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1. 发明授权

US08321003B2 Methods and apparatuses for detection of myocardial ischemia upon exertion 有权
标题翻译：用于检测心肌缺血的方法和装置
公开(公告)号：US08321003B2
公开(公告)日：2012-11-27
申请号：US12508398
申请日：2009-07-23
申请人： Yi Zhang , Kenneth C. Beck , Aaron Lewicke , Yunlong Zhang
发明人： Yi Zhang , Kenneth C. Beck , Aaron Lewicke , Yunlong Zhang
IPC分类号： A61B5/04
CPC分类号： A61B5/0205 , A61B5/02055 , A61B5/0215 , A61B5/03 , A61B5/4519
摘要： Various method embodiments of the present invention concern sensing patient-internal pressure measurements indicative of physiological exertion, identifying one or more steady state periods of physiological exertion based on the patient-internal pressure measurements, sensing extra-cardiac response data and cardiac response data corresponding to the one or more physiological exertion steady state periods, respectively comparing the extra-cardiac response data and the cardiac response data to extra-cardiac response information and cardiac response information associated with equivalent levels of physiological exertion intensity of the one or more steady state periods, and determining the likelihood that myocardial ischemia occurred during the one or more steady state periods based on the comparison of the extra-cardiac response data to the extra-cardiac response information and the cardiac response data to the cardiac response information.
摘要翻译：本发明的各种方法实施例涉及感测指示生理消耗的患者 - 内部压力测量，基于患者内部的压力测量，感测心脏外的心脏反应数据和对应于心脏的心脏反应数据来识别生理消耗的一个或多个稳定状态时段一个或多个生理活动稳态时段，分别将心外反应数据和心脏响应数据与心脏外反应信息和与一个或多个稳态周期的等效生理消耗强度水平相关联的心脏反应信息进行比较，以及基于心外反应数据与心外反应信息和对心脏反应信息的心脏反应数据的比较，确定在一个或多个稳态期间发生心肌缺血的可能性。

2. 发明申请

US20100191076A1 DAYTIME/NIGHTTIME RESPIRATION RATE MONITORING 有权
标题翻译： DAYTIME / NIGHTTIME呼叫率监测
公开(公告)号：US20100191076A1
公开(公告)日：2010-07-29
申请号：US12708655
申请日：2010-02-19
申请人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
发明人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
IPC分类号： A61B5/0205 , A61B5/08
CPC分类号： A61B5/0816 , A61B5/0205 , A61B5/1116 , A61B5/7264 , G06F19/00
摘要： A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.
摘要翻译：一种装置和方法可以根据一天中的时间来监视或趋向于患者的呼吸速率测量。该装置可以植入或外部收集和分类呼吸速率测量随时间的变化。关于呼吸率测量的特定类别的趋势化信息然后被传送到远程外部设备，远程外部设备又提供心力衰竭失代偿指示。呼吸速率测量类别的实例包括每日最大呼吸率值，每日最小呼吸率值，每日最大呼吸率变异值，每日最小呼吸率变异性值和每日中心呼吸率值。这些呼吸率测量可以进一步分为白天或夜间呼吸率测量。

3. 发明授权

US08951203B2 Measures of cardiac contractility variability during ischemia 有权
标题翻译：缺血期心脏收缩变异性测量
公开(公告)号：US08951203B2
公开(公告)日：2015-02-10
申请号：US12761018
申请日：2010-04-15
申请人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
发明人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
IPC分类号： A61B5/02 , A61N1/00 , A61B5/0452 , A61B5/024 , G06F19/00 , A61B5/021 , A61B7/04 , A61N1/362
CPC分类号： A61B5/0452 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B7/04 , A61B2562/0219 , A61N1/3627 , G06F19/00 , G06F19/3418 , G16H50/30
摘要： Systems and methods include obtaining a measure of cardiac contractility. A cardiac contractility variability is determined from the measure of cardiac contractility. Analyzing the cardiac contractility variability, an indication of cardio-vasculature health is provided.
摘要翻译：系统和方法包括获得心脏收缩力的量度。心肌收缩能力的变化由心脏收缩力的测量确定。分析心脏收缩性变异性，提供心血管系统健康的指征。

4. 发明申请

US20100274141A1 MEASURES OF CARDIAC CONTRACTILITY VARIABILITY DURING ISCHEMIA 有权
标题翻译： ISCHEMIA期间心脏适应症变异性的措施
公开(公告)号：US20100274141A1
公开(公告)日：2010-10-28
申请号：US12761018
申请日：2010-04-15
申请人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
发明人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
IPC分类号： A61B5/021 , A61B5/02
CPC分类号： A61B5/0452 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B7/04 , A61B2562/0219 , A61N1/3627 , G06F19/00 , G06F19/3418 , G16H50/30
摘要： Systems and methods include obtaining a measure of cardiac contractility. A cardiac contractility variability is determined from the measure of cardiac contractility. Analyzing the cardiac contractility variability, an indication of cardio-vasculature health is provided.
摘要翻译：系统和方法包括获得心脏收缩力的量度。心肌收缩能力的变化由心脏收缩力的测量确定。分析心脏收缩性变异性，提供心血管系统健康的指征。

5. 发明申请

US20090198139A1 Daytime/nighttime respiration rate monitoring 有权
公开(公告)号：US20090198139A1
公开(公告)日：2009-08-06
申请号：US12384271
申请日：2009-04-02
申请人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
发明人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
IPC分类号： A61B5/0205
CPC分类号： A61B5/0816 , A61B5/0205 , A61B5/1116 , A61B5/7264 , G06F19/00
摘要： A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.

6. 发明授权

US09743859B2 Daytime/nighttime respiration rate monitoring 有权
公开(公告)号：US09743859B2
公开(公告)日：2017-08-29
申请号：US12708655
申请日：2010-02-19
申请人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
发明人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
IPC分类号： A61B5/08 , A61B5/11 , A61B5/00 , A61B5/0205
CPC分类号： A61B5/0816 , A61B5/0205 , A61B5/1116 , A61B5/7264 , G06F19/00
摘要： A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.

7. 发明申请

US20100274147A1 DETECTING ISCHEMIA WITH NONLINEAR HEART RATE VARIABILITY MEASURES 审中-公开
标题翻译：用非线性心率变异性测量法检测ISCHEMIA
公开(公告)号：US20100274147A1
公开(公告)日：2010-10-28
申请号：US12761047
申请日：2010-04-15
申请人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
发明人： Abhilash Patangay , Yi Zhang , Aaron Lewicke , Julie A. Thompson
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B7/04 , A61B2562/0219 , A61N1/3627 , G06F19/3418 , G16H50/30
摘要： Systems and methods include accessing a plurality of cardiac indications. A heart rate variability metric is produced by analyzing the plurality of cardiac indications using a measurement from a class of nonlinear measurements. Nonlinear measurements include, but are not limited to, approximate entropy, X-Y scatter from a Poincaré plot, fractal dimension, and detrended fluctuation analysis, in various examples. Based on the heart rate variability metric, a cardiac ischemic state is detected.
摘要翻译：系统和方法包括访问多个心脏指示。通过使用来自一类非线性测量的测量来分析多个心脏指征来产生心率变异性度量。在各种实施例中，非线性测量包括但不限于近似熵，Poincaré图中的X-Y散射，分形维数和去趋势波动分析。基于心率变异性度量，检测到心脏缺血状态。

8. 发明授权

US07704215B2 Daytime/nighttime respiration rate monitoring 有权
标题翻译：白天/夜间呼吸率监测
公开(公告)号：US07704215B2
公开(公告)日：2010-04-27
申请号：US12384271
申请日：2009-04-02
申请人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
发明人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
IPC分类号： A61B5/00
CPC分类号： A61B5/0816 , A61B5/0205 , A61B5/1116 , A61B5/7264 , G06F19/00
摘要： A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.
摘要翻译：一种装置和方法可以根据一天中的时间来监视或趋向于患者的呼吸速率测量。该装置可以植入或外部收集和分类呼吸速率测量随时间的变化。关于呼吸率测量的特定类别的趋势化信息然后被传送到远程外部设备，远程外部设备又提供心力衰竭失代偿指示。呼吸速率测量类别的实例包括每日最大呼吸率值，每日最小呼吸率值，每日最大呼吸率变异值，每日最小呼吸率变异性值和每日中心呼吸率值。这些呼吸率测量可以进一步分为白天或夜间呼吸率测量。

9. 发明授权

US07530956B2 Daytime/nighttime respiration rate monitoring 有权
标题翻译：白天/夜间呼吸率监测
公开(公告)号：US07530956B2
公开(公告)日：2009-05-12
申请号：US11820002
申请日：2007-06-15
申请人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
发明人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
IPC分类号： A61B5/00
CPC分类号： A61B5/0816 , A61B5/0205 , A61B5/1116 , A61B5/7264 , G06F19/00
摘要： A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.
摘要翻译：一种装置和方法可以根据一天中的时间来监视或趋向于患者的呼吸速率测量。该装置可以植入或外部收集和分类呼吸速率测量随时间的变化。关于呼吸率测量的特定类别的趋势化信息然后被传送到远程外部设备，远程外部设备又提供心力衰竭失代偿指示。呼吸速率测量类别的实例包括每日最大呼吸率值，每日最小呼吸率值，每日最大呼吸率变异值，每日最小呼吸率变异性值和每日中心呼吸率值。这些呼吸率测量可以进一步分为白天或夜间呼吸率测量。

10. 发明申请

US20080262360A1 USING RESPIRATION DISTRESS MANIFESTATIONS FOR HEART FAILURE DETECTION 有权
标题翻译：使用呼吸部分心理失调检测
公开(公告)号：US20080262360A1
公开(公告)日：2008-10-23
申请号：US11736058
申请日：2007-04-17
申请人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
发明人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/1116 , A61B5/4818 , A61B5/686 , A61N1/3627
摘要： Systems and methods for diagnosing one or more respiration distress manifestations by implantably recognizing their occurrence and evaluating information about the same to provide an indication of present or impending worsening heart failure are discussed. Using information produced by an implantable respiration sensor circuit and an implantable physiological sensor circuit, such as at least one of a physical activity sensor circuit or a posture sensor circuit, an implantable or external processor circuit may detect a respiration disturbance and an associated subsequent arousal from stable state occurrence and thereafter evaluate over time arousal from stable state occurrences to provide the indication of present or impending worsening heart failure. In one example, information about a fluid level within a subject is used in determining the indication of worsening heart failure. In various examples, a regimen is initiated or adjusted in response to the indication of present or impending worsening heart failure.
摘要翻译：讨论了通过可植入地识别其发生并评估关于其的信息来诊断一种或多种呼吸困扰表现的系统和方法，以提供现在或即将恶化的心力衰竭的指征。使用由可植入呼吸传感器电路和植入式生理传感器电路产生的信息，例如物理活动传感器电路或姿势传感器电路中的至少一个，可植入或外部处理器电路可以检测呼吸障碍和相关联的随后的唤醒稳定状态发生，然后评估来自稳定状态发生的随着时间的兴奋，以提供目前或即将恶化的心力衰竭的指征。在一个示例中，关于受试者内的液位水平的信息用于确定恶化的心力衰竭的指示。在各种实例中，响应于目前或即将恶化的心力衰竭的指征开始或调整方案。

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