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1. 发明申请

US20100310625A1 METHODS FOR PURIFYING INSOLUBLE BONE GELATIN 审中-公开
标题翻译：净化不溶性骨髓蛋白的方法
公开(公告)号：US20100310625A1
公开(公告)日：2010-12-09
申请号：US12797400
申请日：2010-06-09
申请人： Ying Fan , Ming-Hao Zheng , David Wood
发明人： Ying Fan , Ming-Hao Zheng , David Wood
IPC分类号： A61K35/32 , A61F2/28 , A61Q11/00 , A61P19/04
CPC分类号： A61L27/365 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2310/00383 , A61L27/222 , A61L27/3608 , A61L27/3683 , A61L27/3687 , A61L2430/02 , A61L2430/40
摘要： The present invention provides methods for purifying insoluble bone gelatin and uses for insoluble bone gelatin. The process for isolating insoluble bone gelatin from bone tissue includes grinding the bone tissue into bone powder; washing the bone powder with saline; demineralizing the bone tissue; contacting the bone powder with a neutral salt; and contacting the bone powder with a stabilizer. The present invention also discloses an insoluble bone gelatin including about 10 percent growth factor. Insoluble bone gelatin is useful, for example, in preparing impaction bone grafts.
摘要翻译：本发明提供了不溶骨胶的纯化方法和不溶性骨明胶的用途。从骨组织中分离不溶性骨明胶的方法包括将骨组织研磨成骨粉末; 用盐水洗骨粉; 使骨组织脱矿质; 使骨粉与中性盐接触; 并使骨粉与稳定剂接触。本发明还公开了包含约10％生长因子的不溶性骨明胶。不溶性骨明胶在例如制备冲击骨移植物中是有用的。

2. 发明授权

US09463263B2 Tenocyte containing bioscaffolds and treatment using the same 有权
标题翻译：含有生物支架的Tenocyte和使用它们的治疗
公开(公告)号：US09463263B2
公开(公告)日：2016-10-11
申请号：US12597127
申请日：2008-04-24
申请人： Ming-Hao Zheng
发明人： Ming-Hao Zheng
IPC分类号： A61L27/38
CPC分类号： A61L27/3804 , A61F2310/00365 , A61L27/3662 , A61L27/386 , A61L27/3895 , A61L2430/10
摘要： The present invention relates to methods for preparing bio scaffolds useful in the repair of tears. More specifically, the invention relates to a method of treating rotator cuff tear in a mammalian subject in need thereof comprising the steps of: (i) selectively expanding tenocytes in vitro in culture medium comprising insulin or a functional derivative and a glucocorticoid or a glucocorticoid-like molecule to produce a culture of expanded tenocytes; (ii) seeding a bioscaffold with said expanded tenocytes to produce a tenocyte seeded bioscaffold; and (iii) implanting said tenocyte seeded bioscaffold proximal to the rotator cuff tear. The present invention also relates to a bioscaffold comprising cells, wherein more than 80% of said cells are tenocytes.
摘要翻译：本发明涉及制备用于修复眼泪的生物支架的方法。更具体地，本发明涉及在有需要的哺乳动物受试者中治疗肩袖撕裂的方法，其包括以下步骤：（i）在包含胰岛素或功能性衍生物和糖皮质激素或糖皮质激素的培养基中选择性扩增体外细胞，从而产生扩张的细胞培养物; （ii）用所述扩展的细胞接种生物支架以产生一个十面体种子的生物支架; 和（iii）将所述十面体种子生物支架植入到肩袖撕裂附近。本发明还涉及包含细胞的生物支架，其中超过80％的所述细胞是细胞。

3. 发明申请

US20100233233A1 TENOCYTE CONTAINING BIOSCAFFOLDS AND TREATMENT USING THE SAME 有权
标题翻译：含有生物制品的含量及使用该化合物的处理
公开(公告)号：US20100233233A1
公开(公告)日：2010-09-16
申请号：US12597127
申请日：2008-04-24
申请人： Ming-Hao Zheng
发明人： Ming-Hao Zheng
IPC分类号： A61K9/00 , A61K35/12 , A61P21/00
CPC分类号： A61L27/3804 , A61F2310/00365 , A61L27/3662 , A61L27/386 , A61L27/3895 , A61L2430/10
摘要： The present invention relates to methods for preparing bio scaffolds useful in the repair of tears. More specifically, the invention relates to a method of treating rotator cuff tear in a mammalian subject in need thereof comprising the steps of: (i) selectively expanding tenocytes in vitro in culture medium comprising insulin or a functional derivative and a glucocorticoid or a glucocorticoid-like molecule to produce a culture of expanded tenocytes; (ii) seeding a bioscaffold with said expanded tenocytes to produce a tenocyte seeded bioscaffold; and (iii) implanting said tenocyte seeded bioscaffold proximal to the rotator cuff tear. The present invention also relates to a bioscaffold comprising cells, wherein more than 80% of said cells are tenocytes.
摘要翻译：本发明涉及制备用于修复眼泪的生物支架的方法。更具体地，本发明涉及在有需要的哺乳动物受试者中治疗肩袖撕裂的方法，其包括以下步骤：（i）在包含胰岛素或功能性衍生物和糖皮质激素或糖皮质激素的培养基中选择性扩增体外细胞，从而产生扩张的细胞培养物; （ii）用所述扩展的细胞接种生物支架以产生一个十面体种子的生物支架; 和（iii）将所述十面体种子生物支架植入到肩袖撕裂附近。本发明还涉及包含细胞的生物支架，其中超过80％的所述细胞是细胞。

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