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1. 发明授权

US5378700A Fused pyrimidine derivative, process for preparation of same and pharmaceutical preparation comprising same as active ingredient 失效
标题翻译：熔融嘧啶衍生物，其制备方法和包含与活性成分相同的药物制剂
公开(公告)号：US5378700A
公开(公告)日：1995-01-03
申请号：US839769
申请日：1992-06-09
申请人： Yasuji Sakuma , Masaichi Hasegawa , Kenichiro Kataoka , Kenji Hoshina , Noboru Yamazaki , Takashi Kadota , Hisao Yamaguchi
发明人： Yasuji Sakuma , Masaichi Hasegawa , Kenichiro Kataoka , Kenji Hoshina , Noboru Yamazaki , Takashi Kadota , Hisao Yamaguchi
IPC分类号： A61K31/505 , A61K31/535 , A61K31/54 , A61K31/55 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： Disclosed is a fused pyrimidine of the formula [I] ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are as defined in the specification, Y represents a linking group of the formula ##STR2## wherein n is an integer of from 4 to 6, ##STR3## wherein A is a hydrogen atom or alkyl group; and Z represents a hydrogen atom, or other substituents; or Y and Z together represent an unsubstituted or substituted alkyl, alkenyl or arylalkyl group; or a 5- to 7-member heterocyclic ring which has a nitrogen atom, and further, an oxygen or sulfur atom as a hetero atom other than the nitrogen atom, being bonded via the nitrogen atom therein to the 4-position of the pyrimidine ring of the formula (I), a 5- to 7-member unsaturated heterocyclic ring which has 1 to 3 nitrogen atoms being bonded via the nitrogen atom therein to the 4-position of the pyrimidine ring of the formula (I), or a fused biheterocyclic ring constructed with 5- or 6-membered aromatic or non-aromatic rings, which has 1 to 3 nitrogen atoms in any position, being bonded via the nitrogen atom therein to the 4-position of the pyrimidine ring of the formula (I); andm is an integer of from 1 to 3;and a pharmaceutically acceptable acid addition salt thereof, as well as a process for producing same and a pharmaceutical preparation useful for a treatment of hypoxemia associated with respiratory diseases.
摘要翻译： PCT No.PCT / JP90 / 01313 Sec。 371日期：1992年6月9日 102（e）日期1992年6月9日PCT提交1990年10月11日PCT公布。出版物WO91 / 05784 日期：1991年5月2日。公开是式[I]的融合嘧啶其中R 1，R 2和R 3如说明书中所定义，Y表示式的连接基团，其中n 是4至6的整数，其中A是氢原子或烷基; O（S） Z表示氢原子或其它取代基; 或Y和Z一起表示未取代或取代的烷基，烯基或芳基烷基; 或具有氮原子的5-至7-元杂环，以及作为氮原子以外的杂原子的氧或硫原子通过氮原子键合到嘧啶环的4-位上式（I）的通式（I）中的氮原子数为1〜3的5〜7元不饱和杂环与式（I）的嘧啶环的4-位连接，在其中具有1至3个氮原子的5-或6-元芳族或非芳族环经由其中的氮原子键合到式（I）的嘧啶环的4-位上构成的双杂环， ; m为1〜3的整数，和其药学上可接受的酸加成盐，以及其制备方法和用于治疗与呼吸系统疾病相关的低氧血症的药物制剂。

2. 发明授权

US5661148A Pyrrolo[2,3-d]pyrimidine derivatives, process for producing the same and pharmaceutical preparation comprising the same as active ingredient 失效
标题翻译：吡咯并[2,3-d]嘧啶衍生物，其制备方法以及含有活性成分的药物制剂
公开(公告)号：US5661148A
公开(公告)日：1997-08-26
申请号：US478686
申请日：1995-06-07
申请人： Yasuji Sakuma , Masaichi Hasegawa , Kenichiro Kataoka , Kenji Hoshina , Noboru Yamazaki , Takashi Kadota , Hisao Yamaguchi
发明人： Yasuji Sakuma , Masaichi Hasegawa , Kenichiro Kataoka , Kenji Hoshina , Noboru Yamazaki , Takashi Kadota , Hisao Yamaguchi
IPC分类号： C07D487/04 , C07D519/00 , A61K31/305 , C07D239/48
CPC分类号： C07D487/04
摘要： A pyrrolo[2,3-d]pyrimidine derivative having the general formula [I] ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Y and Z have the same definitions as those given in the description, a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutical preparation comprising the same, are provided.
摘要翻译：具有通式[I]的吡咯并[2,3-d]嘧啶衍生物其中R1，R2，R3，R4，R5，Y和Z具有与说明书中给出的相同的定义，提供其药学上可接受的酸加成盐和包含其的药物制剂。

3. 发明授权

US5689965A Air conditioner 失效
标题翻译：冷气机
公开(公告)号：US5689965A
公开(公告)日：1997-11-25
申请号：US751791
申请日：1996-11-18
申请人： Hiroshi Takenaka , Hirokiyo Terada , Minetoshi Izushi , Kensaku Oguni , Makoto Nagai , Shunji Sasaki , Yasuji Sakuma , Kenji Tokusa
发明人： Hiroshi Takenaka , Hirokiyo Terada , Minetoshi Izushi , Kensaku Oguni , Makoto Nagai , Shunji Sasaki , Yasuji Sakuma , Kenji Tokusa
IPC分类号： F24F11/02 , F24F3/06 , F24F11/00 , F25B13/00 , F25B41/04 , F25B41/06 , F25B49/02 , F25B41/00 , G05D23/00
CPC分类号： F24F3/065 , F24F11/008 , F25B13/00 , F25B41/062 , F24F2011/0043 , F25B2313/023 , F25B2341/0653 , Y02B30/72
摘要： An air conditioner comprises a first unit including a compressor and a heat exchanger, a second unit including a heat exchanger, a refrigerant circuit connecting the compressor and the heat exchanger of the first unit, with the heat exchanger of the second unit, through which a refrigerant flows, a refrigerant pressure reduction valve disposed in the refrigerant circuit and provided in the second unit, a control unit provided in the first unit for controlling the refrigerant pressure reduction valve in the second unit.
摘要翻译：空调机包括：第一单元，包括压缩机和热交换器;第二单元，包括热交换器，连接压缩机和第一单元的热交换器的制冷剂回路与第二单元的热交换器连接，制冷剂流动，设置在制冷剂回路中并设置在第二单元中的制冷剂减压阀，设置在第一单元中的控制单元，用于控制第二单元中的制冷剂减压阀。

4. 发明授权

US6028208A Vitamin D.sub.3 derivative and treating agent for inflammatory respiratory disease using same 失效
标题翻译：维生素D3衍生物和用于炎性呼吸系统疾病的治疗剂
公开(公告)号：US6028208A
公开(公告)日：2000-02-22
申请号：US242665
申请日：1999-02-22
申请人： Qingzhi Gao , Kenji Manabe , Minoru Furuya , Manabu Chokki , Hiroaki Mitsuhashi , Seiichi Ishizuka , Tadashi Kishimoto , Masayasu Tabe , Yasuji Sakuma , Atsuo Hazato , Hiroko Tanaka
发明人： Qingzhi Gao , Kenji Manabe , Minoru Furuya , Manabu Chokki , Hiroaki Mitsuhashi , Seiichi Ishizuka , Tadashi Kishimoto , Masayasu Tabe , Yasuji Sakuma , Atsuo Hazato , Hiroko Tanaka
IPC分类号： C07C401/00 , A61K31/59
CPC分类号： C07C401/00
摘要： Provided are vitamin D.sub.3 derivatives expressed by the following general formula [1] ##STR1## [wherein, R.sub.1 and R.sub.2 are each a hydrogen atom, a trialkylsilyl group, an acetyl group, a methoxymethyl group, or a tetrahydropyranyl group; R.sub.3 and R.sub.4 are each a hydrogen atom, a hydroxyl group, an acyloxy group, an alkyloxy group, an alkylthio group or an alkyl group which is optionally substituted; R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are each a hydrogen atom, a hydroxyl group, an alkyl group or an acyloxy group; R.sub.9 is a hydrogen atom, a hydroxyl group, an alkyl group or an alkylthio group; R.sub.10 is a hydrogen atom, an alkyl group or an alkyloxy group; A and B are each a hydrogen atom, a hydroxyl group, or together express a single bond; X and Y express a carbonyl oxygen, or one of them is a hydrogen atom and the other is a hydroxyl group or an acyloxy group; n is an integer of 0 to 2; m is an integer of 0 to 2], and a method for manufacturing the derivatives.The compounds can be sued as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis and dermatitis.
摘要翻译： PCT No.PCT / JP98 / 02813 Sec。一九九九年二月二十二日 102（e）1999年2月22日PCT提交1998年6月24日PCT公布。公开号WO98 / 58909 日期：1998年12月30日提供由以下通式[1]表示的维生素D3衍生物[其中，R1和R2各自为氢原子，三烷基甲硅烷基，乙酰基，甲氧基甲基或四氢吡喃基; R3和R4各自为氢原子，羟基，酰氧基，烷氧基，烷硫基或任选取代的烷基; R5，R6，R7和R8分别是氢原子，羟基，烷基或酰氧基; R9为氢原子，羟基，烷基或烷硫基; R 10是氢原子，烷基或烷氧基; A和B各自为氢原子，羟基，或一起表示单键; X和Y表示羰基氧，或者其中一个是氢原子，另一个是羟基或酰氧基; n为0〜2的整数， m为0〜2的整数]，以及该衍生物的制造方法。这些化合物可以作为炎性呼吸系统疾病，恶性肿瘤，类风湿性关节炎，骨质疏松症，糖尿病，高血压，脱发，痤疮，牛皮癣和皮炎的治疗剂的活性成分。

5. 发明授权

US5956962A Air conditioner 失效
标题翻译：冷气机
公开(公告)号：US5956962A
公开(公告)日：1999-09-28
申请号：US907159
申请日：1997-08-06
申请人： Hiroshi Takenaka , Hirokiyo Terada , Minetoshi Izushi , Kensaku Oguni , Makoto Nagai , Shunji Sasaki , Yasuji Sakuma , Kenji Tokusa
发明人： Hiroshi Takenaka , Hirokiyo Terada , Minetoshi Izushi , Kensaku Oguni , Makoto Nagai , Shunji Sasaki , Yasuji Sakuma , Kenji Tokusa
IPC分类号： F24F11/02 , F24F3/06 , F24F11/00 , F25B13/00 , F25B41/04 , F25B41/06 , F25B49/02 , F25B41/00 , G05D23/00
CPC分类号： F24F3/065 , F24F11/008 , F25B13/00 , F25B41/062 , F24F2011/0043 , F25B2313/023 , F25B2341/0653 , Y02B30/72
摘要： An air conditioner in accordance with the invention comprises a first unit including a compressor and a heat exchanger; a second unit including a heat exchanger; a refrigerant circuit connecting the compressor and the heat exchanger of the first unit, with the heat exchanger of the second unit, through which a refrigerant flows; a refrigerant pressure reduction valve disposed in the refrigerant circuit and provided in the second unit; a control unit provided in the first unit for controlling the refrigerant pressure reduction valve in the second unit.
摘要翻译：根据本发明的空调器包括：第一单元，包括压缩机和热交换器; 包括热交换器的第二单元; 连接第一单元的压缩机和热交换器的制冷剂回路与制冷剂流过的第二单元的热交换器; 制冷剂减压阀，设置在制冷剂回路中并设置在第二单元中; 控制单元，设置在第一单元中，用于控制第二单元中的制冷剂减压阀。

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