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1. 发明申请

US20060165655A1 Therapeutic furopyrimidines and thienopyrimidines 有权
标题翻译：治疗性呋喃嘧啶和噻吩并嘧啶
公开(公告)号：US20060165655A1
公开(公告)日：2006-07-27
申请号：US11332858
申请日：2006-01-16
申请人： Yarlagadda Babu , Pooran Chand , Minwan Wu , Pravin Kotian , V. Kumar , Tsu-Hsing Lin , Yahya El-Kattan , Ajit Ghosh
发明人： Yarlagadda Babu , Pooran Chand , Minwan Wu , Pravin Kotian , V. Kumar , Tsu-Hsing Lin , Yahya El-Kattan , Ajit Ghosh
IPC分类号： A61K38/21 , A61K31/675 , A61K31/7076
CPC分类号： C07D495/04 , A61K31/675 , A61K31/7076 , A61K38/212 , A61K38/2292 , C07D491/048 , C07D493/04 , C07F9/6561 , C07H7/06 , C07H19/22 , Y02A50/393 , Y02A50/465 , A61K2300/00
摘要： The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and III are useful as anti-viral agents and/or as anti-cancer agents.
摘要翻译：本发明提供了本文所述的式I，II和III的化合物，以及包含该化合物的药物组合物，以及可用于制备化合物的合成方法和中间体。式I，II和III的化合物可用作抗病毒剂和/或作为抗癌剂。

2. 发明申请

US20060234963A1 Hepatitis C therapies 有权
公开(公告)号：US20060234963A1
公开(公告)日：2006-10-19
申请号：US11388060
申请日：2006-03-23
申请人： Yarlagadda Babu , Pooran Chand , Minwan Wu , Pravin Kotian , V. Kumar , Tsu-Hsing Lin , Yahya El-Kattan , Ajit Ghosh
发明人： Yarlagadda Babu , Pooran Chand , Minwan Wu , Pravin Kotian , V. Kumar , Tsu-Hsing Lin , Yahya El-Kattan , Ajit Ghosh
IPC分类号： C07H19/22 , A61K31/7064
CPC分类号： A61K31/7064 , A61K31/7056 , A61K31/7068 , A61K38/212 , A61K38/2292 , A61K45/06 , C07H7/06 , C07H11/04 , C07H19/22 , Y02A50/393 , Y02A50/465
摘要： The invention provides methods for treating hepatitis C viral infections and related viral infections, as well as compounds and compositions that are useful for treating such infections.

3. 发明申请

US20050080053A1 Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases 审中-公开
标题翻译：核苷类，其制备和用作RNA病毒聚合酶的抑制剂
公开(公告)号：US20050080053A1
公开(公告)日：2005-04-14
申请号：US10928177
申请日：2004-08-30
申请人： Yarlagadda Babu , Pooran Chand , Yahya El-Kattan , Pravin Kotian , Minwan Wu
发明人： Yarlagadda Babu , Pooran Chand , Yahya El-Kattan , Pravin Kotian , Minwan Wu
IPC分类号： A61K31/675 , C07F9/6561
CPC分类号： C07F9/65616
摘要： Compounds represented by the formula: Wherein A is —(CH2)n—R, —CH═CH2, —CH2—CH═CH2, —O—(CH2)n—R, —CH(OH)CH3, —CH(OH)—CH2OH, —CH2—CH(OH)CH3, —CH2—CH(OH)—CH2OH, —CH(OH)—CH(OH)—CH3; R is H, OH, F, N3, NH2, CO2H, SH, alkyl, S-alkyl, O-acyl, CONH2, CONH-alkyl; Z and Z′ independently is OR′, OR2, O—(CH2)n—O-alkyl or aminoacids and esters thereof; R1 and R2 independently is H, alkyl, aryl, pivaloyloxymethyl, phthalyl or substituted phthalyl, C(R3)2OC(O) X (R4)a, R3 is —H, C1-C12 alkyl, C5-C12 aryl, C2-C12 alkenyl, C2-C12 alkynyl, C7-C12 alkenylaryl, C7-C12 alkynylaryl, or C6-C12 alkaryl, any of which is unsubstituted or is substituted with 1 or 2 halo, cyano, azido, nitro, or —OR5; R4 is —H, C1-C12 alkyl, C5-C12 aryl, C2-C12 alkenyl, C2-C12 alkynyl, C7-C12 alkenylaryl, C7-C12 alkynylaryl, or C6-C12 alkaryl, any of which is unsubstituted or is substituted with 1 or 2 halo, cyano, azido, nitro, —N(R6)2 or —OR5; R5 is C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl or C5-C12 aryl; provided that at least one R4 is not H; and a is 1 when X is CH2, or direct bond, or 1 or 2 when X is N with the proviso that when a is 2 and X is N, (a) two N-linked R groups can be taken together to form a carbocyclic or oxygen containing heterocycle, (b) one N-linked R4 additionally can be —OR5 or (c) both N-linked R4 groups can be —H; R6 is H or C1-C8 alkyl; R7 is selected from H, alkyl, alkenyl, alkynyl, aryl, acyloxyalkyl, and pivaloyloxyalkyl; n is 1-3; Y is O, S or NH; W is O or S; B is selected from the group consisting of adenine, guanine, and modified purines are provided.
摘要翻译：由下式表示的化合物：其中A是 - （CH2）nR，-CH = CH2，-CH2-CH = CH2，-O-（CH2）nR，-CH（OH）CH3，-CH（OH）-CH2OH， -CH 2 -CH（OH）CH 3，-CH 2 -CH（OH）-CH 2 OH，-CH（OH）-CH（OH）-CH 3; R是H，OH，F，N 3，NH 2，CO 2 H，SH，烷基，S-烷基，O-酰基，CONH 2，CONH-烷基; Z和Z'独立地是OR'，OR 2，O-（CH 2）n -O-烷基或其氨基酸及其酯; R 1和R 2独立地是H，烷基，芳基，新戊酰氧基甲基，邻苯二甲酰基或取代的邻苯二甲酰基，C（R 3）2 OC（O）X（R 4）a，R 3是 - H，C 1 -C 12烷基，C 5 -C 12芳基，C 2 -C 12烯基，C 2 -C 12炔基，C 7 -C 12链烯基芳基，C 7 -C 12炔基芳基或C 6 -C 12烷芳基，其中任何一个是未取代的或被1或2 卤素，氰基，叠氮基，硝基或-OR 5; R 4是-H，C 1 -C 12烷基，C 5 -C 12芳基，C 2 -C 12烯基，C 2 -C 12炔基，C 7 -C 12链烯基芳基，C 7 -C 12炔基芳基或C 6 -C 12烷芳基，其中任何一个是未取代的或被1或2个卤素，氰基，叠氮基，硝基，-N（R 6）2或-OR 5取代; R 5是C 1 -C 12烷基，C 5

4. 发明申请

US20060128789A1 Process for the preparation of substituted pyrrolidine derivatives and intermediates 有权
标题翻译：取代的吡咯烷衍生物和中间体的制备方法
公开(公告)号：US20060128789A1
公开(公告)日：2006-06-15
申请号：US11210691
申请日：2005-08-25
申请人： Pooran Chand , Yahya El-Kattan , Pravin Kotian
发明人： Pooran Chand , Yahya El-Kattan , Pravin Kotian
IPC分类号： A61K31/4015 , C07D207/12
CPC分类号： C07D277/60 , C07D207/12 , C07D207/16 , C07D417/06
摘要： Two syntheses are provided; one for the preparation of (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol, and other for the preparation of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol. (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is prepared using the achiral ylide prepared from benzylamine instead of phenethylamine (Scheme 3) which provides a crystalline intermediate. The synthesis of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is achieved from (S)-diethylmalate as described in Scheme 4. A process for preparing camphor sultam is also provided.
摘要翻译：提供两个合成; （3R，4R）-4-（羟基甲基）吡咯烷-3-醇等制备（3S，4R）-4-（羟基甲基）吡咯烷-3-醇的化合物。（3R，4R）-4-（羟甲基）吡咯烷-3-醇使用由苄胺代替苯乙胺制备的非手性叶立德制备（方案3），其提供了结晶中间体。（3S，4R）-4-（羟甲基）吡咯烷-3-醇的合成如方案4所述从（S） - 二乙基苹果酸得到。还提供了制备樟脑磺酸钠的方法。

5. 发明申请

US20070099942A1 AZA nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases 有权
公开(公告)号：US20070099942A1
公开(公告)日：2007-05-03
申请号：US11157867
申请日：2005-06-22
申请人： Yarlagadda Babu , Pooran Chand , Ajit Ghosh , Pravin Kotian , V. Kumar
发明人： Yarlagadda Babu , Pooran Chand , Ajit Ghosh , Pravin Kotian , V. Kumar
IPC分类号： A61K31/519 , C07D487/02 , C07F7/02
CPC分类号： C07D487/04 , C07D491/048 , C07F9/6561
摘要： Compounds represented by the formula: , and pharmaceutically acceptable salts thereof and prodrugs thereof; wherein R1 is H, CH3, C2H5, C3H7 R2 is H, CH3, C2H5, C3H7, CH═CH2, CH2—OH, CH2F, CF3 R′2 is H, OH, NH2, NH-alkyl, F, N3, OCH3, O—C(O)CH(NH2)alkyl R3 is H, CH3, C2H5, C3H7 R′3 is H, OH, NH2, NH-alkyl, F, N3, OCH3, O—C(O)CH(NH2)alkyl R4 is H, CH3, C2H5, C3H7 At least one of R2, R3, or R4 has to be other than H, when X═NH in B R6 is H, CH3, C2H5, R7 is selected from H, alkyl, alkenyl, aryl, acyloxyalkyl, and pivaloyloxyalkyl, aminoacids, CH2CH2SC(O)alkyl; and B is represented by the following structure: X is independently NR6, O, S, R8 and R9 independently is H, NH2, OH, SH, F, Cl, Br, I, aryl, heterocycle, alkyl, alkene, alkyne, S-alkyl, S-aryl, S(O)-alkyl, SO2-alkyl, SO2NH2, SO2NH-alkyl, SO2NH-aryl, NH-alkyl, NH-aryl, N(alkyl)2, N(aryl)2, O-alkyl, O-aryl, O-heterocycle, NH-(CH2)n-aryl, NH—C(O)-alkyl, NH—C(O)-aryl are useful for inhibiting viral RNA polymerases and treating patients suffering from diseases caused by various RNA viruses.

6. 发明授权

US07994139B2 Antiviral therapeutic agents 失效
标题翻译：抗病毒治疗剂
公开(公告)号：US07994139B2
公开(公告)日：2011-08-09
申请号：US12398866
申请日：2009-03-05
申请人： Yarlagadda S. Babu , Pooran Chand , Pravin Kotian , Minwan Wu , V. Satish Kumar
发明人： Yarlagadda S. Babu , Pooran Chand , Pravin Kotian , Minwan Wu , V. Satish Kumar
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C12N9/99 , C07D487/06 , C07D491/06 , C07D498/06 , C12N9/1241
摘要： The invention provides compounds of Formula I: as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
摘要翻译：本发明提供式I化合物：如本文所述，以及包含该化合物的药物组合物，以及可用于制备化合物的合成方法和中间体。式（I）的化合物可用作抗病毒剂和/或作为抗癌剂。

7. 发明申请

US20120142617A1 ANTIVIRAL THERAPEUTIC AGENTS 审中-公开
标题翻译：抗病毒治疗药物
公开(公告)号：US20120142617A1
公开(公告)日：2012-06-07
申请号：US13181078
申请日：2011-07-12
申请人： Yarlagadda S. Babu , Pooran Chand , Pravin Kotian , Minwan Wu , V. Satish Kumar
发明人： Yarlagadda S. Babu , Pooran Chand , Pravin Kotian , Minwan Wu , V. Satish Kumar
IPC分类号： A61K31/706 , C07H11/04 , A61K31/7068 , A61P35/00 , C12N9/99 , C07H7/06 , A61P31/12
CPC分类号： C12N9/99 , C07D487/06 , C07D491/06 , C07D498/06 , C12N9/1241
摘要： The invention provides compounds of Formula I: as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
摘要翻译：本发明提供式I化合物：如本文所述，以及包含该化合物的药物组合物，以及可用于制备化合物的合成方法和中间体。式（I）的化合物可用作抗病毒剂和/或作为抗癌剂。

8. 发明申请

US20090227524A1 ANTIVIRAL THERAPEUTIC AGENTS 失效
标题翻译：抗病毒治疗药物
公开(公告)号：US20090227524A1
公开(公告)日：2009-09-10
申请号：US12398866
申请日：2009-03-05
申请人： Yarlagadda S. Babu , Pooran Chand , Pravin Kotian , Minwan Wu , V. Satish Kumar
发明人： Yarlagadda S. Babu , Pooran Chand , Pravin Kotian , Minwan Wu , V. Satish Kumar
IPC分类号： A61K31/7052 , C07H7/00 , C12N9/99 , A61P35/00 , A61P31/12
CPC分类号： C12N9/99 , C07D487/06 , C07D491/06 , C07D498/06 , C12N9/1241
摘要： The invention provides compounds of Formula I: as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents.
摘要翻译：本发明提供式I化合物：如本文所述，以及包含该化合物的药物组合物，以及可用于制备化合物的合成方法和中间体。式（I）的化合物可用作抗病毒剂和/或作为抗癌剂。

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