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1. 发明申请

US20090227658A1 Methods and compositions for immunization against hiv 审中-公开
标题翻译：用于免疫接种的方法和组合物
公开(公告)号：US20090227658A1
公开(公告)日：2009-09-10
申请号：US10570512
申请日：2003-10-17
申请人： Yaoxing Huang , David D. Ho , Zhiwei Chen
发明人： Yaoxing Huang , David D. Ho , Zhiwei Chen
IPC分类号： A61K31/7088 , C12N15/63
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C07K2319/00 , C12N7/00 , C12N15/86 , C12N2710/24043 , C12N2710/24143 , C12N2740/16043 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates to nucleic acid and attenuated vaccinia vectors for prophylactic use against HIV infection, as well as methods of eliciting immune responses in subjects susceptible to HIV infection. The prophylactic vaccine regimen of the invention involves immunological priming with an inoculum comprising two novel DNA vectors, followed by boosting with a Modified Vaccinia Ankara (MVA) recombinant viral vector expressing the corresponding HIV proteins.
摘要翻译：本发明涉及用于预防HIV感染的核酸和减毒痘苗载体，以及在易感HIV感染的受试者中引发免疫应答的方法。本发明的预防性疫苗方案涉及用包含两种新型DNA载体的接种物进行免疫引发，随后用表达相应的HIV蛋白质的修饰的痘苗安卡拉（MVA）重组病毒载体进行加强。

2. 发明申请

US20100041740A1 FLU VACCINES AND METHODS OF USE THEREOF 有权
标题翻译：流感疫苗及其使用方法
公开(公告)号：US20100041740A1
公开(公告)日：2010-02-18
申请号：US12417556
申请日：2009-04-02
申请人： Chi-Huey Wong , David D. Ho , Yaoxing Huang , Ting-Jen R. Cheng , Ming Wei Chen , Alice Yu
发明人： Chi-Huey Wong , David D. Ho , Yaoxing Huang , Ting-Jen R. Cheng , Ming Wei Chen , Alice Yu
IPC分类号： A61K31/7088 , C07H21/04 , C07K16/00 , C12N15/63
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/505 , A61K2039/53 , A61K2039/58 , A61K2039/70 , C07K14/005 , C07K16/1018 , C07K2317/76 , C12N2760/16122 , C12N2760/16134
摘要： This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for influenza viral infection.
摘要翻译：本公开特别涉及多核苷酸，多肽，载体，细胞和包含其的组合物，以及它们在影响病毒发病机理中的用途，特别是针对流感病毒感染的用途。

3. 发明授权

US08030029B2 Flu vaccines and methods of use thereof 有权
公开(公告)号：US08030029B2
公开(公告)日：2011-10-04
申请号：US12011032
申请日：2008-01-23
申请人： David D. Ho , Yaoxing Huang , Ming Wei Chen , Rachel TJ Cheng , Chi-Huey Wong , Alice Yu
发明人： David D. Ho , Yaoxing Huang , Ming Wei Chen , Rachel TJ Cheng , Chi-Huey Wong , Alice Yu
IPC分类号： C12N15/44 , A61K48/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K2039/53 , A61K2039/58 , C12N2760/16122 , C12N2760/16134
摘要： This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for influenza viral infection.

4. 发明申请

US20090060949A1 Flu vaccines and methods of use thereof 有权
标题翻译：流感疫苗及其使用方法
公开(公告)号：US20090060949A1
公开(公告)日：2009-03-05
申请号：US12011032
申请日：2008-01-23
申请人： David D. Ho , Yaoxing Huang , Ming Wei Chen , Rachel T.J. Cheng , Chi-Huey Wong , Alice Yu
发明人： David D. Ho , Yaoxing Huang , Ming Wei Chen , Rachel T.J. Cheng , Chi-Huey Wong , Alice Yu
IPC分类号： A61K39/145 , C07H21/04 , C07K14/00 , C07K16/08 , A61P37/04 , C12N15/09 , C12N15/64 , A61K31/711
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K2039/53 , A61K2039/58 , C12N2760/16122 , C12N2760/16134
摘要： This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for influenza viral infection.
摘要翻译：本公开特别涉及多核苷酸，多肽，载体，细胞和包含其的组合物，以及它们在影响病毒发病机理中的用途，特别是针对流感病毒感染的用途。

5. 发明授权

US07981428B2 Flu vaccines and methods of use thereof 有权
标题翻译：流感疫苗及其使用方法
公开(公告)号：US07981428B2
公开(公告)日：2011-07-19
申请号：US12417556
申请日：2009-04-02
申请人： Chi-Huey Wong , David D. Ho , Yaoxing Huang , Ting-Jen R. Cheng , Ming Wei Chen , Alice Yu
发明人： Chi-Huey Wong , David D. Ho , Yaoxing Huang , Ting-Jen R. Cheng , Ming Wei Chen , Alice Yu
IPC分类号： A61K39/145 , A61K48/00 , C12N15/44 , C12N7/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/505 , A61K2039/53 , A61K2039/58 , A61K2039/70 , C07K14/005 , C07K16/1018 , C07K2317/76 , C12N2760/16122 , C12N2760/16134
摘要： This disclosure is directed, inter alia, to polynucleotides, polypeptides, vectors, cells and compositions comprising the same, and their use in affecting viral pathogenesis, in particular for influenza viral infection.
摘要翻译：本公开特别涉及多核苷酸，多肽，载体，细胞和包含其的组合物，以及它们在影响病毒发病机理中的用途，特别是针对流感病毒感染的用途。

6. 发明授权

US06235504B1 Methods for identifying genomic equivalent markers and their use in quantitating cells and polynucleotide sequences therein 有权
标题翻译：用于鉴定基因组等同标记物的方法及其在定量其中的细胞和多核苷酸序列中的用途
公开(公告)号：US06235504B1
公开(公告)日：2001-05-22
申请号：US09481288
申请日：2000-01-11
申请人： Linqi Zhang , Sharon R. Lewin , Leondios Kostrikis , David D. Ho
发明人： Linqi Zhang , Sharon R. Lewin , Leondios Kostrikis , David D. Ho
IPC分类号： C12P1934
CPC分类号： C12Q1/705 , C12Q1/6851 , C12Q1/6883 , C12Q1/703 , C12Q2600/156 , C12Q2600/16
摘要： Methods for identifying genetic sequences useful as genomic equivalent markers for organisms are described. The method involves determining the ratio of the absolute number of copies of wild type and mutant amplicons in a number of samples from organisms heterozygous for the mutation. After establishing the number of copies of a particular genetic sequence per genome, the sequence may be used as a measure of the number of genomes per sample, in order to normalize the analysis of another target sequence to abundance per cell. By way of example, the CCR5 gene was shown to be present at 2 copies per genome, and used to measure the number of copies per cell of HIV-1 provirions, human herpesvirus-8, and &agr; deletion circles, a measure of recent thymic emigrants for assessing immune reconstitution. The genomic equivalent marker may be use to identify other genomic equivalent markers based on their copy number in proportion to a previously established marker; by way of example the copy number of the &bgr;-actin gene was found to be 16 copies per genome. The genomic equivalent marker may also be use to determine number of cells in a sample, such as from a tissue sample.
摘要翻译：描述用于鉴定用作生物体的基因组等效标记物的遗传序列的方法。该方法包括确定在突变中杂合的生物体的数量的样品中野生型和突变型扩增子的绝对数量的比例。在确定每个基因组特定遗传序列的拷贝数之后，该序列可以用作每个样品的基因组数量的量度，以便将另一个靶序列的分析归一化为每个细胞丰度。举例来说，CCR5基因显示以每个基因组2个拷贝存在，并用于测量HIV-1发病细胞，人疱疹病毒-8和α缺失圈的每个细胞的拷贝数，这是最近胸腺的量度移民用于评估免疫重建。基因组等价标记可用于基于其与先前建立的标记成比例的拷贝数来鉴定其他基因组等价标记; 通过实例，发现β-肌动蛋白基因的拷贝数为每个基因组16个拷贝。基因组等同标记物也可用于确定样品中的细胞数，例如来自组织样品。

7. 发明申请

US20110086053A1 Glycolipids And Analogues Thereof As Antigens For NKT Cells 有权
标题翻译：糖脂及其类似物作为NKT细胞的抗原
公开(公告)号：US20110086053A1
公开(公告)日：2011-04-14
申请号：US12958996
申请日：2010-12-02
申请人： Moriya Tsuji , David D. Ho , Chi-Huey Wong , Douglass Wu , Masakazu Fujio , Xiangming Li
发明人： Moriya Tsuji , David D. Ho , Chi-Huey Wong , Douglass Wu , Masakazu Fujio , Xiangming Li
IPC分类号： A61K39/00 , C07H15/203 , C07H15/26 , C07H15/24 , A61P37/02
CPC分类号： C07H15/04 , A61K39/39 , C07H15/10
摘要： This invention relates to immunogenic compounds which serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.
摘要翻译：本发明涉及用作NKT（天然杀伤T）细胞的配体的免疫原性化合物及其在调节免疫应答中的应用。

8. 发明授权

US07534434B2 Glycolipids and analogues thereof as antigens for NK T cells 有权
标题翻译：糖脂及其类似物作为NK T细胞的抗原
公开(公告)号：US07534434B2
公开(公告)日：2009-05-19
申请号：US11317900
申请日：2005-12-27
申请人： Moriya Tsuji , David D. Ho , Chi-Huey Wong , Doug Wu , Masakazu Fujio
发明人： Moriya Tsuji , David D. Ho , Chi-Huey Wong , Doug Wu , Masakazu Fujio
IPC分类号： A61K39/00 , C07H17/02
CPC分类号： C07H15/06 , C07H15/00 , C07H15/18 , C07H15/26
摘要： This invention relates to immunogenic compounds which may serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.
摘要翻译：本发明涉及可用作NKT（天然杀伤T）细胞的配体的免疫原性化合物及其用于调节免疫应答的方法。

9. 发明申请

US20080318204A1 Highly-Sensitive Genomic Assays Employing Chimeric Bacteriophage Standards 审中-公开
标题翻译：采用嵌合噬菌体标准的高度敏感的基因组测定
公开(公告)号：US20080318204A1
公开(公告)日：2008-12-25
申请号：US10497828
申请日：2002-12-04
申请人： Linqi Zhang , David D. Ho
发明人： Linqi Zhang , David D. Ho
IPC分类号： C12Q1/70 , C12N7/00
CPC分类号： C12N7/00 , C12N2730/10122 , C12N2795/14111 , C12N2795/14143 , C12Q1/706 , C12Q2561/113 , C12Q2545/114 , C12Q2545/101
摘要： Methods are provided for sensitively quantitating at least one pre-selected DNA sequence in a biological sample utilizing hybridization methodology, the method employing as an internal standard an infectious bacteriophage particle comprising a detectable target DNA sequence other than that present in the pre-selected DNA sequence or in DNA quantitated from the biological sample, and as an external standard, an infectious bacteriophage particle comprising at least the pre-selected DNA sequence.
摘要翻译：提供了使用杂交方法灵敏定量生物样品中至少一个预先选择的DNA序列的方法，该方法使用包含可检测的靶DNA序列的感染性噬菌体颗粒作为内标，所述感染性噬菌体颗粒除了存在于预先选择的DNA序列之外或在生物样品中定量的DNA中，并且作为外部标准，是至少包含预先选择的DNA序列的感染性噬菌体颗粒。

10. 发明申请

US20150166662A1 GLYCAN-MODIFIED ANTI-CD4 ANTIBODIES FOR HIV PREVENTION AND THERAPY 有权
标题翻译：用于HIV预防和治疗的GLYCAN修饰的抗CD4抗体
公开(公告)号：US20150166662A1
公开(公告)日：2015-06-18
申请号：US14132667
申请日：2013-12-18
申请人： Ruijiang Song , David D. Ho
发明人： Ruijiang Song , David D. Ho
IPC分类号： C07K16/28
CPC分类号： C07K16/2812 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/41 , C07K2317/76
摘要： Disclosed herein are glycan-modified anti-CD4 monoclonal antibodies with N-linked glycans attached to the variable region. Expression vectors and cell lines useful for the production of such antibodies, and use of such antibodies for HIV prevention and therapy are also disclosed.
摘要翻译：本文公开了具有连接到可变区的N-连接聚糖的聚糖修饰的抗CD4单克隆抗体。还公开了可用于产生这种抗体的表达载体和细胞系，以及使用这种抗体用于HIV预防和治疗。

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