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    • 3. 发明授权
    • RNA virus-derived peptides with modified side chains
    • 具有修饰侧链的RNA病毒衍生肽
    • US08524659B2
    • 2013-09-03
    • US13440101
    • 2012-04-05
    • Richard Ping ChengCheng-Hsun WuMing-Huei WengLi-Min Huang
    • Richard Ping ChengCheng-Hsun WuMing-Huei WengLi-Min Huang
    • A01N37/18A61K38/00A61P31/12
    • C07K7/06A61K38/00
    • The present invention provides a RNA virus-derived peptides with modified side chains, wherein the side chains of the RNA virus-derived peptide are modified by altering the side-chain length or charges thereof such that the RNA virus-derived peptide has a high binding affinity for viral RNA and an high cellular uptake capability. The present invention also provides a composition for inhibiting RNA virus wherein the RNA virus-derived peptide can effectively inhibit viral self-replication and treat related diseases by its high affinity for viral RNA. A drug delivery carrier is also provided, wherein the RNA virus-derived peptides can carry desired drugs to the intracellular target due to its cellular uptake capability and thereby enhances the drug-delivery and treating efficiency.
    • 本发明提供了具有修饰侧链的RNA病毒衍生肽,其中通过改变侧链长度或其电荷来修饰RNA病毒衍生肽的侧链,使得RNA病毒衍生肽具有高结合力 对病毒RNA的亲和力和高细胞摄取能力。 本发明还提供了用于抑制RNA病毒的组合物,其中所述RNA病毒衍生的肽可以通过其对病毒RNA的高亲和力有效地抑制病毒自身复制和治疗相关疾病。 还提供了药物递送载体,其中RNA病毒衍生的肽由于其细胞摄取能力而可以将期望的药物携带到细胞内靶,从而增强药物递送和治疗效率。
    • 4. 发明申请
    • RNA VIRUS-DERIVED PEPTIDES WITH MODIFIED SIDE CHAINS
    • 具有修饰侧链的RNA病毒衍生肽
    • US20130109618A1
    • 2013-05-02
    • US13440101
    • 2012-04-05
    • Richard Ping ChengCheng-Hsun WuMing-Huei WengLi-Min Huang
    • Richard Ping ChengCheng-Hsun WuMing-Huei WengLi-Min Huang
    • C07K7/06A61P31/14A61K38/08
    • C07K7/06A61K38/00
    • The present invention provides a RNA virus-derived peptides with modified side chains, wherein the side chains of the RNA virus-derived peptide are modified by altering the side-chain length or charges thereof such that the RNA virus-derived peptide has a high binding affinity for viral RNA and an high cellular uptake capability. The present invention also provides a composition for inhibiting RNA virus wherein the RNA virus-derived peptide can effectively inhibit viral self-replication and treat related diseases by its high affinity for viral RNA. A drug delivery carrier is also provided, wherein the RNA virus-derived peptides can carry desired drugs to the intracellular target due to its cellular uptake capability and thereby enhances the drug-delivery and treating efficiency.
    • 本发明提供了具有修饰侧链的RNA病毒衍生肽,其中通过改变侧链长度或其电荷来修饰RNA病毒衍生肽的侧链,使得RNA病毒衍生肽具有高结合力 对病毒RNA的亲和力和高细胞摄取能力。 本发明还提供了用于抑制RNA病毒的组合物,其中所述RNA病毒衍生的肽可以通过其对病毒RNA的高亲和力有效地抑制病毒自身复制和治疗相关疾病。 还提供了药物递送载体,其中RNA病毒衍生的肽由于其细胞摄取能力而可以将期望的药物携带到细胞内靶,从而增强药物递送和治疗效率。