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1. 发明授权

US06667303B1 Aryl substituted 1,4-diazepanes and method of use thereof 失效
标题翻译：芳基取代的1,4-二氮杂环庚烷及其使用方法
公开(公告)号：US06667303B1
公开(公告)日：2003-12-23
申请号：US10208561
申请日：2002-07-30
申请人： Yansong Gu , Jeffrey Claude Pelletier
发明人： Yansong Gu , Jeffrey Claude Pelletier
IPC分类号： C07D24308
CPC分类号： C07D403/04 , C07D243/08 , C07D417/04
摘要： Aryl substituted 1,4-diazepanes are provided such as derivatives of 6-(1,4-diazepan-1-yl)benzo[cd]indol-2(1H)-one, 6-(1,4-diazepan-1-yl)acenaphthylen-1(2H)-one and 5-(1,4-diazepan-1-yl)-2H-naphtho[1,8-cd]isothiazole-1,1-dioxide. Also provided are pharmaceutical compositions containing one or more of the aryl substituted 1,4-diazepanes. The aryl substituted 1,4-diazepanes are useful for treating disorders or deficiencies associated with the 5-HT2C receptor.
摘要翻译：提供了芳基取代的1,4-二氮杂环丁烷，例如6-（1,4-二氮杂环庚烷-1-基）苯并[cd]吲哚-2（1H） - 酮，6-（1,4-二氮杂环庚烷-1-基）（2H） - 酮和5-（1,4-二氮杂环庚烷-1-基）-2H-萘并[1,8-cd]异噻唑-1,1-二氧化物。还提供含有一个或多个芳基取代的1,4-二氮杂环庚烷的药物组合物。芳基取代的1,4-二氮杂环庚烷可用于治疗与5-HT 2C受体相关的病症或缺陷。

2. 发明授权

US06534491B2 Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors 失效
标题翻译：邻氨基磺酰氨基双环杂芳基异羟肟酸作为基质金属蛋白酶和抑制剂的制备和应用
公开(公告)号：US06534491B2
公开(公告)日：2003-03-18
申请号：US09734146
申请日：2000-12-11
申请人： Jeremy I. Levin , Arie Zask , Yansong Gu , Jay D. Albright , Xuemei Du
发明人： Jeremy I. Levin , Arie Zask , Yansong Gu , Jay D. Albright , Xuemei Du
IPC分类号： C07D47102
CPC分类号： C07D401/12 , C07D215/54 , C07D409/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： This invention provides, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stroinelysins and collagenases) and TNF-&agr; converting enzyme (TACE, tumor necrosis factor-&agr;converting enzyme) which are useful for the treatment of diseases in which these enzymes are implicated.
摘要翻译：本发明提供了可用于治疗涉及这些酶的疾病的基质金属蛋白酶（例如明胶酶，丝氨酸蛋白酶和胶原酶）的非肽抑制剂和TNF-α转化酶（TACE，肿瘤坏死因子 - 共同转录酶）。

3. 发明授权

US08691284B2 Fluorinated block co-polymers 有权
标题翻译：氟化嵌段共聚物
公开(公告)号：US08691284B2
公开(公告)日：2014-04-08
申请号：US13443576
申请日：2012-04-10
申请人： Josef Peter Klein , Floyd Brian Karp , Yansong Gu , Roger Alan Sahm , Luisa Mayorga Szott
发明人： Josef Peter Klein , Floyd Brian Karp , Yansong Gu , Roger Alan Sahm , Luisa Mayorga Szott
IPC分类号： A61K33/00 , C12N5/07 , A61P17/02 , A61P7/00
CPC分类号： C12N5/0068 , C08G69/10 , C08G69/40 , C08G73/0233 , C08G73/028 , C12N2500/02 , C12N2533/30
摘要： A block co-polymer includes a water soluble carrier block; an amino acid-based or acrylic acid-based block; and the amino acid-based or acrylic acid-based block includes a fluorinated alkyl group or a fluorinated alkylene glycol group.
摘要翻译：嵌段共聚物包括水溶性载体嵌段; 基于氨基酸或丙烯酸的嵌段; 氨基酸类或丙烯酸类嵌段包括氟化烷基或氟化亚烷基二醇基。

4. 发明申请

US20120288911A1 BIOREACTOR FOR ENGINEERED TISSUE 有权
标题翻译：工程组织生物反应器
公开(公告)号：US20120288911A1
公开(公告)日：2012-11-15
申请号：US13394471
申请日：2011-05-12
申请人： Marvi A. Matos , William B. Carlson , Ivan Vesely , Yansong Gu
发明人： Marvi A. Matos , William B. Carlson , Ivan Vesely , Yansong Gu
IPC分类号： C12N11/00 , B01J19/18
CPC分类号： C12M25/16 , C12M21/08 , C12M33/00
摘要： A system for generating a tissue construct includes a mixing chamber, a piston chamber, a reaction chamber, and a pump. The mixing chamber is configured to receive a hydrogel solution and a cell suspension solution. The piston chamber includes a first piston and is configured to receive a mixture of the hydrogel solution and the cell suspension solution from the mixing chamber. The first piston is configured to push the mixture through one or more capillaries into the reaction chamber. The reaction is configured to receive the mixture and a cross-linking initiator. The pump is configured to move the mixture through the reaction chamber such that the mixture and the cross-linking initiator combine to form an encapsulated cell material.
摘要翻译：用于产生组织结构的系统包括混合室，活塞室，反应室和泵。混合室构造成接收水凝胶溶液和细胞悬液。活塞室包括第一活塞并且构造成从混合室接收水凝胶溶液和细胞悬浮液的混合物。第一活塞构造成将混合物推动通过一个或多个毛细管进入反应室。该反应被配置为接收混合物和交联引发剂。泵被配置为使混合物移动通过反应室，使得混合物和交联引发剂结合形成封装的细胞材料。

5. 发明申请

US20120202261A1 3D TROPHOBLAST MATRIX FOR PREPARING ORGAN-SPECIFIC STEM CELLS 有权
标题翻译：用于制备有机特异性干细胞的3D TROPHOBLAST MATRIX
公开(公告)号：US20120202261A1
公开(公告)日：2012-08-09
申请号：US13257949
申请日：2011-02-03
申请人： Yansong Gu
发明人： Yansong Gu
IPC分类号： C12N11/12 , C12N11/00 , C12N11/10 , C12N11/02 , C12N5/0775 , C12N5/0735 , C12N5/0797 , C12N5/078 , C12N5/079 , C12N5/071 , C12N11/04
CPC分类号： C12N5/06 , C12N5/0606 , C12N5/0657 , C12N11/04 , C12N11/08 , C12N11/10 , C12N2501/00 , C12N2502/025 , C12N2506/02 , C12N2533/30 , C12N2533/90
摘要： This disclosure relates generally to methods, apparatuses, and cellular compositions and cellular products that use a unique trophoblast-containing 3D matrix as a compartmental chamber for growing embryoid bodies that can be induced to differentiate into organ-specific cell types.
摘要翻译：本公开一般涉及使用独特的含滋养层的3D基质作为生长可诱导分化为器官特异性细胞类型的胚状体的室室的方法，装置和细胞组合物和细胞产品。

6. 发明授权

US07235569B2 Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use 失效
标题翻译：哌啶基吲哚和四氢吡啶基吲哚衍生物及其使用方法
公开(公告)号：US07235569B2
公开(公告)日：2007-06-26
申请号：US10835998
申请日：2004-04-30
申请人： Aranapakam Mudumbai Venkatesan , Osvaldo Dos Santos , Yansong Gu
发明人： Aranapakam Mudumbai Venkatesan , Osvaldo Dos Santos , Yansong Gu
IPC分类号： A61K31/4439 , A06K31/443 , C07D401/14
CPC分类号： C07D405/14 , C07D409/14 , C07D471/04
摘要： 3-Piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed. Methods of using the derivatives and compositions containing the derivatives in the prevention and/or treatment of serotonin disorders, such as depression and anxiety, are also disclosed. Additionally, processes for the preparation of 3-piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed.
摘要翻译： 3-哌啶-4-基-1H-吲哚和3-（1,2,3,6-四氢 - 吡啶-4-基）-1H-吲哚衍生物。还公开了使用含有衍生物的衍生物和组合物在预防和/或治疗5-羟色胺病症例如抑郁和焦虑中的方法。另外，公开了制备3-哌啶-4-基-1H-吲哚和3-（1,2,3,6-四氢 - 吡啶-4-基）-1H-吲哚衍生物的方法。

7. 发明申请

US20060074064A1 Tricyclic 6-alkylidene-penems as beta-lactamase inhibitors 审中-公开
标题翻译：三环6-亚烷基 - 青霉烯作为β-内酰胺酶抑制剂
公开(公告)号：US20060074064A1
公开(公告)日：2006-04-06
申请号：US11283288
申请日：2005-11-18
申请人： Aranapakam Venkatesan , Tarek Mansour , Takao Abe , Ado Mihira , Atul Agarwal , Hideki Ushirogochi , Yansong Gu , Satoshi Tamai , Fuk-Wah Sum
发明人： Aranapakam Venkatesan , Tarek Mansour , Takao Abe , Ado Mihira , Atul Agarwal , Hideki Ushirogochi , Yansong Gu , Satoshi Tamai , Fuk-Wah Sum
IPC分类号： C07D499/48 , A61K31/43 , A61K31/424
CPC分类号： C07D519/00
摘要： The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
摘要翻译：本发明提供式I化合物，药物组合物及其在有需要的患者中治疗细菌感染或疾病的用途。

8. 发明授权

US06939870B2 Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression 失效
公开(公告)号：US06939870B2
公开(公告)日：2005-09-06
申请号：US10652424
申请日：2003-08-29
申请人： Aranapakam M. Venkatesan , Jamie M. Davis , Yansong Gu
发明人： Aranapakam M. Venkatesan , Jamie M. Davis , Yansong Gu
IPC分类号： C07D401/14 , C07D471/04 , C07D417/14 , A61K31/53 , A61K31/549 , A61P25/24 , C07D403/14
CPC分类号： C07D401/14 , A61K31/4745 , A61K31/517 , A61K31/53 , A61K31/549 , C07D471/04
摘要： A compound represented by the formula I: wherein A represents the following heterocycles: and R1-9 are as defined herein, a composition containing this compound and methods for treating disorders of the serotonin-affected neurological systems utilizing such a compound or composition.

9. 发明授权

US06548524B2 Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors 失效
标题翻译：邻氨基磺酰氨基双环杂芳基异羟肟酸作为基质金属蛋白酶和TACE抑制剂的制备和应用
公开(公告)号：US06548524B2
公开(公告)日：2003-04-15
申请号：US09734140
申请日：2000-12-11
申请人： Jeremy I. Levin , Arie Zask , Yansong Gu , Jay D. Albright , Xuemei Du
发明人： Jeremy I. Levin , Arie Zask , Yansong Gu , Jay D. Albright , Xuemei Du
IPC分类号： A61K3159
CPC分类号： C07D215/54 , C07D401/12 , C07D409/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： This invention provides, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-&agr; converting enzyme (TACE. tumor necrosis factor-&agr; converting enzyme) which arc useful for the treatment of diseases in which these enzymes are implicated.
摘要翻译：本发明提供了可用于治疗这些酶涉及的疾病的基质金属蛋白酶（例如明胶酶，基质溶胶蛋白和胶原酶）和TNF-α转化酶（TACE。肿瘤坏死因子-α转化酶）的非肽抑制剂。

10. 发明授权

US5977408A Preparation and use of .beta.-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors 失效
公开(公告)号：US5977408A
公开(公告)日：1999-11-02
申请号：US944189
申请日：1997-10-06
申请人： Jeremy Ian Levin , Arie Zask , Yansong Gu
发明人： Jeremy Ian Levin , Arie Zask , Yansong Gu
IPC分类号： C07C311/29
CPC分类号： C07C311/29 , C07C2101/14
摘要： The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-.alpha. converting enzyme (TACE, tumor necrosis factor-.alpha. converting enzyme) which are useful for the treatment of diseases in which these enzymes are implicated such as arthritis, tumor growth and metastasis, angiogenesis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, proteinuria, aneurysmal aortic disease, degenerative cartilage loss following traumatic joint injury, demyelinating diseases of the nervous system, graft rejection, cachexia, anorexia, inflammation, fever, insulin resistance, septic shock, congestive heart failure, inflammatory disease of the central nervous system, inflammatory bowel disease, HIV infection, age related macular degeneration, diabetic retinopathy, proliferative vitreoretinopathy, retinopathy of prematurity, ocular inflammation, keratoconus, Sjogren's syndrome, myopia, ocular tumors, ocular angiogenesis/neovascularization.The TACE and MMP inhibiting ortho-sulfonamido aryl hydroxamic acids of the present invention are represented by the formula ##STR1## where the hydroxamic acid moiety and the sulfonamido moiety are bonded to adjacent carbons on group A where:A is a 5 to 7 membered, monocyclic, non-aromatic heterocyclic ring having from 1 to 2 heteroatoms independently selected from N, O, and S, optionally substituted by R.sup.1, R.sup.2, R.sup.3 and R.sup.4 ; a --C.sub.3 -C.sub.7 -cycloalkyl containing 0-2 double bonds and optionally substituted with R.sup.1, R.sup.2, R.sup.3 and R.sup.4 ; or --CHR.sup.5 .dbd.CHR.sup.6 --;and Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are described in the specification,and the pharmaceutically acceptable salts thereof,and the optical isomers and diastereomers thereof.

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