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    • 4. 发明申请
    • DRUG FOR ALLEVIATING MOTOR COMPLICATIONS OR PSYCHIATRIC SYMPTOMS OF PARKINSON'S DISEASE
    • 用于表达PARCINSON疾病的电机综合症或心理症状的药物
    • US20100204202A1
    • 2010-08-12
    • US12673786
    • 2008-11-28
    • Yoshihiro TaniMakoto Koyama
    • Yoshihiro TaniMakoto Koyama
    • A61K31/553A61P25/14A61P25/16
    • C07D413/14A61K31/198A61K31/553A61K45/06A61K2300/00
    • A drug containing a compound having the formula (I): or a pharmacologically acceptable salt thereof or their hydrates, which alleviates motor complications associated with a treatment with levodopa for Parkinson's disease, delays the onset of motor complications associated with a treatment with levodopa, and inhibiting or delaying the advance of symptoms of Parkinson's disease is provided. The compound having the formula (I) has a serotonin 1A receptor partial agonist action, does not have an antagonist action against dopamine D2 receptors, has an agonist action against dopamine D3 receptors, has an effect of alleviation and delay of onset of motor complications associated with repeated doses of levodopa and, further, is also effective against associated with psychiatric symptoms in advanced stage Parkinson's disease patients.
    • 含有具有式(I)化合物或其药理学上可接受的盐或其水合物的药物可缓解与用于帕金森病的左旋多巴治疗相关的运动并发症延迟了与左旋多巴治疗相关的运动并发症的发作,以及 提供抑制或延缓帕金森病症状的进展。 具有式(I)的化合物具有5-羟色胺1A受体部分激动剂作用,不具有针对多巴胺D2受体的拮抗作用,具有针对多巴胺D3受体的激动剂作用,具有减轻和延迟运动并发症发作相关的作用 重复剂量的左旋多巴,此外,还有效抵抗晚期帕金森病患者的精神症状。
    • 7. 发明授权
    • Non-halogen series floor material
    • 非卤素系列地板材料
    • US07094715B2
    • 2006-08-22
    • US10695450
    • 2003-10-29
    • Eiji SakaguchiMakoto KoyamaJunichi TakedaYoshiharu NishinoHiroaki Ishii
    • Eiji SakaguchiMakoto KoyamaJunichi TakedaYoshiharu NishinoHiroaki Ishii
    • B32B5/06B32B5/26
    • B32B27/20B32B5/30B32B7/02B32B25/10B32B27/32B32B2309/105B32B2323/10B32B2419/04E04F15/16Y10T428/2495Y10T428/24975Y10T428/26Y10T428/263Y10T428/266Y10T428/268Y10T428/269Y10T442/3886Y10T442/678Y10T442/699
    • A non-halogen series floor material includes a first intermediate resin layer containing filler of 100 to 400 mass parts with respect to resin ingredient of 100 mass parts, the resin ingredient consisting essentially of resin having no chlorine atom in chemical structure, a surface resin layer integrally formed at an upper surface side of the first intermediate resin layer, the surface resin layer containing resin having no chloride atom in chemical structure and having a thickness of 100 to 1,000 μm, a second intermediate resin layer integrally formed at a lower surface side of the first intermediate resin layer, the second intermediate resin layer containing resin having no chloride atom in chemical structure and filler of 0 to 200 mass parts with respect to resin ingredient of 100 mass parts, and a backing layer integrally formed at a lower surface side of the second intermediate resin layer, the backing layer being formed of a fibrous fabric constituted by fibers containing resin having no chloride atom in chemical structure. A content ratio of the filler in the second intermediate resin layer with respect to the resin ingredient thereof is smaller than a content ratio of the filler in the first intermediate resin layer with respect to the resin ingredient thereof. A thickness of the second intermediate resin layer is 100 μm or more. A thickness of the second intermediate resin layer is 50% or less of a total thickness of three resin layers.
    • 非卤素系列地板材料包括相对于100质量份的树脂成分含有100〜400质量份的填料的第一中间树脂层,所述树脂成分基本上由化学结构中没有氯原子的树脂组成,表面树脂层 一体地形成在第一中间树脂层的上表面侧,表面树脂层含有化学结构中没有氯原子的树脂,其厚度为100-1000μm,在第一中间树脂层的下表面一体形成的第二中间树脂层 第一中间树脂层,含有化学结构中不含氯原子的树脂的第二中间树脂层和相对于100质量份的树脂成分为0〜200质量份的填料,以及在第一中间树脂层的下表面侧一体形成的背衬层 第二中间树脂层,背衬层由由含树脂的纤维构成的纤维织物形成 化学结构中没有氯原子。 第二中间树脂层中的填料相对于树脂成分的含有率小于第一中间树脂层中的填料相对于树脂成分的含有比例。 第二中间树脂层的厚度为100μm以上。 第二中间树脂层的厚度为三层树脂层的总厚度的50%以下。
    • 8. 发明申请
    • Non-halogen series floor material
    • 非卤素系列地板材料
    • US20050095412A1
    • 2005-05-05
    • US10695450
    • 2003-10-29
    • Eiji SakaguchiMakoto KoyamaJunichi TakedaYoshiharu NishinoHiroaki Ishii
    • Eiji SakaguchiMakoto KoyamaJunichi TakedaYoshiharu NishinoHiroaki Ishii
    • B32B5/30B32B7/02E04F15/16B32B1/00B32B27/32
    • B32B27/20B32B5/30B32B7/02B32B25/10B32B27/32B32B2309/105B32B2323/10B32B2419/04E04F15/16Y10T428/2495Y10T428/24975Y10T428/26Y10T428/263Y10T428/266Y10T428/268Y10T428/269Y10T442/3886Y10T442/678Y10T442/699
    • A non-halogen series floor material includes a first intermediate resin layer containing filler of 100 to 400 mass parts with respect to resin ingredient of 100 mass parts, the resin ingredient consisting essentially of resin having no chlorine atom in chemical structure, a surface resin layer integrally formed at an upper surface side of the first intermediate resin layer, the surface resin layer containing resin having no chloride atom in chemical structure and having a thickness of 100 to 1,000 μm, a second intermediate resin layer integrally formed at a lower surface side of the first intermediate resin layer, the second intermediate resin layer containing resin having no chloride atom in chemical structure and filler of 0 to 200 mass parts with respect to resin ingredient of 100 mass parts, and a backing layer integrally formed at a lower surface side of the second intermediate resin layer, the backing layer being formed of a fibrous fabric constituted by fibers containing resin having no chloride atom in chemical structure. A content ratio of the filler in the second intermediate resin layer with respect to the resin ingredient thereof is smaller than a content ratio of the filler in the first intermediate resin layer with respect to the resin ingredient thereof. A thickness of the second intermediate resin layer is 100 μm or more. A thickness of the second intermediate resin layer is 50% or less of a total thickness of three resin layers.
    • 非卤素系列地板材料包括相对于100质量份的树脂成分含有100〜400质量份的填料的第一中间树脂层,所述树脂成分基本上由化学结构中没有氯原子的树脂组成,表面树脂层 一体地形成在第一中间树脂层的上表面侧,表面树脂层含有化学结构中没有氯原子的树脂,其厚度为100-1000μm,在第一中间树脂层的下表面一体形成的第二中间树脂层 第一中间树脂层,含有化学结构中不含氯原子的树脂的第二中间树脂层和相对于100质量份的树脂成分为0〜200质量份的填料,以及在第一中间树脂层的下表面侧一体形成的背衬层 第二中间树脂层,背衬层由由含树脂的纤维构成的纤维织物形成 化学结构中没有氯原子。 第二中间树脂层中的填料相对于树脂成分的含有率小于第一中间树脂层中的填料相对于树脂成分的含有比例。 第二中间树脂层的厚度为100μm以上。 第二中间树脂层的厚度为三层树脂层的总厚度的50%以下。