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1. 发明授权

US08835134B2 Cycloastragenol monoglucoside, preparation, pharmaceutical composition and application thereof 有权
标题翻译：环糊精单葡糖苷，其制备方法，药物组合物及其应用
公开(公告)号：US08835134B2
公开(公告)日：2014-09-16
申请号：US12678025
申请日：2008-09-08
申请人： Yingmei Han , Guangping Xia , Weiren Xu , Zhuanyou Zhao , Wulin Liu , Naxia Zhao , Peng Liu , Shijun Zhang , Xiaoli Fu , Yuli Wang , Weiting Wang , Lida Tang
发明人： Yingmei Han , Guangping Xia , Weiren Xu , Zhuanyou Zhao , Wulin Liu , Naxia Zhao , Peng Liu , Shijun Zhang , Xiaoli Fu , Yuli Wang , Weiting Wang , Lida Tang
IPC分类号： C12P19/44 , A61K36/481 , A61K31/7048 , C12P19/56 , C07J17/00
CPC分类号： A61K36/481 , A61K31/7048 , C07J17/005 , C12P19/56
摘要： This invention provides a method for preparing cycloastragenol monoglucoside CMG (cycloastragenol-6-O-β-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-β-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.
摘要翻译：本发明提供了一种制备环草酮醇一葡萄糖苷CMG（环星形胶原蛋白-6-O-＆bgr-D-葡萄糖苷）的方法，包括以下步骤：a。使用常规方法制备的黄芪甲苷或黄芪提取物作为原料，并加入适当的溶剂以形成原料溶液; b。加入水解酶并允许在恒温下水解得到水解产物; C。用大孔吸附树脂分离水解产物; 和d。通过纯化和分离获得产物。本发明还提供了根据本发明的方法制备的环状天门菊胶-6-O-和bgr-D-葡萄糖苷及其在制备用于治疗心血管疾病的药物中的用途以及包含其的药物组合物。

2. 发明申请

US20110218161A1 CYCLOASTRAGENOL MONOGLUCOSIDE, PREPARATION, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF 有权
标题翻译： CYCLOASTRAGENOL MONOGLUCOSIDE，制剂，药物组合物及其应用
公开(公告)号：US20110218161A1
公开(公告)日：2011-09-08
申请号：US12678025
申请日：2008-09-08
申请人： Yingmei Han , Guangping Xia , Weiren Xu , Zhuanyou Zhao , Wulin Liu , Naxia Zhao , Peng Liu , Shijun Zhang , Xiaoli Fu , Yuli Wang , Weiting Wang , Lida Tang
发明人： Yingmei Han , Guangping Xia , Weiren Xu , Zhuanyou Zhao , Wulin Liu , Naxia Zhao , Peng Liu , Shijun Zhang , Xiaoli Fu , Yuli Wang , Weiting Wang , Lida Tang
IPC分类号： A61K31/7048 , C07H15/24 , A61P9/00 , C12P19/56 , B65B31/00
CPC分类号： A61K36/481 , A61K31/7048 , C07J17/005 , C12P19/56
摘要： This invention provides a method for preparing cycloastragenol monoglucoside CMG (cycloastragenol-6-O-β-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-β-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.
摘要翻译：本发明提供了一种制备环草酮醇一葡萄糖苷CMG（环星形胶原蛋白-6-O-＆bgr-D-葡萄糖苷）的方法，包括以下步骤：a。使用常规方法制备的黄芪甲苷或黄芪提取物作为原料，并加入适当的溶剂以形成原料溶液; b。加入水解酶并允许在恒温下水解得到水解产物; C。用大孔吸附树脂分离水解产物; 和d。通过纯化和分离获得产物。本发明还提供了根据本发明的方法制备的环状天门菊胶-6-O-和bgr-D-葡萄糖苷及其在制备用于治疗心血管疾病的药物中的用途以及包含其的药物组合物。

3. 发明申请

US20150274799A1 GLP-1 ANALOGUE, ITS PREPARATION METHODS AND USE THEREOF 审中-公开
标题翻译： GLP-1类似物，其制备方法及其用途
公开(公告)号：US20150274799A1
公开(公告)日：2015-10-01
申请号：US14405060
申请日：2012-02-08
申请人： Min Gong , Gang Fu , Weiren Xu , Lida Tang , Xiaowen Ren , Peng Liu , Yuli Wang , Jiang Wu , Meixiang Zou
发明人： Min Gong , Gang Fu , Weiren Xu , Lida Tang , Xiaowen Ren , Peng Liu , Yuli Wang , Jiang Wu , Meixiang Zou
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A61K38/00
摘要： Provided is a GLP-1 analogue having the structure as shown in the general formula A: 7HAEX10TFTSX15VSSYLEX22QAAKEFIX30WLX33KGRG37n1X1Cn2X2 (general formula A), wherein X10 is glycine or cysteine, X15 is aspartic acid or cysteine, X22 is glycine or cysteine, X30 is alanine or cysteine, X33 is valine or cysteine, and at least one of X10, X15, X22, X30 and X33 is cysteine, X1 and X2 respectively is glycine, alanine or valine, n1=1-30, n2=1-30. The general formula A contains two cysteines to form disulfide bonds. Also provided are the preparation methods and the use of said GLP-1 analogue. Said GLP-1 analogue has a prolonged blood half-life compared with GLP-1, and can be used for the treatment of diabetes and obesity.
摘要翻译：本发明提供具有通式A所示结构的GLP-1类似物：7HAEX10TFTSX15VSSYLEX22QAAKEFIX30WLX33KGRG37n1X1Cn2X2（通式A），其中X10为甘氨酸或半胱氨酸，X15为天冬氨酸或半胱氨酸，X22为甘氨酸或半胱氨酸，X30为丙氨酸或半胱氨酸 X33是缬氨酸或半胱氨酸，X10，X15，X22，X30和X33中的至少一个是半胱氨酸，X1和X2分别是甘氨酸，丙氨酸或缬氨酸，n1 = 1-30，n2 = 1-30。通式A包含形成二硫键的两个半胱氨酸。还提供了所述GLP-1类似物的制备方法和用途。所述GLP-1类似物与GLP-1相比具有延长的血液半衰期，并且可用于治疗糖尿病和肥胖症。

4. 发明授权

US08481577B2 Amide thiazole derivative, preparation method and uses thereof 失效
标题翻译：酰胺噻唑衍生物，其制备方法和用途
公开(公告)号：US08481577B2
公开(公告)日：2013-07-09
申请号：US13162121
申请日：2011-06-16
申请人： Guilong Zhao , Weiren Xu , Yuli Wang , Lida Tang , Yiliang Li , Meixiang Zou , Wei Liu , Hua Shao , Chubing Tan , Peng Liu
发明人： Guilong Zhao , Weiren Xu , Yuli Wang , Lida Tang , Yiliang Li , Meixiang Zou , Wei Liu , Hua Shao , Chubing Tan , Peng Liu
IPC分类号： A61K31/427 , C07D277/46
CPC分类号： C07D277/46 , C07D277/58 , C07D417/12
摘要： The present invention relates to the field of drugs associated with treating diabetes. Particularly, the present invention relates to a dipeptidyl peptidase-IV inhibitor having the structure shown by formula (I), which contains amide thiazole structure and has an effect on treating diabetes, and a preparation method and a pharmaceutical composition containing it, as well as use thereof in manufacture of the drugs for treating the diabetes, wherein, R1 is methyl; R2 is phenyl; phenyl, 2-thienyl substituted in a mono-substituted, bi-substituted manner by fluorine and methyl.
摘要翻译：本发明涉及与治疗糖尿病有关的药物领域。特别地，本发明涉及具有式（I）所示结构的二肽基肽酶-IV抑制剂，其含有酰胺噻唑结构并具有治疗糖尿病的作用，以及含有它的制备方法和药物组合物，以及其用于制备用于治疗糖尿病的药物，其中，R 1为甲基; R2是苯基; 苯基，2-取代的噻吩基，被氟和甲基取代，双取代。

5. 发明申请

US20110281922A1 AMIDE THIAZOLE DERIVATIVE, PREPARATION METHOD AND USES THEREOF 失效
标题翻译：酰胺衍生物，制备方法及其用途
公开(公告)号：US20110281922A1
公开(公告)日：2011-11-17
申请号：US13162121
申请日：2011-06-16
申请人： Guilong ZHAO , Weiren Xu , Yuli Wang , Lida Tang , Yiliang Li , Meixiang Zou , Wei Liu , Hua Shao , Chubing Tan , Peng Liu
发明人： Guilong ZHAO , Weiren Xu , Yuli Wang , Lida Tang , Yiliang Li , Meixiang Zou , Wei Liu , Hua Shao , Chubing Tan , Peng Liu
IPC分类号： A61K31/426 , A61P3/10 , C07D277/38
CPC分类号： C07D277/46 , C07D277/58 , C07D417/12
摘要： The present invention relates to the field of drugs associated with treating diabetes. Particularly, the present invention relates to a dipeptidyl peptidase-IV inhibitor having the structure shown by formula (I), which contains amide thiazole structure and has an effect on treating diabetes, and a preparation method and a pharmaceutical composition containing it, as well as use thereof in manufacture of the drugs for treating the diabetes, wherein, R1 is methyl; R2 is phenyl; phenyl, 2-thienyl substituted in a mono-substituted, bi-substituted manner by fluorine and methyl.
摘要翻译：本发明涉及与治疗糖尿病有关的药物领域。特别地，本发明涉及具有式（I）所示结构的二肽基肽酶-IV抑制剂，其含有酰胺噻唑结构并具有治疗糖尿病的作用，以及含有它的制备方法和药物组合物，以及其用于制备用于治疗糖尿病的药物，其中，R 1为甲基; R2是苯基; 苯基，2-取代的噻吩基，被氟和甲基取代，双取代。

6. 外观设计

USD864282S1 Tripod 有权
公开(公告)号：USD864282S1
公开(公告)日：2019-10-22
申请号：US29624430
申请日：2017-11-01
申请人： Peng Liu
设计人： Peng Liu
摘要： FIG. 1 is a perspective view of a tripod showing my new design;
FIG. 2 is a front elevational view thereof;
FIG. 3 is a rear elevational view thereof;
FIG. 4 is a left side elevational view thereof;
FIG. 5 is a right side elevational view thereof;
FIG. 6 is a top plan view thereof; and,
FIG. 7 is a bottom plan view thereof.

7. 发明申请

US20180144929A1 METHOD FOR FORMING HIGH ASPECT RATIO PATTERNING STRUCTURE 有权
公开(公告)号：US20180144929A1
公开(公告)日：2018-05-24
申请号：US15385884
申请日：2016-12-21
申请人： Peng Liu , Qiyan Feng , Yu Ren , Yukun Lv , Jun Zhu , Hsusheng Chang
发明人： Peng Liu , Qiyan Feng , Yu Ren , Yukun Lv , Jun Zhu , Hsusheng Chang
IPC分类号： H01L21/027 , H01L21/311 , H01L21/02 , G03F7/095
CPC分类号： H01L21/0273 , G03F7/095 , H01L21/02271 , H01L21/02282 , H01L21/3065 , H01L21/3081 , H01L21/31116 , H01L21/31138
摘要： The invention disclosed a method for forming high aspect ratio patterning structure. Firstly, forming a dielectric film ashing stop layer, a first photoresist layer, a first hard mask layer and a second photoresist layer on a semiconductor substrate in turn. A second hard mask layer having a high etch selectivity ratio with the first photoresist layer is formed on top surface and sidewall of the pattern by utilizing a low temperature chemical vapor deposition process, which can be a protect for the pattern sidewall during the later etching process of the first photoresist layer. So, the cone-shaped or the bowling-shaped photoresist morphology caused by plasma bombardment can be avoided. Therefore, the problems of the insufficient of selectivity ratio, burrs at the edge of the pattern and larger critical dimension can be solved, and the implanted ions can be well distributed according to the design of the device.

8. 发明授权

US09000662B2 Field emission device and field emission display having same 有权
标题翻译：场发射器件和场发射显示器具有相同的
公开(公告)号：US09000662B2
公开(公告)日：2015-04-07
申请号：US13630255
申请日：2012-09-28
申请人： Peng Liu , Shou-Shan Fan , Yang Wei
发明人： Peng Liu , Shou-Shan Fan , Yang Wei
IPC分类号： H05B33/02 , H01J3/02 , H01J29/46 , H01J31/12
CPC分类号： H01J3/021 , H01J29/467 , H01J31/127 , H01J2329/463
摘要： A field emission device includes a cathode and a carbon nanotube (CNT) gate electrode. The CNT gate electrode which is electrically insulated from the cathode includes a CNT layer and a dielectric layer. The CNT layer which has a surface includes a number of micropores. The dielectric layer is coated on the surface of the CNT layer and an inner wall of each of the micropores.
摘要翻译：场致发射器件包括阴极和碳纳米管（CNT）栅电极。与阴极电绝缘的CNT栅极包括CNT层和电介质层。具有表面的CNT层包括多个微孔。介电层被涂覆在CNT层的表面和每个微孔的内壁上。

9. 发明授权

US08930839B2 Automatically arranging of icons on a user interface 有权
标题翻译：在用户界面上自动排列图标
公开(公告)号：US08930839B2
公开(公告)日：2015-01-06
申请号：US13301792
申请日：2011-11-22
申请人： Li He , Peng Liu
发明人： Li He , Peng Liu
IPC分类号： G06F3/048 , G06F3/0481
CPC分类号： G06F3/04817
摘要： Automatically arranging icons on a user interface is provided. A plurality of icons associated with items are received and displayed on the user interface. An importance score for each icon of the plurality of icons and a similarity score between two or more of the plurality of icons are determined. Further, a user interface coordinate is assigned to at least a portion of the plurality of icons based on the importance and similarity scores. The user interface is then displayed with the at least a portion of the plurality of icons according to the user interface coordinate.
摘要翻译：提供在用户界面上自动排列图标。与项目相关联的多个图标被接收并显示在用户界面上。确定多个图标的每个图标的重要性得分以及多个图标中的两个或更多个图标之间的相似性得分。此外，基于重要性和相似性得分，向多个图标的至少一部分分配用户界面坐标。然后根据用户界面坐标与多个图标的至少一部分显示用户界面。

10. 发明授权

US08841588B2 Heater 有权
标题翻译：加热器
公开(公告)号：US08841588B2
公开(公告)日：2014-09-23
申请号：US12589828
申请日：2009-10-29
申请人： Peng Liu , Liang Liu , Kai-Li Jiang , Shou-Shan Fan
发明人： Peng Liu , Liang Liu , Kai-Li Jiang , Shou-Shan Fan
IPC分类号： H05B3/06 , H05B3/14
CPC分类号： H05B3/145 , H05B2203/032 , H05B2214/04
摘要： A heater includes a substrate, a plurality of first electrode down-leads, a plurality of second electrode down-leads and a plurality of heating units. The plurality of first electrode down-leads are located on the substrate in parallel to each other and the plurality of second electrode down-leads are located on the substrate in parallel to each other. The first electrode down-leads cross the second electrode down-leads and define a plurality of grids. One heating unit is located in each grid. Each heating unit includes a first electrode, a second electrode and a heating element. The heating element includes a carbon nanotube structure.
摘要翻译：加热器包括基板，多个第一电极下引线，多个第二电极下引线和多个加热单元。多个第一电极下引线彼此平行地位于基板上，并且多个第二电极下引线彼此平行地位于基板上。第一电极下引线穿过第二电极下引线并限定多个栅极。一个加热单元位于每个网格中。每个加热单元包括第一电极，第二电极和加热元件。加热元件包括碳纳米管结构。

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