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1. 发明授权

US08778896B2 Levoisovalerylspiramycin I, II or III, preparations, preparation methods and uses thereof 有权
标题翻译：左旋异戊酰螺杆霉素I，II或III，其制备方法及用途
公开(公告)号：US08778896B2
公开(公告)日：2014-07-15
申请号：US13699459
申请日：2011-05-25
申请人： Yang Jiang , Yuyou Hao
发明人： Yang Jiang , Yuyou Hao
IPC分类号： A61K31/70 , C07H17/08 , C12P19/62 , C12N9/10
CPC分类号： C07H17/08 , C12N9/1029 , C12P19/62
摘要： Disclosed are levoisovalerylspiramycin I, II or III, preparations, preparing methods and uses thereof. The preparations comprise levoisovalerylspiramycin I, II or III and pharmaceutically acceptable carrier and/or adjuvant, wherein the purity of levoisovalerylspiramycin I, II or III is above 90 wt %. The levoisovalerylspiramycin I, II or III has a good antibacterial activity, and the preparations include solution for injection, powder for injection or lyophilized powder for injection.
摘要翻译：公开了左旋异戊酰螺杆霉素I，II或III，其制备方法及其用途。所述制剂包括左旋异戊酰螺杆霉素I，II或III和药学上可接受的载体和/或佐剂，其中左旋异戊酰螺杆霉素I，II或III的纯度高于90重量％。左旋异戊酰螺杆霉素I，II或III具有良好的抗菌活性，制剂包括注射溶液，注射用粉末或注射用冻干粉末。

2. 发明申请

US20130150316A1 LEVOCARRIMYCIN, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF 有权
标题翻译：左旋肉碱，药物组合物，制备方法及其用途
公开(公告)号：US20130150316A1
公开(公告)日：2013-06-13
申请号：US13699358
申请日：2011-05-25
申请人： Yang Jiang , Yuyou Hao
发明人： Yang Jiang , Yuyou Hao
IPC分类号： A61K31/7048 , A61P31/00 , A61P31/04 , C12P19/62
CPC分类号： A61K31/7048 , C07H17/08 , C12P19/62 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483 , A61K2300/00
摘要： The present invention relates to levocarrimycin, its pharmaceutical compositions, preparation methods and application. Levocarrimycin is a mixture of isovalerylspiramycin III, II and I as main components and contains some isobutyrylspiramycin III and II, butyrylspiramycin III and II, propionylspiramycin III and II, as well as acetylspiramycin III and II, among which, the content of isovalerylspiramycin III is no less than 30 wt %, the total content of isovalerylspiramycin III, II and I is no less than 60 wt %, and the content of acylspiramycin is 80-98 wt %. Specific optical rotation of said levocarrimycin is [α]D=−52°˜−57° in the solution of 0.02 g/ml chloroform at temperature of 25° C. The present invention also relates to the crystalline compound of isovalerylspiramycin III, II or I in levocarrimycin, and pharmaceutical compositions containing the said levocarrimycin. In present invention, the active components in levocarrimycin or its pharmaceutical compositions have optical activity and excellent anti-infective effect.
摘要翻译：本发明涉及左卡霉素，其药物组合物，制备方法和用途。莱卡霉素是异戊酰基螺旋霉素III，II和I作为主要成分的混合物，含有一些异丁酰基ir霉素Ⅲ和Ⅱ，丁酰yl霉素Ⅲ和Ⅳ，丙酰基ir霉素Ⅲ和Ⅳ以及乙酰ir霉素Ⅲ和Ⅳ，其中异戊酰ir霉素Ⅲ的含量为小于30重量％，异戊酰螺杆霉素III，II和I的总含量不小于60重量％，酰基丝氨酸的含量为80-98重量％。在0.02g / ml氯仿的溶液中，在25℃的温度下，所述左卡霉素的比旋光度为αD= -52°〜-57°。本发明还涉及异戊酰螺杆霉素III，II或我在左卡波霉素中的药物组合物，以及含有所述的左卡罗明珠霉素的药物组合物。在本发明中，左卡霉素或其药物组合物中的活性成分具有光学活性和优异的抗感染作用。

3. 发明授权

US09089586B2 Levocarrimycin, pharmaceutical compositions, preparation methods and uses thereof 有权
标题翻译：洛伐他汀，药物组合物，制备方法和用途
公开(公告)号：US09089586B2
公开(公告)日：2015-07-28
申请号：US13699358
申请日：2011-05-25
申请人： Yang Jiang , Yuyou Hao
发明人： Yang Jiang , Yuyou Hao
IPC分类号： A61K31/7048 , A61P31/00 , A61P31/04 , C12P19/62 , C07H17/08
CPC分类号： A61K31/7048 , C07H17/08 , C12P19/62 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483 , A61K2300/00
摘要： The present invention relates to levocarrimycin, its pharmaceutical compositions, preparation methods and application. Levocarrimycin is a mixture of isovalerylspiramycin III, II and I as main components and contains some isobutyrylspiramycin III and II, butyrylspiramycin III and II, propionylspiramycin III and II, as well as acetylspiramycin III and II, among which, the content of isovalerylspiramycin III is no less than 30 wt %, the total content of isovalerylspiramycin III, II and I is no less than 60 wt %, and the content of acylspiramycin is 80-98 wt %. Specific optical rotation of said levocarrimycin is [α]D=−52°˜−57° in the solution of 0.02 g/ml chloroform at temperature of 25° C. The present invention also relates to the crystalline compound of isovalerylspiramycin III, II or I in levocarrimycin, and pharmaceutical compositions containing the said levocarrimycin. In present invention, the active components in levocarrimycin or its pharmaceutical compositions have optical activity and excellent anti-infective effect.
摘要翻译：本发明涉及左卡霉素，其药物组合物，制备方法和用途。莱卡霉素是异戊酰基螺旋霉素III，II和I作为主要成分的混合物，含有一些异丁酰基ir霉素Ⅲ和Ⅱ，丁酰yl霉素Ⅲ和Ⅳ，丙酰基ir霉素Ⅲ和Ⅳ以及乙酰基ir霉素Ⅲ和Ⅳ，其中异戊酰ir霉素Ⅲ的含量为小于30重量％，异戊酰螺杆霉素III，II和I的总含量不小于60重量％，酰基丝氨酸的含量为80-98重量％。在0.02g / ml氯仿的溶液中，所述左卡马瑞霉素的比旋光度在25℃的温度下为[α] D = -52°〜57°。本发明还涉及异戊酰螺旋霉素III，II或我在左卡波霉素中的药物组合物，以及含有所述的左卡罗明珠霉素的药物组合物。在本发明中，左卡霉素或其药物组合物中的活性成分具有光学活性和优异的抗感染作用。

4. 发明申请

US20130065848A1 LEVOISOVALERYLSPIRAMYCIN I, II OR III, PREPARATIONS, PREPARTATION METHODS AND USES THEREOF 有权
标题翻译： LEVOISOVALERYLSPIRAMYCIN I，II或III，制备，预处理方法及其用途
公开(公告)号：US20130065848A1
公开(公告)日：2013-03-14
申请号：US13699459
申请日：2011-05-25
申请人： Yang Jiang , Yuyou Hao
发明人： Yang Jiang , Yuyou Hao
IPC分类号： A61K31/7048 , C12P19/62 , A61P31/04 , C07H17/08 , A61P31/00
CPC分类号： C07H17/08 , C12N9/1029 , C12P19/62
摘要： Disclosed are levoisovalerylspiramycin I, II or III, preparations, preparing methods and uses thereof. The preparations comprise levoisovalerylspiramycin I, II or III and pharmaceutically acceptable carrier and/or adjuvant, wherein the purity of levoisovalerylspiramycin I, II or III is above 90 wt %. The levoisovalerylspiramycin I, II or III has a good antibacterial activity, and the preparations include solution for injection, powder for injection or lyophilized powder for injection.
摘要翻译：公开了左旋异戊酰螺杆霉素I，II或III，其制备方法及其用途。所述制剂包括左旋异戊酰螺杆霉素I，II或III和药学上可接受的载体和/或佐剂，其中左旋异戊酰螺杆霉素I，II或III的纯度高于90重量％。左旋异戊酰螺杆霉素I，II或III具有良好的抗菌活性，制剂包括注射溶液，注射用粉末或注射用冻干粉末。

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