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1. 发明申请

US20090087549A1 SELECTIVE COATING OF FUEL CELL ELECTROCATALYST 审中-公开
标题翻译：燃料电池的选择性涂层
公开(公告)号：US20090087549A1
公开(公告)日：2009-04-02
申请号：US11862425
申请日：2007-09-27
申请人： Yanxiu Zhou , Chowdary Ramesh Koripella , Kajal Parekh
发明人： Yanxiu Zhou , Chowdary Ramesh Koripella , Kajal Parekh
IPC分类号： B05D1/18 , B05D3/00
CPC分类号： H01M4/92 , H01M4/8817 , H01M4/8828 , H01M4/8892 , H01M4/926 , H01M8/1009 , H01M8/1011 , Y02E60/523
摘要： A method is provided for selectively coating a catalyst layer (158) on an electrode of a fuel cell. A porous conductive material (154) comprising gold is formed overlying a portion of a dielectric material (114) to form the electrode. The porous conductive material (154) and the dielectric material (114) are coated with the catalyst layer (158) comprising a carbon supported platinum. The catalyst layer (158) is washed with a solvent to substantially remove the catalyst layer (158) from the dielectric material (114). Optionally, an ionomer component is diffused into the catalyst layer (158) remaining on the porous conductive material (154). The catalyst coated (158) circular channels (156) are then filled with an electrolyte layer (162).
摘要翻译：提供了一种用于在燃料电池的电极上选择性地涂覆催化剂层（158）的方法。包含金的多孔导电材料（154）形成在电介质材料（114）的一部分上方以形成电极。多孔导电材料（154）和介电材料（114）涂覆有包含碳负载的铂的催化剂层（158）。催化剂层（158）用溶剂洗涤以从电介质材料（114）基本上除去催化剂层（158）。任选地，离聚物组分扩散到保留在多孔导电材料（154）上的催化剂层（158）中。催化剂涂覆的（158）圆形通道（156）然后用电解质层（162）填充。

2. 发明授权

US09243275B1 Biosensor and method of making same 有权
公开(公告)号：US09243275B1
公开(公告)日：2016-01-26
申请号：US10888342
申请日：2004-07-09
申请人： Kalle Levon , Bin Yu , Yanxiu Zhou
发明人： Kalle Levon , Bin Yu , Yanxiu Zhou
IPC分类号： C12Q1/00 , C07K9/00 , C07K14/32 , C07K17/00 , G01N33/53
CPC分类号： C12Q1/00 , C07K9/00 , C07K14/32 , C07K17/00 , C12Q1/003 , G01N33/53 , G01N33/54353 , G01N33/5438 , G01N33/54393 , G01N33/552
摘要： Sensors suitable for the sensing/detection of biological or chemical agents may be fabricated by immobilizing biological and/or chemical recognition components (selectors or probes) on a substrate by the polymerization of a suitable monomer in the presence of the selectors or probes, for example, by Polysiloxane Monolayer Immobilization (PMI). PMI may involve the polymerization of polysiloxane onto a substrate, onto which selector molecules are adsorbed or otherwise immobilized. The resulting immobilized selector molecule may then be used to interact with specific molecules (targets) within a mixture of molecules, thereby enabling those specific molecules to be detected and/or quantified.

3. 发明申请

US20090061464A1 METHODS FOR DETECTING AND/OR QUANTIFYING A CONCENTRATION OF SPECIFIC BACTERIAL MOLECULES USING BACTERIAL BIOSENSORS 失效
标题翻译：使用细菌生物传感器检测和/或定量特异性细菌分子的浓度的方法
公开(公告)号：US20090061464A1
公开(公告)日：2009-03-05
申请号：US12176942
申请日：2008-07-21
申请人： Kalle LEVON , Bin Yu , Yanxiu Zhou
发明人： Kalle LEVON , Bin Yu , Yanxiu Zhou
IPC分类号： G01N33/554
CPC分类号： C12Q1/00 , C07K9/00 , C07K14/32 , C07K17/00 , C12Q1/003 , G01N33/53 , G01N33/54353 , G01N33/5438 , G01N33/54393 , G01N33/552
摘要： A real-time method employing a portable peptide-containing potentiometric biosensor, can directly detect and/or quantify bacterial spores. Two peptides for specific recognition of B. subtilis and B. anthracis Sterne may be immobilized by a polysiloxane monolayer immobilization (PMI) technique. The sensors translate the biological recognition event into a potential change by detecting, for example, B. subtilis spores in a concentration range of 0.08-7.3×104 CFU/ml. The sensing method exhibited highly selective recognition properties towards Bacillus subtilis spores over other kinds of spores. The selectivity coefficients of the sensors for other kinds of spores are in the range of 0-1.0×10−5. The biosensor method not only has the specificity to distinguish Bacillus subtilis spores in a mixture of B. subtilis and B. thuringiensis (thur.) Kurstaki spores, but also can discriminate between live and dead B. subtilis spores. Furthermore, the sensing method can distinguish a Bacillus subtilis 1A700 from other B. subtilis strain. Assay time may be as low as about 5 minutes for a single test. Rapid identification of B. anthracis Sterne and B. anthracis ΔAmes was also provided.
摘要翻译：采用便携式含肽电位生物传感器的实时方法可以直接检测和/或定量细菌孢子。用于特异性识别枯草芽孢杆菌和炭疽芽孢杆菌的两种肽可以通过聚硅氧烷单层固定（PMI）技术来固定。传感器通过检测例如浓度范围为0.08-7.3×10 4 CFU / ml的枯草芽孢杆菌孢子将生物识别事件转化为潜在的变化。该感测方法在其他种类的孢子上表现出对枯草芽孢杆菌孢子的高选择性识别性能。其他类型孢子的传感器的选择性系数在0-1.0x10-5的范围内。生物传感器方法不仅具有区分枯草芽孢杆菌和苏云金芽孢杆菌（Thur。）Kurstaki孢子的混合物中的枯草芽孢杆菌孢子的特异性，而且可以区分活枯枯病芽孢杆菌孢子和死枯病芽孢杆菌孢子。此外，感测方法可以将枯草芽孢杆菌1A700与其他枯草芽孢杆菌菌株区分开。单次测试的测定时间可能低至约5分钟。炭疽杆菌和炭疽杆菌的快速鉴定也提供了DeltaAmes。

4. 发明申请

US20050272105A1 Bacterial biosensors 审中-公开
标题翻译：细菌生物传感器
公开(公告)号：US20050272105A1
公开(公告)日：2005-12-08
申请号：US10888530
申请日：2004-07-09
申请人： Kalle Levon , Bin Yu , Yanxiu Zhou
发明人： Kalle Levon , Bin Yu , Yanxiu Zhou
IPC分类号： A61F13/15 , C12M1/34 , C12Q1/00 , G01N20060101 , G01N33/543 , G01N33/552 , G01N33/554 , G01N33/569
CPC分类号： C12Q1/00 , C07K9/00 , C07K14/32 , C07K17/00 , C12Q1/003 , G01N33/53 , G01N33/54353 , G01N33/5438 , G01N33/54393 , G01N33/552
摘要： A real-time, portable peptide-containing potentiometric biosensor that can directly identify bacterial spores. Two peptides for specific recognition of B. subtilis and B. anthracis Sterne may be immobilized by a polysiloxane monolayer immobilization (PMI) technique. The sensors translate the biological recognition event into a potential change by detecting, for example, B. subtilis spores in a concentration range of 0.08-7.3×104 CFU/ml. The sensor exhibited highly selective recognition properties towards Bacillus subtilis spores over other kinds of spores. The selectivity coefficients of the sensors for other kinds of spores are in the range of 0-1.0×10−5. The biosensor system not only has the specificity to distinguish Bacillus subtilis spores in a mixture of B. subtilis and B. thuringiensis (thur.) Kurstaki spores, but also can discriminate between live and dead B. subtilis spores. Furthermore, the sensor can distinguish a Bacillus subtilis 1A700 from other B. subtilis strain. Assay time may be as low as about 5 minutes for a single test. Rapid identification of B. anthracis Sterne and B. anthracis ΔAmes was also provided.
摘要翻译：一种可直接鉴定细菌孢子的实时便携式含肽电位生物传感器。用于特异性识别枯草芽孢杆菌和炭疽芽孢杆菌的两种肽可以通过聚硅氧烷单层固定（PMI）技术来固定。传感器通过检测例如浓度范围为0.08-7.3×10 4 CFU / ml的枯草芽孢杆菌孢子将生物识别事件转化为潜在的变化。传感器表现出对枯草芽孢杆菌孢子与其他种类孢子的高选择性识别性能。用于其他种类孢子的传感器的选择性系数在0-1.0×10 -5的范围内。生物传感器系统不仅具有将枯草芽孢杆菌和苏云金芽孢杆菌（thur。）Kurstaki孢子的混合物中的枯草芽孢杆菌孢子区分开的特异性，而且可以区分活枯枯病芽孢杆菌孢子和活枯草芽孢杆菌孢子。此外，传感器可以将枯草芽孢杆菌1A700与其他枯草芽孢杆菌菌株区分开来。单次测试的测定时间可能低至约5分钟。炭疽杆菌和炭疽杆菌的快速鉴定也提供了DeltaAmes。

5. 发明授权

US09594080B2 Molecular recognition matrix and method for making same 有权
标题翻译：分子识别矩阵及其制作方法
公开(公告)号：US09594080B2
公开(公告)日：2017-03-14
申请号：US12694088
申请日：2010-01-26
申请人： Yanxiu Zhou
发明人： Yanxiu Zhou
IPC分类号： G01N33/543
CPC分类号： G01N33/54386
摘要： A molecular recognition matrix which utilizes the interaction between molecular building blocks and the surface of a substrate to develop specific molecular recognition cavities.
摘要翻译：利用分子结构单元与基底表面之间的相互作用开发特定分子识别腔的分子识别矩阵。

6. 发明申请

US20160003813A1 Biosensor and method of making same 有权
标题翻译：生物传感器及其制作方法
公开(公告)号：US20160003813A1
公开(公告)日：2016-01-07
申请号：US10888342
申请日：2004-07-09
申请人： Kalle Levon , Bin Yu , Yanxiu Zhou
发明人： Kalle Levon , Bin Yu , Yanxiu Zhou
IPC分类号： G01N33/543 , C09D183/04 , C07K17/08 , G01N33/545 , G01N27/327
CPC分类号： C12Q1/00 , C07K9/00 , C07K14/32 , C07K17/00 , C12Q1/003 , G01N33/53 , G01N33/54353 , G01N33/5438 , G01N33/54393 , G01N33/552
摘要： Sensors suitable for the sensing/detection of biological or chemical agents may be fabricated by immobilizing biological and/or chemical recognition components (selectors or probes) on a substrate by the polymerization of a suitable monomer in the presence of the selectors or probes, for example, by Polysiloxane Monolayer Immobilization (PMI). PMI may involve the polymerization of polysiloxane onto a substrate, onto which selector molecules are adsorbed or otherwise immobilized. The resulting immobilized selector molecule may then be used to interact with specific molecules (targets) within a mixture of molecules, thereby enabling those specific molecules to be detected and/or quantified.
摘要翻译：适于感测/检测生物或化学试剂的传感器可以通过在选择器或探针的存在下通过合适的单体的聚合将生物和/或化学识别组分（选择器或探针）固定在基底上来制备，例如，通过聚硅氧烷单层固定（PMI）。 PMI可以涉及将聚硅氧烷聚合到底物上，在其上吸附或以其他方式固定选择分子。然后可以使得到的固定化选择分子与分子混合物中的特定分子（靶）相互作用，从而使得能够检测和/或定量那些特异性分子。

7. 发明授权

US09052310B2 Substrate imprinted universal sensors and sensors having nano-tunneling effect 有权
标题翻译：基板印制通用传感器和具有纳米隧道效应的传感器
公开(公告)号：US09052310B2
公开(公告)日：2015-06-09
申请号：US12700927
申请日：2010-02-05
申请人： Yanxiu Zhou
发明人： Yanxiu Zhou
IPC分类号： G01N33/543 , B01J20/30
CPC分类号： G01N33/54373 , B01J20/3057
摘要： A universal sensor fabrication approach, molecular substrate imprinting technique, which utilizes the interaction between molecular building blocks and the surface of a transducer to develop specific molecular recognition cavities has been established. Integration of molecular recognition cavities with the surface of a nanoscale transducer will result in a nano-tunneling effect that takes place which will provide a sensor or a device that exhibits new properties not already exhibited by either the molecular recognition cavities on a bulk transducer or the nanotransducer material. One of the new properties of this nano-tunneling effect is that a universal potentiometric molecular sensor can be fabricated and used to detect any compounds, whether they are ions or molecules, with enhanced selectivity, sensitivity, and stability when molecular recognition cavities or elements are integrated on the surface of a nanoscale transducer.
摘要翻译：已经建立了通用传感器制造方法，分子底物印记技术，其利用分子构建块和换能器表面之间的相互作用来开发特定的分子识别腔。分子识别腔与纳米级换能器的表面的集成将导致发生纳米隧道效应，其将提供传感器或器件，该传感器或器件表现出新的性质，其尚未由体传感器上的分子识别腔或纳米传感器材料。这种纳米隧道效应的新特性之一是可以制造通用电位分子传感器，并用于检测任何化合物，无论它们是离子还是分子，当分子识别腔或元素为集成在纳米尺度传感器的表面上。

8. 发明申请

US20080179191A1 TWO-STEP MOLECULAR SURFACE IMPRINTING METHOD FOR MAKING A SENSOR 审中-公开
标题翻译：用于制造传感器的两步分子表面印刷方法
公开(公告)号：US20080179191A1
公开(公告)日：2008-07-31
申请号：US11668639
申请日：2007-01-30
申请人： Yanxiu Zhou , George N. Maracas
发明人： Yanxiu Zhou , George N. Maracas
IPC分类号： C25D5/00 , B05D3/10
CPC分类号： G01N27/4035 , G01N27/333
摘要： A method is provided for detecting target molecules (60) using a surface-molecularly imprinted sensor (52) and more particularly for detecting hydroxyl containing molecules, heavy metal ions, or thiol- or dialkylamine containing molecules by integrating molecular recognition and sensor transduction. The method includes soaking a support surface (14) in a solution containing a ligand molecule with headgroups that could adsorb on the surface of a substrate, or monomer to create a monolayer, a monolayer of polymerized organosiloxane groups (16), or a conducting film on the support surface (14). Template molecules (18) are then added to the imprinting solution so as to be positioned within the sparsely formed film, wherein the template molecules (18) comprise hydroxyl containing molecules, heavy metal ions, or thiol and dialkylamine containing molecules which prevents the interaction between monomer/ligand molecules and template molecules (18). In this case, there is a competitive reaction between the hydroxyl group on the surface of substrate and hydroxyl in ethanol molecule with monomer, e.g. OTS. The template molecules (18) are removed to define cavities in the imprinted film (16).
摘要翻译：提供一种使用表面分子印迹传感器（52）检测目标分子（60）的方法，更具体地，通过整合分子识别和传感器转导来检测含羟基的分子，重金属离子或含巯基或二烷基胺的分子。该方法包括将支撑表面（14）浸泡在含有配体分子的溶液中，所述溶液具有可吸附在基材表面上的头基，或单体以形成单层，单层聚合的有机硅氧烷基团（16）或导电膜在支撑表面（14）上。然后将模板分子（18）加入到印迹溶液中以便定位在稀疏形成的膜中，其中模板分子（18）包含含羟基的分子，重金属离子或含硫醇和二烷基胺的分子，其阻止了单体/配体分子和模板分子（18）。在这种情况下，底物表面的羟基与乙醇分子中的羟基与单体之间存在竞争性反应，例如。 OTS。去除模板分子（18）以限定印刷膜（16）中的空腔。

9. 发明授权

US10495637B2 Substrate imprinted universal sensors and sensors having nano-tunneling effect 有权
公开(公告)号：US10495637B2
公开(公告)日：2019-12-03
申请号：US14705279
申请日：2015-05-06
申请人： Yanxiu Zhou
发明人： Yanxiu Zhou
IPC分类号： G01N33/543 , B01J20/30 , B29C59/00 , B29L31/00
CPC分类号： G01N33/54373 , B01J20/3057 , B29C59/002 , B29L2031/752
摘要： A universal sensor fabrication approach, molecular substrate imprinting technique, which utilizes the interaction between molecular building blocks and the surface of a transducer to develop specific molecular recognition cavities has been established. Integration of molecular recognition cavities with the surface of a nanoscale transducer will result in a nano-tunneling effect that takes place which will provide a sensor or a device that exhibits new properties not already exhibited by either the molecular recognition cavities on a bulk transducer or the nanotransducer material. One of the new properties of this nano-tunneling effect is that a universal potentiometric molecular sensor can be fabricated and used to detect any compounds, whether they are ions or molecules, with enhanced selectivity, sensitivity, and stability when molecular recognition cavities or elements are integrated on the surface of a nanoscale transducer.

10. 发明授权

US08835078B2 Proton selective membrane for solid polymer fuel cells 有权
标题翻译：用于固体聚合物燃料电池的质子选择膜
公开(公告)号：US08835078B2
公开(公告)日：2014-09-16
申请号：US12704392
申请日：2010-02-11
申请人： Yanxiu Zhou
发明人： Yanxiu Zhou
IPC分类号： H01M8/10 , C08J5/22
CPC分类号： C08J5/2237 , C08J2333/02 , C08J2333/26 , C08J2339/08 , H01M8/1023 , H01M8/1072 , H01M8/1076 , Y02E60/521 , Y02P70/56
摘要： A proton selective membrane for solid polymer electrolyte fuel cells that is produced by providing one or more template molecules, providing one or more functional monomers to interact with the template molecules, providing a cross-linking agent(s) to covalently bond polymer chains created with the template molecules and functional monomers by polymerization, providing an initiating agent to start a chemical reaction which results in an imprinted polymer, and removing the template molecules from the imprinted polymer to create a proton selective membrane.
摘要翻译：用于固体聚合物电解质燃料电池的质子选择膜，其通过提供一个或多个模板分子，提供一种或多种官能单体与模板分子相互作用而产生，提供交联剂以共价键合由通过聚合形成模板分子和官能单体，提供引发剂以开始导致印迹聚合物的化学反应，并从印迹聚合物中除去模板分子以产生质子选择性膜。

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