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    • 1. 发明申请
    • SUSTAINED RELEASE PREPARATION AND METHOD FOR PRODUCTION THEREOF
    • 可持续发布准备及其生产方法
    • US20100172988A1
    • 2010-07-08
    • US12159281
    • 2006-12-26
    • Yasuhiro TakedaMasayuki WatanabeAyumu Nishida
    • Yasuhiro TakedaMasayuki WatanabeAyumu Nishida
    • A61K31/216A61P13/00A61K9/10
    • A61K9/2054A61K9/2027A61K9/2031A61K31/222
    • Disclosed is a sustained release preparation which comprises an active ingredient having a higher release rate at pH 4 compared to that in pH 1.2 or pH 6.8 and exerts a controlled release of the active ingredient in a pH-independent manner. The sustained release preparation comprises ethyl (−)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethyl-phenoxy]acetate hydrochloride as the active ingredient and a pH-independent gel-forming polymer and contains substantially no pH-controlling agent other than the polymer. The sustained release preparation can release the active ingredient in a pH-independent manner in the range from 1.2 to 6.8 and shows a constant release rate for a prolonged period of time. Therefore, the preparation is useful as a therapeutic agent for frequent urination/incontinence of urine which has a long-lasting effect.
    • 公开了一种持续释放制剂,其包含与pH 1.2或pH 6.8相比在pH 4下具有更高释放速率的活性成分,并以pH无关的方式进行有效成分的控制释放。 持续释放制剂包括( - ) - 2- [4- [2 - [[(1S,2R)-2-羟基-2-(4-羟基苯基)-1-甲基乙基]氨基]乙基] - 二甲基 - 苯氧基]乙酸酯盐酸盐作为活性成分,并且与pH无关的凝胶形成聚合物基本上不含聚合物以外的pH控制剂。 持续释放制剂可以以不依赖于pH的方式在1.2至6.8的范围内释放活性成分,并且在长时间内显示恒定的释放速率。 因此,该制剂可用作尿液尿频尿失禁的治疗剂,其具有持久的效果。
    • 4. 发明授权
    • Vehicle steering apparatus and vehicle steering method
    • 车辆转向装置和车辆转向方法
    • US07753162B2
    • 2010-07-13
    • US11492193
    • 2006-07-25
    • Yuuki ShiozawaHiroshi MouriMasahiro KubotaRyota ShiratoNami NagaeMasayuki Watanabe
    • Yuuki ShiozawaHiroshi MouriMasahiro KubotaRyota ShiratoNami NagaeMasayuki Watanabe
    • B62D5/04
    • B62D5/0472B62D6/04
    • A vehicle steering apparatus includes a vehicle steering system and a supplemental steering force applying device. The supplemental steering force applying device is configured and arranged to apply a supplemental steering force to the vehicle steering system to reduce a steering load on the operator. The supplemental steering force applying device includes a steering torque detecting section, a rectilinear driving condition detecting section, a pulling suppression control section. The rectilinear driving condition detecting section is configured and arranged to detect a rectilinear driving condition of the vehicle. The pulling suppression control section is configured and arranged to adjust the supplemental steering force in a direction canceling a pulling force imparted on the vehicle during the rectilinear driving condition by using a pulling suppression force calculated based on historical data of the steering torque detected during the rectilinear driving condition.
    • 车辆转向装置包括车辆转向系统和辅助转向力施加装置。 补充转向力施加装置被构造和布置成向车辆转向系统施加补充转向力以减少操作者的转向负载。 辅助转向力施加装置包括转向转矩检测部,直线驱动条件检测部,牵引抑制控制部。 所述直线行驶状态检测部被构造和配置为检测所述车辆的直线行驶状态。 牵引抑制控制部被构造和布置成通过使用基于在直线状态下检测到的转向扭矩的历史数据计算出的拉力抑制力,在取消在直线行驶状态期间赋予车辆的拉力的方向上调整辅助转向力 驾驶条件。