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1. 发明申请

US20120071629A1 APPOPTOSIN AND USES THEREOF FOR TREATING NEURODEGENERATIVE DISEASE AND CANCER 审中-公开
标题翻译：用于治疗神经病变性疾病和癌症的药物及其用途
公开(公告)号：US20120071629A1
公开(公告)日：2012-03-22
申请号：US13187238
申请日：2011-07-20
申请人： Huaxi Xu , Francesca-Fang Liao , Han Zhang , Yunwu Zhang , Fangfang Zhou , Yeguang Chen
发明人： Huaxi Xu , Francesca-Fang Liao , Han Zhang , Yunwu Zhang , Fangfang Zhou , Yeguang Chen
IPC分类号： C07K14/435 , C07H21/04
CPC分类号： G01N33/57426 , A61K38/1709 , A61K48/00 , C07K14/4711 , C07K14/4747 , G01N33/5011 , G01N2800/2821
摘要： Disclosed herein are compositions and methods relating to the modulation of Appoptosin levels or activity in the treatment of Neurodegenerative disorders or cancer.
摘要翻译：本文公开了与调节神经变性疾病或癌症中的阿朴磷酸水平或活性有关的组合物和方法。

2. 发明申请

US20070299011A1 APPOPTOSIN AND USES THEREOF FOR TREATING NEURODEGENERATIVE DISEASE AND CANCER 审中-公开
标题翻译：用于治疗神经病变性疾病和癌症的药物及其用途
公开(公告)号：US20070299011A1
公开(公告)日：2007-12-27
申请号：US11751183
申请日：2007-05-21
申请人： Yeguang Chen , Fangfang Zhou , Han Zhang , Yunwu Zhang , Francesca-Fang Liao , Huaxi Xu
发明人： Yeguang Chen , Fangfang Zhou , Han Zhang , Yunwu Zhang , Francesca-Fang Liao , Huaxi Xu
IPC分类号： A61K38/00 , A61K48/00 , A61P43/00 , C12N15/00 , C12Q1/02
CPC分类号： G01N33/57426 , A61K38/1709 , A61K48/00 , C07K14/4711 , C07K14/4747 , G01N33/5011 , G01N2800/2821
摘要： Disclosed herein are compositions and methods relating to the modulation of Appoptosin levels or activity in the treatment of Neurodegenerative disorders or cancer.
摘要翻译：本文公开了与调节神经变性疾病或癌症中的阿朴磷酸水平或活性有关的组合物和方法。

3. 发明申请

US20090233993A1 COMPOSITIONS AND METHODS FOR INHIBITING GSK3 ACTIVITY AND USES THEREOF 审中-公开
标题翻译：用于抑制GSK3活性的组合物和方法及其用途
公开(公告)号：US20090233993A1
公开(公告)日：2009-09-17
申请号：US12399850
申请日：2009-03-06
申请人： Huaxi Xu , Limin Li , Francesca-Fang Liao , Yun-wu Zhang , Wu-bo Li , Paul Greengard , Stanley N. Cohen
发明人： Huaxi Xu , Limin Li , Francesca-Fang Liao , Yun-wu Zhang , Wu-bo Li , Paul Greengard , Stanley N. Cohen
IPC分类号： A61K31/7088 , C07H21/00 , C12N15/74 , C12P21/02 , C07K2/00 , C12N5/06 , A61P25/28 , G01N33/567
CPC分类号： C07K14/705 , A61K38/00 , G01N2333/91205 , G01N2800/2821
摘要： Disclosed herein are compositions and methods relating to peptides. The peptides can inhibit amyloid beta (Aβ) generation and reduce GSK-3 activities. Further provided are compositions and methods for treating or preventing, for example, Alzheimer's disease, cancer, and diabetes.
摘要翻译：本文公开了与肽相关的组合物和方法。肽可以抑制淀粉样蛋白β（Abeta）的产生并降低GSK-3活性。还提供了用于治疗或预防例如阿尔茨海默病，癌症和糖尿病的组合物和方法。

4. 发明授权

US08598171B2 Compositions and methods for prevention and treatment of amyloid-β peptide-related disorders 有权
标题翻译：用于预防和治疗淀粉样蛋白β肽相关疾病的组合物和方法
公开(公告)号：US08598171B2
公开(公告)日：2013-12-03
申请号：US13048459
申请日：2011-03-15
申请人： William Netzer , Paul Greengard , Huaxi Xu
发明人： William Netzer , Paul Greengard , Huaxi Xu
IPC分类号： A01N43/58 , A01N43/54 , A01N43/40 , A61K31/50 , A61K31/497 , A61K31/435 , C07D239/42 , C07D401/04
CPC分类号： G01N33/5058 , A61K31/506 , A61K31/519 , A61K45/06 , G01N33/5008 , G01N33/502 , G01N2333/4709 , G01N2800/2821 , A61K2300/00
摘要： The present invention provides methods and compositions for modulating levels of amyloid-β peptide (Aβ) exhibited by cells or tissues. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate Aβ levels. The invention also provides modulation of Aβ levels via selective modulation (e.g., inhibition) of ATP-dependent γ-secretase activity. The invention also provides methods of preventing, treating or ameliorating the symptoms of a disorder, including but not limited to an Aβ-related disorder, by administering a modulator of γ-secretase, including, but not limited to, a selective inhibitor of ATP-dependent γ-secretase activity or an agent that decreases the formation of active (or optimally active) γ-secretase. The invention also provides the use of inhibitors of ATP-dependent γ-secretase activity to prevent, treat or ameliorate the symptoms of Alzheimer's disease.
摘要翻译：本发明提供调节细胞或组织表现出的淀粉样蛋白-β肽（Abeta）水平的方法和组合物。本发明还提供了用于筛选调节Aβ水平的化合物的药物组合物和方法。本发明还通过ATP依赖性γ-分泌酶活性的选择性调节（例如抑制）来提供Aβ水平的调节。本发明还提供通过施用γ-分泌酶的调节剂（包括但不限于ATP-选择性抑制剂）的方法来预防，治疗或改善病症症状，包括但不限于与Aβ相关的病症，依赖性γ-分泌酶活性或降低活性（或最佳活性）γ-分泌酶形成的试剂。本发明还提供了ATP依赖性γ-分泌酶活性抑制剂用于预防，治疗或改善阿尔茨海默病症状的用途。

5. 发明申请

US20110312093A1 COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF AMYLOID-BETA PEPTIDE-RELATED DISORDERS 有权
标题翻译：用于预防和治疗淀粉样多肽相关疾病的组合物和方法
公开(公告)号：US20110312093A1
公开(公告)日：2011-12-22
申请号：US13048459
申请日：2011-03-15
申请人： William NETZER , Paul Greengard , Huaxi Xu
发明人： William NETZER , Paul Greengard , Huaxi Xu
IPC分类号： C12N5/071
CPC分类号： G01N33/5058 , A61K31/506 , A61K31/519 , A61K45/06 , G01N33/5008 , G01N33/502 , G01N2333/4709 , G01N2800/2821 , A61K2300/00
摘要： The present invention provides methods and compositions for modulating levels of amyloid-β peptide (Aβ) exhibited by cells or tissues. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate Aβ levels. The invention also provides modulation of Aβ levels via selective modulation (e.g., inhibition) of ATP-dependent γ-secretase activity. The invention also provides methods of preventing, treating or ameliorating the symptoms of a disorder, including but not limited to an Aβ-related disorder, by administering a modulator of γ-secretase, including, but not limited to, a selective inhibitor of ATP-dependent γ-secretase activity or an agent that decreases the formation of active (or optimally active) γ-secretase. The invention also provides the use of inhibitors of ATP-dependent γ-secretase activity to prevent, treat or ameliorate the symptoms of Alzheimer's disease.
摘要翻译：本发明提供了调节淀粉样蛋白水平的方法和组合物。由细胞或组织表现的肽（A＆bgr）。本发明还提供药物组合物和筛选调节Aβ的化合物的方法; 水平。本发明还提供了A＆bgr的调制; 通过ATP依赖性γ-分泌酶活性的选择性调节（例如，抑制）。本发明还提供了通过施用γ-分泌酶的调节剂（包括但不限于ATP的选择性抑制剂）来预防，治疗或改善病症症状，包括但不限于有关疾病的方法依赖性γ-分泌酶活性或降低活性（或最佳活性）γ-分泌酶形成的试剂。本发明还提供了ATP依赖性γ-分泌酶活性抑制剂用于预防，治疗或改善阿尔茨海默病症状的用途。

6. 发明授权

US07910586B2 Compositions and methods for prevention and treatment of amyloid-β peptide-related disorders 有权
标题翻译：用于预防和治疗淀粉样蛋白的组合物和方法肽相关疾病
公开(公告)号：US07910586B2
公开(公告)日：2011-03-22
申请号：US10337261
申请日：2003-01-06
申请人： William Netzer , Paul Greengard , Huaxi Xu
发明人： William Netzer , Paul Greengard , Huaxi Xu
IPC分类号： A01N43/58 , A01N43/54 , A01N43/40 , A01N43/42 , A61K31/50 , A61K31/435 , A61K31/44 , C07D239/42 , C07D401/04 , C07D471/04 , C07D471/22 , C07D487/04
CPC分类号： G01N33/5058 , A61K31/506 , A61K31/519 , A61K45/06 , G01N33/5008 , G01N33/502 , G01N2333/4709 , G01N2800/2821 , A61K2300/00
摘要： The present invention provides methods and compositions for modulating levels of amyloid-β peptide (Aβ) exhibited by cells or tissues. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate Aβ levels. The invention also provides modulation of Aβ levels via selective modulation (e.g., inhibition) of ATP-dependent γ-secretase activity. The invention also provides methods of preventing, treating or ameliorating the symptoms of a disorder, including but not limited to an Aβ-related disorder, by administering a modulator of γ-secretase, including, but not limited to, a selective inhibitor of ATP-dependent γ-secretase activity or an agent that decreases the formation of active (or optimally active) γ-secretase. The invention also provides the use of inhibitors of ATP-dependent γ-secretase activity to prevent, treat or ameliorate the symptoms of Alzheimer's disease.
摘要翻译：本发明提供了调节淀粉样蛋白水平的方法和组合物。由细胞或组织表现的肽（A＆bgr）。本发明还提供药物组合物和筛选调节Aβ的化合物的方法; 水平。本发明还提供了A＆bgr的调制; 通过ATP依赖性γ-分泌酶活性的选择性调节（例如，抑制）。本发明还提供了通过施用γ-分泌酶的调节剂（包括但不限于ATP的选择性抑制剂）来预防，治疗或改善病症症状，包括但不限于有关疾病的方法依赖性γ-分泌酶活性或降低活性（或最佳活性）γ-分泌酶形成的试剂。本发明还提供了ATP依赖性γ-分泌酶活性抑制剂用于预防，治疗或改善阿尔茨海默病症状的用途。

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