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1. 发明授权

US09074206B2 Compositions and methods for micro-RNA expression profiling of colorectal cancer 有权
标题翻译：大肠癌微小RNA表达谱的组成和方法
公开(公告)号：US09074206B2
公开(公告)日：2015-07-07
申请号：US13129289
申请日：2009-11-13
申请人： Ying Wu , Hongguang Zhu , Jian Li , Liang Xu , Wilhelmus F. J. Verhaegh , Yiping Ren , Angel Janevski , Vinay Varadan , Zhaoyong Li , Nevenka Dimitrova
发明人： Ying Wu , Hongguang Zhu , Jian Li , Liang Xu , Wilhelmus F. J. Verhaegh , Yiping Ren , Angel Janevski , Vinay Varadan , Zhaoyong Li , Nevenka Dimitrova
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12N15/111 , C12N2310/141 , C12N2320/10 , C12N2330/10 , C12N2330/31 , C12Q1/6816 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates compositions and methods for microRNA (miRNA) expression profiling of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a miRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in the target cells and in one or more control cells, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of or the predisposition to develop colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
摘要翻译：本发明涉及用于结肠直肠癌的微小RNA（miRNA）表达谱的组合物和方法。特别地，本发明涉及用于鉴定表现出或具有发生结肠直肠癌倾向的一种或多种哺乳动物靶细胞的分子标记用诊断试剂盒，所述试剂盒包含多个核酸分子，编码miRNA序列的每个核酸分子，其中所述多个核酸分子中的一个或多个在靶细胞和一个或多个对照细胞中差异表达，并且其中所述一个或多个差异表达的核酸分子一起表示指示存在的核酸表达特征或发生结肠直肠癌的倾向。本发明还涉及使用这种核酸表达特征鉴定一种或多种表现出或具有发生结肠直肠癌倾向的哺乳动物靶细胞以及预防或治疗这种病症的相应方法。最后，本发明涉及用于预防和/或治疗结肠直肠癌的药物组合物。

2. 发明申请

US20110281756A1 COMPOSITIONS AND METHODS FOR MICRO-RNA EXPRESSION PROFILING OF COLORECTAL CANCER 有权
标题翻译：组合物和方法用于微小RNA表达色谱分析
公开(公告)号：US20110281756A1
公开(公告)日：2011-11-17
申请号：US13129289
申请日：2009-11-13
申请人： Ying Wu , Hongguang Zhu , Jian Li , Liang Xu , Wilhelmus F.J. Verhaegh , Yiping Ren , Angel Janevski , Vinay Varadan , Zhaoyong Li , Nevenka Dimitrova
发明人： Ying Wu , Hongguang Zhu , Jian Li , Liang Xu , Wilhelmus F.J. Verhaegh , Yiping Ren , Angel Janevski , Vinay Varadan , Zhaoyong Li , Nevenka Dimitrova
IPC分类号： C40B30/04 , C07H21/02 , C12Q1/68
CPC分类号： C12N15/111 , C12N2310/141 , C12N2320/10 , C12N2330/10 , C12N2330/31 , C12Q1/6816 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates compositions and methods for microRNA (miRNA) expression profiling of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a miRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in the target cells and in one or more control cells, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of or the predisposition to develop colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
摘要翻译：本发明涉及用于结肠直肠癌的微小RNA（miRNA）表达谱的组合物和方法。特别地，本发明涉及用于鉴定表现出或具有发生结肠直肠癌倾向的一种或多种哺乳动物靶细胞的分子标记用诊断试剂盒，所述试剂盒包含多个核酸分子，编码miRNA序列的每个核酸分子，其中所述多个核酸分子中的一个或多个在靶细胞和一个或多个对照细胞中差异表达，并且其中所述一个或多个差异表达的核酸分子一起表示指示存在的核酸表达特征或发生结肠直肠癌的倾向。本发明还涉及使用这种核酸表达特征鉴定一种或多种表现出或具有发生结肠直肠癌倾向的哺乳动物靶细胞以及预防或治疗这种病症的相应方法。最后，本发明涉及用于预防和/或治疗结肠直肠癌的药物组合物。

3. 发明申请

US20140040264A1 METHOD FOR ESTIMATION OF INFORMATION FLOW IN BIOLOGICAL NETWORKS 审中-公开
标题翻译：生物网络信息流估计方法
公开(公告)号：US20140040264A1
公开(公告)日：2014-02-06
申请号：US13983651
申请日：2012-01-30
申请人： Vinay Varadan , Prateek Mittal , Sitharthan Kamalakaran , Nevenka Dimitrova , Angel Janevski , Nilanjana Banerjee
发明人： Vinay Varadan , Prateek Mittal , Sitharthan Kamalakaran , Nevenka Dimitrova , Angel Janevski , Nilanjana Banerjee
IPC分类号： G06F19/00
CPC分类号： G06F19/324 , G16B5/00 , G16B25/00 , G16B40/00
摘要： The present invention relates to a method for stratifying a patient into a clinically relevant group comprising the identification of the probability of an alteration within one or more sets of molecular data from a patient sample in comparison to a database of molecular data of known phenotypes, the inference of the activity of a biological network on the basis of the probabilities, the identification of a network information flow probability for the patient via the probability of interactions in the network, the creation of multiple instances of network information flow for the patient sample and the calculation of the distance of the patient from other subjects in a patient database using multiple instances of the network information flow. The invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy wherein the biomedical marker or group of biomedical markers comprises altered biological pathway markers, as well as to an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer. Furthermore, a corresponding clinical decision support system is provided.
摘要翻译：本发明涉及一种用于将患者分层为临床相关组的方法，其包括鉴定来自患者样品的一组或多组分子数据内的改变概率与已知表型的分子数据的数据库相比较，基于概率推断生物网络的活动，通过网络中的交互概率识别患者的网络信息流概率，创建患者样本的多个网络信息流实例和使用网络信息流的多个实例来计算患者与患者数据库中的其他受试者的距离。本发明进一步涉及生物医学标记物或生物医学标记物组，其与受试者对癌症治疗的响应性的高可能性相关联，其中生物医学标记物或生物医学标记物组包括改变的生物学途径标志物，以及用于检测，诊断，毕业，监测或预测医学状况，或用于检测，诊断，监测或预测受试者对于针对所述医学病症，特别是卵巢癌的治疗的反应性。此外，提供了相应的临床决策支持系统。

4. 发明申请

US20130196877A1 IDENTIFICATION OF MULTI-MODAL ASSOCIATIONS BETWEEN BIOMEDICAL MARKERS 审中-公开
标题翻译：鉴定生物医学标记之间的多模式协会
公开(公告)号：US20130196877A1
公开(公告)日：2013-08-01
申请号：US13877346
申请日：2011-10-04
申请人： Nilanjana Banerjee , Angel Janevski , Sitharthan Kamalakaran , Vinay Varadan , Nevenka Dimitrova , Robert Lucito
发明人： Nilanjana Banerjee , Angel Janevski , Sitharthan Kamalakaran , Vinay Varadan , Nevenka Dimitrova , Robert Lucito
IPC分类号： G06F19/20
CPC分类号： G16B25/00 , G16B5/00 , G16B20/00
摘要： The present invention relates to a method for identifying multi-modal associations between biomedical markers which allows for the determination of network nodes and/or high ranking network members or combinations thereof, indicative of having a diagnostic, prognostic or predictive value for a medical condition, in particular ovarian cancer. The present invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy, preferably a platinum based cancer therapy, wherein said bio-medical marker or group of biomedical markers comprises at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 8, 19, 20 or all markers selected from PKMYT1, SKIL, RAB8A, HIRIP3, CTNNB1, NGFR, ZCCHC11, LSP1, CD200, PAX8, CYBRD1, HOXC11, TCEAL1, FZD10,FZD1, BBS4, IRS2, TLX3, TSPAN2, TXN, and CFLAR. Furthermore, an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, 1 diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer, is provided, as well as a corresponding method for classifying a subject comprising and a medical decision support system.
摘要翻译：本发明涉及一种用于识别生物医学标记之间的多模式关联的方法，其允许确定网络节点和/或高排名网络成员或其组合，指示具有用于医疗状况的诊断，预后或预测值，特别是卵巢癌。本发明还涉及与受试者对癌症治疗（优选基于铂的癌症治疗）的高反应性的高可能性相关联的生物医学标记物或生物医学标记物组，其中所述生物医学标记物或生物医学标记物组至少包括 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,8,19,20或选自PKMYT1，SKIL，RAB8A， HIRIP3，CTNNB1，NGFR，ZCCHC11，LSP1，CD200，PAX8，CYBRD1，HOXC11，TCEAL1，FZD10，FZD1，BBS4，IRS2，TLX3，TSPAN2，TXN和CFLAR。此外，提供了用于检测，诊断，毕业，监测或预测医学状况或用于检测1诊断，监测或预测受试者对于针对所述医学病症，特别是卵巢癌的治疗的反应性的测定法，作为以及用于分类受试者的相应方法以及医疗决策支持系统。

5. 发明授权

US10340027B2 Identification of multi-modal associations between biomedical markers 有权
公开(公告)号：US10340027B2
公开(公告)日：2019-07-02
申请号：US13877346
申请日：2011-10-04
申请人： Nilanjana Banerjee , Angel Janevski , Sitharthan Kamalakaran , Vinay Varadan , Nevenka Dimitrova , Robert Lucito
发明人： Nilanjana Banerjee , Angel Janevski , Sitharthan Kamalakaran , Vinay Varadan , Nevenka Dimitrova , Robert Lucito
IPC分类号： G01N33/48 , G16B25/00 , G16B5/00 , G06G7/58 , G16B20/00
摘要： The present invention relates to a method for identifying multi-modal associations between biomedical markers which allows for the determination of network nodes and/or high ranking network members or combinations thereof, indicative of having a diagnostic, prognostic or predictive value for a medical condition, in particular ovarian cancer. The present invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy, preferably a platinum based cancer therapy, wherein said biomedical marker or group of biomedical markers comprises at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 8, 19, 20 or all markers selected from PKMYT1, SKIL, RAB8A, HIRIP3, CTNNB1, NGFR, ZCCHC11, LSP1, CD200, PAX8, CYBRD1, HOXC11, TCEAL1, FZD10, FZD1, BBS4, IRS2, TLX3, TSPAN2, TXN, and CFLAR. Furthermore, an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, 1 diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer, is provided, as well as a corresponding method for classifying a subject comprising and a medical decision support system.

6. 发明申请

US20130282404A1 INTEGRATED ACCESS TO AND INTERATION WITH MULTIPLICITY OF CLINICA DATA ANALYTIC MODULES 审中-公开
标题翻译：综合访问和与临床数据分析模块的多重性相关联
公开(公告)号：US20130282404A1
公开(公告)日：2013-10-24
申请号：US13976170
申请日：2012-01-04
申请人： Angel Janevski , Sitharthan Kamalakaran , Christian Reichelt , Nilanjana Banerjee , Vinay Varadan , Nevenka Dimitrova
发明人： Angel Janevski , Sitharthan Kamalakaran , Christian Reichelt , Nilanjana Banerjee , Vinay Varadan , Nevenka Dimitrova
IPC分类号： G06F19/00
CPC分类号： G16H50/70 , G06F19/325 , G16H40/63
摘要： A state machine (22) stores a current state (30) comprising a clinical context defined by available patient-related information relating to a medical patient, and identifies one or more available analytical tools of a set of analytical tools (24) that are applicable to the current state. A graphical user interface module (16) receives a user selection of an available analytical tool. The state machine loads patient-related information (40) to the user-selected available analytical tool (24sel) and invokes the user-selected available analytical tool to operate on the loaded patient-related information to generate additional patient-related information relating to the medical patient and/or graphical patient-related content relating to the medical patient. The state machine transitions from the current state (30) to a next state (30′) and/or invokes the graphical user interface module to display the graphical patient related content.
摘要翻译：状态机（22）存储当前状态（30），其包括由与医疗患者有关的可用患者相关信息定义的临床上下文，并且识别可应用的一组分析工具（24）中的一个或多个可用分析工具到目前状态。图形用户界面模块（16）接收可用分析工具的用户选择。状态机将患者相关信息（40）加载到用户选择的可用分析工具（24sel），并且调用用户选择的可用分析工具对所加载的患者相关信息进行操作，以生成与患者相关的附加信息与患者有关的医疗病人和/或图形患者相关内容。状态机从当前状态（30）转换到下一状态（30'）和/或调用图形用户界面模块以显示图形的患者相关内容。

7. 发明授权

US07457811B2 Precipitation/dissolution of stored programs and segments 有权
标题翻译：存储的程序和段的沉淀/解散
公开(公告)号：US07457811B2
公开(公告)日：2008-11-25
申请号：US10178015
申请日：2002-06-21
申请人： Angel Janevski , Nevenka Dimitrova , Lalitha Agnihotri
发明人： Angel Janevski , Nevenka Dimitrova , Lalitha Agnihotri
IPC分类号： G06F17/00
CPC分类号： G06F17/30828 , G06F17/30867 , H04N21/44218 , H04N21/44222 , Y10S707/99942 , Y10S707/99943 , Y10S707/99944 , Y10S707/99945
摘要： A content maintenance system uses a time-dependent precipitation function for iteratively augmenting or removing content over time, after an initial demonstration of user interest. A plurality of parallel precipitation processes can be launched simultaneously in response to different facets of a user expression of interest. Precipitation is dependent on highlighting or extracting segment descriptors from content of interest to the user. Then segments are filtered, rated, annotated and/or prioritized from that content. The remaining segments are matched against stored search structures. When the segments match, they are precipitated out for storage and can generate new search structures.
摘要翻译：在用户感兴趣的初步演示之后，内容维护系统使用时间依赖的降水函数来迭代地增加或移除内容。响应于感兴趣的用户表达的不同方面，可以同时启动多个并行降水过程。降水取决于从用户感兴趣的内容中突出显示或提取片段描述符。然后，细分受到过滤，评分，注释和/或从内容中排列。剩余的段与存储的搜索结构匹配。当段匹配时，它们被沉淀出来用于存储，并且可以生成新的搜索结构。

8. 发明申请

US20050229233A1 Method and system for providing complementary information for a video program 有权
标题翻译：为视频节目提供补充信息的方法和系统
公开(公告)号：US20050229233A1
公开(公告)日：2005-10-13
申请号：US10509810
申请日：2003-04-01
申请人： John Zimmerman , Nevenka Dimitrova , Dongge Li , Johanna Bont , Andreas Henricus Lamers , Angel Janevski , Lira Nikolovska
发明人： John Zimmerman , Nevenka Dimitrova , Dongge Li , Johanna Bont , Andreas Henricus Lamers , Angel Janevski , Lira Nikolovska
IPC分类号： H04N7/025 , H04N7/16 , H04N5/445
CPC分类号： H04N21/454 , H04N5/445 , H04N7/163 , H04N7/17318 , H04N21/4307 , H04N21/4331 , H04N21/4532 , H04N21/4622 , H04N21/4722 , H04N21/4782 , H04N21/482 , H04N21/6581 , H04N21/84 , H04N21/8586
摘要： A method for providing complementary information 226 for a video program is provided that includes receiving complementary information 226 for a video program. A query is received from a consumer. The query is related to a specified portion of the complementary information 226. A query response is provided to the consumer based on the specified portion of the complementary information 226.
摘要翻译：提供了一种用于为视频节目提供补充信息226的方法，其包括为视频节目接收补充信息226。从消费者接收到查询。查询与补充信息226的指定部分有关。基于补充信息226的指定部分向消费者提供查询响应。

9. 发明申请

US20140107936A1 CROSS-MODAL APPLICATION OF COMBINATION SIGNATURES INDICATIVE OF A PHENOTYPE 审中-公开
标题翻译：组合标志的交叉模式应用
公开(公告)号：US20140107936A1
公开(公告)日：2014-04-17
申请号：US14124076
申请日：2012-05-22
申请人： Angel Janevski , Kamakalaran Sitharthan , Banerjee Nilanjana , Varadan Vinay , Nevenka Dimitrova , Sankararaman Suryanarayanan
发明人： Angel Janevski , Kamakalaran Sitharthan , Banerjee Nilanjana , Varadan Vinay , Nevenka Dimitrova , Sankararaman Suryanarayanan
IPC分类号： G06F19/18
CPC分类号： G16B20/00
摘要： The present invention relates to a method of adapting a composite signature of a phenotype. The method comprises the steps of providing for a composite signature of a phenotype with at least two different data types, which were respectively generated by two different modalities of measuring a specimen. Due to an adaption of one part of the signature of the phenotype the resulting adapted phenotype signature can be used as an input for a signature evaluation tool that was derived from data measured by a third modality of measurement.
摘要翻译：本发明涉及一种适应表型复合特征的方法。该方法包括以下步骤：提供具有至少两种不同数据类型的表型的复合特征，其分别由测量样本的两种不同方式产生。由于表型的一部分签名的适应，所得到的适应表型签名可以用作从通过第三测量方式测量的数据导出的签名评估工具的输入。

10. 发明申请

US20050273810A1 Method and system for providing personalized news 审中-公开
标题翻译：提供个性化消息的方法和系统
公开(公告)号：US20050273810A1
公开(公告)日：2005-12-08
申请号：US10509725
申请日：2003-04-01
申请人： John Zimmerman , Lira Nikolovska , Johanna Bont , Andreas Lamers , Nevenka Dimitrova , Angel Janevski , Lalitha Agnihotri
发明人： John Zimmerman , Lira Nikolovska , Johanna Bont , Andreas Lamers , Nevenka Dimitrova , Angel Janevski , Lalitha Agnihotri
IPC分类号： G06F17/30 , G06F3/00 , H04N7/025 , H04N7/10 , H04N7/16 , H04N5/445
CPC分类号： H04N21/454 , H04N5/445 , H04N7/163 , H04N21/25891 , H04N21/4331 , H04N21/4532 , H04N21/458 , H04N21/4622 , H04N21/488 , H04N21/8126 , H04N21/858
摘要： A method for providing personalized news to a consumer is provided that includes receiving news from a plurality of external sources. A subset of the received news is identified based on a consumer profile for the consumer. The identified news is stored. The stored news is prioritized. At least a portion of the prioritized news is provided to the consumer.
摘要翻译：提供了一种向消费者提供个性化消息的方法，其包括从多个外部源接收消息。基于消费者的消费者资料识别收到的消息的一个子集。存储已识别的消息。储存的新闻优先。向消费者提供至少一部分优先消息。

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