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1. 发明申请

US20050074825A1 Tankyrase H, compositions involved in the cell cycle and methods of use 审中-公开
公开(公告)号：US20050074825A1
公开(公告)日：2005-04-07
申请号：US10616101
申请日：2003-07-08
申请人： Ying Luo , Eva Chan , Xiang Xu , Betty Huang , Valeria Ossovskaya
发明人： Ying Luo , Eva Chan , Xiang Xu , Betty Huang , Valeria Ossovskaya
IPC分类号： A61K38/00 , C12N9/10 , G01N33/574
CPC分类号： C12N9/1077 , A61K38/00 , C12N2310/111
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

2. 发明授权

US06887675B1 Tankyrase H, compositions involved in the cell cycle and methods of use 失效
标题翻译：催乳素酶H，参与细胞周期的组合和使用方法
公开(公告)号：US06887675B1
公开(公告)日：2005-05-03
申请号：US09843159
申请日：2001-04-25
申请人： Ying Luo , Eva Chan , Xiang Xu , Betty Huang , Valeria Ossovskaya
发明人： Ying Luo , Eva Chan , Xiang Xu , Betty Huang , Valeria Ossovskaya
IPC分类号： A61K38/00 , C12N9/10 , C12N9/12 , C07H21/04 , C12N9/16 , C12O1/44 , C12O1/48
CPC分类号： C12N9/1077 , A61K38/00 , C12N2310/111
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本发明还提供了鉴定介导细胞周期生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

3. 发明授权

US06617102B1 Tankyrase H, compositions involved in the cell cycle and methods of use 有权
公开(公告)号：US06617102B1
公开(公告)日：2003-09-09
申请号：US09696668
申请日：2000-10-25
申请人： Ying Luo , Eva Chan , Xiang Xu , Betty Huang , Valeria Ossovskaya
发明人： Ying Luo , Eva Chan , Xiang Xu , Betty Huang , Valeria Ossovskaya
IPC分类号： C12Q100
CPC分类号： C12N9/1077 , A61K38/00 , C12N2310/111
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

4. 发明授权

US06589725B1 Tankyrase H, compositions involved in the cell cycle and methods of use 失效
标题翻译：催乳素酶H，参与细胞周期的组合和使用方法
公开(公告)号：US06589725B1
公开(公告)日：2003-07-08
申请号：US09427154
申请日：1999-10-25
申请人： Ying Luo , Eva Chan , Xiang Xu , Betty Huang
发明人： Ying Luo , Eva Chan , Xiang Xu , Betty Huang
IPC分类号： C12Q100
CPC分类号： C12N9/1077 , A61K38/00 , C12N2310/111
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

5. 发明申请

US20110126309A1 METHODS AND COMPOSITIONS FOR IDENTIFYING DOWNY MILDEW RESISTANT CUCUMBER PLANTS 有权
标题翻译：用于鉴定抗倒伏抗性植物的方法和组合物
公开(公告)号：US20110126309A1
公开(公告)日：2011-05-26
申请号：US12910478
申请日：2010-10-22
申请人： David Caldwell , Eva Chan , Jeroen de Vries , Tarek Joobeur , Joseph King , Antonio Reina , Nischit Shetty
发明人： David Caldwell , Eva Chan , Jeroen de Vries , Tarek Joobeur , Joseph King , Antonio Reina , Nischit Shetty
IPC分类号： A01H1/04 , A01H5/00 , C07H21/04 , C12N5/04
CPC分类号： A01H5/08 , A01H1/04 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to methods for identifying cucumber lines having increased resistance to Downy Mildew, and identification of genetic markers linked to gene(s) conditioning such increased disease resistance. The present invention also relates to methods of breeding cucumber plants from lines having increased Downy Mildew resistance by marker-assisted selection, compositions including nucleic acid probes or primers which are useful for such marker assisted selection, and plants and plant parts produced by such methods.
摘要翻译：本发明涉及用于鉴定具有增加的霜霉病抗性的黄瓜品系的鉴定方法，以及与基因调理相关的遗传标记的鉴定，如增加的抗病性。本发明还涉及通过标记辅助选择从具有增加的霜霉病抗性的品系中培育黄瓜植物的方法，包括可用于这种标记辅助选择的核酸探针或引物的组合物，以及通过这些方法制备的植物和植物部分的方法。

6. 发明授权

US08809622B2 Methods and compositions for identifying downy mildew resistant cucumber plants 有权
标题翻译：用于鉴定霜霉病黄瓜植物的方法和组合物
公开(公告)号：US08809622B2
公开(公告)日：2014-08-19
申请号：US12910478
申请日：2010-10-22
申请人： David Caldwell , Eva Chan , Jeroen de Vries , Tarek Joobeur , Joseph King , Antonio Reina , Nischit Shetty
发明人： David Caldwell , Eva Chan , Jeroen de Vries , Tarek Joobeur , Joseph King , Antonio Reina , Nischit Shetty
IPC分类号： A01H1/02 , A01H1/04
CPC分类号： A01H5/08 , A01H1/04 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to methods for identifying cucumber lines having increased resistance to Downy Mildew, and identification of genetic markers linked to gene(s) conditioning such increased disease resistance. The present invention also relates to methods of breeding cucumber plants from lines having increased Downy Mildew resistance by marker-assisted selection, compositions including nucleic acid probes or primers which are useful for such marker assisted selection, and plants and plant parts produced by such methods.
摘要翻译：本发明涉及用于鉴定具有增加的霜霉病抗性的黄瓜品系的鉴定方法，以及与基因调理相关的遗传标记的鉴定，如增加的抗病性。本发明还涉及通过标记辅助选择从具有增加的霜霉病抗性的品系中培育黄瓜植物的方法，包括可用于这种标记辅助选择的核酸探针或引物的组合物，以及通过这些方法制备的植物和植物部分的方法。

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