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    • 10. 发明申请
    • NUCLEOSIDE PHOSPHONATE DERIVATIVES
    • 核苷酸磷酸酯衍生物
    • US20090274686A1
    • 2009-11-05
    • US12434146
    • 2009-05-01
    • Yat Sun OrLu YingXiaowen PengCe WangYao-Ling Qiu
    • Yat Sun OrLu YingXiaowen PengCe WangYao-Ling Qiu
    • A61K31/7064C07H19/20C07H19/10A61K31/7076A61K39/395A61P35/00A61P31/12
    • C07H19/10C07H19/20
    • The present invention discloses compounds of formula (I) or (II), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit, preventing or treating abnormal cellular proliferation and/or a viral infection, particularly by HIV, HCV or HBV. Consequently, the compounds of the present invention interfere with the replication cycle of a virus and are also useful as antiviral agents, or interfere with host cellular biochemical process and are also useful as antiproliferative agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from viral infection and/or cell proliferation. The invention also relates to methods of treating a viral infection and/or cell proliferation in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral/anti-proliferative compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral infection in a subject in need of such therapy with said compounds.
    • 本发明公开了式(I)或(II)的化合物或其药学上可接受的盐,酯或前药:其特别是通过HIV,HCV或HBV抑制,预防或治疗异常的细胞增殖和/或病毒感染。 因此,本发明的化合物干扰病毒的复制循环,也可用作抗病毒剂,或干扰宿主细胞生物化学过程,也可用作抗增殖剂。 本发明还涉及药物组合物,其包含用于给患有病毒感染和/或细胞增殖的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的病毒感染和/或细胞增殖的方法。 本发明涉及上文所述的新的抗病毒/抗增殖化合物,包含这些化合物的药物组合物,以及用于治疗或预防需要用所述化合物治疗的受试者的病毒感染的方法。