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1. 发明授权

US06969524B1 Interferon complex and medicinal use thereof 失效
标题翻译：干扰素复合物及其药用
公开(公告)号：US06969524B1
公开(公告)日：2005-11-29
申请号：US10110420
申请日：2000-10-12
申请人： Yasuhiko Tabata , Saburo Sone , Mayumi Seto , Miyuki Sato
发明人： Yasuhiko Tabata , Saburo Sone , Mayumi Seto , Miyuki Sato
IPC分类号： A61K38/21 , A61K47/48 , A61P27/02 , A61P35/00 , A61F2/02
CPC分类号： A61K38/215 , A61K38/21 , A61K47/61
摘要： An object of the present invention is to provide modified IFN so that duration of IFN in blood is prolonged and IFN acts specifically on tissues having neovasculature, particularly tumors or ophthalmic tissues having neovasculature. The present invention provides an interferon-dextran complex obtained by mixing interferon with dextran having chelate ligands in the presence of a metal ion.
摘要翻译：本发明的目的是提供修饰的IFN，使得IFN在血液中的持续时间延长，并且IFN特异性地对具有新血管系统的组织起作用，特别是具有新血管系统的肿瘤或眼科组织。本发明提供通过在金属离子的存在下将干扰素与具有螯合配体的葡聚糖混合而获得的干扰素 - 葡聚糖复合物。

2. 发明授权

US08414924B2 Preparation for treating heart disease used in cell therapy 有权
标题翻译：用于治疗细胞治疗中使用的心脏病的制剂
公开(公告)号：US08414924B2
公开(公告)日：2013-04-09
申请号：US12681940
申请日：2008-10-09
申请人： Hidemasa Oh , Naofumi Takehara , Hiroaki Matsubara , Yasuhiko Tabata
发明人： Hidemasa Oh , Naofumi Takehara , Hiroaki Matsubara , Yasuhiko Tabata
IPC分类号： A61K35/34 , A61K9/00 , A61P9/00
CPC分类号： A61L27/24 , A61L27/222 , A61L27/3834 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/414 , C12N5/0657 , C12N2501/115 , C12N2533/54
摘要： An object of the present invention is to establish a cell transplantation method which can markedly improve the survival of grafted pluripotent stem cells and the efficiency of cardiomyocyte regeneration in cell therapy using pluripotent stem cells derived from heart tissue and can treat heart disease further effectively. Specifically, according to the present invention, enhancement in the survival of grafted pluripotent stem cells and significant improvement in the efficiency of cardiomyocyte regeneration are achieved by using, in combination, pluripotent stem cells derived from heart tissue and a hydrogel containing a basic fibroblast growth factor (bFGF) in cell therapy for heart disease.
摘要翻译：本发明的目的是建立一种可以显着提高移植多能干细胞的存活率和使用源自心脏组织的多能干细胞进行细胞治疗的心肌细胞再生的效率的细胞移植方法，并可进一步有效治疗心脏病。具体地，根据本发明，通过组合使用衍生自心脏组织的多能干细胞和含有碱性成纤维细胞生长因子的水凝胶来实现移植多能干细胞的存活的增强和心肌细胞再生效率的显着改善（bFGF）在心脏病的细胞治疗中。

3. 发明申请

US20100303909A1 PREPARATION FOR TREATING HEART DISEASE USED IN CELL THERAPY 有权
标题翻译：用于治疗细胞治疗中使用的心脏疾病的准备
公开(公告)号：US20100303909A1
公开(公告)日：2010-12-02
申请号：US12681940
申请日：2008-10-09
申请人： Hidemasa Oh , Naofumi Takehara , Hiroaki Matsubara , Yasuhiko Tabata
发明人： Hidemasa Oh , Naofumi Takehara , Hiroaki Matsubara , Yasuhiko Tabata
IPC分类号： A61K35/34 , A61K9/00 , A61P9/00
CPC分类号： A61L27/24 , A61L27/222 , A61L27/3834 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/414 , C12N5/0657 , C12N2501/115 , C12N2533/54
摘要： An object of the present invention is to establish a cell transplantation method which can markedly improve the survival of grafted pluripotent stem cells and the efficiency of cardiomyocyte regeneration in cell therapy using pluripotent stem cells derived from heart tissue and can treat heart disease further effectively. Specifically, according to the present invention, enhancement in the survival of grafted pluripotent stem cells and significant improvement in the efficiency of cardiomyocyte regeneration are achieved by using, in combination, pluripotent stem cells derived from heart tissue and a hydrogel containing a basic fibroblast growth factor (bFGF) in cell therapy for heart disease.
摘要翻译：本发明的目的是建立一种可以显着提高移植多能干细胞的存活率和使用源自心脏组织的多能干细胞进行细胞治疗的心肌细胞再生的效率的细胞移植方法，并可进一步有效治疗心脏病。具体地，根据本发明，通过组合使用衍生自心脏组织的多能干细胞和含有碱性成纤维细胞生长因子的水凝胶来实现移植多能干细胞的存活的增强和心肌细胞再生效率的显着改善（bFGF）在心脏病的细胞治疗中。

4. 发明申请

US20090269404A1 Crosslinked Gelatin Gel, Multilayered Structure, Carrier for Bioactive Factor, Preparation for Release of Bioactive Factor, and Their Production Methods 审中-公开
标题翻译：交联明胶，多层结构，生物活性因子载体，生物活性因子释放制剂及其制备方法
公开(公告)号：US20090269404A1
公开(公告)日：2009-10-29
申请号：US12375920
申请日：2007-07-31
申请人： Tomoyuki Ishiguro , Kenji Fukano , Yasuhiko Tabata
发明人： Tomoyuki Ishiguro , Kenji Fukano , Yasuhiko Tabata
IPC分类号： A61K9/00 , A61K47/42 , A61K38/16 , A61K31/7052 , C08F2/54 , A61P43/00
CPC分类号： A61K38/1825 , A61K47/42
摘要： A multi-layer crosslinked gelatin gel structure having a layer structure that plural layers of crosslinked gelatin gel crosslinked by irradiating gelatin or a gelatin derivative with electron beam under an oxygen-containing atmosphere are arranged adjoiningly to each other, a preparation for release of a bioactive factor with the bioactive factor contained in the multi-layer crosslinked gelatin gel structure, and production processes thereof.
摘要翻译：具有层状结构的多层交联明胶凝胶结构，其中在含氧气氛下通过照射明胶或明胶衍生物与电子束交联的多层交联明胶凝胶彼此相邻地布置，用于释放生物活性的制剂与多层交联明胶凝胶结构中所含的生物活性因子的因素及其制备方法。

5. 发明申请

US20090203768A1 NUCLEIC ACID-CONTAINING COMPLEX 审中-公开
标题翻译：含有核酸的复合物
公开(公告)号：US20090203768A1
公开(公告)日：2009-08-13
申请号：US11740200
申请日：2007-04-25
申请人： Hidezo Mori , Yasuhiko Tabata , Kiyoshi Ando , Etsuro Tanaka , Harukazu Iseki , Hiromi Sakamoto , Naoto Fukuyama , Hirofumi Kasahara
发明人： Hidezo Mori , Yasuhiko Tabata , Kiyoshi Ando , Etsuro Tanaka , Harukazu Iseki , Hiromi Sakamoto , Naoto Fukuyama , Hirofumi Kasahara
IPC分类号： A61K31/7088 , A61P35/00 , A61K9/14
CPC分类号： A61K47/643
摘要： A nucleic acid-containing complex, containing a nucleic acid and a biodegradable polymer, especially a positively-charged water-insoluble biodegradable polymer, is disclosed. The complex has excellent properties of sustainedly releasing a desired nucleic acid, especially DNA, to a site in need of a treatment. Since the complex can be taken up to phagocytes such as macrophages and delivered specifically to the target site, the function of the nucleic acid can be exhibited in a target site specific manner, and thus more specific gene therapy can be achieved. The complex has no adverse effects, such as occurrence of recombinants or toxicity which could be caused by using a virus vector such as adenovirus, or liposome. Thus, the complex is particularly preferable for the field of gene therapy. Furthermore, the complex enhances the biological effect of the nucleic acid introduced into the cells, allowing a gene therapy with a lower dose of nucleic acids.
摘要翻译：公开了含有核酸和可生物降解的聚合物，特别是带正电的水不溶性可生物降解聚合物的含核酸复合物。该复合物具有将期望的核酸，特别是DNA持续释放到需要治疗的部位的优异性质。由于复合物可以被吸收到诸如巨噬细胞的吞噬细胞并且特异性递送到靶位点，因此可以以靶位点特异性方式显示核酸的功能，从而可以实现更具体的基因治疗。该复合物没有不利影响，例如可能由使用病毒载体如腺病毒或脂质体引起的重组体或毒性的发生。因此，该复合物对于基因治疗领域是特别优选的。此外，复合物增强引入细胞的核酸的生物学效应，允许用较低剂量的核酸进行基因治疗。

6. 发明申请

US20060259130A1 Device for blocing blood vessel 审中-公开
标题翻译：血管血管装置
公开(公告)号：US20060259130A1
公开(公告)日：2006-11-16
申请号：US10544621
申请日：2004-02-06
申请人： Yasuhiko Tabata , Susumu Miyamoto , Keisuke Yamada
发明人： Yasuhiko Tabata , Susumu Miyamoto , Keisuke Yamada
IPC分类号： A61F2/06
CPC分类号： A61L31/145 , A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/1219 , A61L31/022 , A61L31/047
摘要： Disclosed is a device for occlusion of blood vessel comprising a metallic coil, a sustained-release element and a cell growth factor. Examples of the cell growth factor include basic fibroblast growth factor (bFGF), acidic fibroblast growth factor (aFGF), platelet-derived growth factor (PDGF), transforming growth factor β1 (TGC-β1), vascular endothelia growth factor (VEGF) and connective tissue growth factor (CTGF). Examples of the sustained-release element include a hydrophilic hydrogel. By using the device for occlusion of blood vessel according to the present invention, a blood vessel site such as aneurysm is occluded, and preferably, organization may be induced in vivo.
摘要翻译：公开了一种用于闭塞血管的装置，其包括金属线圈，缓释元件和细胞生长因子。细胞生长因子的实例包括碱性成纤维细胞生长因子（bFGF），酸性成纤维细胞生长因子（aFGF），血小板衍生生长因子（PDGF），转化生长因子β1（TGC-β1），血管内皮生长因子（VEGF）和结缔组织生长因子（CTGF）。缓释元件的实例包括亲水性水凝胶。通过使用根据本发明的血管阻塞装置，血管部位例如动脉瘤被闭塞，优选地可以在体内诱导组织。

7. 发明授权

US06732738B1 Method to enhance healing of sternum after sternotomy 有权
标题翻译：胸骨切开后胸骨愈合的方法
公开(公告)号：US06732738B1
公开(公告)日：2004-05-11
申请号：US09687379
申请日：2000-10-13
申请人： Masashi Komeda , Yasuhiko Tabata
发明人： Masashi Komeda , Yasuhiko Tabata
IPC分类号： A61B1900
CPC分类号： A61K38/1825
摘要： There are disclosed a method to enhance sternal treatment after sternotomy with or without removal of at least one of thoracic arteries which comprises applying an agent for the treatment of sternum after sternotomy to or at around the sternum, wherein the agent comprises at least one selected from the group consisting of an angiogenetic factor, an osteogenetic factor and their analogues such as bFGF, aFGF, TGF &bgr;, VEGF, HGF, BMP, PDGF, TGF &agr;, other cytokines or gene as an effective ingredient and an agent to be used for the method; and an agent to enhance healing of or treating sternum after sternotomy comprising the same.
摘要翻译：公开了一种在胸骨切开术之后加强或不去除胸廓动脉中的至少一种来增强胸骨治疗的方法，其包括在胸骨切开后或在胸骨周围施用用于治疗胸骨的药剂，其中所述药剂包含选自以下的至少一种：由血管生成因子，成骨因子及其类似物组成的组，例如bFGF，aFGF，TGFβ，VEGF，HGF，BMP，PDGF，TGFα，其他细胞因子或基因作为有效成分，以及用于方法; 以及用于增强胸骨切开术后胸骨愈合或治疗胸骨的药剂。

8. 发明授权

US09259485B2 Kidney-imaging agent comprising recombinant gelatin 有权
标题翻译：包含重组明胶的肾显像剂
公开(公告)号：US09259485B2
公开(公告)日：2016-02-16
申请号：US13387632
申请日：2010-07-30
申请人： Kentaro Nakamura , Yasuhiko Tabata
发明人： Kentaro Nakamura , Yasuhiko Tabata
IPC分类号： A61K49/00 , A61K51/08 , C07K14/78
CPC分类号： A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/78
摘要： An object of the present invention is to provide a kidney-imaging agent which is composed of bioabsorbable materials, transiently accumulates in a kidney for a short period of time, and does not remain in the kidney for a prolonged time after accumulation. The present invention provides a kidney-imaging agent which comprises a gelatin-like protein.
摘要翻译：本发明的目的是提供一种由生物可吸收材料组成的肾脏显像剂，其在肾脏中短时间积累，并且在积累后不滞留在肾脏中延长的时间。本发明提供了包含明胶样蛋白质的肾显像剂。

9. 发明授权

US09107953B2 Sustained release composition containing SDF-1 有权
标题翻译：含有SDF-1的缓释组合物
公开(公告)号：US09107953B2
公开(公告)日：2015-08-18
申请号：US13771511
申请日：2013-02-20
申请人： ONO PHARMACEUTICAL CO., LTD. , Yasuhiko Tabata
发明人： Yasuhiko Tabata
IPC分类号： A61K38/18 , A61K8/65 , A61K9/52 , C07K14/52 , A61K47/42 , A61K9/00 , A61K38/19
CPC分类号： A61K47/42 , A61K9/0002 , A61K9/0019 , A61K9/0024 , A61K38/195
摘要： An object of the present invention is to provide a sustained release composition containing SDF-1. The present invention provides a sustained release composition containing (1) SDF-1 and (2) a hydrogel containing modified gelatin having a carboxyl group and/or a sulfo group. Since the composition can release SDF-1, a chemokine which is a capable of promoting accumulation of vascular progenitor cells in vivo, in the sustained manner, it can be useful for treatment and/or suppression of symptom progression of ischemic disease or bone disease, as pharmaceutical preparations in various formulations.
摘要翻译：本发明的目的是提供含有SDF-1的缓释组合物。本发明提供了含有（1）SDF-1和（2）含有具有羧基和/或磺基的改性明胶的水凝胶的缓释组合物。由于组合物可以以持续的方式释放能够促进体内血管祖细胞积聚的趋化因子SDF-1，因此可用于治疗和/或抑制缺血性疾病或骨疾病症状进展，作为各种制剂中的药物制剂。

10. 发明授权

US09040070B2 Material for induction of hard tissue regeneration 有权
标题翻译：用于诱导硬组织再生的材料
公开(公告)号：US09040070B2
公开(公告)日：2015-05-26
申请号：US13502627
申请日：2010-10-19
申请人： Shinichi Okamoto , Yasuhiko Tabata
发明人： Shinichi Okamoto , Yasuhiko Tabata
IPC分类号： A61F2/28 , A61F2/00 , A61L27/36 , A61L27/46 , A61L27/56
CPC分类号： A61L27/3645 , A61L27/3616 , A61L27/46 , A61L27/56 , A61L2430/02 , C08L89/06
摘要： The present invention relates to a material for induction of hard tissue regeneration, comprising platelet-rich plasma and gelatin β-TCP sponge, which promotes angiogenesis, osteogenesis, chondrogenesis and the like.
摘要翻译：本发明涉及用于诱导硬组织再生的材料，其包含富含血小板的血浆和明胶和-TCP海绵，其促进血管生成，成骨，软骨形成等。

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