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1. 发明申请

US20060135542A1 GTPase inhibitors and use thereof for controlling platelet hyperactivity 失效
公开(公告)号：US20060135542A1
公开(公告)日：2006-06-22
申请号：US11283556
申请日：2005-11-18
申请人： Yi Zheng , Huzoor Akbar , David Williams , Wieslaw Mazur
发明人： Yi Zheng , Huzoor Akbar , David Williams , Wieslaw Mazur
IPC分类号： A61K31/506
CPC分类号： A61K31/506
摘要： The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.

2. 发明申请

US20050142103A1 Mobilization of hematopoietic cells 有权
标题翻译：动员造血细胞
公开(公告)号：US20050142103A1
公开(公告)日：2005-06-30
申请号：US10918328
申请日：2004-08-12
申请人： David Williams , Yi Zheng
发明人： David Williams , Yi Zheng
IPC分类号： A61K31/04 , A61K31/522 , A61K31/7088 , A61K35/12 , A61K35/28 , A61K38/19 , A61K38/20 , C07K14/47 , C12N5/0775 , A61K38/10 , A61K38/08
CPC分类号： A61K31/522 , A61K31/04 , A61K31/7088 , A61K35/28 , A61K38/193 , C07K14/4706 , C07K2319/01 , C12N5/0647 , C12N2500/40 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/23 , C12N2501/26
摘要： Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. The subject's blood can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient and may in the future be utilized to repair a variety of non-hematopoietic tissues. Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. They can also be used for increasing white blood cell survival and for chemotherapy.
摘要翻译：本文提供了改进的方法和药物组合物，用于将造血祖细胞从骨髓移入外周血中，包括单独或组合施用有效量的GTP酶抑制剂，例如Rac1和Rac2。具体地，公开了将造血干细胞移入受试者的外周血中的方法。特别地，该方法的实施方案涉及抑制Rac1和Rac2GTP酶以将造血干细胞的数量增加到受试者的受试者的外周血中。受试者的血液可以被处理并用于重建受体的破坏的淋巴造血系统，并且将来可以用于修复各种非造血组织。因此，通过本发明的方法动员到受试者的外周血中的造血干细胞可用作骨髓移植中的供体细胞来源，用于治疗各种疾病，包括癌症，贫血，自身免疫和免疫缺陷。它们也可用于增加白细胞的存活和化疗。

3. 发明申请

US20050069553A1 Chimeric peptides for the regulation of GTPases 审中-公开
标题翻译：嵌合肽用于调节GTP酶
公开(公告)号：US20050069553A1
公开(公告)日：2005-03-31
申请号：US10918648
申请日：2004-08-12
申请人： Yi Zheng , David Williams
发明人： Yi Zheng , David Williams
IPC分类号： C07K14/47 , C12N9/14 , A61K39/395 , C07K16/44
CPC分类号： C07K14/4706 , C07K2319/01 , C07K2319/02 , C07K2319/03 , C12N9/14 , C12Y306/05002
摘要： Chimeric peptides or fusion proteins are disclosed that include a RhoGAP activity domain and at least one specificity domain that targets a specific Rho protein. The fusion proteins can be used to inhibit any GTPase activity within a cell. The fusion proteins are particularly advantageous for the treatment of cancer. The present invention generally relates to The present invention generally relates to chimeric peptides capable of regulating GTPases, and more particularly, to methods of targeting individual GTPases by using GTPase-activating proteins. Such proteins may be used for the treatment of cancers and other GTPase-related diseases. This invention relates to nucleic acid molecules and the encoded GTPase activating proteins, and variants thereof, and to the use of these molecules in the characterization, diagnosis, prevention, and treatment of cell signaling, immune, and cell proliferative disorders, particularly cancer. Disclosed herein are compounds and methods for regulating transcription of a selected gene. Methods are provided for constructing and for using such compounds to regulate transcription of a selected gene.
摘要翻译：公开了嵌合肽或融合蛋白，其包括RhoGAP活性结构域和至少一个靶向特异性Rho蛋白的特异性结构域。融合蛋白可用于抑制细胞内的任何GTP酶活性。融合蛋白对癌症的治疗特别有利。本发明一般涉及本发明一般涉及能够调节GTP酶的嵌合肽，更具体地，涉及通过使用GTP酶活化蛋白靶向各个GTP酶的方法。这些蛋白质可用于治疗癌症和其它与GTP酶有关的疾病。本发明涉及核酸分子和编码的GTP酶活化蛋白及其变体，以及这些分子在表征，诊断，预防和治疗细胞信号传导，免疫和细胞增殖性疾病，特别是癌症中的用途。本文公开了用于调节所选基因转录的化合物和方法。提供了构建和使用这些化合物调节所选基因转录的方法。

4. 发明授权

US08587897B2 Magnetic field sensor 有权
标题翻译：磁场传感器
公开(公告)号：US08587897B2
公开(公告)日：2013-11-19
申请号：US12565555
申请日：2009-09-23
申请人： Aleksey Andreev , David Williams , Ernesto E. Marinero , Bruce A. Gurney , Thomas D. Boone, Jr.
发明人： Aleksey Andreev , David Williams , Ernesto E. Marinero , Bruce A. Gurney , Thomas D. Boone, Jr.
IPC分类号： G11B5/37
CPC分类号： G01R33/093 , B82Y25/00 , G01R33/095
摘要： A device for sensing a magnetic field is described. The device comprises first, second and third leads and a junction between the leads. The junction and leads are arranged in a plane and the junction is configured to exhibit quantum confinement in a direction perpendicular to the plane. The first lead is arranged on one side of the junction and the second and third leads are arranged on an opposite side of the junction. The first lead is configured to limit angle of spread of charge carriers entering the junction so that, when charge carriers flow into the junction from the first lead, the charge carriers form a substantially nondivergent beam.
摘要翻译：描述用于感测磁场的装置。该装置包括第一，第二和第三引线以及引线之间的连接点。结和引线布置在平面中，并且结被配置为在垂直于平面的方向上展示量子限制。第一引线布置在接头的一侧，第二和第三引线布置在接头的相对侧上。第一引线被配置为限制进入结的电荷载体的扩展角，使得当电荷载流子从第一引线流入结时，电荷载体形成基本上非发散的束。

5. 发明授权

US08260249B2 Method and apparatus of power control for a public warning system 有权
标题翻译：公共警示系统功率控制方法及装置
公开(公告)号：US08260249B2
公开(公告)日：2012-09-04
申请号：US12211513
申请日：2008-09-16
申请人： Niels Peter Skov Andersen , David Williams
发明人： Niels Peter Skov Andersen , David Williams
IPC分类号： H04M11/04
CPC分类号： H04W8/245 , H04W4/90 , H04W76/50 , Y02D70/1222 , Y02D70/1242 , Y02D70/1262 , Y02D70/168 , Y02D70/24 , Y02D70/26
摘要： A method for broadcasting messages in a wireless communication system is provided. The method includes employing a paging channel to receive a broadcast event on a wireless device and utilizing the broadcast event to trigger a warning message on the device. For example, the broadcast event can be detected from a natural disaster such as a primary earthquake warning or tsunami.
摘要翻译：提供了一种在无线通信系统中广播消息的方法。该方法包括采用寻呼信道在无线设备上接收广播事件，并利用广播事件触发设备上的警告消息。例如，可以从诸如主地震警报或海啸的自然灾害中检测广播事件。

6. 发明授权

US08025877B2 Methods of using humanized antibodies and compositions for binding sphingosine-1-phosphate 有权
标题翻译：使用人源化抗体和用于结合鞘氨醇-1-磷酸的组合物的方法
公开(公告)号：US08025877B2
公开(公告)日：2011-09-27
申请号：US12258355
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译：本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如治疗与S1P异常水平相关的疾病和病症。

7. 发明授权

US08000973B2 Management of conversations 有权
标题翻译：对话管理
公开(公告)号：US08000973B2
公开(公告)日：2011-08-16
申请号：US12364807
申请日：2009-02-03
申请人： David Williams , Jeffrey Hill , Yuri Zieman
发明人： David Williams , Jeffrey Hill , Yuri Zieman
IPC分类号： G06F17/20 , G10L15/22
CPC分类号： H04M3/493 , G06F17/30684 , G10L13/027 , G10L15/1822 , G10L15/22 , H04M3/5166
摘要： An embodiment of a method is disclosed wherein a natural language communication is received from a user. A concept recognition process is applied to automatically derive a representation of concepts embodied in the natural language communication. A collection of information likely to be useful in responding to the natural language communication is selected based on correspondence to the representation of concepts. The collection of information is provided to a human agent through an interface. Through the interface, an identification of a particular item of information from the collection is received. The particular item is illustratively a sub-set of the collection of information, the sub-set being a particular proposed response to the natural language communication. The particular proposed response is delivered to the user.
摘要翻译：公开了一种从用户接收到自然语言通信的方法的实施例。应用概念识别过程来自动导出在自然语言通信中体现的概念的表示。基于与概念表示的对应关系，选择可能有助于自然语言交流的信息的集合。信息的收集通过界面提供给人类代理。通过该接口，收到来自集合的特定信息项的标识。特定项目示例性地是信息收集的子集，该子集是对自然语言通信的特定提议的响应。特别提出的响应被传递给用户。

8. 发明申请

US20110170339A1 MAGNETORESISTIVE DEVICE 有权
标题翻译：磁电装置
公开(公告)号：US20110170339A1
公开(公告)日：2011-07-14
申请号：US12687550
申请日：2010-01-14
申请人： Joerg Wunderlich , Jan Zemen , Claude Chappert , Bryan Gallagher , Thibaut Devolder , David Williams
发明人： Joerg Wunderlich , Jan Zemen , Claude Chappert , Bryan Gallagher , Thibaut Devolder , David Williams
IPC分类号： G11C11/00
CPC分类号： G11C11/16 , G11C11/161 , G11C11/165 , G11C11/1675
摘要： A method of operating a magnetoresistive device is described. The device comprises a ferromagnetic region configured to exhibit magnetic anisotropy and to allow magnetisation thereof to be switched between at least first and second orientations and a gate capacitively coupled to the ferromagnetic region. The method comprises applying an electric field pulse to the ferromagnetic region so as to cause orientation of magnetic anisotropy to change for switching magnetisation between the first and second orientations.
摘要翻译：描述了操作磁阻器件的方法。该器件包括铁磁区域，其被配置为表现出磁各向异性并允许其磁化在至少第一和第二取向之间切换，并且栅极电容耦合到铁磁区域。该方法包括将电场脉冲施加到铁磁区域，以使磁各向异性的取向发生变化，以便在第一和第二取向之间切换磁化。

9. 发明申请

US20110116231A1 FIELD SERVICEABLE ELECTRONIC DISPLAY 有权
标题翻译：现场可维修电子显示屏
公开(公告)号：US20110116231A1
公开(公告)日：2011-05-19
申请号：US12618104
申请日：2009-11-13
申请人： William DUNN , Ware Bedell , Don Le , David Williams
发明人： William DUNN , Ware Bedell , Don Le , David Williams
IPC分类号： H05K7/20 , H05K7/00
CPC分类号： H04N5/64 , A47B81/06 , H05K5/0017 , H05K5/0204 , H05K5/0221 , H05K5/0226 , H05K5/06 , Y10T29/4973
摘要： An electronic display which can be serviced without having to remove the display from its mounted position. A front housing and a rear housing are hingedly attached so that the front housing can rotate and allow access to the interior of the display. An axial force mechanism can be used to aid in rotating the front housing to an open position. A locking collar, support member, or axial locking member may be used to ensure that the front housing remains open. A removable front glass assembly or removable glass panel may be used with an exemplary embodiment. The front glass assembly or glass panel can be easily replaced if it becomes damaged by minimally-trained personnel. Gutters may be used between the front and rear housing as well as the front housing and front glass assembly to ensure an adequate seal against contaminates.
摘要翻译：一种电子显示器，可以在不必将显示器从其安装位置移除的情况下进行维修。前壳体和后壳体铰接地连接，使得前壳体可以旋转并允许进入显示器的内部。可以使用轴向力机构来帮助将前壳体旋转到打开位置。可以使用锁定环，支撑构件或轴向锁定构件来确保前壳体保持打开。可以使用可拆卸的前玻璃组件或可移除的玻璃面板，其中示例性实施例。如果受到受过训练的人员造成损坏，前玻璃组件或玻璃面板可以轻松更换。可以在前壳体和后壳体以及前壳体和前玻璃组件之间使用沟槽，以确保对污染物的足够的密封。

10. 发明授权

US07771171B2 Systems for preventing wear on turbine blade tip shrouds 有权
标题翻译：用于防止涡轮叶片尖端罩磨损的系统
公开(公告)号：US07771171B2
公开(公告)日：2010-08-10
申请号：US11638818
申请日：2006-12-14
申请人： Patrick Mohr , Daniel Nowak , Emilio Fernandez , Michael Arnett , David Williams , Carlos Collado
发明人： Patrick Mohr , Daniel Nowak , Emilio Fernandez , Michael Arnett , David Williams , Carlos Collado
IPC分类号： F01D5/22
CPC分类号： F01D5/225 , F05C2201/0463 , F05D2300/506
摘要： A system in a turbine engine for preventing wear on a tip shroud of a turbine blade that includes a pocket formed in a contact surface of the tip shroud and a plug that fits within the pocket and has a durable outer surface. The durable outer surface may include a cobalt-based hardfacing powder. The pocket may be machined out of the contact surface, and the plug may include a plug of predetermined size that fits snugly into the pocket. In some embodiments, the durable outer surface may substantially align with the contact surface after the plug is fitted into the pocket. In other embodiments, the durable outer surface may remain slightly raised from the contact surface after the plug has been fitted into the pocket.
摘要翻译：一种涡轮发动机中的系统，用于防止涡轮机叶片的尖端护罩上的磨损，该系统包括形成在尖端护罩的接触表面中的凹穴和装配在口袋内并且具有耐用的外表面的塞子。耐用的外表面可以包括钴基硬化粉末。口袋可以从接触表面加工出来，并且塞子可以包括预先规定尺寸的塞子，该栓塞紧贴地配合到口袋中。在一些实施例中，在将塞子装配到口袋中之后，耐用的外表面可以与接触表面大致对准。在其他实施例中，在插头已经装配到口袋中之后，耐用的外表面可以保持从接触表面稍微升高。

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