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1. 发明授权

US08093050B2 mTOR inhibtors and mTOR signaling pathway inhibitors induce differentiation of human embryonic stem cells into the osteoblastic lineage 有权
标题翻译： mTOR抑制剂和mTOR信号通路抑制剂诱导人胚胎干细胞分化成成骨细胞谱系
公开(公告)号：US08093050B2
公开(公告)日：2012-01-10
申请号：US12671362
申请日：2007-08-17
申请人： Yee Sook Cho , Kyu-Won Lee
发明人： Yee Sook Cho , Kyu-Won Lee
IPC分类号： C12N15/00
CPC分类号： A61K31/436 , C12N5/0654 , C12N2500/38 , C12N2500/42 , C12N2501/04 , C12N2501/39 , C12N2501/70 , C12N2502/02
摘要： Disclosed are a composition for introducing the osteogenic differentiation of human embryonic stem cells and a method for differentiating human embryonic stem cells into an osteoblastic lineage by inhibiting the mTOR signaling pathway. When cultured in the presence of an inhibitor of the mTOR signaling pathway, human embryonic stem cells are effectively induced to differentiate into an osteoblastic lineage. The osteogenic differentiation of human embryonic stem cells using the method and the composition is useful in examining the development and differentiation mechanism of osteoblasts and the cause of metabolic bone diseases, including osteoporosis. In addition, the method and the composition can be applied to the development of osteogenic differentiation techniques for generating clinically useful, terminally differentiated mature cells or progenitor cells.
摘要翻译：公开了用于引入人胚胎干细胞的成骨分化的组合物和通过抑制mTOR信号通路将人胚胎干细胞分化成成骨细胞谱系的方法。当在mTOR信号通路抑制剂存在下培养时，人胚胎干细胞被有效诱导分化为成骨细胞谱系。使用该方法和组合物的人胚胎干细胞的成骨分化可用于检查成骨细胞的发育和分化机制以及代谢骨疾病（包括骨质疏松症）的原因。此外，该方法和组合物可用于开发用于产生临床有用的终末分化的成熟细胞或祖细胞的成骨分化技术。

2. 发明申请

US20100297755A1 Method for Differentiating of Human Embryonic Stem Cells Into the Osteoblastic Lineage 有权
标题翻译：将人胚胎干细胞分化成成骨细胞谱系的方法
公开(公告)号：US20100297755A1
公开(公告)日：2010-11-25
申请号：US12671362
申请日：2007-08-17
申请人： Yee Sook Cho , Kyu-Won Lee
发明人： Yee Sook Cho , Kyu-Won Lee
IPC分类号： C12N5/0735
CPC分类号： A61K31/436 , C12N5/0654 , C12N2500/38 , C12N2500/42 , C12N2501/04 , C12N2501/39 , C12N2501/70 , C12N2502/02
摘要： Disclosed are a composition for introducing the osteogenic differentiation of human embryonic stem cells and a method for differentiating human embryonic stem cells into an osteoblastic lineage by inhibiting the mTOR signaling pathway. When cultured in the presence of an inhibitor of the mTOR signaling pathway, human embryonic stem cells are effectively induced to differentiate into an osteoblastic lineage. The osteogenic differentiation of human embryonic stem cells using the method and the composition is useful in examining the development and differentiation mechanism of osteoblasts and the cause of metabolic bone diseases, including osteoporosis. In addition, the method and the composition can be applied to the development of osteogenic differentiation techniques for generating clinically useful, terminally differentiated mature cells or progenitor cells.
摘要翻译：公开了用于引入人胚胎干细胞的成骨分化的组合物和通过抑制mTOR信号通路将人胚胎干细胞分化成成骨细胞谱系的方法。当在mTOR信号通路抑制剂存在下培养时，人胚胎干细胞被有效诱导分化为成骨细胞谱系。使用该方法和组合物的人胚胎干细胞的成骨分化可用于检查成骨细胞的发育和分化机制以及代谢骨疾病（包括骨质疏松症）的原因。此外，该方法和组合物可用于开发用于产生临床有用的终末分化的成熟细胞或祖细胞的成骨分化技术。

3. 发明授权

US08628963B2 Medium composition comprising neuropeptide Y for the generation, maintenance, prolonged undifferentiated growth of pluripotent stem cells and method of culturing pluripotent stem cell using the same 有权
标题翻译：包含用于产生，维持，多能干细胞的长期未分化生长的神经肽Y的培养基组合物和使用其培养多能干细胞的方法
公开(公告)号：US08628963B2
公开(公告)日：2014-01-14
申请号：US13378912
申请日：2010-06-16
申请人： Yee Sook Cho , Mi-Young Son
发明人： Yee Sook Cho , Mi-Young Son
IPC分类号： C12N5/00 , C12N5/02 , C12N5/071
CPC分类号： C12N5/0606 , C12N5/0696 , C12N2501/15 , C12N2501/835
摘要： The present invention relates to a medium composition comprising neuropeptide Y, effective for proliferation and maintenance of undifferentiated pluripotent stem cells, and a method for culturing undifferentiated pluripotent stem cells using the same. The present invention improves the culture conditions for undifferentiated pluripotent stem cells, and ultimately, the present invention can be effectively used for the development of large-scale culture systems, thereby acquiring clinically applicable pluripotent stem cells. Further, the present invention relates to a dedifferentiation medium composition comprising neuropeptide Y (NPY), and a method for inducing dedifferentiation (or reprogramming) using the same. The present invention improves the culture conditions for dedifferentiation and contributes to develop technology of producing clinically applicable induced pluripotent stem cells, thereby being used for the development of stem cell therapy.
摘要翻译：本发明涉及包含对未分化多能干细胞的增殖和维持有效的神经肽Y的培养基组合物，以及使用该组合物培养未分化多能干细胞的方法。本发明改善了未分化多能干细胞的培养条件，最终本发明可有效地用于大规模培养系统的开发，从而获得临床适用的多能干细胞。此外，本发明涉及包含神经肽Y（NPY）的去分化培养基组合物和使用其的诱导去分化（或重编程）的方法。本发明改善去分化的培养条件，有助于开发临床应用的诱导多能干细胞的生产技术，从而用于干细胞治疗的发展。

4. 发明申请

US20140024119A1 CELL REPROGRAMMING COMPOSITION COMPRISING REX1 AND AN INDUCED PLURIPOTENT STEM CELL PRODUCTION METHOD USING THE SAME 审中-公开
标题翻译：包含REX1的细胞再分解组合物和使用其的诱导的细胞干细胞生产方法
公开(公告)号：US20140024119A1
公开(公告)日：2014-01-23
申请号：US13979674
申请日：2012-01-16
申请人： Yee Sook Cho , Mi Young Son
发明人： Yee Sook Cho , Mi Young Son
IPC分类号： C12N5/074
CPC分类号： C12N5/0696 , C07K14/47 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2501/998 , C12N2510/00
摘要： A reprogramming inducing composition including the Rex1 protein or a nucleic acid molecule coding for the Rex1 protein for producing induced pluripotent stem cells from body cells or non-embryonic cells through a reprogramming process. A method for producing induced pluripotent stem cells by using the Rex1 is also disclosed.
摘要翻译：包含Rex1蛋白的重编程诱导组合物或编码Rex1蛋白的核酸分子，用于通过重编程过程从体细胞或非胚胎细胞产生诱导多能干细胞。还公开了通过使用Rex1产生诱导性多能干细胞的方法。

5. 发明申请

US20120171766A1 MEDIUM COMPOSITION COMPRISING NEUROPEPTIDE Y FOR THE GENERATION, MAINTENANCE, PROLONGED UNDIFFERENTIATED GROWTH OF PLURIPOTENT STEM CELLS AND METHOD OF CULTURING PLURIPOTENT STEM CELL USING THE SAME 有权
标题翻译：包含神经元Y的中成组合物用于产生，维持，扩大的PLUIPOTETE STEM细胞的不成熟生长以及使用该培养基的培养细胞干细胞的方法
公开(公告)号：US20120171766A1
公开(公告)日：2012-07-05
申请号：US13378912
申请日：2010-06-16
申请人： Yee Sook Cho , Mi-Young Son
发明人： Yee Sook Cho , Mi-Young Son
IPC分类号： C12N5/071 , C12N5/0735 , C12N5/02
CPC分类号： C12N5/0606 , C12N5/0696 , C12N2501/15 , C12N2501/835
摘要： The present invention relates to a medium composition comprising neuropeptide Y, effective for proliferation and maintenance of undifferentiated pluripotent stem cells, and a method for culturing undifferentiated pluripotent stem cells using the same. The present invention improves the culture conditions for undifferentiated pluripotent stem cells, and ultimately, the present invention can be effectively used for the development of large-scale culture systems, thereby acquiring clinically applicable pluripotent stem cells. Further, the present invention relates to a dedifferentiation medium composition comprising neuropeptide Y (NPY), and a method for inducing dedifferentiation (or reprogramming) using the same. The present invention improves the culture conditions for dedifferentiation and contributes to develop technology of producing clinically applicable induced pluripotent stem cells, thereby being used for the development of stem cell therapy.
摘要翻译：本发明涉及包含对未分化多能干细胞的增殖和维持有效的神经肽Y的培养基组合物，以及使用该组合物培养未分化多能干细胞的方法。本发明改善了未分化多能干细胞的培养条件，最终本发明可有效地用于大规模培养系统的开发，从而获得临床适用的多能干细胞。此外，本发明涉及包含神经肽Y（NPY）的去分化培养基组合物和使用其的诱导去分化（或重编程）的方法。本发明改善去分化的培养条件，有助于开发临床应用的诱导多能干细胞的生产技术，从而用于干细胞治疗的发展。

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