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1. 发明授权

US07884107B2 Substituted piperidines that increase P53 activity and the uses thereof 有权
标题翻译：增加P53活性的替代哌啶及其用途
公开(公告)号：US07884107B2
公开(公告)日：2011-02-08
申请号：US11769030
申请日：2007-06-27
申请人： Yao Ma , Brian Robert Lahue , Gerald W. Shipps, Jr. , Yaolin Wang , Stephane L. Bogen , Matthew Ernst Voss , Latha G. Nair , Yuan Tian , Ronald J. Doll , Zhuyan Guo , Corey O. Strickland , Rumin Zhang , Mark A. McCoy , Weidong Pan , Elise M. Siegel , Craig R. Gibeau
发明人： Yao Ma , Brian Robert Lahue , Gerald W. Shipps, Jr. , Yaolin Wang , Stephane L. Bogen , Matthew Ernst Voss , Latha G. Nair , Yuan Tian , Ronald J. Doll , Zhuyan Guo , Corey O. Strickland , Rumin Zhang , Mark A. McCoy , Weidong Pan , Elise M. Siegel , Craig R. Gibeau
IPC分类号： A61K31/54 , C07D413/00 , C07D403/00 , C07D405/00
CPC分类号： C07D409/14 , C07D401/06 , C07D401/14
摘要： In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明公开了作为HDM2蛋白的制备方法的抑制剂的新型化合物，包括一种或多种这样的化合物的药物组合物，治疗，预防，抑制与HDM2蛋白相关的一种或多种疾病的方法或P53使用这些化合物或药物组合物。

2. 发明授权

US08859776B2 Substituted piperidines that increase p53 activity and the uses thereof 有权
标题翻译：增加p53活性的替代哌啶及其用途
公开(公告)号：US08859776B2
公开(公告)日：2014-10-14
申请号：US13501685
申请日：2010-10-05
申请人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Gerald W. Shipps, Jr. , Malcolm MacCoss
发明人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Gerald W. Shipps, Jr. , Malcolm MacCoss
IPC分类号： C07D401/00 , A01N43/40 , C07D401/14 , C07D409/14
CPC分类号： C07D401/14 , C07D409/14
摘要： The present invention provides a compound of Formula 1 as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译：本发明提供本文所述的式1的化合物或其药学上可接受的盐，溶剂合物或酯。该化合物可用作HDM2蛋白的抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。

3. 发明申请

US20120208844A1 SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF 有权
标题翻译：增加P53活性的替代品PIPERIDIN及其用途
公开(公告)号：US20120208844A1
公开(公告)日：2012-08-16
申请号：US13501685
申请日：2010-10-05
申请人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Cynthia Seidel-Dugan , Gerald W. Shipps, JR. , Malcolm MacCoss
发明人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Cynthia Seidel-Dugan , Gerald W. Shipps, JR. , Malcolm MacCoss
IPC分类号： A61K31/4545 , A61P35/02 , A61P35/00 , C07D409/14 , C07D401/14
CPC分类号： C07D401/14 , C07D409/14
摘要： The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译：本发明提供本文所述的式（1）化合物或其药学上可接受的盐，溶剂合物或酯。该化合物可用作HDM2蛋白的抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。

4. 发明申请

US20080004287A1 Substituted Piperidines that Increase P53 Activity and the Uses Thereof 有权
标题翻译：增加P53活性及其用途的替代哌啶子
公开(公告)号：US20080004287A1
公开(公告)日：2008-01-03
申请号：US11769030
申请日：2007-06-27
申请人： Yao Ma , Brian Lahue , Gerald Shipps , Yaolin Wang , Stephane Bogen , Matthew Voss , Latha Nair , Yuan Tian , Ronald Doll , Zhuyan Guo , Corey Strickland , Rumin Zhang , Mark McCoy , Weidong Pan , Elise Siegel , Craig Gibeau
发明人： Yao Ma , Brian Lahue , Gerald Shipps , Yaolin Wang , Stephane Bogen , Matthew Voss , Latha Nair , Yuan Tian , Ronald Doll , Zhuyan Guo , Corey Strickland , Rumin Zhang , Mark McCoy , Weidong Pan , Elise Siegel , Craig Gibeau
IPC分类号： A61K31/497 , A61P43/00 , C07D401/14
CPC分类号： C07D409/14 , C07D401/06 , C07D401/14
摘要： In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明公开了作为HDM2蛋白的抑制剂的新化合物，制备这些化合物的方法，包含一种或多种这样的化合物的药物组合物，治疗，预防，抑制与HDM2相关的一种或多种疾病的方法蛋白质或P53使用这些化合物或药物组合物。

5. 发明申请

US20140315916A1 MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF 有权
标题翻译：增加p53活性及其用途的MACROCYCLES
公开(公告)号：US20140315916A1
公开(公告)日：2014-10-23
申请号：US14354303
申请日：2012-10-23
申请人： Latha G. Nair , Stephane L. Bogen , Ronald J. Doll , Yao Ma , Yuan Tian
发明人： Latha G. Nair , Stephane L. Bogen , Ronald J. Doll , Yao Ma , Yuan Tian
IPC分类号： C07D498/14
CPC分类号： C07D498/14 , C07D409/14
摘要： The present invention provides a compound of Formula (1): as described herein or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译：本发明提供式（1）的化合物：如本文所述或其药学上可接受的盐或溶剂化物。该化合物可用作HDM2蛋白的抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。

6. 发明授权

US08987274B2 Macrocycles that increase p53 activity and the uses thereof 有权
标题翻译：增加p53活性的大环化合物及其用途
公开(公告)号：US08987274B2
公开(公告)日：2015-03-24
申请号：US14354303
申请日：2012-10-23
申请人： Latha G. Nair , Stephane L. Bogen , Ronald J. Doll , Yao Ma , Yuan Tian
发明人： Latha G. Nair , Stephane L. Bogen , Ronald J. Doll , Yao Ma , Yuan Tian
IPC分类号： A61K31/497 , C07D498/14 , C07D409/14
CPC分类号： C07D498/14 , C07D409/14
摘要： The present invention provides a compound of Formula (1): as described herein or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译：本发明提供式（1）的化合物：如本文所述或其药学上可接受的盐或溶剂化物。该化合物可用作HDM2蛋白的抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。

7. 发明授权

US09967254B2 Dynamically selecting a DHCP server for a client terminal 有权
公开(公告)号：US09967254B2
公开(公告)日：2018-05-08
申请号：US14352058
申请日：2012-08-24
申请人： Yuan Tian , Hongqiang Yu
发明人： Yuan Tian , Hongqiang Yu
IPC分类号： H04L29/06 , H04L29/12
CPC分类号： H04L63/10 , H04L61/2015 , H04L63/0869
摘要： Dynamically selecting a DHCP server for a DHCP client terminal device may include triggering, by a network device, an authentication performed by an authentication server on a DHCP client terminal device user when receiving a DHCP packet for requesting a configuration parameter sent from a DHCP client terminal device, receiving, by the network device, an identity of a DHCP server designated by the authentication server for the DHCP client terminal device user when the DHCP client terminal device user passes the authentication, and establishing an entry for user information of the DHCP client terminal device user and the identity of the designated DHCP server, and matching, by the network device, the user information carried in a packet with established entries when receiving the packet subsequently sent from the DHCP client terminal device, and forwarding the packet using the identity of the DHCP server in the entry matching the user information.

8. 发明申请

US20140135408A1 SILICONE CONTAINING MONOMERS WITH HYDROPHILIC END GROUPS 审中-公开
标题翻译：含硅胶的单体含有疏水末端基团
公开(公告)号：US20140135408A1
公开(公告)日：2014-05-15
申请号：US13982713
申请日：2012-02-01
申请人： Shanger Wang , Xuwei Jiang , Yuan Tian
发明人： Shanger Wang , Xuwei Jiang , Yuan Tian
IPC分类号： G02B1/04
CPC分类号： G02B1/043 , C07F7/0838 , C07F7/1804 , C07F9/091 , C07F9/092 , C07F9/65742 , C08G77/045 , C08G77/12 , C08G77/16 , C08G77/20 , C08G77/38 , C08G77/388 , C08G77/392 , C08G77/395 , C08K5/5425 , C08L101/14 , C08L83/04 , C08F2230/085 , C08F220/20 , C08F220/54 , C08F2220/286
摘要： Silicone containing reactive monomers with hydrophilic end-groups of formula I useful in the manufacture of biocompatible medical devices are disclosed, wherein R1 is H or CH3, a is 0 or 1, p is an integer from 1 to 6, q is an integer from 1 to 3 and for each q, the end groups R51, R52, R53 are independently an alkyl, alkyl ether, trimethylsiloxy group, or a substituted or non-substituted aromatic group and at least one of them has a hydrophilic group attached, preferably to the terminal end of R51, R52, R53, X is O or NR54, where R54 is H or a monovalent alkyl group with 1 to 4 carbons, n is an integer from 1 to 100, R2 and R3 are independently an alkyl, alkyl ether, or a substituted or non-substituted aromatic group, preferred R2 and R3 include methyl, ethyl, and phenyl, L is a divalent linker comprising substituted and unsubstituted alkylene groups having 1-14 carbon atoms, which may be straight or branched, substituted and unsubstituted alkoxy groups having 2-12 carbons, polyethers, oxazolines, and substituted and unsubstituted heterocyclic groups. Suitable substituents include aryl, amine, ether, amide, hydroxyl groups, combinations thereof and the like. In another embodiment, L comprises a straight or branched alkylene group having 2 to 12 carbons. The reactive monomers combine oxygen permeable silicone components with hydrophilic terminal groups capable of reaching to the device-bio-logic interface thus providing bulk and surface characteristics useful in the manufacture of medical devices, particularly ophthalmic devices.
摘要翻译：公开了含有亲水性末端基团的含有有机硅的反应性单体，其可用于制造生物相容性医疗器械，其中R1为H或CH3，a为0或1，p为1至6的整数，q为 1至3，对于q，端基R 51，R 52，R 53独立地为烷基，烷基醚，三甲基甲硅烷氧基或取代或未取代的芳族基团，并且其中至少一个具有连接的亲水基团，优选至 R51，R52，R53，X的末端是O或NR54，其中R54是H或具有1至4个碳的一价烷基，n是1到100的整数，R2和R3独立地是烷基，烷基醚，或取代或未取代的芳族基团，优选的R 2和R 3包括甲基，乙基和苯基，L是包含具有1-14个碳原子的取代和未取代的亚烷基的二价连接基，其可以是直链或支链的，取代的和具有2-12个碳原子的未取代的烷氧基，聚醚，恶唑啉，以及取代和未取代的杂环基。合适的取代基包括芳基，胺，醚，酰胺，羟基，它们的组合等。在另一个实施方案中，L包含具有2至12个碳的直链或支链亚烷基。反应性单体将透氧硅氧烷组分与能够达到器件 - 生物逻辑界面的亲水端基组合，从而提供用于制造医疗装置，特别是眼用装置的体积和表面特性。

9. 发明授权

US08576785B2 Method of wireless communication using authentication information 有权
标题翻译：使用认证信息的无线通信方法
公开(公告)号：US08576785B2
公开(公告)日：2013-11-05
申请号：US12339505
申请日：2008-12-19
申请人： Abtin Keshavarzian , Yuan Tian , Lakshmi Venkatraman
发明人： Abtin Keshavarzian , Yuan Tian , Lakshmi Venkatraman
IPC分类号： H04W4/00
CPC分类号： H04W12/10 , H04L63/123 , H04L67/12
摘要： A data communication method includes providing a sender node having a data packet of information. The data packet includes at least one first field and a second field. The second field has content that is dependent upon actual content of the at least one first field. The content of the second field of the data packet is transmitted from the sender node to a receiver node. The receiver node is used to predict the actual content of the first field of the data packet. The receiver node is used to calculate the content of the second field of the data packet based upon the predicted content of the first field. The predicted content of the first field is confirmed to be equivalent to the actual content of the first field. The confirming step includes comparing the calculated content of the second field to the transmitted content of the second field.
摘要翻译：数据通信方法包括提供具有信息的数据分组的发送者节点。数据分组包括至少一个第一场和第二场。第二字段具有取决于至少一个第一字段的实际内容的内容。数据分组的第二字段的内容从发送方节点发送到接收方节点。接收器节点用于预测数据包的第一个字段的实际内容。接收器节点用于基于第一场的预测内容来计算数据分组的第二场的内容。确认第一场的预测内容等于第一场的实际内容。确认步骤包括将计算出的第二场内容与第二场的发送内容进行比较。

10. 发明申请

US20110207897A1 IONOMERS FOR IMPROVED COMPRESSION SET IN CERTAIN COPOLYMERS 审中-公开
标题翻译：在某些共聚物中进行改进的压缩物的衍生物
公开(公告)号：US20110207897A1
公开(公告)日：2011-08-25
申请号：US12809217
申请日：2008-12-17
申请人： Keith R. Mccrba , Robert S. Ward , Yuan Tian , Jim Yang , Keith Kurczewski
发明人： Keith R. Mccrba , Robert S. Ward , Yuan Tian , Jim Yang , Keith Kurczewski
IPC分类号： C08G77/458 , C08G18/87
CPC分类号： C08G18/61 , C08G18/0828 , C08G18/288
摘要： Block copolymer having improved compression set comprising 40-98 wt-% soft segment, 1.9-20 wt-% hard segment, and 0.05-3 wt-% monofunctional ionic endgroups. The incorporation of ionomers into diisocyanate-based thermoplastic polyurethane materials greatly improves compression set with little impact on the overall TPU formulation. A typical formulation for making the block copolymer contains 84.2% polydimethylsiloxane, 12.9% diisocyanate, 2.9% diamine chain extender, 0.15% sodium 2-[bis(2-hydroxyethyl)amino]ethylsulfonate, and 0.05% isethionic acid. The polymeric material may be configured, for instance, as a contact lens, prosthetic spinal nucleus, orthopedic bearing surface, gasket, or sealant.
摘要翻译：嵌段共聚物具有改进的压缩变形，其包含40-98重量％的软链段，1.9-20重量％的硬链段和0.05-3重量％的单官能离子端基。将离子交联聚合到二异氰酸酯基热塑性聚氨酯材料中极大地改善了对整个TPU配方影响很小的压缩永久变形。用于制备嵌段共聚物的典型制剂包含84.2％聚二甲基硅氧烷，12.9％二异氰酸酯，2.9％二胺增链剂，0.15％2- [双（2-羟乙基）氨基]乙基磺酸钠和0.05％羟乙磺酸。聚合物材料可以被配置为例如隐形眼镜，假肢脊髓核，矫形支承表面，垫圈或密封剂。

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