tamura , Yohei Fukuoka , Joji Nishikido , Setsuo Yamamatsu , Yoshio Suzuki
IPC分类号： C07D213/81 , B01J23/00 , C07B61/00 , C07C67/00 , C07C231/00 , C07C231/10 , C07D213/82 , C07D307/68 , C07D295/10
CPC分类号： C07D307/68 , C07C231/00
摘要： Carboxylic amides can be produced simply and in good yield by reacting primary alcohols with at least one compound selected from ammonia, primary amines, and secondary amines, in the presence of a molecular oxygen-containing gas and a palladium or platinum catalyst under oxidative conditions.
摘要翻译： PCT No.PCT / JP79 / 00201 Sec。 371日期：1980年4月3日 102e日期：1980年3月28日PCT申请日：1979年8月1日。在存在的情况下，可通过使伯醇与至少一种选自氨，伯胺和仲胺的化合物反应，简单地且以良好的收率生产羧酸酰胺的氧化条件下的分子含氧气体和钯或铂催化剂。

6. 发明授权

US4256645A Process for producing glucona-delta-lactone from glucose 失效
标题翻译：从葡萄糖生产葡萄糖酸-δ-内酯的方法
公开(公告)号：US4256645A
公开(公告)日：1981-03-17
申请号：US75457
申请日：1979-09-14
申请人： Joji Nishikido , Nobuhiro Tamura , Yohei Fukuoka
发明人： Joji Nishikido , Nobuhiro Tamura , Yohei Fukuoka
IPC分类号： C07D309/30
CPC分类号： C07D309/30
摘要： A process for producing glucono-delta-lactone from glucose by bringing glucose into contact with molecular oxygen in the presence of an organic solvent and a palladium or platinum catalyst. The process optionally includes an acid treatment.
摘要翻译：通过在有机溶剂和钯或铂催化剂存在下使葡萄糖与分子氧接触来从葡萄糖生产葡萄糖酸-δ-内酯的方法。该方法任选地包括酸处理。

7. 发明授权

US4250110A Method of preparing metoclopramide 失效
标题翻译：制备甲氧氯普胺的方法
公开(公告)号：US4250110A
公开(公告)日：1981-02-10
申请号：US58809
申请日：1979-07-19
申请人： Joji Nishikido , Nobuhiro Tamura , Yohei Fukuoka , Hiroyuki Yamane
发明人： Joji Nishikido , Nobuhiro Tamura , Yohei Fukuoka , Hiroyuki Yamane
IPC分类号： C07C231/00 , A61K31/165 , C07C67/00 , C07C231/02 , C07C231/12 , C07C235/50 , C07C235/60 , C07C237/44 , G07C20060101 , C07C103/82 , C07C101/42
CPC分类号： C07C235/50 , C07C231/02 , C07C231/12 , C07C235/46
摘要： 2-Chloro-4-N-(.beta.-diethylaminoethyl)aminocarbonyl-5-methoxy-benzamide of the formula, ##STR1## a process for their preparation and a process for preparing metoclopramide of the formula, ##STR2## using the above described 2-chloro-4-N-(.beta.-diethylaminoethyl)aminocarbonyl-5-methoxybenzamide.
摘要翻译：具有下式的2-氯-4-N-（β-二乙基氨基乙基）氨基羰基-5-甲氧基 - 苯甲酰胺，其制备方法和制备下式的甲氧氯普胺的方法，使用上述2 - 氯-4-N-（β-二乙基氨基乙基）氨基羰基-5-甲氧基苯甲酰胺。

8. 发明授权

US4616081A Cephalosporin compounds 失效
标题翻译：头孢菌素化合物
公开(公告)号：US4616081A
公开(公告)日：1986-10-07
申请号：US511183
申请日：1983-07-06
申请人： Joji Nishikido , Eiji Kodama , Chisei Shibuya
发明人： Joji Nishikido , Eiji Kodama , Chisei Shibuya
IPC分类号： C07D213/55 , C07D233/90 , C07D501/24 , C07D501/36 , C07D501/46 , C07D505/00 , A61K31/545
CPC分类号： C07D233/90 , C07D213/55 , C07D505/00 , Y02P20/55
摘要： Novel cephalosporin compounds having antibacterial activity, which are represented by the following compounds of the general formula (I), ##STR1## wherein R.sub.1 represents an amino group or a protected amino group; .circle.A represents a 5- or 6-membered heterocyclic ring containing therein 1 to 4 nitrogen, oxygen or sulfur atoms;R.sub.2 represents a normal alkyl group having 1 to 6 carbon atoms, a branched alkyl group having 3 to 6 carbon atoms, an alkoxyalkyl group having 2 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms; a cycloalkenyl group having 3 to 6 carbon atoms; an aromatic organic residue; a 3- to 6-membered heterocyclic ring containing 1 to 4 nitrogen, sulfur or oxygen atoms or, ##STR2## wherein Ra and Rb each, which may be the same or different, represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms;R.sub.3 represents an organic residue containing an amino group or a protected amino group and a carboxyl group or a protected carboxyl group;X represents a sulfur atom or an oxygen atom; andR.sub.4 represents a hydrogen atom or a protective group of carboxyl group.The general formula (I) described above can also be used as physiologically acceptable addition salts.The compounds exhibit excellent intestinal absorption as well as high blood concentration and longer biological half-life.
摘要翻译：具有抗菌活性的新型头孢菌素化合物，其由以下通式（I）的化合物，其中R 1表示氨基或被保护的氨基; ＆Cir＆A表示含有1至4个氮，氧或硫原子的5-或6-元杂环; R2表示碳原子数1〜6的正烷基，碳原子数3〜6的支链烷基，碳原子数2〜6的烷氧基烷基，碳原子数3〜6的环烷基。具有3〜6个碳原子的环烯基; 芳香族有机残基; 含有1至4个氮，硫或氧原子的3至6元杂环，或者其中每个R a和R b可以相同或不同，表示氢原子或具有1-4个碳原子的烷基碳原子 R3表示含有氨基或被保护的氨基，羧基或被保护的羧基的有机残基; X表示硫原子或氧原子; R 4表示氢原子或羧基的保护基。上述通式（I）也可以用作生理上可接受的加成盐。该化合物显示出优异的肠吸收以及高血液浓度和更长的生物半衰期。

9. 发明授权

US06436866B1 Lewis acid catalyst composition 失效
标题翻译：路易斯酸催化剂组合物
公开(公告)号：US06436866B1
公开(公告)日：2002-08-20
申请号：US09578862
申请日：2000-05-26
申请人： Joji Nishikido , Hitoshi Nakajima
发明人： Joji Nishikido , Hitoshi Nakajima
IPC分类号： B01J3100
CPC分类号： B01J31/122 , B01J31/0224 , B01J31/0227 , B01J31/0231 , B01J31/0252 , B01J31/0271 , B01J2231/326 , B01J2231/341 , B01J2231/342 , B01J2231/346 , B01J2231/348 , B01J2231/4205 , B01J2231/70
摘要： Disclosed is a Lewis acid catalyst composition comprising a specific mixed medium and a Lewis acid catalyst (II), wherein the specific mixed medium is mixed medium (I) comprising a perfluorinated aliphatic hydrocarbon (A) and at least one non-fluorinated hydrocarbon or a mixed medium (I′) comprising a perfluorinated aliphatic hydrocarbon (A), a perfluorinated aromatic hydrocarbon (C) and water (D), and wherein the Lewis acid catalyst (II) is at least one compound selected from the group consisting of compounds respectively represented by the following formulae (1), (2) and (3): (RfSO3)nM (1), [(RfSO2)2N]nM (2), and [(RfSO2)3C]nM (3). Also disclosed is a Lewis acid catalyst represented by the above-mentioned formula (3).
摘要翻译：公开了包含特定混合介质和路易斯酸催化剂（II）的路易斯酸催化剂组合物，其中特定混合介质是包含全氟化脂族烃（A）和至少一种非氟化烃的混合介质（I）或包含全氟化脂族烃（A），全氟化芳烃（C）和水（D）的混合介质（I'），其中路易斯酸催化剂（II）分别是选自化合物中的至少一种化合物由下式（1），（2）和（3）表示：并且还公开了由上述式（3）表示的路易斯酸催化剂。

10. 发明授权

US4902793A Process for preparing 3-alkoxymethylcephalosporins 失效
标题翻译： 3-烷氧基甲基头孢菌素的制备方法
公开(公告)号：US4902793A
公开(公告)日：1990-02-20
申请号：US103217
申请日：1987-10-01
申请人： Joji Nishikido , Kentaro Fukuzaki
发明人： Joji Nishikido , Kentaro Fukuzaki
IPC分类号： A61K31/545 , C07D501/04 , C07D501/26
CPC分类号： C07D501/04 , C07D501/26
摘要： A process for preparing 3-alkoxymethylcephalosporins which are useful as an intermediate for various cephalosporin derivatives having a high antimicrobial activity is disclosed. According to the process of the present invention, the 3-alkoxymethylcephalosporins can be easily obtained in high yield on a commercial scale.
摘要翻译：公开了可用作具有高抗微生物活性的各种头孢菌素衍生物的中间体的3-烷氧基甲基头孢菌素的方法。根据本发明的方法，3-烷氧基甲基头孢菌素可以以商品化的高收率容易地获得。

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