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1. 发明申请

US20060134177A1 Amphiphilic block copolymers and their use 有权
标题翻译：两亲嵌段共聚物及其用途
公开(公告)号：US20060134177A1
公开(公告)日：2006-06-22
申请号：US11314930
申请日：2005-12-20
申请人： Yan Liu , Jons Hilborn , Hendrik Haitjema , Sverker Norrby , Thom Terwee
发明人： Yan Liu , Jons Hilborn , Hendrik Haitjema , Sverker Norrby , Thom Terwee
IPC分类号： A61F2/16 , A61K31/695
CPC分类号： A61K31/695 , A61L24/046 , A61L27/34 , Y10S623/926 , C08L83/04
摘要： The present invention relates to amphiphilic block copolymers comprising at least one block of hydrophilic units and at least one block of hydrophobic units, wherein at least one hydrophobic block contains siloxane units. The present invention may be particularly useful as a tissue adhesive or as a coating for an intraocular lens (IOL). As an IOL coating, copolymers according to the invention may be used, for example, to promote tissue adhesion for the prevention of posterior capsule opacification.
摘要翻译：本发明涉及包含至少一个亲水单元嵌段和至少一个疏水单元嵌段的两亲嵌段共聚物，其中至少一个疏水嵌段含有硅氧烷单元。本发明可以特别用作组织粘合剂或用作眼内透镜（IOL）的涂层。作为IOL涂层，根据本发明的共聚物可用于例如促进组织粘连以防止后囊混浊。

2. 发明申请

US20060134173A1 Polysiloxanes, method of synthesis and ophthalmic compositions 审中-公开
标题翻译：聚硅氧烷，合成方法和眼用组合物
公开(公告)号：US20060134173A1
公开(公告)日：2006-06-22
申请号：US11303889
申请日：2005-12-16
申请人： Yan Liu , Jons Hilborn , Hendrik Haitjema
发明人： Yan Liu , Jons Hilborn , Hendrik Haitjema
IPC分类号： A61F2/16 , A61K31/695 , C07F7/02
CPC分类号： A61K31/695 , C08G77/08 , C08G77/24
摘要： A linear polysiloxane copolymer has at least one terminal hydroxyalkyl group. The copolymer is preparable by a process comprising a combination of a base-catalysed polymerisation with an acid-catalysed redistribution, and is suitable for preparing ophthalmic compositions for forming an intraocular lens in situ.
摘要翻译：线性聚硅氧烷共聚物具有至少一个末端羟烷基。共聚物可通过包括碱催化的聚合与酸催化的再分布的组合的方法制备，并且适用于制备用于原位形成眼内透镜的眼用组合物。

3. 发明授权

US09585987B2 Composition for the formation of gels 有权
标题翻译：用于形成凝胶的组合物
公开(公告)号：US09585987B2
公开(公告)日：2017-03-07
申请号：US12920117
申请日：2009-02-13
申请人： Kristoffer Bergman , Tim Bowden , Thomas Engstrand , Jons Hilborn , Dmitri Ossipov
发明人： Kristoffer Bergman , Tim Bowden , Thomas Engstrand , Jons Hilborn , Dmitri Ossipov
IPC分类号： A61K31/728 , A61L27/54 , A61L24/00 , A61L24/08 , A61L27/20 , A61L27/44 , A61L27/52 , C08B37/08 , C08J3/075 , C08L5/08 , A61K31/785 , A61K31/74
CPC分类号： A61L27/54 , A61K31/728 , A61K31/74 , A61K31/785 , A61L24/0015 , A61L24/0031 , A61L24/08 , A61L27/20 , A61L27/44 , A61L27/52 , A61L2300/602 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08
摘要： A composition, which upon activation, spontaneously forms a cross-linked hydrogel in aqueous liquid, includes: a) a formulation containing a hyluronan (HA-formulation) which includes a hyaluronan backbone (HA backbone) and a plurality of a reactive substituent group (reactive HA substituent) which i) is directly attached to the HA backbone, and ii) exhibits the reactive HA-group, and b) a formulation of a homo-multifunctional cross-linking reagent (CLR-formulation) exhibiting a plurality of a reactive group (reactive CLR-group). The two reactive groups are selected as a pair of counterparts that mutually and selectively react with each other to form a linkage structure. The hydrogel contains a cross-linking structure which a) is attached to the hyaluronan via two or more of the linkage structure and is defined by the reagent. The cross-linking structure exhibits a plurality of hydroxyl groups. The composition can be used in vivo or ex vivo as a support matrix.
摘要翻译：一种组合物，其在活化后自发地在含水液体中形成交联的水凝胶，包括：a）含有乙醛醛酸（HA-制剂）的制剂，其包括透明质酸骨架（HA骨架）和多个反应性取代基反应性HA取代基），其i）直接连接到HA骨架上，和ii）表现出反应性HA基团，和b）表现出多个反应性的多功能交联剂（CLR-制剂）组（反应性CLR组）。两个反应性基团被选择为彼此相互选择性反应以形成连接结构的一对对应物。水凝胶含有交联结构，a）通过两个或多个连接结构连接到透明质酸上，并由试剂定义。交联结构表现出多个羟基。组合物可以在体内或离体使用作为支持基质。

4. 发明申请

US20110008444A1 COMPOSITION FOR THE FORMATION OF GELS 有权
标题翻译：组合物形成凝胶
公开(公告)号：US20110008444A1
公开(公告)日：2011-01-13
申请号：US12920117
申请日：2009-02-13
申请人： Kristoffer Bergman , Tim Bowden , Thomas Engstrand , Jons Hilborn , Dmitri Ossipov
发明人： Kristoffer Bergman , Tim Bowden , Thomas Engstrand , Jons Hilborn , Dmitri Ossipov
IPC分类号： A61K9/00 , C07H5/06 , A61K47/36 , A61P43/00 , C08F216/06 , C08G69/00 , C08G65/00 , C08G63/91
CPC分类号： A61L27/54 , A61K31/728 , A61K31/74 , A61K31/785 , A61L24/0015 , A61L24/0031 , A61L24/08 , A61L27/20 , A61L27/44 , A61L27/52 , A61L2300/602 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08
摘要： A composition, which upon activation, spontaneously forms a cross-linked hydrogel in aqueous liquid, includes: a) a formulation containing a hyluronan (HA-formulation) which includes a hyaluronan backbone (HA backbone) and a plurality of a reactive substituent group (reactive HA substituent) which i) is directly attached to the HA backbone, and ii) exhibits the reactive HA-group, and b) a formulation of a homo-multifunctional cross-linking reagent (CLR-formulation) exhibiting a plurality of a reactive group (reactive CLR-group). The two reactive groups are selected as a pair of counterparts that mutually and selectively react with each other to form a linkage structure. The hydrogel contains a cross-linking structure which a) is attached to the hyaluronan via two or more of the linkage structure and is defined by the reagent. The cross-linking structure exhibits a plurality of hydroxyl groups. The composition can be used in vivo or ex vivo as a support matrix.
摘要翻译：一种组合物，其在活化后自发地在含水液体中形成交联的水凝胶，包括：a）含有乙醛醛酸（HA-制剂）的制剂，其包括透明质酸骨架（HA骨架）和多个反应性取代基反应性HA取代基），其i）直接连接到HA骨架上，和ii）表现出反应性HA基团，和b）表现出多个反应性的多功能交联剂（CLR-制剂）组（反应性CLR组）。两个反应性基团被选择为彼此相互选择性反应以形成连接结构的一对对应物。水凝胶含有交联结构，a）通过两个或多个连接结构连接到透明质酸上，并由试剂定义。交联结构表现出多个羟基。组合物可以在体内或离体使用作为支持基质。

5. 发明申请

US20060205910A1 Polyureaurethane material and method of producing a polyureaurethane material 审中-公开
标题翻译：聚脲氨酯材料及其制备方法
公开(公告)号：US20060205910A1
公开(公告)日：2006-09-14
申请号：US11076039
申请日：2005-03-10
申请人： Basse Asplund , Jons Hilborn , Torbjorn Mathisen
发明人： Basse Asplund , Jons Hilborn , Torbjorn Mathisen
IPC分类号： C08G18/00
CPC分类号： C08G18/4277 , C08G18/10 , C08G18/73 , C08G18/7621 , C08G18/7664 , C08G18/771 , C08G2230/00 , C08G18/302
摘要： The present invention relates to a linear polyureaurethane polymer, comprising in its hard blocks, at least two urea groups. The hard block of the polyureaurethane material is preferably synthesized by using diisocyante groups in the form of lysine diisocyanate (LDI). The soft block component of the polyureaurethane material is preferably poly(epsilon-caprolactone) (PCL). The invention also relates to a method of producing a polyureaurethane polymer, which in short comprises the steps of reacting a soft block component with a diisocyante group in order to prepare a prepolymer component, combining the prepolymer component with a catalyst in order to define a reaction solution and adding water to the reaction solution, preferably carried to the reaction solution in vapour phase.
摘要翻译：线性聚脲聚氨酯聚合物本发明涉及一种在其硬块中包含至少两个脲基的线型聚脲氨酯聚合物。优选通过使用赖氨酸二异氰酸酯（LDI）形式的二异氰酸酯基团来合成聚脲氨酯材料的硬块。聚脲氨酯材料的软嵌段成分优选为聚（ε-己内酯）（PCL）。本发明还涉及一种制备聚脲氨酯聚合物的方法，其中包括以下步骤：使软嵌段组分与二异氰酸酯基反应，以制备预聚物组分，将预聚物组分与催化剂组合以限定反应溶液并向反应溶液中加入水，优选以气相方式携带到反应溶液中。

6. 发明申请

US20060211839A1 Polyureaurethane material and method of producing a polyureaurethane material 审中-公开
标题翻译：聚脲氨酯材料及其制备方法
公开(公告)号：US20060211839A1
公开(公告)日：2006-09-21
申请号：US11356441
申请日：2006-02-17
申请人： Basse Asplund , Jons Hilborn , Torbjorn Mathisen
发明人： Basse Asplund , Jons Hilborn , Torbjorn Mathisen
IPC分类号： C08G18/00
CPC分类号： C08G18/10 , C08G18/4277 , C08G18/73 , C08G18/7621 , C08G18/7664 , C08G18/771 , C08G2230/00 , C08G18/302
摘要： The present invention relates to a linear polyureaurethane polymer, produced without the use of any chain extender. The hard block of the resulting polymer thus consists of diisocyante groups linked to each other via without the presence of any chain extender component. The hard block of the polyureaurethane material is preferably synthesized by using diisocyante groups in the form of lysine diisocyanate (LDI). The soft block component of the polyureaurethane material is preferably poly(epsilon-caprolactone) (PCL). The invention also relates to a method of producing a polyureaurethane polymer, which in short comprises the steps of reacting a soft block component with a diisocyante group in order to prepare a prepolymer component, combining the prepolymer component with a catalyst in order to define a reaction solution and adding water to the reaction solution, preferably carried to the reaction solution in vapour phase.
摘要翻译：本发明涉及在不使用任何扩链剂的情况下生产的线型聚脲聚氨酯聚合物。因此，所得聚合物的硬嵌段由相互连接的二异氰酸酯基组成，而不存在任何扩链剂组分。优选通过使用赖氨酸二异氰酸酯（LDI）形式的二异氰酸酯基团来合成聚脲氨酯材料的硬块。聚脲氨酯材料的软嵌段成分优选为聚（ε-己内酯）（PCL）。本发明还涉及一种制备聚脲氨酯聚合物的方法，其中包括以下步骤：使软嵌段组分与二异氰酸酯基反应，以制备预聚物组分，将预聚物组分与催化剂组合以限定反应溶液并向反应溶液中加入水，优选以气相方式携带到反应溶液中。

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