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    • 9. 发明授权
    • Quinolonecarboxylic acid compounds having 5-HT4 receptor agonistic activity
    • 具有5-HT 4受体激动活性的喹诺酮羧酸化合物
    • US07964727B2
    • 2011-06-21
    • US10595948
    • 2004-11-10
    • Tomoki KatoKiyoshi KawamuraMikio MoritaChikara Uchida
    • Tomoki KatoKiyoshi KawamuraMikio MoritaChikara Uchida
    • C07D221/02C07D215/00C07D413/00A01N43/40A01N43/42A61K31/435A61K31/44
    • C04B35/632C07D401/12C07D401/14C07D405/14
    • This invention provides a compound of the formula (I): wherein Het represents a heterocyclic group having one nitrogen atom, to which B binds directly, and from 4 to 7 carbon atoms, and said heterocyclic group being unsubstituted or substituted by 1 to 4 substituents independently selected from the group consisting of substituents α1; A represents an alkylene group having from 1 to 4 carbon atoms; B represents a covalent bond or an alkylene group having from 1 to 5 carbon atoms; R1 represents an isopropyl group, a n-propyl group or a cyclopentyl group; R2 represents a methyl group, a fluorine atom or a chlorine atom; R3 independently represents (i) an oxo group, a hydroxy group, an amino group, an alkylamino group or a carboxyl group; (ii) a cycloalkyl group having from 3 to 8 carbon atoms, and said cycloalkyl group being substituted by 1 to 5 substituents, or (iii) a heterocyclic group having from 3 to 8 atoms, and said heterocyclic group being unsubstituted or substituted by 1 to 5 substituents, and n is 1, 2 or 3, or a pharmaceutically acceptable salts thereof. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.
    • 本发明提供式(I)化合物:其中Het表示具有一个氮原子的杂环基团,B直接与该碳原子结合,并且具有4至7个碳原子,所述杂环基团未被取代或被1至4个取代基取代 独立地选自取代基α1; A表示具有1至4个碳原子的亚烷基; B表示共价键或具有1至5个碳原子的亚烷基; R1表示异丙基,正丙基或环戊基; R2表示甲基,氟原子或氯原子; R3独立地表示(i)氧代基,羟基,氨基,烷基氨基或羧基; (ii)具有3至8个碳原子的环烷基,所述环烷基被1至5个取代基取代,或(iii)具有3至8个原子的杂环基,所述杂环基未被取代或被1 至5个取代基,n为1,2或3,或其药学上可接受的盐。 这些化合物具有5-HT 4受体激动活性,因此可用于治疗哺乳动物特别是人类的胃食管反流病,非溃疡性消化不良,功能性消化不良,肠易激综合征等。
    • 10. 发明授权
    • Polymer, crosslinked polymer, composition for solid polymer electrolyte, solid polymer electrolyte, and adhesive composition
    • 聚合物,交联聚合物,固体聚合物电解质的组合物,固体聚合物电解质和粘合剂组合物
    • US07645830B2
    • 2010-01-12
    • US11795783
    • 2006-01-18
    • Takeshi NiitaniMasato AmaikeMikiya ShimadaKiyoshi Kawamura
    • Takeshi NiitaniMasato AmaikeMikiya ShimadaKiyoshi Kawamura
    • C08F118/02C08L31/02C09J167/06
    • C08F293/005C08F290/06C08F293/00C08F297/02C08F297/026C08G18/6229C08L25/04C08L27/16C08L29/02C08L53/00C08L71/02C08L75/04C08L2205/05C08L2666/02C09J153/00H01M10/052H01M10/0565H01M2300/0082C08L2666/04
    • A polymer including a block chain A which is formed from a random copolymer containing a repeating unit (I) represented by the formula (I) wherein R1 to R3 each independently represents hydrogen or C1-10 hydrocarbon and R1 and R3 may bond to form a ring; R4a and R4b each independently represents hydrogen or methyl; R5 represents hydrogen, hydrocarbon, acyl, or silyl; and m represents any integer of 1 to 100 and when m is 2 or more and each R4a may be the same or different from one another and each R4b may be the same or different from one another; and a repeating unit (II) represented by the formula (II) wherein R6 and R8 each independently represents hydrogen or C1-10 hydrocarbon and R6 and R8 may bond to form a ring; R7 represents hydrogen, C1-10 hydrocarbon, hydroxyl, hydrocarbonoxy, carboxyl, acid anhydride, amino, ester, or an organic group having at least one functional group selected from the group consisting of hydroxyl, carboxyl, epoxy, acid anhydride, and amino; and R9 represents an organic group having at least one functional group selected from the group consisting of hydroxyl, carboxyl, epoxy, acid anhydride, and amino; and a block chain B having a repeating unit (III) represented by the formula (III) wherein R10 to R12 each independently represents hydrogen or C1-10 hydrocarbon and R13 represents aryl or heteroaryl; and wherein an arrangement order thereof is B, A, B.
    • 一种包含嵌段链A的聚合物,其由含有式(I)表示的重复单元(I)的无规共聚物形成,其中R 1至R 3各自独立地表示氢或C 1-10烃,并且R 1和R 3可以键合形成 环; R4a和R4b各自独立地表示氢或甲基; R5表示氢,烃,酰基或甲硅烷基; m表示1〜100的整数,m为2以上时,各R​​ 4a可以相同也可以不同,各R 4a可以相同也可以不同。 和由式(II)表示的重复单元(II),其中R6和R8各自独立地表示氢或C1-10烃,R6和R8可以键合形成环; R7表示氢,C1-10烃,羟基,烃氧基,羧基,酸酐,氨基,酯或具有至少一个选自羟基,羧基,环氧基,酸酐和氨基的官能团的有机基团; 并且R 9表示具有至少一个选自羟基,羧基,环氧基,酸酐和氨基的官能团的有机基团; 和具有由式(III)表示的重复单元(III)的嵌段链B,其中R10至R12各自独立地表示氢或C1-10烃,R13表示芳基或杂芳基; 其布置顺序为B,A,B。