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1. 发明申请

US20120034611A1 METHOD FOR DETECTING PRESUMED IGA NEPHROPATHY AND METHOD FOR SCREENING IGA NEPHROPATHY PATIENTS 失效
标题翻译：检测IGA神经病变的方法及筛选IGA神经病患者的方法
公开(公告)号：US20120034611A1
公开(公告)日：2012-02-09
申请号：US13148344
申请日：2010-02-10
申请人： Yasuyuki Nagasawa , Kenichiro Ito , Yoshitaka Isaka , Shinji Fukuda , Hiroshi Ohno
发明人： Yasuyuki Nagasawa , Kenichiro Ito , Yoshitaka Isaka , Shinji Fukuda , Hiroshi Ohno
IPC分类号： C12Q1/68 , C07K16/12 , G01N33/569
CPC分类号： C12Q1/689 , C12Q1/04 , G01N33/6893 , G01N2800/347 , Y02A50/451
摘要： Based on detection of Treponema bacteria or Campylobacter bacteria present in a sample derived from the tonsil of a subject who has a positive result on at least one of a urinary protein test and a urinary occult blood test, or of a patient diagnosed with possible IgA nephropathy, presumed IgA nephropathy can be detected with a high accuracy, in a simple and quick manner without physical burden on subjects. Also, an IgA nephropathy patient for whom tonsillectomy is effective in therapy of IgA nephropathy can be selected with a high accuracy, in a simple and quick manner without physical burden on subjects.
摘要翻译：基于检测来源于受试者的扁桃体的样品中的梅毒螺旋体细菌或弯曲杆菌细菌，其在至少一种尿蛋白测试和尿液潜血试验中具有阳性结果，或者被诊断患有可能的IgA肾病的患者推测IgA肾病可以以高精度，简单快速的方式检测，无需对受试者造成身体负担。此外，扁桃体切除术有效治疗IgA肾病的IgA肾病患者可以以高精度，简单快速的方式选择，无需对受试者造成身体负担。

2. 发明授权

US08592159B2 Method for detecting presumed IgA nephropathy and method for screening IgA nephropathy patients 失效
标题翻译：检测推测的IgA肾病的方法及IgA肾病患者筛查方法
公开(公告)号：US08592159B2
公开(公告)日：2013-11-26
申请号：US13148344
申请日：2010-02-10
申请人： Yasuyuki Nagasawa , Kenichiro Iio , Yoshitaka Isaka , Shinji Fukuda , Hiroshi Ohno
发明人： Yasuyuki Nagasawa , Kenichiro Iio , Yoshitaka Isaka , Shinji Fukuda , Hiroshi Ohno
IPC分类号： C12Q1/68 , C07H21/04 , C07H21/02
CPC分类号： C12Q1/689 , C12Q1/04 , G01N33/6893 , G01N2800/347 , Y02A50/451
摘要： A process for detecting presumed IgA nephropathy by detection of Treponema bacteria and/or Campylobacter bacteria present in a sample from the tonsil of a subject who, optionally, has a positive result in a urinary protein test and/or a urinary occult blood test, or whom is diagnosed with possible IgA nephropathy. Also, a process for detecting an IgA nephropathy patient for whom tonsillectomy is effective by detecting Treponema bacteria or Campylobacter bacteria.
摘要翻译：通过检测来自受试者的扁桃体的样品中存在的梅毒螺旋体细菌和/或弯曲菌属细菌来检测推测的IgA肾病的方法，所述样本选择性地在尿蛋白测试和/或尿液潜血试验中具有阳性结果，或被诊断患有可能的IgA肾病。此外，通过检测梅毒螺旋体细菌或弯曲杆菌属细菌，检测扁桃体切除术有效的IgA肾病患者的方法。

3. 发明申请

US20140147936A1 METHOD FOR DETERMINING PROGNOSIS OF RENAL FAILURE 审中-公开
标题翻译：确定肾功能衰竭预后的方法
公开(公告)号：US20140147936A1
公开(公告)日：2014-05-29
申请号：US14113805
申请日：2012-04-23
申请人： Takayuki Hamano , Yoshitaka Isaka , Isao Matsui
发明人： Takayuki Hamano , Yoshitaka Isaka , Isao Matsui
IPC分类号： G01N33/82 , G01N33/68
CPC分类号： G01N33/82 , G01N33/6893 , G01N33/74 , G01N2333/50 , G01N2800/347 , G01N2800/50
摘要： The present invention relates to a method for determining the prognosis of renal failure, which comprises measuring fibroblast growth factor-23 and 25-hydroxyvitamin D in a biological sample, and a kit for determining the prognosis of renal failure, which comprises a reagent for measuring fibroblast growth factor-23 and a reagent for measuring 25-hydroxyvitamin DThe present invention provides a method for determining the prognosis of renal failure and a kit for determining the prognosis of renal failure, which are useful for deciding on a therapeutic strategy, such as selection of medication, introduction of a stricter diet therapy, and early introduction of dialysis treatment.
摘要翻译：本发明涉及一种确定肾功能衰竭预后的方法，其中包括测量生物样品中的成纤维细胞生长因子-23和25-羟基维生素D，以及用于测定肾衰竭预后的试剂盒，其包括用于测量的试剂成纤维细胞生长因子-23和用于测定25-羟基维生素D的试剂本发明提供了一种测定肾功能衰竭的预后的方法和用于确定肾衰竭预后的试剂盒，其可用于决定治疗策略，例如选择药物，引入更严格的饮食疗法，以及早期引入透析治疗。

4. 发明授权

US08263756B2 Method of gene transfer via vascular system or ureter 有权
标题翻译：通过血管系统或输尿管进行基因转移的方法
公开(公告)号：US08263756B2
公开(公告)日：2012-09-11
申请号：US10474142
申请日：2002-03-22
申请人： Shiro Takahara , Enyu Imai , Yoshitaka Isaka
发明人： Shiro Takahara , Enyu Imai , Yoshitaka Isaka
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： C07K14/4753 , A61K38/1833 , A61K48/00 , A61K48/0075
摘要： The present invention provides a method for gene transfer through the vascular system or a ureter. In a preferable embodiment of this invention, an aqueous solution containing an expression vector comprising a desired gene is injected through the vascular system or a ureter of a desired organ to introduce the gene into the injected area. Specifically, the method of the present invention is effective for ex vivo gene therapy wherein the hepatocyte growth factor (HGF) gene is introduced by electroporation into a kidney to be transplanted. According to the present invention, the HGF functions continuously on the kidney to be transplanted, and the HGF within the treated area does not affect other organs of the body. Thus, the method of the present invention is a safe and effective treatment for maintaining the survival of transplanted kidneys.
摘要翻译：本发明提供了通过血管系统或输尿管进行基因转移的方法。在本发明的优选实施方案中，通过所需器官的血管系统或输尿管注射含有包含所需基因的表达载体的水溶液，以将基因引入注射区域。具体地说，本发明的方法对离体基因治疗是有效的，其中通过电穿孔将肝细胞生长因子（HGF）基因导入待移植的肾脏中。根据本发明，HGF连续在肾脏上移植，处理区域内的HGF不影响身体的其他器官。因此，本发明的方法是保持移植肾的存活的安全有效的治疗方法。

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