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1. 发明申请

US20110071413A1 MORPHOLOGY BASED ISCHEMIA DETECTION USING INTRACARDIAC ELECTROGRAMS 审中-公开
标题翻译：基于形态学的ISCHEMIA检测使用内皮细胞电泳
公开(公告)号：US20110071413A1
公开(公告)日：2011-03-24
申请号：US12888900
申请日：2010-09-23
申请人： Yi Zhang , Shibaji Shome , Kritika Gupta , Dan Li , Julie A. Thompson
发明人： Yi Zhang , Shibaji Shome , Kritika Gupta , Dan Li , Julie A. Thompson
IPC分类号： A61B5/0452 , A61N1/365
CPC分类号： A61B5/04525 , A61B5/0464
摘要： An apparatus comprises an ambulatory cardiac signal sensing circuit configured to provide an electrical cardiac signal representative of cardiac activity of a subject and processor. The processor includes a feature module, a correlation module, and an ischemia detection module. The feature module is configured to identify a fiducial feature in the cardiac signal and locate one or more cardiac features in the cardiac signal using the fiducial feature. The correlation module is configured to calculate a measure of similarity of morphology for a segment of the cardiac signal that includes the cardiac features. The ischemia detection module is configured to detect a change in the measure of similarity and determine whether the detected change in the measure of similarity is indicative of ischemia.
摘要翻译：一种装置包括动态心脏信号感测电路，其被配置为提供代表对象和处理器的心脏活动的电心脏信号。处理器包括特征模块，相关模块和缺血检测模块。特征模块被配置为识别心脏信号中的基准特征并且使用基准特征来定位心脏信号中的一个或多个心脏特征。相关模块被配置为计算包括心脏特征的心脏信号的片段的形态的相似度的度量。缺血检测模块被配置为检测相似度测量的变化，并确定检测到的相似性测量的变化是否指示缺血。

2. 发明申请

US20100312130A1 GRADED RESPONSE TO MYOCARDIAL ISCHEMIA 审中-公开
标题翻译：对MYOCARDIAL ISCHEMIA的评分
公开(公告)号：US20100312130A1
公开(公告)日：2010-12-09
申请号：US12860152
申请日：2010-08-20
申请人： Yi Zhang , Kent Lee , Shibaji Shome , Qi An , Ramesh Wariar
发明人： Yi Zhang , Kent Lee , Shibaji Shome , Qi An , Ramesh Wariar
IPC分类号： A61B5/02
CPC分类号： A61B5/02 , A61B5/0402 , A61B5/0535 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/3702 , A61N1/37252
摘要： Severity and confidence level of a myocardial ischemia event can be determined, such as including using an ambulatory medical device, and such information can be used to determine a graded response to the myocardial ischemia event.
摘要翻译：可以确定心肌缺血事件的严重性和置信水平，例如包括使用移动医疗装置，并且可以使用这些信息来确定对心肌缺血事件的分级响应。

3. 发明授权

US08951203B2 Measures of cardiac contractility variability during ischemia 有权
标题翻译：缺血期心脏收缩变异性测量
公开(公告)号：US08951203B2
公开(公告)日：2015-02-10
申请号：US12761018
申请日：2010-04-15
申请人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
发明人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
IPC分类号： A61B5/02 , A61N1/00 , A61B5/0452 , A61B5/024 , G06F19/00 , A61B5/021 , A61B7/04 , A61N1/362
CPC分类号： A61B5/0452 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B7/04 , A61B2562/0219 , A61N1/3627 , G06F19/00 , G06F19/3418 , G16H50/30
摘要： Systems and methods include obtaining a measure of cardiac contractility. A cardiac contractility variability is determined from the measure of cardiac contractility. Analyzing the cardiac contractility variability, an indication of cardio-vasculature health is provided.
摘要翻译：系统和方法包括获得心脏收缩力的量度。心肌收缩能力的变化由心脏收缩力的测量确定。分析心脏收缩性变异性，提供心血管系统健康的指征。

4. 发明申请

US20100274141A1 MEASURES OF CARDIAC CONTRACTILITY VARIABILITY DURING ISCHEMIA 有权
标题翻译： ISCHEMIA期间心脏适应症变异性的措施
公开(公告)号：US20100274141A1
公开(公告)日：2010-10-28
申请号：US12761018
申请日：2010-04-15
申请人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
发明人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
IPC分类号： A61B5/021 , A61B5/02
CPC分类号： A61B5/0452 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B7/04 , A61B2562/0219 , A61N1/3627 , G06F19/00 , G06F19/3418 , G16H50/30
摘要： Systems and methods include obtaining a measure of cardiac contractility. A cardiac contractility variability is determined from the measure of cardiac contractility. Analyzing the cardiac contractility variability, an indication of cardio-vasculature health is provided.
摘要翻译：系统和方法包括获得心脏收缩力的量度。心肌收缩能力的变化由心脏收缩力的测量确定。分析心脏收缩性变异性，提供心血管系统健康的指征。

5. 发明申请

US20100274147A1 DETECTING ISCHEMIA WITH NONLINEAR HEART RATE VARIABILITY MEASURES 审中-公开
标题翻译：用非线性心率变异性测量法检测ISCHEMIA
公开(公告)号：US20100274147A1
公开(公告)日：2010-10-28
申请号：US12761047
申请日：2010-04-15
申请人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
发明人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B7/04 , A61B2562/0219 , A61N1/3627 , G06F19/3418 , G16H50/30
摘要： Systems and methods include accessing a plurality of cardiac indications. A heart rate variability metric is produced by analyzing the plurality of cardiac indications using a measurement from a class of nonlinear measurements. Nonlinear measurements include, but are not limited to, approximate entropy, X-Y scatter from a Poincaré plot, fractal dimension, and detrended fluctuation analysis, in various examples. Based on the heart rate variability metric, a cardiac ischemic state is detected.
摘要翻译：系统和方法包括访问多个心脏指示。通过使用来自一类非线性测量的测量来分析多个心脏指征来产生心率变异性度量。在各种实施例中，非线性测量包括但不限于近似熵，Poincaré图中的X-Y散射，分形维数和去趋势波动分析。基于心率变异性度量，检测到心脏缺血状态。

6. 发明申请

US20100094102A1 MULTI-SENSOR STRATEGY FOR HEART FAILURE PATIENT MANAGEMENT 有权
标题翻译：心脏失败患者管理的多传感器策略
公开(公告)号：US20100094102A1
公开(公告)日：2010-04-15
申请号：US12576453
申请日：2009-10-09
申请人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
发明人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
IPC分类号： A61B5/02
CPC分类号： A61B5/02055 , A61B5/0008 , A61B5/0031 , A61B5/01 , A61B5/02028 , A61B5/0205 , A61B5/0215 , A61B5/026 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/0531 , A61B5/0538 , A61B5/0816 , A61B5/085 , A61B5/1118 , A61B5/121 , A61B5/14542 , A61B5/686 , A61B5/6869 , A61B5/7275 , A61B7/04 , A61N1/36585 , G06F19/00
摘要： An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.
摘要翻译：一种装置包括多个传感器和一个处理器。每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化状态根据第一和第二规则发生。

7. 发明授权

US08738119B2 Multi-sensor strategy for heart failure patient management 有权
标题翻译：心脏病患者管理的多传感器策略
公开(公告)号：US08738119B2
公开(公告)日：2014-05-27
申请号：US12576453
申请日：2009-10-09
申请人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
发明人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
IPC分类号： A61B5/02
CPC分类号： A61B5/02055 , A61B5/0008 , A61B5/0031 , A61B5/01 , A61B5/02028 , A61B5/0205 , A61B5/0215 , A61B5/026 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/0531 , A61B5/0538 , A61B5/0816 , A61B5/085 , A61B5/1118 , A61B5/121 , A61B5/14542 , A61B5/686 , A61B5/6869 , A61B5/7275 , A61B7/04 , A61N1/36585 , G06F19/00
摘要： An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.
摘要翻译：一种装置包括多个传感器和一个处理器。每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化状态根据第一和第二规则发生。

8. 发明申请

US20080281367A1 SYSTEM AND METHOD TO DETERMINE HEMODYNAMIC TOLERABILITY 有权
标题翻译：确定血液动力学耐受性的系统和方法
公开(公告)号：US20080281367A1
公开(公告)日：2008-11-13
申请号：US11745016
申请日：2007-05-07
申请人： Yi Zhang , Allan C. Shuros , Dan Li
发明人： Yi Zhang , Allan C. Shuros , Dan Li
IPC分类号： A61N1/362
CPC分类号： A61N1/36521 , A61B5/02028 , A61B5/0464 , A61B5/0535 , A61B5/0538 , A61B5/7264
摘要： An implantable medical device detects a tachyarrhythmia of a heart. During the detected tachyarrhythmia, the device determines a local myocardial impedance. Using the local myocardial impedance, the device determines whether there is sufficient perfusion to the heart. The device can then either deliver a less aggressive device therapy in response to the detected tachyarrhythmia when there is sufficient perfusion to the heart, or deliver a more aggressive device therapy in response to the detected tachyarrhythmia when there is insufficient perfusion to the heart. The perfusion information can also be used to alter tachyarrhythmia detection or classification.
摘要翻译：可植入医疗装置检测心脏的快速性心律失常。在检测到的快速性心律失常期间，该装置确定局部心肌阻抗。使用局部心肌阻抗，该装置确定心脏是否有足够的灌注。然后，当心脏充分灌注时，该装置可以响应于检测到的快速性心律失常而递送较不激进的装置疗法，或者当心脏灌注不充分时响应于检测到的快速性心律失常而递送更积极的装置疗法。灌注信息也可用于改变快速性心律失常检测或分类。

9. 发明申请

US20090234211A1 Systems and Methods for Myocardial Ischemia Detection 有权
标题翻译：心肌缺血检测系统与方法
公开(公告)号：US20090234211A1
公开(公告)日：2009-09-17
申请号：US12402224
申请日：2009-03-11
申请人： Dan Li , Haresh G. Sachanandani , Michael John Kane , Yi Zhang
发明人： Dan Li , Haresh G. Sachanandani , Michael John Kane , Yi Zhang
IPC分类号： A61B5/1468 , A61B5/04
CPC分类号： A61B5/0402 , A61B5/0468 , A61B5/14532 , A61B5/14546 , A61B5/1459 , A61N1/3627 , A61N1/36585
摘要： Embodiments of the invention are related to devices and methods for myocardial ischemia detection, amongst other things. In an embodiment, the invention includes an implantable medical device including control circuitry, an electrical field sensor in communication with the control circuitry, the electrical field sensor configured to generate a signal corresponding to cardiac electrical fields. The implantable medical device can also include a chemical sensor in communication with the control circuitry, the chemical sensor configured to generate a signal corresponding to the concentration of a physiological analyte that affects cardiac electrical field waveform morphology. The control circuitry can be configured to monitor for the presence of myocardial ischemia by evaluating both the signal generated by the electrical field sensor and the signal generated by the chemical sensor. Other embodiments are also included herein.
摘要翻译：本发明的实施方案涉及用于心肌缺血检测的装置和方法等。在一个实施例中，本发明包括可植入医疗装置，其包括控制电路，与控制电路通信的电场传感器，电场传感器被配置为产生对应于心脏电场的信号。可植入医疗装置还可以包括与控制电路通信的化学传感器，化学传感器被配置为产生对应于影响心电场波形形态的生理分析物的浓度的信号。控制电路可以被配置为通过评估由电场传感器产生的信号和由化学传感器产生的信号来监测是否存在心肌缺血。本文还包括其它实施例。

10. 发明授权

US08532762B2 Discriminating polymorphic and monomorphic cardiac rhythms using template generation 有权
标题翻译：使用模板生成区分多态性和单态心律
公开(公告)号：US08532762B2
公开(公告)日：2013-09-10
申请号：US11312279
申请日：2005-12-20
申请人： Shelley Cazares , Carlos Ricci , Dan Li , Yayun Lin , Yi Zhang , Jaeho Kim , Joseph Bocek
发明人： Shelley Cazares , Carlos Ricci , Dan Li , Yayun Lin , Yi Zhang , Jaeho Kim , Joseph Bocek
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61B5/04525 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/7264 , A61N1/3702 , A61N1/3962
摘要： Cardiac arrhythmias are classified based on the morphology of the arrhythmia episode beats. Templates are formed using morphological features of the cardiac beats of the episode. The arrhythmia episode is classified as a monomorphic tachyarrhythmia or polymorphic tachyarrhythmia based on the one or more templates. The arrhythmia episode may be classified based on a number templates formed from the arrhythmia episode. The templates are formed by determining a measure of similarity between morphological features of a cardiac beat to a template. The similarities can be determined based on a pairing rule that determines which beat morphologies are compared. Selection of therapy for treating the arrhythmia episode may depend on the historical success of a therapy at mitigating previous arrhythmias of the same type as the arrhythmia episode.
摘要翻译：心律失常根据心律失常发作的形态进行分类。使用情节心脏搏动的形态学特征形成模板。基于一个或多个模板，心律失常发作被分类为单形性快速性心律失常或多态性快速性心律失常。心律失常发作可以基于由心律失常发作形成的数字模板进行分类。模板通过确定心跳的形态特征与模板之间的相似性的度量来形成。可以基于确定哪些拍子形态进行比较的配对规则来确定相似度。选择治疗心律失常发作的治疗可能取决于治疗在缓解与心律失常事件相同类型的以前心律失常方面的历史成功。

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