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1. 发明授权

US08167852B2 Microneedle device and method for producing the same 有权
标题翻译：微针装置及其制造方法
公开(公告)号：US08167852B2
公开(公告)日：2012-05-01
申请号：US12599860
申请日：2008-04-01
申请人： Ying-shu Quan , Fumio Kamiyama , Yoshikazu Tobinaga , Tomoya Kitagawa , Kentaro Ohshima , Akira Yamamoto
发明人： Ying-shu Quan , Fumio Kamiyama , Yoshikazu Tobinaga , Tomoya Kitagawa , Kentaro Ohshima , Akira Yamamoto
IPC分类号： A61M5/32 , A61M35/00 , A61K9/02
CPC分类号： A61M37/0015 , A61M2037/0046 , A61M2037/0053 , Y10T83/0467
摘要： Microneedle device is provided, which include microneedles that can be easily inserted into skin and dissolve or swell in skin. The microneedle devices comprise a substrate and cone-shaped or pyramid-shaped microneedles for skin insertion set on the substrate. The microneedles for skin insertion contain over 50 weight percent of one or multiple biomaterials chosen from chitosan, collagen, gelatin, hyaluronic acid, and they are fabricated from the materials that can dissolve or swell in the body.
摘要翻译：提供微针装置，其包括可以容易地插入皮肤并溶解或溶胀在皮肤中的微针。微针装置包括用于皮肤插入的衬底和锥形或金字塔形的微针，其设置在衬底上。用于皮肤插入的微针含有超过50重量％的选自壳聚糖，胶原，明胶，透明质酸的一种或多种生物材料，并且它们由可在体内溶解或溶胀的材料制成。

2. 发明申请

US20100228203A1 MICRONEEDLE DEVICE AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：微型器件及其制造方法
公开(公告)号：US20100228203A1
公开(公告)日：2010-09-09
申请号：US12599860
申请日：2008-04-01
申请人： Ying-shu Quan , Fumio Kamiyama , Yoshikazu Tobinaga , Tomoya Kitagawa , Kentaro Ohshima , Akira Yamamoto
发明人： Ying-shu Quan , Fumio Kamiyama , Yoshikazu Tobinaga , Tomoya Kitagawa , Kentaro Ohshima , Akira Yamamoto
IPC分类号： A61M5/00 , B26D7/06
CPC分类号： A61M37/0015 , A61M2037/0046 , A61M2037/0053 , Y10T83/0467
摘要： Microneedle device is provided, which include microneedles that can be easily inserted into skin and dissolve or swell in skin. The microneedle devices comprise a substrate and cone-shaped or pyramid-shaped microneedles for skin insertion set on the substrate. The microneedles for skin insertion contain over 50 weight percent of one or multiple biomaterials chosen from chitosan, collagen, gelatin, hyaluronic acid, and they are fabricated from the materials that can dissolve or swell in the body.
摘要翻译：提供微针装置，其包括可以容易地插入皮肤并溶解或溶胀在皮肤中的微针。微针装置包括用于皮肤插入的衬底和锥形或金字塔形的微针，其设置在衬底上。用于皮肤插入的微针含有超过50重量％的选自壳聚糖，胶原，明胶，透明质酸的一种或多种生物材料，并且它们由可在体内溶解或溶胀的材料制成。

3. 发明申请

US20100266670A1 TRANSDERMALLY ABSORPTIVE PREPARATION 审中-公开
标题翻译：超吸收制剂
公开(公告)号：US20100266670A1
公开(公告)日：2010-10-21
申请号：US12746594
申请日：2008-12-09
申请人： Akira Yamamoto , Toshiyasu Sakane , Hidemasa Katsumi , Fumio Kamiyama , Ying-shu Quan
发明人： Akira Yamamoto , Toshiyasu Sakane , Hidemasa Katsumi , Fumio Kamiyama , Ying-shu Quan
IPC分类号： A61K9/70 , A61K31/663 , A61P19/10 , A61P3/14
CPC分类号： A61K31/663 , A61K9/7061 , A61K47/10 , A61K47/28 , A61K47/32
摘要： This invention is to provide a transdermal administration type pharmaceutical preparation which has better transdermal absorptivity, safety and practical application for treatment of bone calcium metabolic diseases, such as high calcium in blood which resulted from osteoporosis, osteitis deformans and malignant tumors.A percutaneous administration type pharmaceutical preparation in tape form comprising a flexible backing, which is not permeable by the active ingredient, and an adhesive base layer formed on said flexible backing; said adhesive base layer consisting essentially of an adhesive base material of acrylic copolymer, polyhydric alcohol and bisphosphonate or its derivatives, wherein the bisphosphonate or its derivatives are in their therapeutic dose, adhesive base material and polyhydric alcohol in a concentration ratio of 100:150 to 600 by weight; said acrylic copolymer are copolymerized by acrylic acid, 2-ethylhexyl acrylate and polar monomer (except for acrylic acid) in the concentration ratio of 50 to 88%:8 to 40%:1 to 40% by weight respectively. PEG modify and antioxidants are also applicable to reduce the skin stimulation.
摘要翻译：本发明提供一种透皮给药型药物制剂，其具有较好的经皮吸收性，安全性和实际应用，用于治疗由骨质疏松症，变形性骨畸形和恶性肿瘤引起的骨钙代谢疾病如血钙高。一种胶带形式的经皮给药型药物制剂，其包含不能被活性成分渗透的柔性背衬和形成在所述柔性背衬上的粘合剂基层; 所述粘合剂基层主要由丙烯酸共聚物，多元醇和二膦酸盐或其衍生物的粘合剂基材组成，其中双膦酸盐或其衍生物的治疗剂量为粘合剂基材和多元醇，浓度比为100:50至 600重量份; 所述丙烯酸共聚物由丙烯酸，丙烯酸2-乙基己酯和极性单体（丙烯酸除外）以50〜88％的浓度比分别为8〜40％：1〜40重量％。 PEG修饰和抗氧化剂也适用于减少皮肤刺激。

4. 发明申请

US20140257189A1 MICRONEEDLE DEPOSITION METHOD 有权
标题翻译： MICRONEEDLE沉积方法
公开(公告)号：US20140257189A1
公开(公告)日：2014-09-11
申请号：US14352397
申请日：2011-10-20
申请人： Ying-shu Quan , Fumio Kamiyama
发明人： Ying-shu Quan , Fumio Kamiyama
IPC分类号： A61K9/00 , A61M37/00
CPC分类号： A61K9/0021 , A61K9/08 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： The present invention provides a microneedle array which holds a drug only in the microneedle portions, and a method of manufacturing the same.The microneedle array 2A which holds the drug only on the tips of the microneedles can be manufactured by the microneedle deposition method, i.e. a) the microneedle array 2 is prepared using an water-soluble polymer as a base material; b) a drug solution 1 to be applied to the tips of the microneedle array 2 is prepared; and c) the tips of the microneedle array 2 are contacted with the drug solution 1 for a short time. When the drug solution 1 is a water solution, the biodegradable polymer is of water-soluble, and in addition to the drug, the biodegradable polymer is dissolved in the solution at high concentration, the applied drug is integrated with the microneedle so that only the drug does not fall away during insertion.
摘要翻译：本发明提供了仅在微针部分中保持药物的微针阵列及其制造方法。可以通过微针沉积法制造仅存在微针尖端的微针阵列2A，即a）使用水溶性聚合物作为基材制备微针阵列2; b）制备施加到微针阵列2的末端的药液1; 和c）微针阵列2的尖端与药物溶液1短时间接触。当药物溶液1为水溶液时，生物降解性聚合物是水溶性的，除了药物之外，可生物降解的聚合物以高浓度溶解在溶液中，所施用的药物与微针一体化，使得只有药物在插入过程中不会脱落。

5. 发明申请

US20100136092A1 TRANSDERMAL IMMUNE PREPARATION, METHOD FOR PRODUCTION OF THE SAME, AND TRANSDERMAL IMMUNIZATION METHOD USING THE SAME 审中-公开
标题翻译：透皮免疫制剂，其制造方法和使用该抗体的透皮免疫方法
公开(公告)号：US20100136092A1
公开(公告)日：2010-06-03
申请号：US12529200
申请日：2008-02-28
申请人： Shinsaku Nakagawa , Naoki Okada , Takuya Fujita , Fumio Kamiyama , Ying-shu Quan
发明人： Shinsaku Nakagawa , Naoki Okada , Takuya Fujita , Fumio Kamiyama , Ying-shu Quan
IPC分类号： A61K9/70 , A61K31/7088 , A61K39/00 , A61K39/12 , A61K31/7105 , A61K38/43 , A61P31/04 , A61P31/12 , A61P31/10 , A61P33/00 , A61P37/04
CPC分类号： A61K31/7088 , A61K9/7053 , A61K9/7061 , A61K39/00 , A61K39/12 , A61K39/235 , A61K39/292 , A61K39/35 , A61K48/0041 , A61K48/005 , A61K48/0075 , A61K2039/53 , A61K2039/54 , A61K2039/555 , C12N2710/10034 , C12N2730/10134
摘要： This invention is concerned with transdermal immune preparations which can exhibit a high immunological activity without containing any adjuvant, methods for producing the preparation, and transdermal immunization methods using the preparation.The transdermal immune preparations can regulate the immune response by applying the preparation to an intact skin, and which comprises a base material and an antigen or artificial synthetic nucleic acid laminated on the surface of the base material; the methods for producing transdermal immune preparations which comprises putting drops of an aqueous solution or suspension prepared by dissolving or suspending an antigen in water or a water-containing alcohol on the surface of a base material in order for the water or the water-containing alcohol to be absorbed in the base material, thereby forming an layer containing the antigen in a concentrated state on the surface of the base material; and the transdermal immunization methods which is characterized by applying the transdermal immune preparation to an intact skin to regulate the immune response.
摘要翻译：本发明涉及可以在不含任何佐剂的情况下表现出高免疫学活性，制备该制剂的方法和使用该制剂的透皮免疫方法的透皮免疫制剂。透皮免疫制剂可以通过将制剂应用于完整皮肤来调节免疫应答，其包含层压在基材表面上的基材和抗原或人造合成核酸; 用于生产透皮免疫制剂的方法，其包括将通过将抗原溶解或悬浮在水或含水醇中而制备的水溶液或悬浮液滴在基材的表面上，以使水或含水醇被吸收在基材中，从而在基材的表面上形成浓缩状态的含有抗原的层; 和经皮免疫方法，其特征在于将透皮免疫制剂应用于完整的皮肤以调节免疫应答。

6. 发明授权

US08393199B2 Apparatus for measuring diffusion of transdermal absorption preparation 有权
标题翻译：用于测量经皮吸收制剂扩散的装置
公开(公告)号：US08393199B2
公开(公告)日：2013-03-12
申请号：US12525305
申请日：2007-01-31
申请人： Fumio Kamiyama , Ying-shu Quan
发明人： Fumio Kamiyama , Ying-shu Quan
IPC分类号： G01N13/04
CPC分类号： G01N13/00 , G01N2013/003
摘要： This invention is to provide a diffusion testing device to facilitate determination of diffusivity of prolonged release of drugs from transdermal therapeutic preparation.The diffusion testing device is characterized by a receptor liquid reservoir; a diffusion testing cell having a receptor chamber functioning to be full of receptor liquid and within which a stirrer be placed, a receptor liquid supply unit, a thermostat bath to hold the diffusion testing cell, a stirring apparatus located beneath the thermostat bath to cause the rotation action of the stirrer set in the receptor chamber, a sampling unit permitting sampling and storage of receptor liquid dissolving permeated drugs. Said receptor liquid reservoir, said receptor chamber, said receptor liquid supply unit and said sampling unit are connected with each other via infusion tube. Said thermostat bath comprises aperturees or through-holes functioning to hold the diffusion testing cells, and metal block which has temperature regulation unit to be installed.
摘要翻译：本发明提供一种扩散测试装置，以便于确定药物从经皮治疗制剂中延长释放的扩散性。扩散测试装置的特征在于受体液体储存器; 扩散测试电池，其具有充满受体液体并且其中放置搅拌器的受体室，受体液体供应单元，用于保持扩散测试电池的恒温槽，位于恒温槽下方的搅拌设备，受体室中设置的搅拌器的旋转作用，允许取样和储存受溶液溶解渗透药物的取样单元。所述受体液体储存器，所述受体室，所述受体液体供应单元和所述取样单元通过输注管相互连接。所述恒温槽包括用于保持扩散测试电池的孔或通孔，以及具有要安装的温度调节单元的金属块。

7. 发明授权

US09993423B2 Microneedle deposition method 有权
公开(公告)号：US09993423B2
公开(公告)日：2018-06-12
申请号：US14352397
申请日：2011-10-20
申请人： Ying-shu Quan , Fumio Kamiyama
发明人： Ying-shu Quan , Fumio Kamiyama
IPC分类号： A61M37/00 , A61K9/00 , A61K9/08
CPC分类号： A61K9/0021 , A61K9/08 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： The present invention provides a microneedle array which holds a drug only in the microneedle portions, and a method of manufacturing the same.The microneedle array 2A which holds the drug only on the tips of the microneedles can be manufactured by the microneedle deposition method, i.e. a) the microneedle array 2 is prepared using an water-soluble polymer as a base material; b) a drug solution 1 to be applied to the tips of the microneedle array 2 is prepared; and c) the tips of the microneedle array 2 are contacted with the drug solution 1 for a short time. When the drug solution 1 is a water solution, the biodegradable polymer is of water-soluble, and in addition to the drug, the biodegradable polymer is dissolved in the solution at high concentration, the applied drug is integrated with the microneedle so that only the drug does not fall away during insertion.

8. 发明申请

US20090148504A1 TRANSDERMAL PHARMACEUTICAL PREPARATION 审中-公开
标题翻译：超声波药物制备
公开(公告)号：US20090148504A1
公开(公告)日：2009-06-11
申请号：US12359073
申请日：2009-01-23
申请人： Fumio Kamiyama , Ying-shu Quan
发明人： Fumio Kamiyama , Ying-shu Quan
IPC分类号： A61F13/02 , A61K31/4468
CPC分类号： A61K9/7053 , A61K9/7061 , A61K31/4468
摘要： A percutaneous administration type pharmaceutical preparation in tape form comprising a flexible backing, which is not permeable by the active ingredient, and an adhesive base layer formed on said flexible backing; said adhesive base layer consisting essentially of an adhesive base material, ingredients, and an active ingredient, wherein said adhesive base is a copolymer containing one or more (meth) alkyl acrylate monomers and one or more monomers copolymerizable with the (a) monomer selected from the group of unsaturated ethylenically unsaturated monomers, and said ingredients are diethylene glycol monocetyl ether, octanoic acid and/or oleic acid, lauric acid diethanolamide, polyvinylpyrollidone; and said active ingredient is fentanyl.
摘要翻译：一种胶带形式的经皮给药型药物制剂，其包含不能被活性成分渗透的柔性背衬和形成在所述柔性背衬上的粘合剂基层; 所述粘合剂基层基本上由粘合剂基材，成分和活性成分组成，其中所述粘合剂基是含有一种或多种丙烯酸（甲基）丙烯酸酯单体和一种或多种可与（a）单体共聚的单体的共聚物，所述单体选自不饱和烯属不饱和单体组，所述成分是二甘醇单乙醚，辛酸和/或油酸，月桂酸二乙醇酰胺，聚乙烯吡咯烷酮; 所述活性成分是芬太尼。

9. 发明授权

US09539418B2 Proteoglycan-containing microneedle array 有权
标题翻译：含蛋白多糖的微针阵列
公开(公告)号：US09539418B2
公开(公告)日：2017-01-10
申请号：US13635813
申请日：2011-03-18
申请人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
发明人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
IPC分类号： A61M37/00 , A61K9/00 , A61Q19/00 , A61Q19/08 , A61K8/98
CPC分类号： A61M37/0015 , A61K8/981 , A61K8/987 , A61K9/0021 , A61K2800/87 , A61K2800/91 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61Q19/00 , A61Q19/08
摘要： A microneedle array is provided which has (1) the strength to withstand insertion into the skin surface layer and/or stratum corneum, (2) the fineness and flexibility to cause no pain or bleeding in the skin surface layer and/or stratum corneum at the insertion site of the microneedles, and (3) solubility or biodegradability of the microneedle portions under the skin. The microneedle array is produced by forming microneedles using proteoglycan as a base material.
摘要翻译：提供了一种微针阵列，其具有（1）抵抗插入皮肤表面层和/或角质层的强度，（2）在皮肤表面层和/或角质层中不产生疼痛或出血的细度和柔韧性微针的插入部位，（3）皮肤下的微针部分的溶解度或生物降解性。微针阵列通过使用蛋白多糖作为基材形成微针来制造。

10. 发明申请

US20130012882A1 PROTEOGLYCAN-CONTAINING MICRONEEDLE ARRAY 有权
标题翻译：含蛋白质包含微阵列
公开(公告)号：US20130012882A1
公开(公告)日：2013-01-10
申请号：US13635813
申请日：2011-03-18
申请人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
发明人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
IPC分类号： A61M5/00 , B29C47/06
CPC分类号： A61M37/0015 , A61K8/981 , A61K8/987 , A61K9/0021 , A61K2800/87 , A61K2800/91 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61Q19/00 , A61Q19/08
摘要： An object of the present invention is to provide a novel microneedle array that has (1) the strength to withstand insertion into the skin surface layer and/or stratum corneum, (2) the fineness and flexibility to cause no pain or bleeding in the skin surface layer and/or stratum corneum at the insertion site of the microneedles, and (3) solubility or biodegradability of the microneedle portions under the skin.[Method for Achieving the Object]The microneedle array is produced by forming microneedles using proteoglycan as a base material.
摘要翻译：本发明的目的是提供一种新颖的微针阵列，其具有（1）抵抗插入皮肤表面层和/或角质层的强度，（2）细度和柔韧性，使皮肤无疼痛或出血表面层和/或角质层在微针的插入位置，和（3）皮肤下的微针部分的溶解度或生物降解性。 [实现对象的方法]微针阵列通过使用蛋白多糖作为基材形成微针来制造。

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