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1. 发明授权

US07955800B2 Metastasis-associated gene profiling for identification of tumor tissue, subtyping, and prediction of prognosis of patients 有权
标题翻译：用于鉴别肿瘤组织的转移相关基因谱，亚型和预测患者的预后
公开(公告)号：US07955800B2
公开(公告)日：2011-06-07
申请号：US11437607
申请日：2006-05-22
申请人： Yeh-Tze Chou , Harn-Jing Terng , Hsuan-Yu Chen , Sung-Liang Yu , Jeremy J. W. Chen , Pan-Chyr Yang
发明人： Yeh-Tze Chou , Harn-Jing Terng , Hsuan-Yu Chen , Sung-Liang Yu , Jeremy J. W. Chen , Pan-Chyr Yang
IPC分类号： C12Q1/68 , C12P19/34 , C12M1/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： Methods for determining a tumor in a human is disclosed. Also disclosed are methods for identifying adenocarcinoma, and methods for identifying squamous cell carcinoma in a human tumor sample. In addition, methods for predicting prognosis of metastasis and survival in a human having a tumor is disclosed.
摘要翻译：公开了确定人体肿瘤的方法。还公开了用于鉴定腺癌的方法，以及用于鉴定人肿瘤样品中鳞状细胞癌的方法。此外，公开了用于预测具有肿瘤的人的转移和存活预后的方法。

2. 发明授权

US07655779B2 Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences 失效
标题翻译： Collapsin应答介质蛋白-1（CRMP-1）转录调控核酸序列
公开(公告)号：US07655779B2
公开(公告)日：2010-02-02
申请号：US11785701
申请日：2007-04-19
申请人： Pan-Chyr Yang , Tse-Ming Hong , Jeremy J. W. Chen , Cheng-Chung Wu , Jin-Yuan Shin , Yi-Jen Lee
发明人： Pan-Chyr Yang , Tse-Ming Hong , Jeremy J. W. Chen , Cheng-Chung Wu , Jin-Yuan Shin , Yi-Jen Lee
IPC分类号： C07H21/02
CPC分类号： C12N15/85 , A61K48/00 , C12N2830/00
摘要： This invention provides a transcription unit which is isolated from the upstream nucleic acid sequence of the collapsing response mediator protein-1 (CRMP-1) gene, an invasion-suppressor gene. The transcription unit contains a nucleic acid regulatory sequence which demonstrates promoter and/or regulatory activities (such as providing a transcription factor binding site) to enhance the expression of the CRMP-1 and/or a reporter protein. The invention also provides a DNA construct containing this transcription unit which can be transfected into a host cell. Additionally, the invention provides methods to enhance the expression of CRMP-1 and/or the reporter protein. The over-expression of CRMP-1 in a cancer cell can inhibit the metastasis of the cancer cell.
摘要翻译：本发明提供了从塌陷反应介质蛋白-1（CRMP-1）基因的上游核酸序列，侵袭抑制基因中分离的转录单位。转录单元含有证明启动子和/或调节活性（例如提供转录因子结合位点）以增强CRMP-1和/或报道蛋白表达的核酸调节序列。本发明还提供含有该转录单位的DNA构建体，其可转染入宿主细胞。另外，本发明提供了增强CRMP-1和/或报道蛋白表达的方法。癌细胞中CRMP-1的过度表达可以抑制癌细胞的转移。

3. 发明授权

US07211660B2 Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences 失效
标题翻译： Collapsin应答介质蛋白-1（CRMP-1）转录调控核酸序列
公开(公告)号：US07211660B2
公开(公告)日：2007-05-01
申请号：US11051328
申请日：2005-02-07
申请人： Pan-Chyr Yang , Tse-Ming Hong , Jeremy J. W. Chen , Cheng-Chung Wu , Jin-Yuan Shin , Yi-Jen Lee
发明人： Pan-Chyr Yang , Tse-Ming Hong , Jeremy J. W. Chen , Cheng-Chung Wu , Jin-Yuan Shin , Yi-Jen Lee
IPC分类号： C07H21/04 , C12P21/04 , C12N15/86
CPC分类号： C12N15/85 , A61K48/00 , C12N2830/00
摘要： This invention provides a transcription unit which is isolated from the upstream nucleic acid sequence of the collapsing response mediator protein-1 (CRMP-1) gene, an invasion-suppressor gene. The transcription unit contains a nucleic acid regulatory sequence which demonstrates promoter and/or regulatory activities (such as providing a transcription factor binding site) to enhance the expression of the CRMP-1 and/or a reporter protein. The invention also provides a DNA construct containing this transcription unit which can be transfected into a host cell. Additionally, the invention provides methods to enhance the expression of CRMP-1 and/or the reporter protein. The over-expression of CRMP-1 in a cancer cell can inhibit the metastasis of the cancer cell.
摘要翻译：本发明提供了从塌陷反应介质蛋白-1（CRMP-1）基因的上游核酸序列，侵袭抑制基因中分离的转录单位。转录单元含有证明启动子和/或调节活性（例如提供转录因子结合位点）以增强CRMP-1和/或报道蛋白表达的核酸调节序列。本发明还提供含有该转录单位的DNA构建体，其可转染入宿主细胞。另外，本发明提供了增强CRMP-1和/或报道蛋白表达的方法。癌细胞中CRMP-1的过度表达可以抑制癌细胞的转移。

4. 发明授权

US07354709B2 Collapsin response mediator protein-1 有权
标题翻译： Collapsin应答介质蛋白-1
公开(公告)号：US07354709B2
公开(公告)日：2008-04-08
申请号：US10180198
申请日：2002-06-25
申请人： Pan-Chyr Yang , Jin-Yuan Shih , Jeremy J. W. Chen , Konan Peck , Cheng-Wen Wu , Tse-Ming Hong , Shuenn-Chen Yang
发明人： Pan-Chyr Yang , Jin-Yuan Shih , Jeremy J. W. Chen , Konan Peck , Cheng-Wen Wu , Tse-Ming Hong , Shuenn-Chen Yang
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , C07K14/47 , C07K16/28 , C07K16/30 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： This invention is based on the discovery of an association of Collapsin Response Mediator Protein-1 (CRMP-1) with tumor metastasis. The level of CRMP-1 protein or mRNA can be used as an indicator of cellular invasiveness and of a test compound's ability to alter cellular invasiveness. The level of CRMP-1 protein can also be altered, e.g., to reduce invasiveness.
摘要翻译：本发明基于Collapsin Response Mediator Protein-1（CRMP-1）与肿瘤转移的关联的发现。 CRMP-1蛋白或mRNA的水平可作为细胞侵袭的指标，也可用于测试化合物改变细胞侵袭能力。也可以改变CRMP-1蛋白的水平，例如降低侵袭性。

5. 发明授权

US06218114B1 Methods for detecting differentially expressed genes 失效
标题翻译：检测差异表达基因的方法
公开(公告)号：US06218114B1
公开(公告)日：2001-04-17
申请号：US09049569
申请日：1998-03-27
申请人： Konan Peck , Jeremy J. W. Chen , Pan-Chyr Yang , Reen Wu , Fu Chang , Yi-Wen Chu , Cheng-Wen Wu
发明人： Konan Peck , Jeremy J. W. Chen , Pan-Chyr Yang , Reen Wu , Fu Chang , Yi-Wen Chu , Cheng-Wen Wu
IPC分类号： C12Q168
CPC分类号： C12Q1/6809
摘要： The invention relates to a method of detecting a differentially expressed gene in a first sample of nucleic acids representing a first population of RNA transcripts and a second sample of nucleic acids representing a second population of RNA transcripts. The nucleic acids in the samples are labled with a member of specific binding pair, and the labeled nucleic acids in each sample are then hybridized to an excess of copies of a gene-specific sequence. The hybridized nucleic acids in each sample are further labeled by binding a second member of the specific binding pair to the first member, in which the second member has an activity to convert a chromogenic substrate into a chromogen. As a result of contacting the second member with the chromogenic substrate, the chromogenic substrate is converted into the chromogen. A difference in the amounts of chromogen produced from assaying the two samples indicate that the gene-specific sequence is differentially expressed in the samples.
摘要翻译：本发明涉及检测代表第一RNA转录物群体的核酸的第一样本中的差异表达基因的方法和表示第二RNA转录物群体的第二核酸样品。样品中的核酸用特异性结合对的成员进行标记，然后将每个样品中的标记的核酸与过量的基因特异性序列的拷贝杂交。通过将特异性结合对的第二成员与第一成员结合来进一步标记每个样品中的杂交核酸，其中第二成员具有将显色底物转化为色原体的活性。作为使第二构件与显色底物接触的结果，将显色底物转化为色原体。通过测定两个样品产生的色原体的量的差异表明基因特异性序列在样品中差异表达。

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