专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4857538A New compounds for the study and treatment of microfilament organization in cells 失效
标题翻译：用于研究和处理细胞中微丝组织的新化合物
公开(公告)号：US4857538A
公开(公告)日：1989-08-15
申请号：US126364
申请日：1987-11-30
申请人： Yoel Kashman , Ilan Spector , Shmuel Carmely , Dina Blasberger
发明人： Yoel Kashman , Ilan Spector , Shmuel Carmely , Dina Blasberger
IPC分类号： C07D417/04 , C07D493/08
CPC分类号： C07D417/04 , C07D493/08
摘要： A compound, and composition including same, for effecting irreversible change in cell morphology having the following structures: ##STR1## wherein R is --(CH.sub.2).sub.n ZH in which n=1, 2, 3 and 4 and Z is O, S, or NH, and ##STR2## wherein R.sub.1 and R.sub.2 can be --OH, alkyl and acyl.
摘要翻译：包含它们的化合物及其组合物，用于实现具有以下结构的细胞形态的不可逆变化：其中R是 - （CH 2）n ZH，其中n = 1,2,3和4 Z是O，S或NH，和Latrunculin I，其中R 1和R 2可以是-OH，烷基和酰基。

2. 发明授权

US5432172A Biological applications of alkaloids derived from the tunicate Eudistoma sp. 失效
标题翻译：生物应用生物碱衍生自细枝柄菌（Eudistoma sp。）
公开(公告)号：US5432172A
公开(公告)日：1995-07-11
申请号：US28322
申请日：1993-03-09
申请人： Ilan Spector , Nava R. Shochet , Yoel Kashman , Amira Rudi , Gary Gellerman
发明人： Ilan Spector , Nava R. Shochet , Yoel Kashman , Amira Rudi , Gary Gellerman
IPC分类号： A61K31/44 , C07D215/38 , C07D215/48 , C07D219/08 , C07D471/04 , C07D471/06 , C07D471/16 , C07D471/22 , A61K31/54
CPC分类号： C07D471/04 , A61K31/44 , C07D215/38 , C07D215/48 , C07D219/08 , C07D471/06
摘要： Biological applications of synthetic and natural alkaloids derived from the tunicate Eudistoma sp. are disclosed. A method regulating cell growth includes contacting one or more cells with an effective concentration of a compound for regulating cell growth. These compounds include: Segoline A, Segoline B, Isosegoline A, Norosegoline, Debromoshermilamine, Eilatin, 4-methylpyrido[2,3,4-kl]acridine, pyrido[2,3,4-kl]acridine, 1-acetyl-2,6-dimethylpyrido[2,3,4-kl]acridine, and derivatives and combinations of these compounds. An effective concentration range for using these compounds can range from approximately 0.1 .mu.M to 100 .mu.M. The effective concentration range for Eilatin, the most potent of these compounds is from 0.01 .mu.M to 0.99 .mu.M, and the effective concentration range for the other compounds of the present invention is from about 1.0 .mu.M to 100 .mu.M. The method has been shown to suppress growth of tumor cells, to induce differentiation of the tumor cells, and induce reverse transformation of the tumor cells. In transformed cells, the method induces reverse transformation. The method also inhibits the proliferation of cells. The examples show that the method of the present invention affects cyclic AMP mediated biological processes. At the effective concentrations this method affects the cyclic AMP mediated biological processes of cells to achieve the results described above.
摘要翻译：合成和天然生物碱的生物应用来源于调味汁。被披露。调节细胞生长的方法包括使一种或多种细胞与有效浓度的化合物接触以调节细胞生长。这些化合物包括：Segoline A，Segoline B，Isosegoline A，Norosegoline，脱氯西米明，Eilatin，4-甲基吡啶并[2,3,4-kl]吖啶，吡啶并[2,3,4-kl]吖啶，1-乙酰基-2 ，6-二甲基吡啶并[2,3,4-k]]吖啶，以及这些化合物的衍生物和组合。使用这些化合物的有效浓度范围可以为约0.1μM至100μM。这些化合物中最有效的Eilatin的有效浓度范围为0.01μM至0.99μM，并且对于本发明的其它化合物为约1.0μM至100μM。已经显示该方法抑制肿瘤细胞的生长，诱导肿瘤细胞的分化，并诱导肿瘤细胞的逆转化。在转化细胞中，该方法诱导逆转化。该方法还抑制细胞增殖。实施例表明本发明的方法影响环AMP介导的生物过程。在有效浓度下，该方法影响环AMP介导的细胞生物过程，以达到上述结果。

3. 发明授权

US5278168A Biological applications of alkaloids derived from the tunicate Eudistoma sp. 失效
标题翻译：生物应用生物碱衍生自细枝柄菌（Eudistoma sp。）
公开(公告)号：US5278168A
公开(公告)日：1994-01-11
申请号：US924194
申请日：1992-08-03
申请人： Ilan Spector , Nava R. Shochet , Yoel Kashman , Amira Rudi
发明人： Ilan Spector , Nava R. Shochet , Yoel Kashman , Amira Rudi
IPC分类号： A61K31/44 , C07D215/38 , C07D215/48 , C07D219/08 , C07D471/04 , C07D471/06 , C07D471/16 , C07D471/22 , A61K31/04 , C07D221/18
CPC分类号： A61K31/44 , C07D215/38 , C07D215/48 , C07D219/08 , C07D471/04 , C07D471/06
摘要： Biological applications of synthetic and natural alkaloids derived from the tunicate Eudistoma sp. are disclosed. A method regulating cell growth includes contacting one or more cells with an effective concentration of a compound for regulating cell growth. These compounds include: Segoline A, Segoline B, Isosegoline A, Norosegoline, Debromoshermilamine, Eilatin, 4-methylpyrido[2,3,4-kl] acridine, pyrido[2,3,4-kl]acridine, 1-acetyl-2,6-dimethylpyrido[2,3,4-kl]acridine, and derivatives and combinations of these compounds. An effective concentration range for using these compounds can range from approximately 0.1 .mu.M to 100 .mu.M. The effective concentration range for Eilatin, the most potent of these compounds is from 0.01 .mu.M to 0.99 .mu.M, and the effective concentration range for the other compounds of the present invention is from about 1.0 .mu.M to 100 .mu.M. The method has been shown to suppress growth of tumor cells, to induce differentiation of the tumor cells, and induce reverse transformation of the tumor cells. In transformed cells, the method induces reverse transformation. The method also inhibits the proliferation of cells. The examples show that the method of the present invention affects cyclic AMP mediated biological processes. At the effective concentrations this method affects the cyclic AMP mediated biological processes of cells to achieve the results described above.
摘要翻译：合成和天然生物碱的生物应用来源于调味汁。被披露。调节细胞生长的方法包括使一种或多种细胞与有效浓度的化合物接触以调节细胞生长。这些化合物包括：Segoline A，Segoline B，Isosegoline A，Norosegoline，脱氯西米明，Eilatin，4-甲基吡啶（2,3,4-kl）吖啶，吡啶并（2,3,4-kl）吖啶，1-乙酰基-2 ，6-二甲基吡啶（2,3,4-kl）吖啶，以及这些化合物的衍生物和组合。使用这些化合物的有效浓度范围可以从大约0.1（我）M到100（my）M。这些化合物中最有效的Eilatin的有效浓度范围为0.01（my）M至0.99（my）M，本发明其它化合物的有效浓度范围为约1.0（my）M至100 （我的）M。已经显示该方法抑制肿瘤细胞的生长，诱导肿瘤细胞的分化，并诱导肿瘤细胞的逆转化。在转化细胞中，该方法诱导逆转化。该方法还抑制细胞增殖。实施例表明本发明的方法影响环AMP介导的生物过程。在有效浓度下，该方法影响环AMP介导的细胞生物过程，以达到上述结果。

4. 发明申请

US20110038914A1 CORAL-DERIVED COLLAGEN AND METHODS OF FARMING SAME 有权
标题翻译：珊瑚衍生的胶原蛋白及其相似方法
公开(公告)号：US20110038914A1
公开(公告)日：2011-02-17
申请号：US12934704
申请日：2009-03-25
申请人： Yehuda Benayahu , Dafna Benayahu , Yoel Kashman , Amira Rudi , Yoram Lanir , Ido Sella , Einat Raz
发明人： Yehuda Benayahu , Dafna Benayahu , Yoel Kashman , Amira Rudi , Yoram Lanir , Ido Sella , Einat Raz
IPC分类号： C07K14/78 , C12N5/071 , A61F2/00
CPC分类号： A61F2/02 , A61L27/24 , A61L27/50 , A61L27/56 , C07K14/78
摘要： An isolated collagen fiber is disclosed, wherein a length of the fiber prior to stretching by about 15%, is identical to a length of the fiber following said stretching by about 15%. The fiber comprises a Nuclear Magnetic Resonance (NMR) spectroscopic profile as shown in FIG. 1. Uses thereof and method of isolating are also disclosed.
摘要翻译：公开了一种分离的胶原纤维，其中在拉伸之前纤维的长度约15％与所述拉伸后纤维的长度相同约15％。纤维包含如图1所示的核磁共振（NMR）光谱分布。还公开了其用途和隔离方法。

5. 发明申请

US20090291904A1 CHEMICAL DERIVATIVES OF JASMONATE, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：佐剂的化学衍生物，药物组合物及其使用方法
公开(公告)号：US20090291904A1
公开(公告)日：2009-11-26
申请号：US12095908
申请日：2006-12-07
申请人： Yoel Kashman , Eliezer Flescher , Max Herzberg
发明人： Yoel Kashman , Eliezer Flescher , Max Herzberg
IPC分类号： A61K31/7004 , C07D215/48 , C07H15/203 , A61K31/47 , C12N5/06 , A61P35/00
CPC分类号： C07D215/32 , C07C49/493 , C07C69/007 , C07C69/716 , C07C69/738 , C07C235/78 , C07C2601/02 , C07C2601/08 , C07F7/1804 , C07H13/08
摘要： The present invention relates to novel jasmonate derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for prevention and treatment of cancers.
摘要翻译：本发明涉及新颖的茉莉酸衍生物，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物和组合物，特别是作为预防和治疗癌症的化学治疗剂的方法。

6. 发明申请

US20080319066A1 Jasmonate Derivative Compounds, Pharmaceuticals Compounds and Methods of Use Thereof 有权
标题翻译：茉莉酸衍生物，药物化合物及其使用方法
公开(公告)号：US20080319066A1
公开(公告)日：2008-12-25
申请号：US12198559
申请日：2008-08-26
申请人： Eliezer FLESCHER , Yoel Kashman , Dorit Reischer , Shiri Shimony
发明人： Eliezer FLESCHER , Yoel Kashman , Dorit Reischer , Shiri Shimony
IPC分类号： A61K31/215 , C07C69/66 , A61P35/00
CPC分类号： C07C69/716 , C07C2601/08
摘要： The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of cancers, especially mammalian cancers.
摘要翻译：本发明提供新颖的茉莉酸衍生物化合物，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物和组合物，特别是作为治疗癌症尤其是哺乳动物癌症的化学治疗剂的方法。

7. 发明授权

US5591770A Calanolide and related antiretroviral compounds, compositions, and uses thereof 失效
标题翻译：卡拉宁内酯和相关的抗逆转录病毒化合物，组合物及其用途
公开(公告)号：US5591770A
公开(公告)日：1997-01-07
申请号：US65618
申请日：1993-05-21
申请人： Michael R. Boyd , John H. Cardellina, II , Kirk R. Gustafson , James B. McMahon , Richard W. Fuller , Gordon M. Cragg , Yoel Kashman , Doel Soejarto
发明人： Michael R. Boyd , John H. Cardellina, II , Kirk R. Gustafson , James B. McMahon , Richard W. Fuller , Gordon M. Cragg , Yoel Kashman , Doel Soejarto
IPC分类号： A61K31/365 , A61K31/366 , A61K36/18 , A61K45/06 , A61P31/12 , A61P31/18 , C07D493/14 , C07D493/22 , A61K31/37
CPC分类号： C07D493/14 , C07D493/22
摘要： The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.
摘要翻译：根据本发明的方法，本发明提供了可以从植物中分离或衍生自Calophyllum属植物的化合物的新的抗病毒化合物，被称为calanolides，相关化合物及其衍生物。化合物及其衍生物可以单独使用或与组合物如药物组合物中的其它抗病毒剂组合用于抑制病毒如逆转录病毒，特别是人类免疫缺陷病毒，特别是HIV-1的生长或复制或HIV-2。

8. 发明申请

US20100311757A1 Salarins And Tulearins, Compositions And Uses Thereof 审中-公开
标题翻译： Salarins和Tulearins，作曲及其用途
公开(公告)号：US20100311757A1
公开(公告)日：2010-12-09
申请号：US12680405
申请日：2008-09-25
申请人： Yoel Kashman , Maurice Aknin , Amira Rudi , Ashgan Bishara , Drorit Neumann , Nathalie Ben Califa
发明人： Yoel Kashman , Maurice Aknin , Amira Rudi , Ashgan Bishara , Drorit Neumann , Nathalie Ben Califa
IPC分类号： A61K31/395 , C07D498/04 , C07D313/00 , A61K31/424 , C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D313/00 , C07D487/04 , C07D498/04 , C07D498/18
摘要： Salarines and Tulearins isolated from Fascaplysinopsis sp. sponge and synthetic derivatives thereof are provided.
摘要翻译：从Fascaplysinopsis sp。中分离出的鱼类和Tulearins。海绵及其合成衍生物。

9. 发明授权

US07425651B2 Jasmonate derivative compounds, pharmaceuticals compounds and methods of use thereof 有权
标题翻译：茉莉酸衍生物化合物，药物化合物及其使用方法
公开(公告)号：US07425651B2
公开(公告)日：2008-09-16
申请号：US10581546
申请日：2004-12-01
申请人： Eliezer Flescher , Yoel Kashman , Dorit Reischer , Shiri Shimony
发明人： Eliezer Flescher , Yoel Kashman , Dorit Reischer , Shiri Shimony
IPC分类号： C07C61/00 , C07C69/74 , A61K31/215
CPC分类号： C07C69/716 , C07C2601/08
摘要： The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of cancers, especially mammalian cancers.
摘要翻译：本发明提供新颖的茉莉酸衍生物化合物，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物和组合物，特别是作为治疗癌症尤其是哺乳动物癌症的化学治疗剂的方法。

10. 发明授权

US5859049A Calanolide and related antiviral compounds, compositions, and uses thereof 失效
公开(公告)号：US5859049A
公开(公告)日：1999-01-12
申请号：US653006
申请日：1996-05-24
申请人： Michael R. Boyd , John H. Cardellina, II , Kirk R. Gustafson , James B. McMahon , Richard W. Fuller , Gordon M. Cragg , Yoel Kashman , Doel Soejarto
发明人： Michael R. Boyd , John H. Cardellina, II , Kirk R. Gustafson , James B. McMahon , Richard W. Fuller , Gordon M. Cragg , Yoel Kashman , Doel Soejarto
IPC分类号： A61K31/365 , A61K31/366 , A61K36/18 , A61K45/06 , A61P31/12 , A61P31/18 , C07D493/14 , C07D493/22 , A61K31/37
CPC分类号： C07D493/14 , C07D493/22
摘要： The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式