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1. 发明授权

US5834028A Soluble thrombomodulin-containing composition 失效
标题翻译：含可溶性血栓调节蛋白的组合物
公开(公告)号：US5834028A
公开(公告)日：1998-11-10
申请号：US505337
申请日：1995-08-17
申请人： Yasuyuki Kunihiro , Ryo Tanaka , Seishichi Hata , Shigeharu Suzuki , Yumio Kudoh
发明人： Yasuyuki Kunihiro , Ryo Tanaka , Seishichi Hata , Shigeharu Suzuki , Yumio Kudoh
IPC分类号： A61K9/19 , A61K38/00 , A61K38/36 , A61K47/18 , A61K47/26 , C07K14/745 , A61K35/22 , A61K35/14 , A61K38/54
CPC分类号： C07K14/7455 , A61K47/183 , A61K47/26 , A61K9/0019 , A61K9/19 , A61K38/00
摘要： The present invention is directed to a soluble thrombomodulin-containing composition comprising at least one molecular species of soluble thrombomodulin, and at least one member selected from the group consisting of maltose, lactose, sucrose, arginine and a salt thereof, and a nonionic surface-active agent; and a production method therefor; as well as a stabilizing agent; a stabilization method; an anti-adsorption agent; and an anti-adsorption method for the soluble thrombomodulin. The present invention provides a soluble thrombomodulin-containing lyophilized preparation which is useful as a prophylactic or therapeutic agent for diseases associated with abnormalities in blood coagulation, and which is stable for a prolonged period of time and would not become adsorbed onto the container; and a production method therefor; as well as a stabilization agent; a stabilization method; an anti-adsorption agent; and an anti-adsorption method for the soluble thrombomodulin.
摘要翻译： PCT No.PCT / JP94 / 02128 Sec。 371日期：1995年8月17日 102（e）日期1995年8月17日PCT 1994年12月16日PCT PCT。公开号WO95 / 16460 日期：1995年6月22日本发明涉及含有至少一种可溶性血栓调节素分子种类的可溶性血栓调节素组合物和选自麦芽糖，乳糖，蔗糖，精氨酸及其盐中的至少一种，和非离子表面活性剂; 及其生产方法; 以及稳定剂; 稳定方法; 抗吸附剂; 和可溶性血栓调节素的抗吸附方法。本发明提供一种可溶性血栓调节蛋白的冻干制剂，其可用作与血液凝固异常有关的疾病的预防或治疗剂，其长期稳定且不会吸附到容器上; 及其生产方法; 以及稳定剂; 稳定方法; 抗吸附剂; 和可溶性血栓调节素的抗吸附方法。

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